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Results for “Vaginal Neoplasms”

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At least 145 records · Page 8Linked to original sources
PubMed1979

Severe dysplasia and carcinoma in situ of the vagina.

Papanicolaou smears for early detection of carcinoma in situ of the cervix has been a well-recognized method of screening patients for over 30 years. The necessity for Papanicolaou smears following hysterectomy, especially for benign disease, has been a controversial subject. Twenty-two cases of carcinoma in situ of the vagina, over a period of 18 years, at the Huntington Memorial Hospital in Pasadena, California, are presented. Ninety-five percent of the lesions were first suspected by use of the Papanicolaou smears. Approximately half of previous hysterectomies were performed for benign disease. The various methods of treatment employed and the complications in these patients are discussed.

Carcinoma in Situ↗
PubMed1985

Management of condyloma acuminatum.

This article describes an approach to the evaluation and treatment of condyloma acuminatum (anogenital warts) that is based on the results of new clinical research on the biology of the human papillomavirus. A more extensive diagnostic protocol, including routine cervicovaginal examination and Papanicolaou smear, is proposed for female patients because of the close association of genital human papillomavirus infections with cervical carcinoma. Two highly effective therapies, cryosurgery and carbon dioxide laser photocoagulation, are described and compared with older regimens. Recent developments in immunotherapy for resistant condyloma acuminatum are also discussed.

Clinical Trials as Topic↗
PubMedDate not supplied

Invasive adenocarcinoma of the vagina following surgery for adenocarcinoma in situ of the cervix--recurrence or implantation?

A 51-year-old woman underwent cervical conization for severe glandular abnormal cells. Histology noted adenocarcinoma in situ (AIS) with incomplete excision margins. Four months later, hysterectomy revealed no residual disease. Six months subsequently she developed invasive adenocarcinoma of the upper vagina. This report documents the unusual behavior of AIS and its management difficulties.

Adenocarcinoma↗
PubMed2002

Outcome of colposcopy in women presenting with postcoital bleeding and negative or no cytology--results of a 1-year audit.

We set out to identify histological abnormalities in women presenting with postcoital bleeding at the colposcopy clinic and the detection rate of abnormalities. This was a retrospective study based on the colposcopy clinic at Scunthorpe General Hospital. We investigated 45 patients with postcoital bleeding, 12 with negative referral smears and 33 with no referral smears. We found that 8.33% of patients with a negative referral smear had a histological abnormality. In patients with no referral smear the rate was 24.24%. The overall incidence of histological abnormality in the study group was 20% and of cytological abnormality 11.11%. Colposcopically directed biopsy is almost twice as effective as cytology in the detection of abnormality. Patients referred with negative cytology have a lower incidence of histological abnormality than those with no cytology. Women with postcoital bleeding should be seen in the colposcopy clinic.

Coitus↗
PubMed1978

Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol.

Squamous cell abnormalities of the vagina and cervix were evaluated in 1424 women exposed to diethylstilbestrol (DES) in utero. The prevalence of dysplasia was 2.1% and the incidence 0.85/100 person-years of followup. The dysplastic epithelial changes were almost always mild in women with no prior history of dysplasia and was slightly more frequent in the cervix than the vagina. Severe dysplasia and carcinoma in situ (CIS) were encountered only in those subjects specifically referred because of those abnormalities. The most common problem in the diagnosis of these squamous cell changes was the misinterpretation of mature and immature metaplastic cells for dysplastic squamous cells. Discordance between biopsy and cytology was common-place in the detection and followup of dysplasia, especially when it was mild. There were no instances in the study where cytology and biopsy samples from the vagina were both abnormal concurrently. Colposcopically directed biopsies did not increase the frequency of confirmation of cytologic findings. These data suggest that both cytology and biopsy of abnormal segments of the vagina and cervix remain an integral part of the examination of the DES-exposed female during long-term follow-up studies.

Adolescent↗
PubMedDate not supplied

Recurrence in a Schuchardt incision after Schauta-Amreich radical vaginal hysterectomy for cervical cancer.

A Schuchardt incision is frequently performed to facilitate access to the parametrium during radical vaginal hysterectomy for cervical cancer. We report an adenocarcinoma recurrence in a Schuchardt incision 12 months after radical vaginal hysterectomy for FIGO stage IB1 cervical cancer. Histology of the primary tumor had shown a well-differentiated adenocarcinoma and poorly differentiated squamous cell carcinoma of the cervix 2.6 cm in maximum diameter. After further surgical therapy and adjuvant radiotherapy, the patient died of disease 51 months after the initial operation. Cervical cancers can implant and recur in perineal incisions. Thus, it appears prudent to avoid such incisions or, if they are made, to irrigate them copiously before closing them.

Adenocarcinoma↗