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Results for “UTERUS NEOPLASMS”

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At least 145 records · Page 8Linked to original sources
PubMed1980

Ectopic vaginal trophoblast in association with a partial mole.

A case of ectopic vaginal trophoblast in association with a blighted ovum showing hydropic degeneration is presented. This combination satisfied the histological criteria of Szulman and Surti for inclusion as a partial mole. Subsequent follow-up revealed non-progression of the condition. The problems of obtaining a satisfactory classification for proliferative trophoblastic lesions are outlined.

Adult↗
PubMedDate not supplied

Detection of chromosomal aberrations by fluorescence in situ hybridization in cervicovaginal biopsies from women exposed to diethylstilbestrol in utero.

Epidemiologic studies have associated estrogens with human neoplasms such as those in the endometrium, cervix, vagina, breast, and liver. Perinatal exposure to natural (17beta-estradiol [17beta-E(2)]) and synthetic (diethylstilbestrol [DES]) estrogens induces neoplastic changes in humans and rodents. Previous studies demonstrated that neonatal 17beta-E(2) treatment of mice results in increased nuclear DNA content of cervicovaginal epithelium that precedes histologically evident neoplasia. In order to determine whether this effect was associated with chromosomal changes in humans, the frequencies of trisomy of chromosomes 1, 7, 11, and 17 were evaluated by the fluorescence in situ hybridization (FISH) technique in cervicovaginal tissue from 19 DES-exposed and 19 control women. The trisomic frequencies were significantly elevated in 4 of the 19 (21%) DES-exposed patients. One patient presented with trisomy of chromosomes 1, 7, and 11, while trisomy of chromosome 7 was observed in one patient. There were two patients with trisomy of chromosome 1. Trisomy of chromosomes 1, 7, 11, and 17 was not observed in the cervicovaginal tissue taken from control patients. These data suggest that DES-induced chromosomal trisomy may be an early event in the development of cervicovaginal neoplasia in humans.

Adenocarcinoma, Clear Cell↗
PubMed1994

DES exposure: an update.

Little is known about DES grandchildren except that they're often born before term. While we wait for information to accumulate on this third generation, pediatricians need to keep current on the status of DES mothers and daughters. Here's the latest on risks and recommended management.

Adenocarcinoma, Clear Cell↗