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At least 145 records · Page 8Linked to original sources
PubMed1986

Disturbances in exploratory behavior and functional recovery in the Y and radial mazes following dopamine depletion of the lateral septum.

The effects of 6-hydroxydopamine (6-OHDA) injected into the lateral septum in rats were investigated for spontaneous alternation behavior in a Y maze and for spatially oriented behavior in an 8-arm radial maze. The performance of the animals in these tests was assessed under two physiological states, food-satiated and food-deprived. The selective depletion of septal dopaminergic concentrations leads to behavioral disturbances in both the Y and the radial mazes. These deficits disappeared when the animals with 6-OHDA lesions were food-deprived. These results confirm other studies from our laboratory and support two conclusions. First, lesions of dopaminergic neurons lead to behavioral impairments which resemble those found after the total lesion of the structure they innervate. Second, these behavioral impairments are responsive to therapeutic treatments, manipulations of the internal or external environment, or the level of arousal, since under certain conditions a recovery of function can occur in the absence of dopaminergic neurons. These two points provide additional support for a nonspecific role for the dopaminergic neurons originating in the ventral tegmental area. These neurons could have a permissive role in the functioning of the forebrain structures they innervate.

Animals↗
PubMed1975

Long term changes in nest condition and pup grouping following handling of rat litters.

Observation of rat litters over the entire preweaning period revealed long term changes to result from handling pups. Handled litters had fewer good nests and were less likely to be found in a single group than control litters. These differences are not attributable to the disturbances per se, as litters where the mother was removed did not differ significantly from undisturbed controls. The differences occurred predominantly in the daytime when maternal activity was at its lowest.

Animals↗
PubMed1977

The association of population density, reduced space, and uncomfortable temperatures with misconduct in a prison community.

This study investigated the relation of population size, amount of personal space, and population density to the incidence of disruptive behavior over a 3-year period in a correctional institution for male youthful offenders. Population size was significantly correlated with the number but not the rate of disciplinary violations. The total amount of personal space and the index of population density were significantly correlated with both the number and the rate of violations. A post hoc analysis showed that the incidence of uncomfortably hot days had no relation to disruptive behavior. These results are contrasted with laboratory data on human crowding reporting no relation between population density and behavior pathology. It is suggested that the chronic high density explored in the present field study differs from temporarily crowded conditions produced in laboratory research on human crowding.

Adolescent↗
PubMedDate not supplied

Behavioral changes induced by the thyrotropin-releasing hormone analogue, RGH 2202.

The behavioral activity of the thyrotropin-releasing hormone (TRH) analogue, L-6-ketopiperidine-2- carbonyl-leucyl-L-prolinamide (RGH 2202), has been studied in the rat. The number of errors in a radial maze test was reduced after acute intraperitoneal (IP) injection of RGH 2202 at the dose of 5 or 10 mg/kg. Grooming activity was increased with a lower dose, 1 mg/kg. Hypoxia-induced amnesia, as assessed with active and passive avoidance behavior tests, was reversed in rats treated with 5 or 10 mg/kg of the drug. The loss of learning and memory capacity shown by aged rats in the same behavioral tests was also reduced after injection of RGH 2202. In a test for sexual activity of male rats, the higher dose of the drug induced a facilitation of mounting and ejaculations, while smaller doses were ineffective. The rotorod test revealed a decreased number of falls in animals treated with 5 or 10 mg/kg of RGH 2202. In all behavioral tests, the same doses of natural thyrotropin-releasing hormone (TRH) were less effective, indicating that this analogue may be qualified as a potentially active drug in human pathologies.

Animals↗
PubMed1988

Electric activity in the neocortex of freely moving young and aged rats.

Electroencephalographic activity of the neocortex was evaluated in young (5-7 months) and aged (26-28 months) rats. All animals in the aged group showed behavioral impairment in a spatial task (water maze). A neocortical electroencephalogram was derived simultaneously from 16 different neocortical locations and was subjected to spectral analysis. The frequency of occurrence and duration of high-voltage spindles was determined in two sessions, each involving a total of 30 min alert immobility. Changes in spectral characteristics and high-voltage spindles in response to scopolamine administration were also evaluated. The power of high-frequency activity (8-20 Hz) was significantly reduced in the aged subjects. This was greatest in the temporo-occipital regions, while no significant changes were seen in the mediofrontal region. Scopolamine resulted in a large power increase in all frequency bands, but the increase in the higher-frequency range (8-20 Hz) was significantly less in the aged group. The incidence of high-voltage spindles was 6 times higher and their total duration was 9 times longer in aged rats, with virtually no overlap with the young group. In young rats, scopolamine increased the incidence and total duration of high-voltage spindles, while it decreased both parameters in the aged subjects. Cholinergic neurons in the nucleus basalis appeared shrunken in the aged animals. These findings demonstrate that reliable electroencephalographic changes are present in the neocortex of the aged rat, and that some of the physiological alterations may be due to the pathological changes in the cholinergic nucleus basalis.

Aging↗
PubMed1976

Hormonal control of female sexual attractiveness proceptivity, and receptivity in rhesus monkeys.

The sexual behavior of 18 female and 11 male rhesus monkeys was observed in pair tests, in two experiments. In one experiment the females controlled the occurrence of pair tests. The females were ovariectomized and treated with estradiol, two dosages of testosterone, estradiol plus testosterone, estradiol plus dexamethasone, or no hormone; and the effects of the treatment on female attractiveness, proceptivity, and receptivity were examined. Sexual attractiveness of females to males (the effectiveness of the female as a sexual stimulus) was affected by estrogen and androgen. Estrogen enhanced attractiveness, but the effect of androgen depended on the dose. Female sexual proceptivity (the extent to which the female seeks out the male and elicits sexual behavior) was heightened by estrogen and androgen. Female sexual receptivity (willingness to receive a male in copulation was somewhat stimulated by estradiol, but not by testosterone. Both estradiol and testosterone had a greater effect on attractiveness and proceptivity than on receptivity. The hypothesis that testosterone is the "libidinal hormone" in female primates was not supported.

Animals↗
PubMed1986

Effect of space allowance and tylosin feeding on performance of growing-finishing pigs. NCR-89 Committee on Confinement Management of Swine.

The relationship between space allowance and tylosin feeding of growing-finishing pigs was investigated at nine experiment stations in the North Central Region. The experiment involved 1,352 pigs in 23 replications of treatments. Pigs allowed .46 m2 from 25 to 57 kg body weight and .74 m2 from 57 to 96 kg grew faster in the grower (P less than .001), finisher (P less than .05) and grower-finisher (P less than .001) periods than did pigs allowed .32 m2 and .56 m2 for the two weight periods, respectively. Feed efficiency was improved (P less than .005) by the more liberal space allowance in the grower, but not in the finisher period. Tylosin at 44 mg/kg changed to 22 mg/kg at 57 kg body weight caused an increase (P = .07) in rate of gain for the overall grower-finisher period and an improvement in feed efficiency in the grower (P = .07) and the grower-finisher (P less than .05) periods. In no instance was there an interaction between space allowance and tylosin feeding. Station effects were significant for all performance estimates, but there were no interactions between station and space-tylosin treatments. The results of the experiment indicate that crowding depressed performance of growing-finishing pigs, that tylosin feeding slightly improved performance and that the space allowance and the tylosin growth responses were independent.

Animals↗
PubMed1989

Intrahippocampal grafts of fetal basal forebrain tissue alter place fields in the hippocampus of rats with fimbria-fornix lesions.

Intrahippocampal grafts of fetal basal forebrain tissue have been shown to restore several aspects of neural function, including some degree of behavioral recovery in spatial memory tasks, in rats with fimbria-fornix lesions. Place fields, the behavioral correlates of complex-spike unit activity recorded in the hippocampus of rats, are altered by fimbria-fornix lesions, and provide an important measure of the functioning circuitry of the hippocampus after grafts. To investigate the effects of grafts on hippocampal circuitry, complex-spike units were recorded while the rats traversed a radial maze. Quantitative analyses of spatial activity showed that units in normal rats had spatially clustered, reliable place fields that were stable despite alterations of the maze. In contrast, units in rats with fimbria-fornix lesions had more dispersed, less reliable place fields that were disrupted when the maze was covered or rotated. Compared to rats with fimbria-fornix lesions, rats with grafts and units with more tightly clustered, more reliable, and more stable place fields when the maze was altered. The results suggest that: (1) fimbria-fornix lesions disrupt some aspects of complex-spike place field activity; (2) the functioning of hippocampal circuitry is influenced by fetal basal forebrain grafts; and (3) the grafts may ameliorate the effects of lesions on spatial behaviors by influencing critical aspects of place field activity in the hippocampus.

Action Potentials↗
PubMed1990

Behavioral determination of the spatial selectivity of contrast adaptation in cats: some evidence for a common plan in the mammalian visual system.

An aftereffects paradigm was used to behaviorally measure contrast sensitivity of cats to gratings of three different test spatial frequencies after adaptation to gratings of various spatial frequencies, contrasts, and durations. Post-adaptation reductions in sensitivity occurred even after short periods of adaptation (less than 7 s) and could be as large as 1.0 log unit under some conditions. The magnitude of the adaptation effect varied monotonically with (1) adaptation grating contrast, (2) duration, and (3) the contrast sensitivity for the test grating. Average half-width (at half-height) of the spatial-frequency tuning curves constructed from the data was 1.4 octaves, and was not dependent upon the level of adaptation or the spatial frequency of the test grating. Post-adaptation psychometric functions of the cats showed reduced slopes and maxima suggesting that, unlike humans, in cats apparent contrast grows more slowly with increases in physical contrast after contrast adaptation. All of the characteristics observed are in excellent agreement with electrophysiologically measured properties of neurons in striate cortex of cats. In addition, there was a remarkable similarity of the cat tuning functions, both in shape and bandpass, to those measured in man with a similar paradigm suggesting that (1) the two visual systems are sufficiently similar to make the cat a useful spatial vision model and (2) there is a common functional plan to all mammalian visual systems despite significant anatomical differences between species.

Adaptation, Ocular↗
PubMed1975

Origins of anthropoid intelligence.

The development of the extrastriate visual system relative to the striate system was estimated indirectly by measuring the volumes of the lateral posteriorpulvinar complex and lateral geniculate nucleus in six varieties of mammals selected on the basis of their propinquity with Anthropoidea [oppossums, hedgehogs, rats, squirrels, tree shrews and bushbabies]. The same animals were tested on two related behavioral tasks [spatial and visual reversal learning] whose successful achievement requires a simple sort of abstraction. The results show that the ability to learn visual reversal, but not spatial reversal, corresponds closely to the relative degree of development of the extrastriate system. Since the variation in both these behavioral and morphological characteristics also parallels the phylogenetic dimension, the recency of common ancestry to anthropoids, the evolutionary origin of the anthropoid capacity for visual abstraction is suggested.

Animals↗
PubMed1976

An analysis of adult social spacing tendencies and related social interactions in a colony of spider monkeys (Ateles geoffroyi) at the San Francisco zoo.

Observations on adult interindividual spacing and social interactions for 13 spider monkeys (Ateles geoffroyi) of an approximately 48 animal captive colony were made from mid-June through August 1972. In this analysis the interanimal distances, general activities, and social interactions per minute observation for each subject were compared for a sample of 7 sexually mature males and 6 sexually mature females. Association tendencies between members of the same sex were significantly high as were exchanges of the taxon-specific 'pectoral sniff and embrane" interactions and grooming. The direction and nature of agonistic interactions was predominantly intersexual and involved frequent attacks by single or multiple males against females. Comparisons with a feral population of spider monkeys (Ateles belzebuth) revealed marked similarities in spatial affinities and patterns of social interaction.

Agonistic Behavior↗