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Suture materials and suture techniques used in tendon repair.

Immediately after a tendon repair, the tendon contributes nothing to the strength of repair. During that time, the suture itself and suture technique are the sole contributors to the strength of repair. Although stainless steel is the strongest material that can be used at the time of repair, it has serious disadvantages. It is difficult to work with and makes a bulky knot. Conversely, all absorbable sutures become too weak too soon to be of value. At this time, nonabsorbable, synthetic fibers that are relatively strong, such as Supramid or prolene, are the most desirable materials available. Regarding suture techniques, the lateral trap and end-weave techniques produce the strongest repairs; however, the end-weave technique can only be used with tendon grafts and the lateral trap, though it can be used for end-to-end primary repairs. It is too bulky for use in the fingers and hand but is ideal for the forearm and wrist. In the hand and fingers, the strongest repair techniques available are the Bunnell, Kessler, and Mason-Allen; however, the Bunnell stitch is more strangulating to the microcirculation of the tendon than the latter two stitches; thus, it contributes to tendomalacia and gap formation. The simplest and least traumatic suture technique, though weakest at first, will allow tendon healing to proceed more rapidly. If such a repair is protected from tension by splinting the wrist and metacarpophalangeal joints in flexion during healing (while allowing controlled passive motion of the finger joints), there will be a rapid increase in tensile strength of the tendon juncture with minimal gap formation, as the repaired hand is progressively stressed up until about 90 days postrepair. At that point, strength plateaus and maximum stress can be applied to the repaired tendon. Somewhere between three and six weeks post-tendon repair, the suture material and technique become secondary to tendon healing as the primary provider of tensile strength to the tendon wound. The less traumatic suture techniques facilitate closure of the tendon sheath, which not only acts as a mechanical barrier to the ingrowth of extrasheath adhesion, which produces fibroblasts, but also re-establishes the continuity of the synovial fluid system, which is a major source of nutrition to the tendon. The healing tendon then can be thought of as a delicate structure, one not to be overmanipulated, traumatized, strangulated, or stretched.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model.

UNLABELLED: A variety of intraluminal sutures have been used in the middle cerebral artery occlusion model (MCAO) of focal ischemia. In the present study we tested commercially available silicon-coated nylon suture in the MCAO model and compared the results to traditional monofilament nylon suture occlusion. Twelve Sprague-Dawley male rats were randomly divided two groups, MCAO with 4-0 nylon suture (Group N, n=6) and MCAO with silicone-coated 4-0 nylon suture (Group S, n=6). Rats were sacrificed 24 h after reperfusion. Assessment included mortality rates, neurological evaluation, and infarct volume. One rat died in each group from subarachanoid hemorrhage. Neurological evaluation demonstrated that Group S tended to have worse neurological outcomes than Group N, although this difference was not statistically significant. On TTC stain Group S had significantly larger infarct volumes than Group N. We conclude that the commercially available silicone-coated occlusion suture provides better occlusion of the middle cerebral artery than the traditional uncoated nylon suture. CLASSIFICATION: Disease-related neuroscience (Section 6).

Animals↗

Influence of suture technique and suture material selection on the mechanics of end-to-end and end-to-side anastomoses.

Experiments were performed in dogs to evaluate the mechanics of 26 end-to-end and 42 end-to-side artery-vein graft anastomoses constructed with continuous polypropylene sutures (Surgilene; Davis & Geck, Division of American Cyanamid Co., Danbury, Conn.), continuous polybutester sutures (Novafil; Davis & Geck), and interrupted stitches with either suture material. After construction, the grafts and adjoining arteries were excised, mounted in vitro at in situ length, filled with a dilute barium sulfate suspension, and pressurized in 25 mm Hg steps up to 200 mm Hg. Radiographs were obtained at each pressure. The computed cross-sectional areas of the anastomoses were compared with those of the native arteries at corresponding pressures. Results showed that for the end-to-end anastomoses at 100 mm Hg the cross-sectional areas of the continuous Surgilene anastomoses were 70% of the native artery cross-sectional areas, the cross-sectional areas of the continuous Novafil anastomoses were 90% of the native artery cross-sectional areas, and the cross-sectional areas of the interrupted anastomoses were 107% of the native artery cross-sectional areas (p < 0.05). At physiologic pressures, there were no differences in compliance among the three types of anastomosis. These data suggest that when constructing an end-to-end anastomosis in a small vessel, one should use an interrupted suture line or possibly continuous polybutester suture. Forty-two end-to-side anastomoses demonstrated no differences in cross-sectional areas or compliance for the three suture techniques. This suggests that, unlike with end-to-end anastomoses, when constructing an end-to-side anastomosis in patients any of the three suture techniques may be acceptable.

Anastomosis, Surgical↗

Modified arthroscopic suture fixation of displaced tibial eminence fractures using a suture loop transporter.

Current arthroscopic suture fixation techniques of tibial eminence fractures are time consuming and the number of anchor sutures that can be placed is limited by the cumbersome and repetitive numerous needle threading steps. This occurs at 2 stages: first, when placing anchoring sutures through the avulsed anterior cruciate ligament stump with a suture punch, and second, when there is a need to traverse the tibial bone canal with the suture ends. We describe a modification that reduces the reliance on conventional rigid instruments and instead uses a loop transporter made from readily available suture material. The suture loop transporter being malleable reduces the necessary width of the tibial bone canal to be made and has a further advantage of minimizing the bone loss during the reaming of the bone tunnel. The subsequent potential for a stress fracture at these tunnel sites is also substantially reduced. Our technique is more user friendly, more accurate, and quicker to perform.

Adult↗

The three-loop pulley suture versus two locking-loop sutures for the repair of canine achilles tendons.

OBJECTIVE: To compare a 3-loop pulley suture pattern with 2 locking-loop sutures for the repair of components of the canine Achilles mechanism. STUDY DESIGN: In vitro biomechanical study. ANIMALS: Forty-eight paired tendons collected from 9 canine cadavers. METHODS: Paired tendons were repaired with either a 3-loop pulley suture or 2 locking-loop sutures and tensile tested to failure. To ensure accurate anastomosis gap measurement a direct, non-contact, method of gap measurement, using digital video, was devised. Load initiating gap formation (defined as load at a 1 mm gap) and load producing a 3 mm gap were evaluated in addition to maximum load, gap at failure, mode of failure, and time spent placing the sutures. RESULTS: Maximum load values were similar for both repairs. The mean 1 mm gap loads were 44.0 and 18.4 N, and the mean 3 mm gap loads were 56.3 and 34.7 N, for the 3-loop pulley pattern and the 2 locking-loops, respectively; these differences were statistically significant. The 3-loop pulley pattern was faster to place and resulted in a smaller gap at failure. All but 2 repairs failed by suture pull out. CONCLUSIONS: The 3-loop pulley pattern is more resistant to gap formation during tensile loading, and is quicker to place, than 2 locking-loop sutures. CLINICAL RELEVANCE: Gap formation can significantly delay tendon healing. Tendon repairs with a gap >3 mm are reported to be at increased risk of rupture during the first 6 weeks postoperatively.

Achilles Tendon↗

Vasal reanastomosis using fibrin glue combined with sutures: which combination of sutures in a delayed protocol? Experimental study in rats.

OBJECTIVES: The actual number of transmural sutures needed to ensure a successful fibrin-glued vasovasostomy is a key study parameter of the few experimental works already published. The present work was done to evaluate fibrin-glued vasovasostomy in rats in combination with only 2 transmural sutures. We compared the results to our previous study in which we demonstrated the efficiency of a combination of the use of fibrin glue with 3 sutures in comparison with a conventional microsurgical technique. MATERIALS AND METHODS: Twenty Sprague-Dawley rats underwent bilateral vasectomy followed 2 weeks later by bilateral vasovasostomy using fibrin glue combined with 2 transmural sutures. Each animal was sacrificed 7 weeks postoperatively after a 3-week mating period with a Sprague-Dawley female rat, the vasal specimens were evaluated for sperm granuloma formation. Mean operative time and fertility rates were recorded. RESULTS: The combination of fibrin glue with 2 transmural sutures gave evidence of less successful performances than the combination with 3 transmural sutures and the conventional microsurgical technique for all parameters evaluated but the mean operative time. CONCLUSION: Our study underlines the need for a third transmural suture placed 120 degrees apart from the others when performing a fibrin glue delayed vasovasostomy. This allows a better vas lumen opening at the anastomotic site and therefore a more efficient vasal anastomosis in a delayed protocol.

Anastomosis, Surgical↗

Comparison of delayed absorbable suture v nonabsorbable suture for treatment of incompetent cervix.

UNLABELLED: This is a retrospective study of McDonald cerclages comparing absorbable suture v. nonabsorbable suture and showing no adverse outcomes associated with the absorbable cerclage group. OBJECTIVE: To compare the efficacy of traditional nonabsorbable suture to delayed absorbable suture for use in McDonald cervical cerclage. STUDY DESIGN: A retrospective analysis was conducted examining all cerclage procedures over a one year interval, from 7/01/97 until 6/03/98. Cases were stratified by the type of suture material, specifically nonabsorbable versus delayed absorbable. Demographic data, as well as selected perinatal outcomes were analyzed for each group. Statistical analysis was performed using Chi-square and Fishers Exact test for categorical data, and the Student t-test for continuous variables. A p < .05 was considered statistically significant. RESULTS: Eighteen patients who underwent a McDonald cerclage were analyzed. In fourteen a nonabsorbable cerclage was utilized and in four an absorbable cerclage was used. The mean gestational age at delivery for the nonabsorbable suture group was 36.9 weeks compared to 39.2 weeks for the patients receiving an absorbable cerclage (P = 0.2). The mean birth weights for each group were 2732 +/- 183 grams and 3616 +/- 343 grams, respectively (P = 0.04). CONCLUSION: Based on our findings delayed absorbable suture material may be a reasonable alternative during cerclage placement, with the added benefit of spontaneous degradation versus surgical removal.

Absorption↗

Keratometric results during the first year after keratoplasty: adjustable single running suture technique versus double running suture technique.

BACKGROUND AND OBJECTIVE: To compare the 3-month and 1-year postoperative keratometric results in a retrospective sequential series of corneal grafts performed with either a double running suture technique or an adjustable single running suture technique. MATERIALS AND METHODS: Keratometry values obtained 3 months and 1 year after penetrating keratoplasty, when sutures were still present, were compared between 31 grafts with double running sutures and 27 grafts with single running sutures, 15 of which had been adjusted postoperatively. RESULTS: No significant difference in mean keratometry between the 2 groups was found either 3 months or 12 months after keratoplasty. Mean keratometric astigmatism was significantly less in the single running group at both 3 months (2.2 +/- 1.9 vs 4.5 +/- 2.8, mean +/- SD, P <0.001) and 12 months (3.0 +/- 2.2 vs 4.2 +/- 2.1, P = 0.03). Within groups, there was no significant change from 3 months to 12 months in either mean keratometry or keratometric astigmatism. CONCLUSION: The single running suture technique, with postoperative adjustments, produced less keratometric astigmatism during the first postoperative year, when sutures were still in place.

Astigmatism↗

A modified suture placement technique to avoid suture drag or "cheese wire" effect.

A modified technique is described for microsurgical suture placement, irrespective of the closure technique, to prevent suture drag and loosening of the suture following postoperative wound edema. Fine, elastic, non-absorbable sutures which loosen as a result of suture drag or "cheese wiring" have no more reliability than do absorbable or silk sutures. Predictable and reproducible results of suture placement are necessary to allow the surgeon to effectively use the operating keratometer in the control and modification of corneal astigmatism following anterior segment surgery.

Astigmatism↗

Chemistry and safety of triclosan, and its use as an antimicrobial coating on Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 suture with triclosan).

BACKGROUND: The safety of the antimicrobial agent triclosan was reviewed, and the biocompatibility of coated polyglactin 910 suture with triclosan was evaluated. METHODS: Acute single exposure LD(50) values for triclosan were determined in multiple species by several routes of administration. Subacute to chronic toxicity for dermal and oral exposure to triclosan was determined in multiple species in studies of up to one year's duration. Chronic oral toxicity/carcinogenicity potential was determined in 2-year studies in rodents and non-rodents. The genotoxicity potential of triclosan was determined using a battery of standard assays. Reproductive toxicity and teratology studies were conducted in rodents and non-rodents. Immunotoxicity studies in guinea pigs and the repeat-insult patch test in humans were conducted to assess the potential for sensitization reactions. Pharmacokinetic studies were conducted in animals and humans to understand the metabolic profile of triclosan. Preclinical biocompatibility studies conducted on coated polyglactin 910 suture with triclosan included in vitro cytotoxicity, in vivo intracutaneous reactivity, material-mediated pyrogenicity, and intramuscular tissue reaction/absorption studies. RESULTS: The oral LD(50) values for triclosan ranged from 3,750 to 5,000 mg/kg, whereas the LD(50) after subcutaneous injection was >14,600 mg/kg. Safety factors calculated from repeated daily dosing studies ranged from 1,000 to 25,000 times the no-observed-effect levels. There was no evidence of carcinogenic potential in either species, and genotoxicity studies were negative. Reproductive toxicity studies did not reveal any evidence of teratogenic potential. There was no evidence of skin sensitization potential in controlled studies. Pharmacokinetic studies in animals and humans have shown that triclosan is rapidly absorbed, well distributed in the body, metabolized in the liver, and excreted by the kidneys, with no indication of accumulation over time. Biocompatibility studies showed that coated polyglactin 910 suture with triclosan was non-cytotoxic, non-irritating, and not a chemical pyrogen. In addition, an intramuscular implantation study demonstrated a tissue reaction, a healing response, and an absorption profile comparable to current polyglactin 910 suture. CONCLUSION: The extensive toxicology database supporting the safety of triclosan and the biocompatibility studies conducted on coated polyglactin 910 suture with triclosan demonstrate the safety of this suture for clinical use. Considering the clinical relevance of surgical site infections and the relatively low level of triclosan required to inhibit bacterial colonization of the suture, the use of this antimicrobial technology is well suited to this application.

Animals↗

A 28-day study of the effect of Coated VICRYL* Plus Antibacterial Suture (coated polyglactin 910 suture with triclosan) on wound healing in guinea pig linear incisional skin wounds.

BACKGROUND: This study evaluated the effect of coated polyglactin 910 suture with triclosan on tissue response and wound healing over a 28-day period on full-thickness linear wounds in the hairless guinea pig model. METHODS: In situ wound strength was assessed, and histopathologic effects on tissue response and wound healing were evaluated. Four (1.9 cm) full-thickness incisional wounds were created on the dorsolateral region (two left and two right, approximately 3 cm apart) in 40 Hartley male hairless guinea pigs (400-500 g). A 1.9-cm segment of suture material was implanted "length-wise" into the incision and the sites closed with simple interrupted closure with 3-0 nylon sutures. The test material was 2-0 coated polyglactin 910 suture with triclosan and the control material was 2-0 Coated VICRYL* Suture (coated polyglactin 910 suture). On days 3, 7, 14, and 28 postimplantation (n = 10/time interval), body weights were recorded, tissue specimens harvested, and bursting strength testing performed. RESULTS: There was no significant difference (P > 0.05) in bursting strength between the study groups for any of the time intervals studied. The bursting strengths (mm Hg) for the sutures with triclosan were 95.8 (day 3), 268.8 (day 7), 542.6 (day 14), and 633.8 (day 28). Both materials demonstrated comparable tissue response to implantation, and there were no significant differences (P > 0.05) observed in wound healing based on cellular response and collagen formation and orientation. CONCLUSION: Based on the in vivo biomechanical testing and histological results, no evidence of impedance to wound healing was detected.

Animals↗

[Animal experiment studies of suture material and suture technic of the stomach].

The aim of these examinations was a comparison of the tensile strength and the histology of single and two-layer sutured gastrotomies applied to rats. Independent of the applied suture material and suture technique all experiments resulted in the same tensile strength of the suture between the 5th and 7th postoperative day as in the control group. Differences of anastomotic dehiscence did not exist. The single-layer can be loaded as well as the two-layer suture. Any difference of the tensile strength of anastomosis depending on the suture material does not exist.

Animals↗

Embedded cross-stitch suture: an alternative to current cross-stitch peripheral suture.

The cross-stitch peripheral suture has good strength, but the large amount of exposed suture on the tendon surface has restricted its clinical usage. We report a method of embedded cross-stitch that incorporates cross-stitches into peripheral sutures and reduces the amount of exposed suture on the tendon surface. Thirty-three fresh pig flexor tendons were divided equally into three groups and repaired with cross-stitch, embedded cross-stitch, or modified Halsted sutures. The tendons were tested in an Instron tensile machine to assess the mechanical performance of these repairs. With an identical number of strands across the repair site, the gap formation and ultimate forces of the embedded cross-stitch method were statistically greater than those of the cross-stitch and modified Halsted methods. The embedded cross-stitch method also had significantly greater stiffness and energy to failure than the cross-stitch method. The embedded cross-stitch method, with little suture exposure on the tendon and sufficient strength, presents an alternative to the current cross-stitch peripheral repair.

Animals↗

Modified Caspari technique for traumatic anterior shoulder instability: comparison of absorbable sutures versus absorbable plus nonabsorbable sutures.

The efficacy of the Caspari technique using a combination of absorbable and nonabsorbable sutures was compared with that of using only absorbable sutures. Forty-four patients (45 shoulders) underwent our modified Caspari technique for traumatic anterior shoulder instability and were followed-up for 2 to 3 years postoperatively. The average age at operation was 22 years. Among 27 patients treated using all absorbable PDS sutures, 7 patients had recurrent instability (success rate, 74%). Among 18 patients treated using both PDS and nonabsorbable polypropylene sutures, only one showed apprehension after a direct blow to the shoulder sustained by falling from a height (success rate, 94%). The mean stability score according to Rowe's criteria was significantly higher in the combination of absorbable and nonabsorbable group (P = .0412). External rotation increased more slowly in the combination of absorbable and nonabsorbable group than in the absorbable group. The mean limitation of external rotation was 8.4 degrees and 2.7 degrees, respectively (P = .0129). The modified Caspari technique using both absorbable and nonabsorbable sutures achieved excellent stability according to Rowe's criteria and external rotation showed more gradual improvement compared to repair with absorbable sutures alone.

Absorbable Implants↗

Fixation strength of rotator cuff repairs with suture anchors and the transosseous suture technique.

The strength of classic transosseous suture repair of rotator cuff tendons was compared with similar repairs with four "third-generation" suture anchors. Results demonstrate the repair construct selected had a significant influence on failure at ultimate load (p = 0.005). Among the anchors tested the Statak design was significantly stronger than the other three. Furthermore Statak, Harpoon, and Superanchor designs were all significantly stronger than the Revo screw. No significant difference was seen between the strength of repairs performed with the Statak, the Harpoon, or the Superanchor compared with the transosseous suture technique. The transosseous suture technique was significantly stronger than repairs performed with the Revo. We conclude suture anchor design has evolved to a point where initial fixation of torn rotator cuff tendons is equivalent to more traditional techniques using only sutures.

Aged↗

[Suture and suture material in the surgery of finger tendons].

The authors describe two methods of suturing injured finger tendons and requirements to suture material. A polyamide monofilament thread with a conventional number 3/0 used by the authors for a removable suture of the tendon is the suture material of choice. For a buried suture it is expedient to use absorbable threads which begin degrading within three weeks after operation. The developed by the authors loop-shaped removable and buried sutures are strong, atraumatic and simple for fulfillment.

Finger Injuries↗

[Microsurgical nerve and blood vessel sutures using a resorbable suture material].

Anastomosis of A. carotis and of N. ischiadicus of the rat were carried out by microsurgical technique in comparison to the nonabsorbable suture material Ethilon and the absorbable Vicryl, both 0,2 metric. There occurred no suture insufficiencies with either sutured nerves or vessels. After 70-84 days the Vicryl sutures were completely absorbed. In particular with nerve sutures Vicryl proved to be superior to Ethilon, as the displacement of axons in the area of granuloma decreased with progressing absorption of the suture and thus also resulting less renewed and thus also resulting less renewed degeneration of the axons.

Animals↗

A review of absorbable suture materials in head & neck surgery and introduction of monocryl: a new absorbable suture.

Absorbable sutures are used frequently in the practice of surgery yet there have been no studies in the literature that review the currently available sutures. A newly released suture was used in a series of 80 head and neck patients and the results compared to the surgeon's experience with other absorbable suture materials. The literature regarding absorbable sutures is reviewed and background information on currently available sutures is provided. The tensile strength and absorption of various materials are compared. Degree of tissue reactivity in animals is presented. Results of the evaluation of Monocryl in 80 cases suggest that it has many preferable qualities including ease of handling, low tissue reactivity, superior tensile strength, and lower cost.

Absorption↗