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[Hepatic abscesses: is simple aspiration puncture with echography control an alternative to catheter drainage?].

UNLABELLED: Percutaneous drainage is currently the treatment of choice in liver abscess. The most commonly used technique is catheter placement but this procedure is not free of complications. OBJECTIVE: To analyze the safety and efficacy of needle aspiration in the treatment of liver abscesses. PATIENTS AND METHODS: Non-random, prospective study of nine patients with pyogenic liver abscess who underwent simple needle aspiration with sonographic guidance. RESULTS: In all patients, aspiration identified the etiologic agent. In eight patients (88.9%) the procedure was effective and in the remaining patients, the abscess was finally drained by sonographically guided catheter placement. In five patients, aspiration was successful at the first attempt and only one abscess required more than two attempts. No complications were observed. CONCLUSIONS: In our experience, needle aspiration with sonographic guidance is safe and effective in the treatment of pyogenic liver abscesses. Use of catheters is reserved for cases of rapid reaccumulation of exudate without general improvement in the patient.

Adult↗

Use and accuracy of fine-needle aspiration cytology in histologically proven thyroid carcinoma: an audit using a national nathology database.

BACKGROUND: Fine-needle aspiration cytology is recommended as the first and most decisive diagnostic step in the workup of patients with nodular thyroid disease. METHODS: A retrospective analysis of all thyroid carcinomas diagnosed was conducted using the Netherlands Pathology Database PALGA, which covers all cytologic and histologic examinations in the Netherlands, with the aim of investigating nationwide whether fine-needle aspiration cytology of the thyroid (FNAC-t) actually had been used prior to surgery for thyroid carcinoma and if so, with what result. RESULTS: FNAC-t was used in 591 of the 890 patients (66%) analyzed, with a total of 769 aspirations (a single FNAC-t in 459 patients, multiple FNAC-ts in 132 patients). The overall sensitivity rate was 57%; when restricting the FNAC-ts to the most recent one for each patient, the sensitivity rate rose to 70%. Sensitivity was lowest for follicular carcinoma (67%) and was highest for anaplastic and medullary carcinomas (89%). Limiting these calculations to aspirations from patients with tumors > 10 mm was found to have very little influence on these rates (FNAC rate: 71%; overall sensitivity rate: 58%). CONCLUSIONS: If the application rate (66%) and sensitivity for the most recent aspiration (70%) were considered regardless of the tumor size, only 47% of the malignancies were detected by FNAC-t. When patients with tumors > 10 mm and all FNAC-ts in this group are considered, only 41% of thyroid carcinoma cases were detected cytologically. Contrary to common belief based on current guidelines for the workup of patients with nodular thyroid disease, the majority of thyroid carcinoma cases are not detected by FNAC-t.

Adolescent↗

Replace fine needle aspiration cytology with automated core biopsy in the triple assessment of breast cancer.

All patients presenting with a symptomatic breast lump are assessed by means of triple assessment (clinical examination, radiology in the form of mammography and cytology by means of a fine needle aspiration) performed by the clinician in the rapid access breast clinic at the Royal Gwent Hospital, Newport, UK. In our initial experience, it was found that a significant number of patients were returning to clinic for the results of the triple assessment to find that the cytology was not conclusive and hence needed a core biopsy, thus delaying diagnosis and definitive treatment. Therefore, a prospective study was carried out over a 6-month period, where all patients presenting with a symptomatic lump with a clinical or radiological suspicion of breast cancer had, in addition to the standard triple assessment, an automated core biopsy, thus giving rise to the quadruple assessment of the breast lump. A total of 52 patients with a clinical or radiological suspicion of breast cancer were included over this 6-month period. Of these 52 patients, 31 had a definitive diagnosis of breast cancer on fine needle aspiration (sensitivity 60%) compared with 50 of the 52 patients on core biopsy (sensitivity 96%). When radiology was diagnostic of breast cancer (R 5), the sensitivity of cytology was 61% compared with 97% with core biopsy. However, when radiology was not diagnostic of cancer (R 1-4), the sensitivity of cytology fell to 53% while the sensitivity of core biopsy remained high at 95%. The overall cellularity rate for cytology was 96%, which exceeds the BASO requirement for fine needle aspiration cytology. From these results, we conclude that automated core biopsy has a superior diagnostic power when compared with fine needle aspiration cytology and hence should replace fine needle aspiration cytology in the assessment of symptomatic breast lumps.

Biopsy↗

Percutaneous aspiration and sclerotherapy for treatment of spermatoceles.

PURPOSE: Spermatoceles are commonly treated with open surgical ablation. With the increasing shift towards minimally invasive surgery and heightened awareness, both patient and surgeon accept and prefer the less intrusive approach. Treatment of spermatoceles translates into the use of aspiration and sclerotherapy rather than open excision. We report on our prospective study of percutaneous aspiration and sclerotherapy with sodium tetradecyl sulfate for treatment of spermatoceles to determine safety, efficacy and cost-effectiveness. MATERIALS AND METHODS: Patients with symptomatic cystic scrotal lesions were prospectively enrolled in an aspiration and sclerotherapy protocol between October 1998 and June 2000. All patients underwent aspiration followed by sclerotherapy with a sodium tetradecyl sulfate solution. Followup included clinical assessment and scrotal ultrasonography at 12 weeks and on a needed basis thereafter. RESULTS: A total of 28 patients with 34 spermatoceles were enrolled in the protocol. Mean patient age was 61.0 years and mean spermatocele volume was 89.3 ml. Complete followup was available for 31 of 34 (91%) spermatoceles, and the mean duration of followup was 24.6 weeks. Results were cure in 29% success in 36%, partial success in 19% and failure in 16% of cases. Patient satisfaction was 85% and there were no complications. The total cost of each procedure was only $104 (Canadian), and none took more than 10 minutes. CONCLUSIONS: Percutaneous aspiration and sclerotherapy with sodium tetradecyl sulfate is a minimally invasive, simple, safe, inexpensive and reasonably efficacious treatment option for spermatoceles. Initial failures can be salvaged with second treatment.

Adult↗

Herpesvirus type 1-8 in sinus aspirates from HIV-infected patients and immunocompetent individuals.

Sinusitis is frequently occurring in HIV-infected patients, but in a substantial number of cases the etiology is unknown. The purpose of this study was by PCR 1) to determine the prevalence of the eight human herpesviruses in sinus aspirates from 24 HIV-positive/AIDS patients with sinusitis 2) to relate the presence of herpesvirus DNA to clinical and immunological parameters and 3) to compare the prevalence of herpesvirus DNA in sinus aspirates from HIV-infected patients with the prevalence observed in 50 immunocompetent patients with sinusitis. DNA from HSV-1, EBV, CMV and HHV-8 was detected in 8 (33%) of the sinus aspirates from HIV-infected patients. In the immunocompetent patients, one of the herpesviruses, HHV-6, was found in one sinus aspirate. These data indicate that herpesviruses are frequently found in sinus aspirates from HIV-infected patients with sinusitis, whereas they do not seem to be related to clinical signs of sinusitis in immunocompetent individuals. The cause of these discrepancies may be due to uncontrolled reactivation of herpesviruses, which is known to occur in immunocompromised individuals. It remains to be established whether the herpesviruses play a pathogenic role in the development of sinusitis in HIV-infected patients.

Adult↗

[MRI-guided transcutaneous aspiration biopsy of liver lesions].

OBJECTIVE: To evaluate the clinical application of MR-guided aspiration biopsy of liver lesions. METHODS: MR-guided aspiration biopsy of liver lesions with 0.5 T Conventional MR system and 19 gauge MRI-compatible aspiration needle was performed in 13 patients. For MR guidance, fast gradient echo sequence or fast spin echo sequence was used. RESULTS: MR-guided aspiration liver biopsy was performed successfully without any complication on all patients. The accurate needle puncture rate was 100%, accurate diagnosis rate 92.3%, and false negative rate 7.7%. CONCLUSION: MR-guided transcutaneous aspiration biopsy of liver lesions is a safe, accurate and effective method for diagnosis and differential diagnosis.

Adult↗

Correlation of fine needle aspiration cytology, smear and culture in tuberculous lymphadenitis: a prospective study.

BACKGROUND AND AIM: Bacteriological studies are necessary to confirm the diagnosis of tuberculous lymphadenitis, as cytological appearances mimic other granulomatous lesions. The objective was to assess the diagnostic role of culture of fine needle aspiration done on clinically suspected cases of tuberculous lymphadenitis and to determine the prevalence of drug resistance in M. tuberculosis isolates. SETTING AND DESIGN: A prospective, double-blind study over a period of one year in a tertiary care hospital. MATERIAL AND METHODS: Fine needle aspiration cytology and culture were done on 250 patients with clinical suspicion of tuberculous lymphadenitis. STATISTICAL ANALYSIS: Data was statistically analysed using chi square test. Sensitivity, specificity, positive predictive and negative predictive values and likelihood ratio were also calculated. RESULT: Of the 161 cytologically or microbiologically proven cases of tuberculous lymphadenitis, cytological changes consistent with tuberculosis were observed in 133 patients, out of which mycobacteria were isolated in 102 aspirates. Mycobacteria were also isolated from 28 aspirates cytologically missed as tuberculous lymphadenitis. Of the 130-mycobacterial isolates, 5 were non-tuberculous mycobacteria. Culture positivity was significantly higher (P<0.001) than smear positivity. Drug susceptibility studies showed resistance to one or more drugs in 61% of isolated strains with maximum resistance to isoniazid (16% primary and 48% secondary) and minimum to ethambutol (4% primary and 12% secondary). CONCLUSION: Culture for mycobacteria should be carried out on all aspirates from patients suspected with tuberculous lymphadenitis.

Adolescent↗

Percutaneous aspiration of fluid for management of peritonitis in space.

BACKGROUND: As a medical emergency that can affect even well-screened, healthy individuals, peritonitis developing during a long-duration space exploration mission may dictate deviation from traditional clinical practice due to the absence of otherwise indicated surgical capabilities. Medical management can treat many intra-abdominal processes, but treatment failures are inevitable. In these circumstances, percutaneous aspiration under sonographic guidance could provide a "rescue" strategy. HYPOTHESIS: Sonographically guided percutaneous aspiration of intra-peritoneal fluid can be performed in microgravity. METHODS: Investigations were conducted in the microgravity environment of NASA's KC-135 research aircraft (0 G). The subjects were anesthetized female Yorkshire pigs weighing 50 kg. The procedures were rehearsed in a terrestrial animal lab (1 G). Colored saline (500 mL) was introduced through an intra-peritoneal catheter during flight. A high-definition ultrasound system (HDI-5000, ATL, Bothell, WA) was used to guide a 16-gauge needle into the peritoneal cavity to aspirate fluid. RESULTS: Intra-peritoneal fluid collections were easily identified, distinct from surrounding viscera, and on occasion became more obvious during weightless conditions. Subjectively, with adequate restraint of the subject and operators, the procedure was no more demanding than during the 1-G rehearsals. CONCLUSIONS: Sonographically guided percutaneous aspiration of intra-peritoneal fluid collections is feasible in weightlessness. Treatment of intra-abdominal inflammatory conditions in spaceflight might rely on pharmacological options, backed by sonographically guided percutaneous aspiration for the "rescue" of treatment failures. While this risk mitigation strategy cannot guarantee success, it may be the most practical option given severe resource limitations.

Animals↗

Needle aspiration as a diagnostic tool and therapeutic modality in suppurative lymphadenitis following Bacillus Calmette Guerin vaccination.

OBJECTIVES: Outbreaks are known to occur after Bacillus Calmette Guerin (BCG) vaccination. An outbreak of suppurative lymphadenitis in 18 infants, following BCG vaccination is reported from Sikkim, with incidence of 8.6%. The outbreak occurred after a change of vaccine. METHODS: In a prospective study the cases of suppurative lymphadenitis were diagnosed by needle aspiration cytology and culture of the material aspirated and managed only with repeated needle aspiration and no antitubercular treatment was given. RESULTS: Cytomorphology revealed necrosis alone in 66.6% and necrotizing granulomas in 22.2%. Acid and alcohol fast bacilli were detected in 77.7% cases. Mycobacterium bovis was isolated in eight cases. One case of staphylococcal suppurative lymphadenitis was detected. Sixteen cases were managed with weekly aspiration with mean period of resolution in eight weeks. CONCLUSIONS: Needle aspiration is useful in the diagnosis and effective in the management of these cases. No antitubercular treatment is desired and required in the cases of suppurative lymphadenitis following BCG vaccination.

Adjuvants, Immunologic↗

[Percutaneous transthoracic fine needle aspiration of lung tumors by computed tomography examination].

Morbidity of lung cancer in Lithuania is increasing. Early diagnostics of this disease is important, difficult and necessary. During 2001, 169 patients with first and second stages of lung cancer were treated in Department of Thoracic Surgery at Kaunas Oncology Hospital. Age of patients was 30-80 years. We have analysed 20 patients with small peripheral lung tumors. Diagnosis was not confirmed by X-ray and fibrobronchoscopic examination. Percutaneous transthoracic fine needle aspiration of small lung tumors was determined by computed tomography (CT) examination. The diameter of tumors were 2.5-4.5 cm. After percutaneous transthoracic fine needle aspiration the diagnosis of lung cancer was confirmed to 15 (70.5 perc.) patients: carcinoma planocellulare - 13, Adenocarcinoma - 2 patients. Metastasis (solitary) from carcinoma renis to 1, abscessus pulmonis (necrotic masses) to 2, tuberculoma (tuberculosis) to 1 patients. After CT examination, percutaneous transthoracic fine needle aspiration and histologic examination diagnosis were confirmed: Carcinoma pulmonis stage I (T1N0M0-T2N0M0) to 5 patients, Carcinoma pulmonis stage II (T2N1M0-T3N0M0) to 9 patients, Carcinoma pulmonis III (T2N2M0) to 1 patient. There were 3 complications after percutaneous transthoracic needle aspiration: hemorrhage in tumor place to 2 patients, local pneumothorax to 1 patient. In all cases when we can not confirm diagnosis of small peripheral lung tumors we have to do CT examination and percutaneous transthoracic fine needle aspiration.

Adenocarcinoma↗

[The role of cells originating from seminal vesicles in aspiration biopsy smears of the prostate (author's transl)].

328 (30.7%) of 1068 prostatic aspirates obtained from 874 patients contained cells of seminal vesicle origin. Cells originating from the seminal vesicles were recognized in aspirates obtained from 27.6% of the untreated patients and in aspirates from 60.4% of the treated patients. Patients of the latter group had received hormonal treatment or radation therapy, or both, or had been surgically treated by prostatectomy. The occurrence of cells derived from seminal vesicles was due to the site of the needled prostatic lesion in 21% of the aspirates obtained, to treatment in 21% and to incorrect biopsy technique in the remaining 58%. A false cytologic report was made in the case of 6 aspirates (1.6%).

Biopsy, Needle↗

The diagnostic value of fine needle aspiration cytology in thyroid swellings in a university hospital, Yemen.

OBJECTIVE: To evaluate the correlation between the fine needle aspiration (FNA) cytology and the histopathological findings in cases of the thyroid swellings and to assess the accuracy of cytological examination of thyroid nodules. METHODS: This study was carried out at Kuwait University Hospital, Sana'a, Yemen. There were 243 thyroid FNAs of which 199 had subsequent excisional histopathological examination in the period 1997 to 2001. All the records of cytology and histology were reviewed. Cases were classified into 6 subsets: benign follicular lesion, thyroiditis, follicular neoplasm, suspicious for papillary carcinoma, malignant, and non-diagnostic aspirate. For statistical analysis, we excluded cases, which had not had subsequent histopathological examination (n=44), and cases with non-diagnostic aspirate (n=3), so only the histology and medical records of 196 cases were reviewed and correlated with the cytology results. RESULTS: There were 156 (78.4%) cases of benign aspirate, 31 (15.6%) cases of follicular neoplasm, 4 (2%) cases that were suspicious for papillary carcinoma, 4 (2%) cases of papillary carcinoma, and 3 (1.5%) cases of non-diagnostic aspirates. The 196 cases, which underwent cytological and histopathological examinations, were classified as non-neoplastic and neoplastic (including follicular neoplasm and malignancy) according to postoperative histopathology and correlation which, was carried out with preoperative cytology. There were 115 true negatives, 26 true positives, 42 false negatives, and 13 false positives. This gives a sensitivity of 38%, specificity of 89.9%, positive predictive value of 66.7%, negative predictive value of 73.2%, and accuracy of 72%. CONCLUSION: The sensitivity of FNA cytology in this study is very low compared to published studies, which had adversely affected the surgical decision making as well as the outcome. We should realise that negative FNA cytology does not exclude malignancy and we have to seriously evaluate the situation and to rethink on how to raise the scale of sensitivity in FNA cytology in the diagnosis of thyroid nodules, and to improve the level of expertise in cytology.

Adenoma↗

Fine needle aspiration cytology in the diagnosis of liver lesions.

BACKGROUND: Fine needle aspiration cytology (FNAC) is a less invasive, inexpensive and rapid method for pathologic evaluation of hepatic masses. This study was to investigate the role of fine needle aspiration cytology in the early diagnosis of liver disease. METHODS: Fourty-six patients received fine needle (1 mm diameter or 18G) aspiration for the diagnosis of liver disease under ultrasonography or computed tomography guidance. The diagnosis was verified by using hematoxylin and eosin (HE) staining and immunohistochemistry. RESULTS: Of the 46 patients, 19 had hepatocellular carcinoma (HCC), 2 cholangiocarcinoma, 1 lymphoma, 1 carcinoid tumor, 1 squamous cell carcinoma, 1 tuberculosis, 14 no abnormality, and 6 red blood cells. Cytological diagnosis of 3 patients was inconsistent with histological diagnosis after surgery: incorrect diagnosis (2), and false-negative for failure of aspiration (1). CONCLUSIONS: Cytological diagnosis should mostly depend on cellular morphology. In addition, immunohistochemistry and special staining are helpful for diagnosis if cytologic preparation is available. Fine needle aspiration cytology of the liver is a diagnostic method that can be used to identify the vast majority of neoplasms of primary or metastatic nature.

Biopsy, Needle↗

Correlation between fine needle aspiration biopsy and histologic findings in parotid masses. Personal experience.

Pre-operative fine-needle aspiration biopsy findings have been compared with those of post-operative histopathology in 146 patients with parotid masses. Post-operative histology showed 124 benign and 22 malignant lesions: pre-operative fine-needle aspiration biopsy correctly identified 118/124 (95.1%) benign masses with an accurate classification of the tumour in 111/118 cases (94%). Fine-needle aspiration biopsy identified malignancy in 12/22 cases (>50%). In the remaining 7 cases (six benign lesions and one malignant), cytology was not diagnostic. There were no false positive cases. In the present study, the accuracy, sensitivity and specificity of cytologic findings were, respectively, 94%, 57.2% and 100%. The accuracy of fine-needle aspiration biopsy was seen to be higher in benign than in malignant lesions. Fine-needle aspiration biopsy represents a first choice diagnostic tool for the study of palpable head and neck masses excluding abscesses and vascular neoplasms. However, for a correct diagnosis, great skill is required and cytology does not always reach the sensitivity and specificity of post-operative histology. Therefore, in the presence of a palpable head and neck mass, resistant to medical treatment, surgery is still strongly indicated and cytology is very useful in planning the surgical approach.

Adolescent↗

[Diagnosis of disseminated mycobacterial infection in AIDS patients by US-guided fine needle aspiration biopsy of lymphnodes and spleen].

Our aim was to evaluate the efficacy of abdominal US and fine-needle aspiration biopsy (FNAB) in the diagnosis of disseminated mycobacteriosis (DM) in patients with Acquired Immunodeficiency Syndrome (AIDS). We reviewed the US and clinical records of 18 AIDS patients (12 males; 22-43 years) with DM studied with abdominal US. 18 patients underwent fine-needle aspiration biopsy of enlarged abdominal lymphnodes and 11 underwent FNAB of the spleen. All aspirates were studied with acid-fast stain for fast examination and cultures for isolation of mycobacteria. Abdominal US showed: enlarged abdominal lymphnodes (diameter range: 5-35 mm; mean 17 mm) splenomegaly (spleen diameter range: 14-22 cm; mean: 16.2 cm) and hepatomegaly (right hepatic lobe thickness range: 14.5-18.5 cm) in all patients; multiple splenic abscesses (diameter range: 3-20 mm) in 11 patients; small intestine wall thickening in 5 patients (maximum bowel wall thickness range: 7-15 mm); mild to moderate ascites in 8 patients; pleural effusion in 4 patients; hyperechogenicity of the kidney cortex in 5 patients; peritoneal abscesses in one and a retroperitoneal abscess in one patient. fast-acid-stain of spleen and/or lymphnode FNAB specimens allowed early diagnosis of mycobateriosis in 18/18 cases (100%). Cultures of lymphnode aspirates grew mycobacteria in 10/18 patients (56%). Spleen aspirates grew mycobacteria in 11/11 patients (100%) Blood cultures were positive in 6/18 patients (33%). Diagnosis of species was M. tuberculosis in 9 and M. avium in 6 patients. In 3/18 patients (17%) all cultures were negative. In conclusion, abdominal US features suggest DM in AIDS patients. Spleen and/or lymphnode FNAB allows a specific diagnosis in 100% of the patients.

AIDS-Related Opportunistic Infections↗

[Emergency manual aspiration for severe hypertensive cerebellar hemorrhage].

We treated 16 patients with hypertensive cerebellar hemorrhage and coma, or deep coma. Their ages ranged from 44 to 79 years (mean age: 66.3 years). Manual aspiration was performed in 9 patients and suboccipital craniectomy was performed in 7 patients. The difference in outcome between the manual aspiration group and the suboccipital craniectomy group with severe hypertensive cerebellar hemorrhage was then evaluated. Manual aspiration was performed for 4 patients in coma, and 5 in deep coma, with a mean age of 69.0 years. The average size of the hematoma was 48.7mm and the mean volume was 31. 7ml on CT scan. The mean interval from admission to operation was about 60 minutes. The mean aspiration rate was 79.6% and 7 patients (77.8%) had a good response to drainage. The suboccipital craniectomy patients included 5 in coma, and 2 in deep coma, with a mean age of 63.4 years. The average size of the hematoma was 51.1 mm and the mean volume was 33.1 ml on CT scan. The mean interval from admission to operation was about 112 minutes and the mean evacuation rate was 86.4%. The results were as follows: 1) After manual aspiration, 5 patients (55.6%) had a good outcome and 2 patients (40%) with deep coma showed good recovery. In contrast, after suboccipital craniectomy only 2 patients (28.6%) had a good outcome and all of the deep coma patients showed poor recovery. 2) The outcome may be most strongly influenced by the duration from admission to operation. 3) All patients with a hematoma volume of over 30 ml had a poor outcome.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Management of breast problems in gynecologic office practice using sonography and fine-needle aspiration.

Breast-related problems were studied in 500 consecutive gynecologic patients by clinical assessment and mammography. Sonography and fine-needle aspiration were performed to clarify inconclusive clinical or mammographic findings. Cysts were correctly diagnosed by sonography in 175 of 189 patients (four of 193 with cysts had no ultrasound examination). Fine-needle aspiration provided immediate treatment in 116. Cysts were not aspirated in 75 patients, and two women required a biopsy because of atypical or suspicious cytologic changes. Carcinoma was detected in 23 patients; palpation was correctly positive in 15, sonography in 12 of 17, mammography in 18 of 22, and fine-needle aspiration in five of seven. We believe that sonography and fine-needle aspiration are useful extensions of the physical examination for benign breast disease, providing immediate diagnosis of cysts and facilitating the diagnosis of cancer. Our data, in agreement with the literature, indicate that no single method is completely reliable in diagnosing carcinoma. Therefore, a judicious combination of all available techniques should be used.

Ambulatory Care↗

Microbiology of sinus puncture versus middle meatal aspiration in acute bacterial maxillary sinusitis.

BACKGROUND: Maxillary sinus puncture is considered the gold standard for diagnosing acute bacterial maxillary sinusitis (ABMS) and for identifying bacterial pathogens in antimicrobial trials of ABMS. However, sinus puncture and aspiration is all invasive, time-consuming procedure that is limited by discomfort to the patient and possible complications. Therefore, the diagnostic usefulness in clinical practice and patient enrollment in studies of ABMS is hindered and alternatives for maxillary sinus puncture are being investigated. METHODS: We designed a prospective clinical and microbiological outpatient study. Cultures obtained by endoscopically guided middle meatal aspiration were compared with those from sinus puncture and aspiration in 24 patients with ABMS. RESULTS: Considering puncture and aspiration as the gold standard, endoscopy cultures provided a sensitivity of 80%, specificity of 100%, positive predictive value of 100%, negative predictive value of 78.6%, and correlation of 88.5%. CONCLUSION: In our study, endoscopic sampling compared favorably with sinus puncture and aspiration.

Adolescent↗