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PubMedDate not supplied

[Absorption of diethylstilbestrol (DES) by plants. Dangers of using manure of animals treated with DES].

Diethylstilboestrol, an anabolist used per os or in sub-cutaneous implants in a number of countries, but not in France, on animals of the bovine species, is absorbed by plants when spread on alfafa cultures. As this product is eliminated to a great extent through the fecal matter, its presence in fertilisers constitutes a danger to the environment, in view of its toxicity, whether direct or transmitted. This is a further reason for its use to be banned.

Absorption↗
PubMed1976

[Effect of antenatal administration of diethylstilbestrol and progesterone on the blood system of newborn rats].

The effect of sex hormones administered to pregnant women on the blood system of their progeny was revealed. The changes were noted in different portions of the system: the peripheral blood, bone marrow, spleen, liver. The sex hormones intensified the hemopoiesis in the bone marrow and the spleen of the fetus and inhibited it in the liver. The noted shifts were assessed as the process of acceleration of the functional maturation of the blood system maturation in the fetus.

Animals↗
PubMed2000

Risk factors for diethylstilbestrol-associated clear cell adenocarcinoma.

OBJECTIVE: To assess the influence of postnatal factors on the development of clear cell adenocarcinoma in women exposed to diethylstilbesterol (DES), particularly factors related to exogenous or endogenous hormone exposures, and to reassess the relation of season of birth. METHODS: For the analysis of postnatal factors, 244 cases were compared with 244 age-matched DES-exposed women. Information was obtained from telephone interviews, with questions asked in reference to an index age, the age at which clear cell adenocarcinoma was diagnosed. For the analysis of season of birth, 604 cases, living or deceased, were compared with 1749 DES-exposed women. RESULTS: Neither oral contraceptive (OC) use nor pregnancy was associated with risk of clear cell adenocarcinoma: the odds ratios (OR) were 1.1 (95% confidence interval [CI] 0.7, 1.8) for OC use and 1.3 (95% CI 0.7, 2.3) for pregnancy. The OR for fall season of birth relative to all other seasons was 1.2 (95% CI 0.9, 1.4). CONCLUSION: Pregnancy and OCs do not increase risk of DES-associated clear cell adenocarcinoma. In addition, season of birth does not appear to be a material factor; the previous finding of an increased risk for fall season of birth is most likely not valid and probably a chance finding due to small sample size.

Adenocarcinoma, Clear Cell↗