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At least 145 records · Page 8Linked to original sources

Does pornography-blocking software block access to health information on the Internet?

CONTEXT: The Internet has become an important tool for finding health information, especially among adolescents. Many computers have software designed to block access to Internet pornography. Because pornography-blocking software cannot perfectly discriminate between pornographic and nonpornographic Web sites, such products may block access to health information sites, particularly those related to sexuality. OBJECTIVE: To quantify the extent to which pornography-blocking software used in schools and libraries limits access to health information Web sites. DESIGN AND SETTING: In a simulation of adolescent Internet searching, we compiled search results from 24 health information searches (n = 3206) and 6 pornography searches (n = 781). We then classified the content of each site as either health information (n = 2467), pornography (n = 516), or other (n = 1004). We also compiled a list of top teen health information sites (n = 586). We then tested 6 blocking products commonly used in schools and libraries and 1 blocking product used on home computers, each at 2 or 3 levels of blocking restrictiveness. MAIN OUTCOME MEASURE: Rates of health information and pornography blocking. RESULTS: At the least restrictive blocking setting, configured to block only pornography, the products blocked a mean of only 1.4% of health information sites. The differences between blocking products was small (range, 0.6%-2.3%). However, about 10% of health sites found using some search terms related to sexuality (eg, safe sex, condoms) and homosexuality (eg, gay) were blocked. The mean pornography blocking rate was 87% (range, 84%-90%). At moderate settings, the mean blocking rate was 5% for health information and 90% for pornography. At the most restrictive settings, health information blocking increased substantially (24%), but pornography blocking was only slightly higher (91%). CONCLUSIONS: Blocking settings have a greater impact than choice of blocking product on frequency of health information blocking. At their least restrictive settings, overblocking of general health information poses a relatively minor impediment. However, searches on some terms related to sexuality led to substantially more health information blocking. More restrictive blocking configurations blocked pornography only slightly more, but substantially increased blocking of health information sites.

Access to Information↗

MFDTool: a software program for designing optimal multifunction displays.

This paper describes a software program called MFDTool. MFDTool is used to design multifunction displays (MFDs), which enable people to interact with computer information systems. MFDTool characterizes the problem of MFD design as the identification of how people interact with the system and what types of constraints should be imposed by the designer to shape the properties of the MFD. Once this information is provided, MFDTool uses an optimization procedure to build a variety of candidate MFD designs and to identify the MFD design that best satisfies the constraints. An example of MFD design is discussed.

Algorithms↗

Computer-based design of novel protein structures.

Over the past 10 years there has been tremendous success in the area of computational protein design. Protein design software has been used to stabilize proteins, solubilize membrane proteins, design intermolecular interactions, and design new protein structures. A key motivation for these studies is that they test our understanding of protein energetics and structure. De novo design of novel structures is a particularly rigorous test because the protein backbone must be designed in addition to the amino acid side chains. A priori it is not guaranteed that the target backbone is even designable. To address this issue, researchers have developed a variety of methods for generating protein-like scaffolds and for optimizing the protein backbone in conjunction with the amino acid sequence. These protocols have been used to design proteins from scratch and to explore sequence space for naturally occurring protein folds.

Algorithms↗

BASIC-language software for simultaneous monitoring of blood glucose level and neuronal firing frequency.

We have designed software for an Apple II GS microcomputer allowing simultaneous on-line monitoring of blood glucose level and neuronal firing frequency in experimental rats. Blood glucose level in the carotid blood was continuously measured by a glucose analyzer and digitized through an A/D board. The firing rate of a brain neuron, recorded by a classical technique, was counted by a versatile interface adapter. Both parameters are graphically displayed on the screen. They can also be exported to another computer for off-line analysis. This software is adaptable to other experimental applications in electrophysiology, involving the monitoring of glycemia or other biological parameters.

Animals↗

Expanding the capabilities of laboratory instruments using built-in microprocessors and serial interfaces: adapting an LKB Ultrospec II UV spectrophotometer for scanning and enzyme kinetic analyses.

An IBM-compatible microcomputer was used to enable an LKB Ultrospec II UV-Visible spectrophotometer to perform two features which are not available on the basic unit: wavelength scanning and enzyme kinetic analyses. The spectrophotometer was controlled using a simple BASIC program, an RS232c interface and the instrument's own built-in microprocessor. This technique required no special analogue to digital conversion hardware or software and only a rudimentary knowledge of programming. User-designed software permits a greater degree of flexibility in routines and output formats than is offered in most pre-programmed instruments, while offering substantial savings.

Data Display↗

West Nile virus surveillance: A simple method for verifying the integrity of RNA in mosquito (Diptera: Culicidae) pools.

In a West Nile virus (WNV) -free ecosystem, it is essential to verify the integrity of RNA before concluding that RNA extracted from mosquito specimens is negative for WNV gene sequences. The primary objective of our study was to develop a rapid molecular assay to rapidly screen mosquitoes for the presence of 18S RNA and WNV gene sequences. Mosquitoes, collected from multiple sites on the island of O'ahu, were pooled into groups of 1-50 mosquitoes according to capture site, date, and species. Using primer design software and the GenBank database, generic oligonucleotide primer pairs were designed to amplify mosquito18S rRNA gene sequences from different species. RNA was extracted from mosquito pools, and reverse transcriptase-polymerase chain reaction (RT-PCR) was performed for the presence of mosquito18S rRNA and WNV gene sequences. Three of the seven primer pairs successfully detected 18S rRNA sequences for both Aedes and Culex by RT-PCR, and one primer pair successfully amplified 18S rRNA sequences for 15 different mosquito species. All 64 mosquito pools from 10 different sites on the island of Oahu, Hawaii, were negative for WNV nonstructural protein-5 gene sequences. This simple, one-step RT-PCR method for screening mosquito pools for arboviruses will become an increasingly valuable tool as WNV becomes endemic throughout the Americas.

Aedes↗

[Orthopedic treatment of scoliosis: new technique using impression by optic procedure].

The authors present a new procedure for acquiring the whole external trunk shape. The construction of braces starts with corrected a positive mold using computer-assisted design software connected to a digital tooling machine. The computer-assisted design and construction of braces enable the determination, measurement, and modification of a three-dimensional image of the trunk, which allows the positive to be corrected. The outer-trunk can be re-balanced, derotated or rectified in the sagittal or frontal plane and the inner modeling of the spine and chest can be rectified. Moreover, in the case of scoliosis or kyphosis, the software produces automatic correction. This rapid (acquisition time < 2 seconds), non invasive, safe and painless procedure can also be used to detect and follow mild spinal deformities.

Adolescent↗

[Validation of a new in vivo measurement method to measure subsidence of a cemented Exeter femoral stem].

PURPOSE OF THE STUDY: Total hip arthroplasty has become one of the most common procedures in orthopedic surgery. These patients must nevertheless be followed with care due to the risk of instability. Knowledge of early migration behavior can provide an indirect assessment of implant fixation. The purpose of this work was to develop a new measurement tool for early assessment of the femoral component. MATERIAL AND METHODS: We analyzed the x-rays of ten Exeter stems (Stryker-Howmedica) implanted between 1996 and 2001 using a simple software designed to calculate the vertical subsidence of each implant. The technical precision and inter-observer reproducibility were checked. RESULTS: The software provided a precision of 0.14-0.3 millimeters. The overall precision of the technique was 1.2 millimeters. There was no statistically significant inter-observer variability. We observed a mean subsidence of 1.3+/-0.7 millimeters at six Months, followed by no further migration. DISCUSSION AND CONCLUSION: This new method was found to be reliable. It is useful for identifying implant migration at different bone-cement-implant interfaces. The time course of subsidence appears to be important to determine threshold values for failure. This tool provides an easy-to-use method for both retrospective and prospective analysis. With minor modifications of the software program, this tool can be used for other types of implants.

Adult↗

Predictive functional control (PFC) and its application in chlorinated polyethylene process.

The main principle and the characteristic of Predictive Functional Control (PFC) strategy are presented in this paper and the corresponding control system aid design software APC-PFC is also introduced. For a chlorinated polyethylene (CPE) process, a design scheme of cascade predictive functional control system is described and the control performance is improved obviously.

Algorithms↗

Component-based integration of chemistry and optimization software.

Typical scientific software designs make rigid assumptions regarding programming language and data structures, frustrating software interoperability and scientific collaboration. Component-based software engineering is an emerging approach to managing the increasing complexity of scientific software. Component technology facilitates code interoperability and reuse. Through the adoption of methodology and tools developed by the Common Component Architecture Forum, we have developed a component architecture for molecular structure optimization. Using the NWChem and Massively Parallel Quantum Chemistry packages, we have produced chemistry components that provide capacity for energy and energy derivative evaluation. We have constructed geometry optimization applications by integrating the Toolkit for Advanced Optimization, Portable Extensible Toolkit for Scientific Computation, and Global Arrays packages, which provide optimization and linear algebra capabilities. We present a brief overview of the component development process and a description of abstract interfaces for chemical optimizations. The components conforming to these abstract interfaces allow the construction of applications using different chemistry and mathematics packages interchangeably. Initial numerical results for the component software demonstrate good performance, and highlight potential research enabled by this platform.

Journal Article↗

A new composite model of objects for Monte Carlo simulation of radiological imaging.

A composite object model is proposed for Monte Carlo simulation of radiological imaging systems. The composite model contains four components: a set of regular and 'voxelized' primitives, a 'modular' inclusion tree, a set of designated constructive solid geometry (CSG) trees, and a mapping from the set of CSG trees to the inclusion tree. The voxelized primitive is a primitive containing a stack of voxels whose intersections with a photon path are calculated based on Siddon's method. The inclusion tree is employed to describe the inclusion relationships of homogeneous subregions of material characteristics in larger regions in an object. The model is designed so that the 'divide-and-conquer' principle for modular software design can be used to construct an inclusion tree for a complex object. The designated CSG trees are used to model source distributions. The mapping from the inclusion tree to the CSG trees provides the fundamental information for the initial location of a photon history in the tree. Computational issues are addressed for the new model. For the modular inclusion tree, a computationally efficient algorithm is proposed in conjunction with the determination of the photon-ray intersections with primitive and voxel boundaries as well as with the identification of the material characteristics for each ray segment between two adjacent intersections. For source distributions, the designated CSG trees are defined based on the set intersections-difference-unions (IDU) operation sequence. The IDU operations present computation advantages over existing source modelling based on a single inclusion tree. For voxelized primitives, a new sampling technique called the fractional photon emission technique is introduced to reduce sampling computations for existing techniques based on single photon emission. The composite model is an extension of existing simple-geometry, solid-geometry, and voxel-based models and hence provides greater flexibility for model optimization. Based on the composite model, two objects were simulated: an anthropomorphic thorax with lesion inserts for transmission studies and a 3D Hoffman brain phantom with lesion inserts for emission studies. The simulations demonstrate the flexibility of the composite approach in modelling objects for clinically significant applications.

Computer Simulation↗

A Jini service to reconstruct tomographic data.

Distributed computing that uses dynamic networks will change the way we work and communicate thanks to the interaction of devices and services, that are automatically added and removed from the network as needed. The Jini technology, which is built atop the Java programming language, provides a homogenous view of the network and extends the ability of code to migrate in Java. This software design model simplifies the configuration and access to hardware devices and software services in a network. Thus, it becomes possible to execute new services without pre-installing software on client machines. This new programming paradigm is especially important in medical applications, where the reliable transmission of information is essential. This paper demonstrates how single photon emission computerized tomography data can be iteratively reconstructed using a Jini service.

Computer Communication Networks↗

The design and structure of clinical research information systems. Implications for data retrieval and statistical analyses.

Data management software designed to support clinical data bases typically provides the user with the ability to "enter" and "retrieve" information according to simple user-specified criteria. In the medical research environment, such data base management systems can be self-limiting unless the user has carefully structured the data base schema to be consistent with subsequent statistical procedures used for analysis. For statistical purposes, the data base schema must be configured such that the dependent and independent variables are structurally situated to facilitate the use of statistical application programs. Furthermore, the analysis of time-oriented, prospective studies often requires the data base to be "relational." This may be inconsistent with data collection procedures that result in "hierarchical" schemata. Methodology for ensuring compatibility between the data base schema and subsequent statistical analyses is presented using examples derived from a multicenter clinical trial of diabetes and an observational data bank approach to disease surveillance in rheumatology.

Computers↗

Automating combinatorial chemistry: a primer on benchtop robotic systems.

Benchtop robotic systems are inexpensive, flexible automation tools with potential applications in a wide array of disciplines such as combinatorial chemistry, high-throughput screening, and genomics. We explain the basic components of a benchtop system and explore factors to consider when purchasing or customizing a robot, such as automation benefits, vendor selection, and current system limitations. Issues involving system specification, software design, and hardware customization are then discussed. Additionally, system optimization, validation, and support are detailed. Given a properly designed and implemented system, the combinatorial laboratory can markedly increase compound synthesis and purification.

Computers↗

A Two-Dimensional X-ray Scattering System for In-Situ Time-Resolving Studies of Polymer Structures Subjected to Controlled Deformations.

A two-dimensional X-ray scattering system developed around a CCD-based area detector is presented, both in terms of hardware employed and software designed and developed. An essential feature is the integration of hardware and software, detection and sample environment control which enables time-resolving in-situ wide-angle X-ray scattering measurements of global structural and orientational parameters of polymeric systems subjected to a variety of controlled external fields. The development and operation of a number of rheometers purpose-built for the application of such fields are described. Examples of the use of this system in monitoring degrees of shear-induced orientation in liquid-crystalline systems and crystallization of linear polymers subsequent to shear flow are presented.

Journal Article↗

Development and validation of a computed tomography-based methodology to measure carpal kinematics.

Motion of the wrist bones is complicated and difficult to measure. Noninvasive measurement of carpal kinematics using medical images has become popular This technique is difficult and most investigators employ custom software. The objective of this paper is to describe a validated methodology for measuring carpal kinematics from computed tomography (CT) scans using commercial software. Four cadaveric wrists were CT imaged in neutral, full flexion, and full extension. A registration block was attached to the distal radius and used to align the data sets from each position. From the CT data, triangulated surface models of the radius, lunate, and capitate bones were generated using commercial software. The surface models from each wrist position were read into engineering design software that was used to calculate the centroid (position) and principal mass moments of inertia (orientation) of (1) the capitate and lunate relative to the fixed radius and (2) the capitate relative to the lunate. These data were used to calculate the helical axis kinematics for the motions from neutral to extension and neutral to flexion. The kinematics were plotted in three dimensions using a data visualization software package. The accuracy of the method was quantified in a separate set of experiments in which an isolated capitate bone was subjected to two different known rotation/translation motions for ten trials each. For comparison to in vivo techniques, the error in distal radius surface matching was determined using the block technique as a gold standard. The motion that the lunate and capitate underwent was half that of the overall wrist flexion-extension range of motion. Individually, the capitate relative to the lunate and the lunate relative to the radius generally flexed or extended about 30 deg, while the entire wrist (capitate relative to radius) typically flexed or extended about 60 deg. Helical axis translations were small, ranging from 0.6 mm to 1.8 mm across all motions. The accuracy of the method was found to be within 1.4 mm and 0.5 deg (95% confidence intervals). The mean error in distal radius surface matching was 2.4 mm and 1.2 deg compared to the use of a registration block. Carpal kinematics measured using the described methodology were accurate, reproducible, and similar to findings of previous investigators. The use of commercially available software should broaden the access of researchers interested in measuring carpal kinematics using medical imaging.

Adult↗

ScriptWriter. A relational database to manage outpatient medical treatment.

ScriptWriter is database software designed to replicate the process of a physician writing a prescription. The software also includes standard demographic and progress note information; however the focus of the software is on automating the process of writing prescriptions. The software is especially adept at creating patient medication lists, generating medication histories and keeping track of medication expiration dates. Other strengths include its ability to organize patient assignments and assist in the generation of progress notes. The application is network capable and fully graphical. A psychiatric outpatient clinic is currently using the software. Practitioners in non-psychiatric settings can also benefit from the software.

Ambulatory Care↗

The integrated design of mechanical bi-leaflet prosthetic heart valves.

A flow model utilizing an irrotational, inviscid algorithm of vortex-ring elements simulating the leaflets and source/sink elements simulating the aortic root coupled with a boundary layer model has been developed to model the internal flow phenomena of bi-leaflet mechanical heart valves implanted in the aortic root. The inviscid representation evaluates the aerodynamic lift, the induced drag, the pitching moment and flow velocity along the leaflet surface thus providing data for evaluating the boundary-layer thickness, the shear stress and flow separation point by the boundary layer theory. Full integration with the geometry enables immediate updates of the flow solution when changes in geometry have been made. It is shown that the effects of the internal flow domain model are necessary in the correct evaluation of lift and drag for subsequent dynamic analysis. The environment presented provides for the ability to produce significant and immediate design changes so that crucial decisions may be made whilst still within the software design loop. New designs are shown along with data for the improved flow model.

Algorithms↗