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At least 1,441 records · Page 80Linked to original sources
PubMed1975

Standardized treatment of 154 consecutive cases of eclampsia.

Since 1955 standardized treatment applied uniformly to all cases of eclampsia at Parkland Memorial Hospital has consisted of (1) magnesium sulfate intravenously and intramuscularly to control convulsions, (2) intravenous hydralazine intermittently to lower diastolic blood pressure when it exceeded 110 mm. Hg, and (3) steps to effect vaginal delivery as soon as the woman has regained consciousness. The dosage schedules for magnesium sulfate and hydralazine, while empiric, have been extensively tested for both efficacy and toxicity. Delivery usually was accomplished vaginally and conduction anesthesia was avoided. Neither diuretics nor osmotic agents in the form of hypertonic glucose, mannitol, or albumin were used to treat eclampsia. Heparin was never given. To date 154 cases of eclampsia have been so treated with no maternal death. All fetuses alive when treatment was started and weighing 1,800 Gm. (4 pounds) or more survived. The results provide a standard against which new drugs and treatment regimens can be compared.

Abruptio Placentae↗
PubMed1977

Perinatal addiction: outcome and management.

The care of the pregnant drug-dependent woman and her newborn infant has become a major and controversial health problem requiring specific approaches to this high-risk mother and neonate. A comprehensive approach to the care of 278 pregnant drug-dependent women and their infants at the Philadelphia General Hospital has significantly reduced maternal and infant morbidity heretofore associated with pregnancies complicated by opiate addiction. Most significantly, the incidence of low birth weight has been reduced to below 20 per cent, and a decrease in severe withdrawal in infants born to mothers in the comprehensive care program has occurred. We propose that application of this approach to women whose pregnancies are complicated by drug dependency is a significant factor in successful management.

Abruptio Placentae↗
PubMed1987

Maternal age and primary cesarean section rates: a multivariate analysis.

To study the effect of maternal age on primary cesarean section rates, 3458 consecutive deliveries were analyzed. The cesarean section rates in primiparous women less than 25, 25 to 34, and over 34 years of age were 13.1%, 18.5%, and 28.2%, respectively. A similarly dramatic rise with advancing maternal age was seen in multiparous women with rates of 3.4%, 4.7%, and 10.1%, respectively, in the three age groups. The strong association between cesarean section and maternal age persisted after multivariate adjustment for induction of labor, epidural anesthesia, meconium-stained amniotic fluid, and fetal distress, and thus these factors do not explain the relationship.

Abruptio Placentae↗
PubMed1980

Measurement of fibrinogen degradation products by a sandwich enzyme immunoassay technique.

We describe a highly sensitive enzyme immunoassay technique using beta-D-galactosidase from Escherichia coli as a label to quantify fibrinogen and its degradation products. The minimum detectable concentrations of fibrinogen, fragment D and fragment E, were 0.6, 0.06 and 0.2 ng/ml of reaction mixture, respectively. The cross-reactions of the assay-system for fragment E with fibrinogen and fragments X, Y and D were 5, 8, 56 and 0% respectively. The assay system for fragment D did not cross-react with fragment E, but did cross-react with fragments X, Y and fibrinogen (38, 10 and 15% respectively). Fractionation of the serum sample on Sephadex G-200 column allowed specific quantification of fragments D and E in serum samples.

Abruptio Placentae↗