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PubMed2005

Is poor performance on recognition memory effort measures indicative of generalized poor performance on neuropsychological tests?

The detection of suboptimal effort has become crucial in clinical neuropsychological practice in order to make accurate diagnoses, prognoses, and referrals. Symptom Validity Testing (SVT) has been the most commonly utilized model for assessing effort, and frequently includes recognition memory tasks. Some conflicting views on this model purport, however, that measures of effort gathered from a recognition memory paradigm do not necessarily extend to effort in other cognitive domains and other areas of performance. The present study sought to investigate whether performance on an SVT measure, which utilizes recognition memory, the TOMM, could predict performance on other measures that do not evaluate recognition memory or just memory per se in a group of mildly traumatic brain-injured litigants. Results indicated that poor performance on the TOMM was significantly correlated with poorer performance on the WAIS-R and the HRNB-A. Further, experimental exploration of these results indicated that the overall neuropsychological performance of litigants with suboptimal effort was poorer than what is generally expected from mild TBI individuals, and was also lower than the other mild TBI examinees in the study, who were not classified by the TOMM as exhibiting suboptimal effort. These findings support the proposition that poor effort as measured by recognition memory effort measures is not restricted to recognition and memory measures. In fact, in the present study it appears that a poor performance on the TOMM is predictive of a generalized poorer performance on standardized measures such as the WAIS-R and the HNRB-A.

Adolescent↗
PubMed2005

Transient inactivation of perirhinal cortex disrupts encoding, retrieval, and consolidation of object recognition memory.

Damage to perirhinal cortex (PRh) impairs object recognition memory in humans, monkeys, and rats when tested in tasks such as delayed nonmatching to sample, visual paired comparison, and its rodent analog, the spontaneous object recognition task. In the present study, we have capitalized on the discrete one-trial nature of the spontaneous object recognition task to investigate the role of PRh in several distinct stages of object recognition memory. In a series of experiments, transient inactivation of PRh was accomplished with bilateral infusions of lidocaine directly into PRh immediately before the sample phase (encoding), immediately before the choice phase (retrieval), or within the retention delay after the sample phase (storage-consolidation). Compared with performance on trials in which they received saline infusions, rats were significantly impaired when lidocaine was infused before the sample phase, regardless of the length of the retention delay. Similarly, delay-independent deficits were observed after immediate pre-choice infusions of lidocaine. Finally, PRh inactivation immediately and 20 min after the sample phase, but not 40, 60, or 80 min after, also disrupted subsequent object recognition when the retention delay was sufficiently long to ensure the dissipation of the actions of lidocaine during the choice phase. The effects of pre-sample and pre-choice inactivation indicate involvement of PRh in encoding and retrieval stages of object recognition, and the time course of post-sample inactivation effects suggests a role for PRh in the maintenance of the object trace during memory consolidation.

Animals↗
PubMed2005

Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats.

AIM: To examine the basic expression levels of N-methyl-D-aspartate (NMDA) receptor NR1 and NR2B subunits in six brain regions of Sprague-Dawley (SD) rats with different visual recognition memory. METHODS: Rats were tested by a novel-object-recognition model and grouped into the high and the low visual recognition memory groups. The expression levels of NR1 and NR2B subunits in the cortex, hippocampus, striatum, amygdala, diencephalon, and olfactory bulb were measured by semiquantitative immunoblotting. RESULTS: The NR1 and NR2B subunit protein levels in the hippocampus of the high visual recognition memory group were 35.9% (P<0.01) and 53.4% (P<0.05) higher respectively than those in the low group. In addition, the NR2B level in the striatum in the high visual recognition memory group was 25.0% (P<0.05) higher than that in the low one. However, no significant difference was found in the levels of the subunits between the two groups in other brain regions. CONCLUSION: The visual recognition memory in rats is related to the basic expression level of NMDA receptor NR1/NR2B subtype in the hippocampus and striatum.

Animals↗
PubMed1995

False positives in recognition memory produced by cohort activation.

Cohort theory in spoken-word recognition assumes that a cohort of word candidates consistent with incoming sensory information is activated implicitly as a spoken sound stimulus unfolds over time. Five experiments examined implications of this internal-generation-of-words mechanism. In Experiments 1 and 2, a "base" word was disqualified (the sensory information was no longer consistent with the word) either early or late in the presentation of a spoken stimulus. On a later recognition-memory test, significantly more false-positive errors occurred to base words following presentations of study items that had late, compared to early, disqualification points. Experiments 3-5 tested whether this phenomenon could be accounted for in terms of overlapping features between non-word stimuli and their base words or in terms of a post-identification processing mechanism. Experiment 3 replicated Experiments 1 and 2, and demonstrated that differences in early and late disqualification points for non-word targets, unlike word targets, were not related to false-positive recognition memory errors. The study inter-item interval in Experiment 4 was reduced to 1 s to minimize the role of post-identification processing activities, and the results for both word and non-word targets were consistent with Experiment 3. A word-association task in Experiment 5 revealed that the late non-word derivations used in this research were on the average more effective stimuli than the early non-word derivations in eliciting their base words. However, even when comparisons were restricted to item sets with early and late non-words that were equally effective in eliciting base words, false-positive recognition memory errors to target words were higher following prior presentations of their late derived non-words than following prior presentations of their early derived non-words.

Adult↗
PubMed1995

Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man.

Three groups of neurosurgical patients with temporal lobe excisions, frontal lobe excisions or unilateral amygdalo-hippocampectomy were assessed on a computerized battery of tasks designed to investigate visuo-spatial short-term recognition memory and learning. A double dissociation is reported between deficits of pattern recognition memory and spatial recognition memory which were observed in the two posterior groups and frontal lobe patients, respectively. In addition, both the temporal lobe and amygdalo-hippocampectomy patients were also impaired on a delayed matching-to-sample paradigm whilst frontal lobe patients performed at an equivalent level to controls. Finally, whilst the impaired performance of the three groups was indistinguishable on a test of paired-associate learning, quite different patterns of deficit were observed on a test of spatial working memory. These results are discussed with reference to recent suggestions that visual recognition memory is mediated by a neural system which includes, as major components, the inferotemporal cortex, the medial temporal lobe structures and particular sectors of the frontal lobe, and are compared to previous findings from patients with idiopathic Parkinson's disease and dementia of the Alzheimer type.

Adult↗
PubMed1999

Relaxing decision criteria does not improve recognition memory in amnesic patients.

An important question about the organization of memory is whether information available in non-declarative memory can contribute to performance on tasks of declarative memory. Dorfman, Kihlstrom, Cork, and Misiaszek (1995) described a circumstance in which the phenomenon of priming might benefit recognition memory performance. They reported that patients receiving electroconvulsive therapy improved their recognition performance when they were encouraged to relax their criteria for endorsing test items as familiar. It was suggested that priming improved recognition by making information available about the familiarity of test items. In three experiments, we sought unsuccessfully to reproduce this phenomenon in amnesic patients. In Experiment 3, we reproduced the methods and procedure used by Dorfman et al. but still found no evidence for improved recognition memory following the manipulation of decision criteria. Although negative findings have their own limitations, our findings suggest that the phenomenon reported by Dorfman et al. does not generalize well. Our results agree with several recent findings that suggest that priming is independent of recognition memory and does not contribute to recognition memory scores.

Aged↗
PubMed1998

Structural MRI correlates of recognition memory in Alzheimer's disease.

Neuroimaging and lesion studies have demonstrated that hippocampal volume correlates with memory performance, but material-specific lateralization of this structure-function relationship has been inconsistent. This MRI study examined the relative contributions of left and right temporal lobe volumes to verbal and nonverbal recognition memory in a group of 20 Alzheimer's disease (AD) patients. There was a significant relationship between extent of right hippocampal and right temporal gray matter tissue volume deficit and performance on the face recognition subtest of the Warrington Recognition Memory Test. The face recognition test correlated with right hemisphere volume but not to left, indicating a material-specific relationship between brain structure and function in this patient group. Right temporal horn volume did not account for a significant proportion of variance in face recognition memory. Although word recognition was not significantly correlated with either left or right hippocampal volume in the total group, there was a strong correlation between left hippocampal volume and word recognition memory in the female AD patients. Thus, face recognition shows a material specific relationship with select lateralized hippocampal and temporal cortical volumes in AD patients, regardless of gender, whereas the verbal recognition-left-hippocampal volume relationship may be mediated by gender.

Adult↗
PubMed1997

Possible role of nitric oxide-cyclic GMP pathway in object recognition memory: effects of 7-nitroindazole and zaprinast.

The effects of 7-nitroindazole, a putative selective inhibitor of neuronal nitric oxide (NO) synthase and zaprinast, a cGMP-selective phosphodiesterase inhibitor, were evaluated on recognition memory of rats in the object recognition test. This test is based on the differential exploration of a new and a familiar object. Two doses of 7-nitroindazole (10 and 30 mg/kg) and zaprinast (3 and 10 mg/kg) were used. The substances were administered i.p. immediately after the exposure to two identical objects, i.e., at the start of the delay interval. After a delay interval of 1 h, control rats spent more time exploring the new object which demonstrates that they recognized the familiar one. Both doses of 7-nitroindazole impaired the discrimination between the two objects after the 1 h interval. After a 4 h interval, control rats did not discriminate between the objects. The highest dose of zaprinast facilitated object recognition after the 4 h interval. In addition, this dose of zaprinast (10 mg/kg) reversed the recognition memory deficit induced by 7-nitroindazole (10 mg/kg) at the 1 h interval. The highest dose of 7-nitroindazole slightly increased mean arterial blood pressure 1 h after its administration. 4 h after administration of zaprinast (10 mg/kg), mean arterial blood pressure was also slightly increased, but not after 1 h after zaprinast administration. However, these effects on blood pressure do not explain the differential effects on object recognition memory. These results therefore suggest that NO-cGMP signal transduction is involved in object recognition memory independently of its cardiovascular role. Finally, since 7-nitroindazole affected mean arterial blood pressure it can not be regarded as a selective inhibitor of neuronal NO synthase.

Animals↗
PubMed1983

Effects of lateral reversal on recognition memory for photographs of faces.

Recognition memory for photographs of faces, which were initially shown in the normal orientation, then tested either normally (unchanged) or laterally reversed (changed), was examined in four experiments involving different experimental designs (between and within group) and different methods of testing (yes-no and forced-choice). Although the overall effect of the transformation was not as powerful as others (e.g. hair style change) which have been applied to faces, and even failed to attain statistical significance in a fifth experiment in which all the photographs were initially reversed at presentation then tested unchanged or changed back to their normal orientation, the main findings were as follows: (a) subjects recognized fewer reversed (changed) than normal (unchanged) photographs whether or not they were informed of the transformation; (b) the adverse effect of reversal occurred on faces looking straight ahead (full-faces) and, to a slightly lesser extent, on those looking to the left of the observer (left-lookers); (c) left-lookers and right-lookers (the left-lookers initially reversed in Expt 5) were less well recognized than full-faces; and (d) subjects had difficulty identifying orientation, where accuracy fell almost to chance level. These results are taken as support for a feature (rather than Gestalt) model of facial recognition in which the two sides of the face are differentiated in its memory representation.

Adolescent↗
PubMedDate not supplied

Impaired auditory recognition memory in amnesic patients with medial temporal lobe lesions.

Two tests of auditory recognition memory were given to four patients with bilateral hippocampal damage (H+) and three patients with large medial temporal lobe lesions and additional variable damage to lateral temporal cortex (MTL+). When single stimuli were presented, performance was normal across delays as long as 30 sec, presumably because information could be maintained in working memory through rehearsal. When lists of 10 stimuli were presented, performance was impaired after a 5-min delay. Patients with MTL+ lesions performed marginally worse than patients with H+ lesions, consistent with findings for recognition memory in other modalities. The findings show that auditory recognition, like recognition memory in other sensory modalities, is dependent on the medial temporal lobe.

Acoustic Stimulation↗
PubMed2000

Recognition memory impairment in Parkinson's disease: power and meta-analyses.

Contrary findings notwithstanding, the prevailing notion is that recognition memory is little affected by Parkinson's disease (PD). Both a power analysis and a meta-analysis were conducted to help clarify the degree of recognition memory deficit associated with PD. The power analysis confirmed that, in general, memory studies of PD participants have been underpowered. This analysis indicated the need to pool study results in a subsequent meta-analysis, the main finding of which was that recognition memory deficits do occur with PD. The largest deficit occurs in PD participants with dementia. Nevertheless, deficits also occur in PD participants without dementia on medication, but nondopaminergic central nervous system abnormalities are more likely to underlie this deficit than PD medication itself. Future development of a theory of cognitive dysfunction in PD should take into account these recognition memory deficits, which may increase with disease progression.

Aged↗
PubMed2004

The impact of left and right intracranial tumors on picture and word recognition memory.

This study investigated the effects of left and right intracranial tumors on picture and word recognition memory. We hypothesized that left hemispheric (LH) patients would exhibit greater word recognition memory impairment than right hemispheric (RH) patients, with no significant hemispheric group picture recognition memory differences. The LH patient group obtained a significantly slower mean picture recognition reaction time than the RH group. The LH group had a higher proportion of tumors extending into the temporal lobes, possibly accounting for their greater pictorial processing impairments. Dual coding and enhanced visual imagery may have contributed to the patient groups' similar performance on the remainder of the measures.

Adult↗
PubMed2003

Human recognition memory: a cognitive neuroscience perspective.

For many years the cognitive processes underlying recognition memory have been the subject of considerable interest in experimental psychology. To account for a broad range of behavioral findings, psychologists have put forward a variety of 'dual-process' models, all of which propose that recognition memory is supported by two forms of memory - familiarity and recollection - that differ in their speed of operation and the specificity of the retrieved information. More recently, the dual-process framework has been extended to encompass findings from studies investigating the neural basis of recognition memory. Results from neuropsychological, ERP and functional neuroimaging studies can be accommodated within the framework, and suggest that familiarity and recollection are supported by distinct neural mechanisms.

Journal Article↗
PubMed2006

Neural substrates of cross-modal olfactory recognition memory: an fMRI study.

Ten young adults (aged 20 to 25 years) participated in a functional Magnetic Resonance Imaging (fMRI) study to investigate neural substrates of cross-modal olfactory recognition memory. Before entering the scanner, participants were presented with 16 familiar odors selected from the COLT (Murphy, C., Nordin, S., Acosta, L., 1997. Odor learning, recall, and recognition memory in young and elderly adults. Neuropsychology 11, 126-137) and were then scanned for 3 runs according to a paradigm derived from Stark and Squire (Stark, C.E., Squire, L.R., 2000. Functional magnetic resonance imaging (fMRI) activity in the hippocampal region during recognition memory. J. Neurosci. 20, 7776-7781). During each run, participants were shown names of odors presented (targets) or not presented (foils) at encoding. Participants distinguished targets from foils via button press. Each run alternated 4 'ON' periods containing 7 targets and 2 foils (36 s) and 4 'OFF' periods with 7 foils and 2 targets (36 s). Data were processed with AFNI (Cox, R.W., 1996. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput. Biomed. Res. 29, 162-173) and compared ON and OFF periods, extracting activation in regions that responded during the cross-modal olfactory recognition memory task. Group analysis showed that regions activated during the first run included right hippocampus, piriform/amygdalar area, superior temporal gyrus, anterior cingulate gyrus, inferior frontal/orbitofrontal gyrus, superior/medial frontal gyrus, and bilateral parahippocampal gyrus, inferior parietal lobule, supramarginal gyrus, cerebellum, lingual/fusiform area and middle/posterior cingulate gyrus. Region of interest analysis showed that degree of activation significantly decreased from run 1 to run 3 in the right hippocampus, fusiform gyrus, lingual gyrus, parahippocampal gyrus and middle frontal gyrus but not in other regions, suggesting that these regions sustain a specific function in olfactory recognition memory that attenuates as foils become more familiar with repeated presentation.

Adult↗
PubMed2003

The effect of dehydroepiandrosterone (DHEA) on recognition memory decision processes and discrimination in postmenopausal women.

In this article, the theoretical distinction between recognition memory decision and discrimination processes is used to explore the effect of dehydroepiandrosterone (DHEA) in postmenopausal women. DHEA is an adrenal steroid that diminishes with aging. It has enhanced memory in laboratory animals. An 8-week placebo-controlled, double-blind experiment in which 30 women (ages 39-70) received a 50-mg/day oral dose of DHEA for 4 weeks demonstrated that DHEA made subjects more conservative (i.e., less likely to call test items "old") in their recognition memory decisions and enhanced recognition memory discrimination for items presented briefly. The former result may reflect an empirical regularity (Hirshman, 1995) in which recent strong memory experiences make participants more conservative. The latter result may reflect the effect of DHEA on visual perception, with consequent effects on memory. These results suggest the methodological importance of focusing on decision processes when examining the effects of hormones on memory.

Administration, Oral↗
PubMed2001

Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory.

A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this behavioural task. Ibotenate-induced hippocampal lesions led to locomotor hyperactivity and a marked spatial working-memory impairment on the elevated T-maze. In addition, they also led to increased social investigation. However, despite these clear effects, there was no effect of the lesions on social-recognition memory. These results suggest that the hippocampus proper does not subserve social-recognition memory; but does not, however, preclude the possibility that other areas of the hippocampal formation (e.g. entorhinal cortex or subiculum) may support this memory process.

Animals↗
PubMed1996

Conceptual automaticity in recognition memory: levels-of-processing effects on familiarity.

Recognition memory can reflect both conscious recollection and automatically generated feelings of familiarity. Previous research has suggested that perceptual factors mediate familiarity. Three experiments show that familiarity can also arise from prior conceptual (meaning-based) processing. Each experiment manipulated level of processing (LoP) and tested recognition memory using two response-signal delays (500 and 1500 ms). In Experiment 1, a modality effect was found for fast, but not slow, responses, thus supporting dual-process theories; the LoP effect was reliable at both points in time. In Experiment 2, recollection was set in opposition to familiarity by telling subjects to accept only test items from a to-be-remembered list which followed the incidental (LoP) study list; fast responses were associated with significantly more "false-alarms" to words encoded semantically than those encoded nonsemantically. Experiment 3 used the process dissociation procedure (Jacoby, 1991) to obtain quantitative estimates of recollection and familiarity. Both estimates were elevated by prior conceptual processing. Moreover, estimates of recollection, but not familiarity, were affected by response-signal delay, suggesting functional independence between the two processes. Relations to implicit memory are discussed.

Adult↗
PubMed1987

Some comments on the technical acceptability of Warrington's Recognition Memory Test.

The technical merits of Warrington's Recognition Memory Test are reviewed. The test has a number of attractive features, but also a number of significant limitations including defects in the initial validation studies, ceiling effects for the verbal recognition memory test, and inadequate documentation of the effects of educational level so as to permit interpretation of individual test data. In addition, no reliability data, such as test-retest or inter-examiner reliability correlations, are reported. It is suggested, therefore, that in its present form the test has limitations as an instrument for use in routine neuropsychological assessment.

Brain Diseases↗