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[Salicylamide].

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Arthritis↗

Synthesis of some N-substituted salicylamides structurally related to certain antimicrobials.

The condensation of 5-nitrosalicoylchloride and 5-sulphamoylsalicylic acid with certain amines is described. Reacting the acid chloride with 3-amino-2-oxazolidone, 4-aminophenazone, thiosemicarbazide, 1-aminohydantoin and 2-aminopyridine yielded the correspondong N-substituted 5-nitrosalicylamides (1a-c), while with semicarbazide a disubstituted product type 2 was obtained. On the other hand, when 5-sulphamoylsalicylic acid was condensed with o-chloroaniline, m-chloroaniline and 4-aminophenazone in the presence of phosphorus trichloride, instead of affording the expected condensation products type 3, it yielded N1N5-disubstituted 5-sulphamoylsalicylamides (4a-c). The synthesized compounds were screened for antimicrobial activity.

Antifungal Agents↗