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At least 145 records · Page 8Linked to original sources
PubMed1982

[Diagnosis of vertebral diseases by vertebral biopsy].

Vertebral biopsies were performed in 28 patients, 17 males and 11 females, because of vertebral body and disc changes between June 1978 and May 1982. In two patients biopsy was performed in two segments. Punctures were done in local and superficial anaesthesia of the vertebral body periosteum during continuous fluoroscopy control using Jamshidi's instrumentation. Aspiration and tissue cylinders were evaluated histologically and bacteriologically. There were no complications among the 8 thoracic and 22 lumbar biopsies. A histologic diagnosis could be established in 22 cases (78.6%): plasmocytoma (n = 2), spontaneous deformation of the spine in osteoporosis (n = 3), Scheuermann's disease (n = 1), specific (n = 2) and nonspecific (n = 14) spondylitis. Demonstration of bacteria was possible in 5 out of the 16 cases of spondylitis (31.25%): in two cases tubercle bacilli were demonstrated and once each salmonella group B, Haemophilus aphrophilus and coagulase-negative staphylococci. Only in 6 cases a diagnosis could not be established from the biopsy material.

Adolescent↗
PubMed1992

The treatment of osteoporotic-posttraumatic vertebral collapse using the Kaneda device and a bioactive ceramic vertebral prosthesis.

Twenty-two patients with neurologic deficit due to delayed posttraumatic vertebral collapse after osteoporotic compression fractures of the thoracolumbar spine underwent anterior decompression and reconstruction with bioactive Apatite-Wollastonite containing glass ceramic vertebral prosthesis and Kaneda instrumentation. Eighteen patients previously had minor trauma that resulted in a mild vertebral compression fracture without any neurologic involvement and were either conservatively treated or not treated at all. Four had no history of back injury. The preoperative neurologic status was incomplete paralysis in all patients. The average age at surgery was 66 (53-79) years. The average follow-up was 34 (20-58) months after surgery. All patients had returned to their daily living with neurologic recovery and stable spine. This type of anterior procedure is effective in the osteoporotic patients and there was a very low incidence of instrumentation failure and very low morbidity.

Aged↗
PubMed1998

Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.

apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.

Amino Acid Sequence↗
PubMed1996

Vertebral fluid collection associated with vertebral collapse.

OBJECTIVE: Three elderly women with osteoporotic compression fractures of a vertebral body underwent MR imaging because of neurologic signs and symptoms. Atypical fluid collections were shown by MR imaging in all three patients. For histologic characterization of these vertebral fluid collections, CT-guided biopsies and aspirations were done for all three patients. CONCLUSION: After studying the clinical, histologic, and imaging features of these fluid collections associated with vertebral fracture, we suggest that they are most likely associated with underlying avascular necrosis.

Aged↗
PubMed2002

[Vertebral joint meniscoids in the norm and in functional blocking of the vertebral segment].

Meniscoids have been studied of the intervertebral joints in normal subjects and in blocking of the vertebral locomotory segment. Development of changes in meniscoids in functional blocking of the vertebral segment is shown as is in different degrees of incomplete dislocation in the intervertebral joint. In an unremoved blocking of the vertebral segment the soft tissues of the joint gradually undergo accelerated dystrophy (the joint capsule, meniscoid, articular cartilage). In the early periods of blocking meniscoid becomes hyperplastic (edema), it comes to be wedged in the cavity of the joint rendering it immobile. The findings secured are helpful when it comes to choosing between different policies of managing vertebrogenic disorders and to administering prophylaxis thereof.

Animals↗
PubMed2005

A new syndrome within the oculo-auriculo-vertebral spectrum: microtia, atresia of the external auditory canal, vertebral anomaly, and complex cardiac defects.

We describe a patient whose features represent a new entity within the oculo-auriculo-vertebral spectrum. The boy had right microtia, atresia of the external auditory canal, growth retardation, a complex heart defect, and extra-lobar pulmonary sequestration. The cardiac anomalies were persistent left superior vena cava, aortic stenosis, bicuspid aortic valves and subaortic membrane. Spinal films revealed complete fusion of the C2-C3 and C5-C6 vertebrae, and scoliosis of the lumbar spine. The patient's mental development was normal, and there were no abnormalities on ophthalmological examination. This report, reviews features of similar published cases, and argues why this may represent a 'new' entity within the oculo-auriculo-vertebral spectrum. The cardinal features are microtia, atresia of the external auditory canal, complex cardiac defects, growth retardation, normal mental and motor development in most cases and vertebral anomalies. All six of the patients reviewed were male raising the possibility of X-linked inheritance.

Abnormalities, Multiple↗
PubMed1990

Measurement variations in scoliotic angle, vertebral rotation, vertebral body height, and intervertebral disc space height.

Thirty consecutive posteroanterior and lateral radiographs of patients with adolescent idiopathic scoliosis with a mean Cobb angle of 24.4 degrees were read. In measuring the scoliotic angle, the interobserver error (SD) was 2.8 degrees and the intraobserver, 1.8 degrees. Rotation of the apical vertebra was estimated by measuring the translation of the pedicle on posteroanterior radiographs. For vertebral rotation, the interobserver measurement error (SD) was 3.4 and the intraobserver, 1.8%. The height of the apical vertebral body and the intervertebral disc space next inferior to it were measured on lateral radiographs as the anterior angles of the diagonals of the respective body or disc space. In measuring the vertebral body height, the interobserver error (SD) was 3.2 and the intraobserver, 2.6 degrees, and in measuring the intervertebral disc space height, the interobserver error was 2.4 and the intraobserver, 1.8 degrees. The angles can be transformed to a corresponding height/length ratio by a simple trigonometrical formula.

Adolescent↗
PubMed1995

[MR imaging of infected spondylodiskitis: interval signal change in vertebral body (including enhanced image of vertebral body)].

A retrospective evaluation of MRI was carried out in 22 patients with spondylodiskitis. Low signal intensity on T1-weighted images and high or low signal intensity on T2-weighted images were observed. Sixteen patients underwent follow-up examinations after the initial examination. Various signal changes in the vertebral body were recognized. The longer the period of follow-up, the less abnormal the signal intensity became on both T1- and T2-weighted images. Several cases showed no change in signal intensity. In all of 17 patients re-examined after injection of Gd-DTPA, infected vertebral bodies were enhanced. We classified the enhancing patterns of infected vertebral bodies in three types: A) homogeneous, B) homogeneous with strong enhancement adjacent to the end plate, C) inhomogeneous. Pyogenic spondylodiskitis tended to show patterns A or B, and tuberculous spondylodiskitis pattern C. The enhancement effect disappeared after normalization or remission of laboratory findings. In two cases, the enhancement effect remained even after laboratory findings became normal. Contrast MRI was useful for understanding infectious state.

Adolescent↗
PubMed1997

[Prevalence of vertebral deformity in Hungary: the European Vertebral Osteoporosis Study].

Prevalence and distribution of vertebral deformity regarded as classic marker of osteoporosis are reported on the basis of the results of the first Hungarian cross-sectional population-based survey. The clinical-epidemiological project is conducted by the National Institute of Rheumatology and Physiotherapy in Hungary in the frame of the European Vertebral Osteoporosis Study which comprises 19 countries and 36 centres. A random sample of 324 females and 300 males aged 50 years and over stratified in 5-year age bands was recruited. Lateral spinal X-rays were evaluated centrally by two different morphometric methods. Based on the McCloskey-Kanis criteria the prevalence of all deformities was 16.7% in females and 18.7% in males. These values from Hungary have been considered high compared to the prevalence rates of other European countries, approaching, and in males exceeding, the highest rates gained from Sweden. In females the prevalence increased with age, men aged 50-59 years and women aged 75 years and over had higher prevalence of deformity compared to the other sex. In females vertebra thoracic 11, in males that of lumbar 3 were mostly affected, wedge deformities occurred most frequently. Extrapolating the results we can conclude that vertebral deformity found in both sexes similarly, affects approximately 500,000 individuals in Hungary along with the potential deterioration of quality of life. This enormous burden requires the consistent fulfillment of the National Osteoporosis Program and other preventive-curative strategies.

Aged↗
PubMed1992

Duplicated origin of right vertebral artery with rudimentary and accessory left vertebral arteries.

We observed a rare cerebrovascular anomaly in a patient with brain-stem infarction. Two right vertebral arteries arose from the subclavian artery and communicated directly with each other under the transverse foramen of the fourth cervical vertebra. The left vertebral artery consisted of a rudimentary artery that arose from the left subclavian artery, ran through the transverse foramen of the sixth cervical vertebra and then tapered down to disappear at the fourth/fifth cervical vertebrae, plus a second, accessory artery that arose from a branch of the left thyrocervical trunk, ran through the transverse foramen of the fifth cervical vertebra and tapered off to disappear at the first/second cervical vertebrae.

Adult↗
PubMed1999

Identification of renal podocytes in multiple species: higher vertebrates are vimentin positive/lower vertebrates are desmin positive.

We sought to characterize podocytes in the kidneys of numerous species from amphibians to mammals because of the pivotal function of these cells in renal diseases. For this purpose, intermediate filament (IF) proteins of podocytes were examined by immunofluorescence microscopy using antibodies against vimentin, cytokeratins, and desmin. These staining patterns were then compared to those of parietal cells of Bowman's capsule and tubular cells of the first portion of the proximal tubule from the same sources. As a result, podocytes from mammals (rat, rabbit, dog, cow, and human) and birds (chicken) showed intense vimentin staining without exception, but rarely staining for cytokeratins or desmin. Parietal cells from all these animals were highly heterogeneous with respect to cytokeratin or vimentin staining. Of the tubular cells, only those from humans and chickens were reactive and then only with anti-cytokeratin antibodies. In the reptiles (Chrysemys scripta elegans, Chinemys reeveri, Elaphe quadrivirgata, and Anolis carolinensis), podocytes and other epithelial cells were positive for cytokeratins. Vimentin staining differed among the species, but was not characteristic for podocytes. Anti-desmin antibody reacted strongly only with podocytes from Anolis. In amphibians (Rana catesbeiana and Xenopus laevis), anti-desmin antibody stained podocytes more intensely than any other cell. Cytokeratin and vimentin staining did not differentiate podocytes from the other cell types. These findings indicate that podocytes are characterized by intense vimentin staining in the higher vertebrates and by desmin staining in the lower vertebrates denoting potentially distinctive physiological functions of IF proteins in podocytes from each of these groups.

Amphibians↗
PubMed1987

Cervical vertebral erosion due to tortuous vertebral artery.

A case of cervical vertebral erosion due to tortuous vertebral artery is presented. This entity is rare and only 11 cases have been reported in the literature. The present case is the first to be demonstrated by magnetic resonance imaging. The importance of considering this vascular anomaly in the differential diagnosis of cervical spinal tumors is discussed.

Adult↗
PubMed1987

Pepsinogen-like immunoreactivity among vertebrates: occurrence of common antigenicity to an anti-chicken pepsinogen antiserum in stomach gland cells of vertebrates.

Stomachs of 14 species selected from five classes of vertebrate were surveyed concerning the reactivity to an anti-adult chicken pepsinogen antiserum (anti-ACPg) with indirect immunofluorescence method. Gland cells of all these stomachs showed reactivity to the antiserum. Crude extract of stomachs from five representatives of mammals, birds, amphibians and fish showed peptic activity (at pH 2.2) of which 70-90% were pepstatin-sensitive. Zymogram and immunoblotting of crude extract revealed that the anti-ACPg-reactive proteins have peptic activity. Molecular weights of anti-ACPg-reactive proteins determined by immunoblotting coincided with the values of purified pepsinogens previously reported for these animals. These results indicate that pepsinogens have been conserved well during vertebrate evolution.

Animals↗
PubMed2003

The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.

A previously undetected domain, named CW for its conserved cysteine and tryptophan residues, appears to be a four-cysteine zinc-finger motif found exclusively in vertebrates, vertebrate-infecting parasites and higher plants. Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized. However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development.

Amino Acid Sequence↗
PubMed1975

[Anastomoses between the vertebral and external occipital arteries in occlusion of the external carotid and vertebral arteries (author's transl)].

Five cases of anastomose formation between the external carotid and the vertebral arteries are reported. In 2 cases occlusion of the vertebral artery in the upper section of the cervical spine were present. In 2 further cases there were occlusions of the external carotid artery. In only a single case did angiographic examination show no pathological change. From these observations it is concluded that, when the formation of such collaterals is established, occlusions and important part-occlusions of the large cervical vessels should be sought.

Adult↗
PubMed1988

Insulin-related materials in the nervous system of vertebrates and non-vertebrates: possible extrapancreatic production.

Studies from multiple laboratories with a range of methods raised the possibility that insulin production occurs naturally at extrapancreatic sites. Part A covers the presence of insulin-related materials in organisms that do not have an endocrine pancreas, including unicellular prokaryotes and eukaryotes as well as multicellular non-vertebrate animals (insects et al.) and plants. Part B covers possible production of insulin by extrapancreatic tissues of vertebrates that are remote from a source of pancreatic insulin e.g. early chick embryos and mammalian cells in culture. Part C covers possible extrapancreatic insulin production in mammals in vivo. Each section ends with an outline summary with evidence in favor of and against the hypothesis.

Amino Acid Sequence↗
PubMed2004

Major events in the genome evolution of vertebrates: paranome age and size differ considerably between ray-finned fishes and land vertebrates.

It has been suggested that fish have more genes than humans. Whether most of these additional genes originated through a complete (fish-specific) genome duplication or through many lineage-specific tandem gene or smaller block duplications and family expansions continues to be debated. We analyzed the complete genome of the pufferfish Takifugu rubripes (Fugu) and compared it with the paranome of humans. We show that most paralogous genes of Fugu are the result of three complete genome duplications. Both relative and absolute dating of the complete predicted set of protein-coding genes suggest that initial genome duplications, estimated to have occurred at least 600 million years ago, shaped the genome of all vertebrates. In addition, analysis of >150 block duplications in the Fugu genome clearly supports a fish-specific genome duplication (approximately equal to 320 million years ago) that coincided with the vast radiation of most modern ray-finned fishes. Unlike the human genome, Fugu contains very few recently duplicated genes; hence, many human genes are much younger than fish genes. This lack of recent gene duplication, or, alternatively, the accelerated rate of gene loss, is possibly one reason for the drastic reduction of the genome size of Fugu observed during the past 100 million years or so, subsequent to the additional genome duplication that ray-finned fishes but not land vertebrates experienced.

Amino Acid Sequence↗
PubMed1999

Unilateral exophthalmos caused by traumatic vertebral artery to vertebral and jugular vein fistula: problems in diagnosis and management.

Skull base venous fistulas are rare. A 15-year-old boy was stabbed in the left side of his neck, just below the mastoid process. Two years later, he presented with a protruded and pulsating left eye with red sclera. A soft murmur was audible all over his head and neck. Angiography revealed an arteriovenous fistula between the third portion of the vertebral artery (V3) and the vertebral venous plexus, as well as the ipsilateral jugular vein (VVJF). The fistula recruited several arterial feeders and rising the venous pressure along the outflow system of the skull base had led to unilateral exophthalmos.

Adolescent↗