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At least 145 records · Page 8Linked to original sources
PubMed1979

Ovarian sex cord tumor with annular tubules. Clinicopathologic report of two benign and one malignant cases with long follow-ups.

The clinicopathologic features of three new cases of ovarian sex cord tumors with annular tubules are presented, thereby increasing to 23 the number of the published cases in the world literature. These three observations, along with another one which was previously published, were found in the files of the Institute of Pathology of the University of Lausanne from 1939 to 1978. Forty-seven granulosa cell tumors and eight Sertoli and/or Leydig cell tumors of the ovary were found during the same 40-year period. The patients were 48, 64 and 71 years of age. No sign of the Peutz-Jeghers syndrome was noticed in the three patients. All three tumors caused metrorrhagias as a cardinal sign. They were bulky, unilateral and were formed by solid tissue with cystic spaces. Histologically, the most characteristic pattern consisted of simple and complex tubular structures as described by Scully in 1970. Two patients, in which the mitotic indexes of the tumors were lower than 5 mitoses per 10 HPF, died without evidence of a recurrence 36 and 37 years after surgical ablation of the tumor. The third patient, whose neoplasm featured fewer well differentiated tubular structures than the two previous ones and had a mitotic index of over 70 mitoses per 10 HPF, died from massive abdominal recurrence after 5 years and 5 months.

Aged↗
PubMed1991

[Data analysis in long-term follow-ups of previously treated orthodontic patients].

The structure of former orthodontically treated patients, who underwent a long-term follow-up study in October 1989, was evaluated. An attempt was made to contact 1429 former patients, whereby 28.8% did not get the invitations because they had changed their address. As the compliance of approximately 17 years postretention of the 1,018 patients depends on change of address, job, interest and death, 20% of these were willing to participate and get examined. A structural conformity of the controlled group and the patient total cannot be presumed due to the patients' answers in the follow-up study. Questionnaires will be sent to patients, who did not participate in the analysis, in order to avoid unilateral results.

Age Factors↗
PubMed1975

[Posttraumatic unilateral aphakia and contact lens -binocular functions of grown-ups].

The binocular results are only subnormal and comparable to former squinting patients. The results are better if one succeeds in reaching a visual acuity of at least 1.0. One can try to prevent a divergence by prescribing a contact lens as early as possible. Presbyopic patients have better binocular functions because the lost accommodation is the most interfering component (factor). It has disadvantageous effects especially on those patients who are yet presbyopic. The aniseikonia is in contrary to this not an as important interfering factor.

Accommodation, Ocular↗
PubMed2004

Audit of a shared-care program for persons with diabetes: baseline and 3 annual follow-ups.

In Italy, data on shared-care programs for diabetes are lacking. We described the characteristics of type 2 diabetic population assisted in general practice and evaluated 3 years of follow-up outcomes and performance indicators in a shared-care program in Modena, Italy (1998-2001); only well-controlled diabetic patients were considered. Forty-nine percent of territorial GPs adhered to the project (257 out of 521) and 77% of them sent 6409 paired baseline and follow-up datasheets. Altogether, 97.8% patients had type 2 diabetes, mean age 68.6+/-11.7 years, disease duration 9.6+/-7.5 years, BMI 28.6+/-4.8 kg/m2, HbA(1c) 7.6%+/-1.6%, 16.1% of them were disabled. Among the non-disabled patients, 23.6% had optimal glycemic control (HbA(1c) < or =6.5%); at baseline the prevalence of micro- and macrovascular diabetic complications was: 8.2% microalbuminuria and 2.4% macroalbuminuria plus nephropathy, 11.0% nonproliferative and 3.0% preproliferative retinopathy, 7.0% neuropathy, 1.8% diabetic foot; 8.5% angina, 6.9% TIA or stroke, 6.3% infarction, 5.2% intermittent claudication, 4.1% heart failure. Among the disabled patients 27.9% had optimal glycemic control, but they had more diabetic complications. The performance indicators significantly improved over the 3-year study period: glycemic control indicators increased from 66%-75% to 83%-90% and micro- and macrovascular indicators from 59%-65% to 75%-81%. The outcome indicators also improved: mean HbA(1c) value changed from 7.6%+/-1.6% to 7.3%+/-1.3% and the percentage of people with HbA(1c)< or =6.5% significantly improved over time. Similar trends were observed in both disabled and non-disabled diabetic patients.

Aged↗
PubMed2006

Monitoring the ups and downs of pulsed dye laser energy output.

The internal energy meter reading of a Chromos pulsed dye laser (PDL) set at 50% of maximum pumping energy was recorded at the start of every clinical session over an 898 day period and compared with the measurement from an Ophir Optronics 'Nova' external energy meter. This quick and inexpensive process improved quality control procedures for the use of the PDL and enabled the performance of laser components such as the dye, pumping mechanism and optics to be monitored. The stability of the laser output energy was also monitored during three simulated clinics on days 665, 870 and 898. External energy meter readings were recorded every 100 pulses during each simulated clinic comprising six series of 500 pulses. As the energy output was shown to be stable during each clinic (SD<4.7%) recalibration during treatments of up to 500 pulses with this laser was deemed to be unnecessary. However, it was noted that this output energy stability was maintained by varying the pumping energy from 42 to 88% of maximum. Subsequent measurements of pulse width conducted with an ET-2000 Silicon Photodetector demonstrated that although the nominal pulse width was 450 mus, this varied from 240 to 390 mus as the pumping energy increased from 20 to 50%.

Lasers↗
PubMed1995

Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis.

The H2A.X gene was cloned from the C3H mouse strain, and its structure was determined. Sequence analysis revealed that this gene is situated in close proximity to the porphobilinogen deaminase (PBGD) gene in the opposite orientation. The synteny is conserved in human. This permits us to assign the H2A.X gene to chromosome 9 and 11q23 in mouse and human, respectively.

Amino Acid Sequence↗
PubMed2006

Biotechnology SMEs, start-ups, spin-offs or microenterprises are they molecules coming from the research results? If so, what place do they hold in the global industrial tissue?

In recent years, the number of biotech enterprises in Europe has grown spectacularly, largely fueled by the increasing number of entrepreneurial initiatives from Europe's leading research institutes. The place held on the economic market by these enterprises, is a question that market analysts have been asking themselves since their rapid growth and, more particularly, their over valuation which, at times, has led to the crash of their shares on the stock markets. To be sure, this article does not claim to go into an in-depth financial analysis to explain the details of certain "shipwrecks". Rather, it just would like to provide some useful indications for all those having embarked, or desirous of doing so, in the creation of biomedical enterprises.

Academies and Institutes↗
PubMed2003

Calcium signalling: the ups and downs of protein kinase C.

Oscillations in intracellular calcium levels control a plethora of physiological processes, but how they are decoded by a cell remains unclear. In a recent study, advances in FRET technology have been used to describe how calcium oscillations are decoded through phase-locked oscillations in substrate phosphorylation catalysed by protein kinase C.

Animals↗
PubMed2004

The ups and downs of modeling the cell cycle.

We discuss the impact of mathematical modeling on our understanding of the cell cycle. Although existing, detailed models confirm that the known interactions in the cell cycle can produce oscillations and predict behaviors such as hysteresis, they contain many parameters and are poorly constrained by data which are almost all qualitative. Questions about the basic architecture of the oscillator may be more amenable to modeling approaches that ignore molecular details. These include asking how the various elaborations of the basic oscillator affect the robustness of the system and how cells monitor their size and use this information to control the cell cycle.

Biological Clocks↗