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At least 145 records · Page 8Linked to original sources
PubMed1992

On estimating processing variance: commentary and reanalysis of Kail's "Developmental functions for speeds of cognitive processes".

A recent paper by Kail (1988) in this journal appears to contain a significant error in the data analysis. The "goodness-of-fit" coefficients reported which suggest that overall about 94% of the variance can be accounted for by the model seem to be a substantial overestimation as a result of inappropriate procedures for statistical modeling. Using the data made available to us by Kail, we have reanalyzed these results. The corrected values range from 0.9 to 92.1% for the individual tasks with an overall average between 40 and 60%. We suggest that the support for the original conclusions is considerably weaker than reported.

Aptitude↗
PubMed1984

Affective disorders and ABO blood groups: new data and a reanalysis of the literature using the logistic transformation of proportions.

No statistically significant associations were found between ABO blood group distributions and RDC subtype diagnoses in 79 subjects with unipolar (single episode and recurrent) and bipolar major depressive disorder using data from our sample. We discuss methodological issues related to the control samples and choice of statistical methods in the reported studies which have looked for associations between ABO blood types and patients diagnosed as having an affective disorder. After presenting our rationale for employing the logarithm of the cross product ratio (lambda) in place of the more traditionally utilized chi-squared, we used lambda to reanalyze the original data from nine studies in the literature. The individual studies are equivocal on the basic issue of an association between type O blood and bipolar I illness, either compared to controls or to recurrent unipolar patients. The combined (weighted average) measure of association indicates a small but definite association, but statistical analysis of the dispersion of the individual estimates around this combined estimate reveals that the studies have a higher degree of heterogeneity in results than expected by chance. The consequences of this finding are discussed, and possible explanations are offered.

ABO Blood-Group System↗
PubMed1989

Behavioral teratogenic insult of methylmercury assessed by using sets of measures: reanalysis of data from the Collaborative Behavioral Teratology Study of National Center for Toxicological Research.

The data of the Collaborative Behavioral Teratology Study were analyzed by using sets of measures simultaneously. A set of preweaning measures offered far more information as to treatment effects than a set of postweaning measures. The treatment effect observed in behavioral measures was also explained considerably by physical measures. However, the effect explained by uniquely behavioral measures (i.e., magnitude of semipartial R2) was also observed in some degree. A sex-related difference was observed in auditory startle response habituation appearing only later or earlier in life. The usefulness of using a set of measures and assessing the relationship among sets in behavioral teratology, in addition to conventional single measure analysis, was discussed.

Animals↗
PubMed1990

A temporally detailed reanalysis of the conditional heart rate response in dog.

We used rapid (500 Hz) digital sampling to derive a detailed analysis of the HR conditional response in dog (n = 11) to a 30-sec tone (CS+) followed by a 1/2-sec shock. We found an initial bradycardia at 1.5 +/- 1.0 sec in 6 of 11 dogs from a pre-CS+ control of 85 +/- 26 bpm (mean +/- SD) to 74 +/- 25 bpm (p less than 0.05). In 9 of the 11 dogs there was a subsequent rapid (19.9 +/- 6.7 bpm/sec) increase (+26 +/- 10 bpm) in HR lasting from 1.3 +/- 0.9 to 2.7 +/- 1.0 sec. This was followed by a second, larger (+41 +/- 16, p less than 0.05), but slower (4.0 +/- 2.4 bpm/sec, p less than 0.05) tachycardia which lasted from 4.9 +/- 1.0 to 13.5 +/- 2.6 sec. The peak HR (131 +/- 27 bpm) was attained at 15.0 +/- 3.8 sec, after which HR fell slowly (-2.4 +/- 1.4 bpm/sec) to an average of 92 +/- 29 bpm at 28.6 +/- 1.4 sec (i.e., approximately 1.4 sec prior to shock delivery). This analysis revealed trends in the conditional HR response which were not discernible in individual trials and were obscured in the more traditional analyses of the conditional HR response.

Animals↗
PubMed1982

The health effects of air pollution: a reanalysis.

"Using a newly assembled data base, [the authors] explore the relationship between mortality and measures of sulfates and suspended particulates in 96 cities, counties, and metropolitan areas (SMSAs) of the United States. The data fit the previously estimated Lave-Seskin model and [the authors] cannot reject the null hypothesis of identical air-pollution coefficients in 1960, 1969, and 1974 cross sections." The findings show that "a strong, consistent, and statistically significant association between sulfates and mortality persists. The association is changed little by adding variables for smoking and alcohol consumption, by using a generalized least-squares estimator instead of OLS, by using city or county instead of SMSA data, or by adding medical care and nutrition variables and using a simultaneous equation framework. These results can be used to support stringent abatement of sulfur-oxides air pollution."

Alcohol Drinking↗
PubMed1990

The genetics of neurotic-reactive depression: a reanalysis of Shapiro's (1970) twin study using diagnostic criteria.

The present study explored the role of genetic factors in the development of neurotic depression. Case studies of 16 monozygotic (MZ) and 14 same-sex dizygotic (DZ) twins from Robert Shapiro's 1970 study of non-endogenous depression were rediagnosed by two raters blind to the zygosity and identity of each twin. Diagnoses were made using Research Diagnostic Criteria (RDC) and George Winokur's 1985 criteria for neurotic-reactive depression. When neurotic depression was operationally defined using Winokur's criteria plus RDC major or definite minor depression, the concordance rate for MZ twins was significantly greater than that for DZ twins. Our results contrast with Shapiro's negative findings, probably due to our use of formal diagnostic criteria and Shapiro's requirement that cotwins be hospitalized to be considered concordant. The present results suggest that genetic factors play a role in the etiology of at least some forms of neurotic depression.

Adjustment Disorders↗
PubMed1993

Life stress, social support and clinical depression: a reanalysis of the literature.

In recent years, theorists and researchers have disagreed about the relationship between social support and mental health. Some believe that support is a direct provoking agent (i.e. lack of support constitutes strain), whereas others maintain that support is a vulnerability factor moderating the effect of life stress. Focusing on clinical depression, the article reviews the arguments and evidence supporting a strain hypothesis of social support versus a vulnerability hypothesis. Reanalyzing cross-classified data from 12 community studies of clinical depression, the study shows that the choice of model depends on the specification of functional form of the stress-clinical depression relationship. The linear probability specification suggests a vulnerability hypothesis, whereas the logit and probit specifications support a strain hypothesis. However, theoretical and statistical arguments tend to favor a logit or probit specification, and an additional analysis of data from Brown and Harris [Social Origins of Depression: A Study of Psychiatric Disorder in Women. The Free Press, New York, 1978] supports these arguments. Thus, the study concludes that the strain hypothesis of social support is more consistent with the available data.

Depression↗
PubMed1982

A reanalysis of the ventrolateral input in slow and fast pyramidal tract neurons of the cat motor cortex.

In deeply anesthetized cats the temporal characteristics of ventro-lateral (thalamic) excitatory postsynaptic potentials (EPSPs) induced in pyramidal tract cells were studied with an averaging technique. Stimulation of the ventrolateral thalamus induced EPSPs in all pyramidal tract neurons at latencies of 1-5 ms. It was found that there was a positive relationship between the latency and rise time of stimulation-induced EPSPs and the latency of antidromic invasions of pyramidal tract neurons. In response to two closely spaced shocks the second EPSP had the same latency and amplitude as the first one in both slow and fast pyramidal tract neurons. Moreover, the span of antidromic latencies of ventrolateral thalamic relay cells to motor cortex stimulation showed that these thalamic neurons had the necessary conduction velocities to account for the distribution EPSP latencies recorded in pyramidal tract neurons. From these electrophysiological results, it has been concluded that slow and fast pyramidal tract morphological evidence, obtained at the electron-microscopic level, supporting this conclusion. Terminal degeneration induced by a lesion in the ventrolateral thalamus was found on the apical dendrite of a slow pyramidal tract neurons that had been injected with horseradish peroxidase. It is proposed that the matching between the latencies of EPSPs evoked from the ventrolateral thalamus and the latencies of antidromic invasions of pyramidal tract neurons may reflect a matching between the conduction velocity of thalamocortical and cortico-spinal neurons and/or it may be due to the electrotonic properties of the apical dendrites.

Animals↗
PubMed1995

Prevalence of psychosis among the Hutterites: a reanalysis of the 1950-53 study.

Psychiatric case records from Eaton and Weil's 1950-53 study of the Hutterites were rediagnosed using DSM-III-R criteria. The results confirmed that the Hutterites have a very low prevalence of both schizophrenia (0.9 per 1000) and bipolar disorder (0.6 per 1000). Genetic and/or environmental explanations are both possible. Because of their unusual genetics and lifestyle, the Hutterites are an invaluable potential research resource.

Alberta↗
PubMed2026

Comparative effectiveness of torsemide vs furosemide in the management of heart failure patients: Win-ratio reanalysis of the TRANSFORM-HF trial.

BACKGROUND: Loop diuretics are widely used for managing congestion in patients with heart failure (HF). The TRANSFORM-HF trial is a multicenter randomized study that enrolled heart failure patients, comparing a strategy of torsemide vs furosemide. The time-to-event analysis demonstrated neutral effects on all-cause death at 30 months and the composite of all-cause death and first rehospitalization at 12 months. We evaluated whether a hierarchical win-ratio (WR) framework integrating mortality, recurrent hospitalization, and patient-reported health status provides additional interpretive insight. METHODS: This study is a secondary analysis of the pragmatic, multicenter, open-label, randomized TRANSFORM-HF trial, conducted across 60 US hospitals that randomized 2,859 patients hospitalized with HF to torsemide or furosemide. The primary 12-month hierarchical composite outcome was defined as (1) all-cause mortality, (2) recurrent all-cause hospitalizations, and (3) lack of improvement in the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS). The primary statistical method was a WR analysis adjusting covariates via inverse probability weighting. Subgroup analyses evaluated potential heterogeneity across patient demographics and clinical characteristics. RESULTS: In the primary 12-month intention-to-treat analysis, the adjusted WR was 1.07 (95% CI, 0.98-1.16; P = .13), indicating no significant difference between torsemide and furosemide. A supplementary 30-month analysis with extended mortality follow-up yielded a similar estimate (adjusted WR, 1.06; 95% CI, 0.98-1.16; P = .14); hospitalization and KCCQ-CSS components were assessed through 12 months. As-treated sensitivity analyses were consistent with the neutral primary findings. Exploratory subgroup analyses were not adjusted for multiplicity and should be considered hypothesis-generating. CONCLUSIONS: The overall WR comparison between torsemide and furosemide showed no statistically significant difference in the primary 12-month analysis. The WR framework provided an interpretive decomposition across outcome domains but did not establish superiority of either loop diuretic strategy. All findings should be considered exploratory. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03296813, https://clinicaltrials.gov/study/NCT03296813.

Aged↗
PubMed2001

Premorbid polysomnographic signs in depressed adolescents: a reanalysis of EEG sleep after longitudinal follow-up in adulthood.

BACKGROUND: This is a report of a clinical follow-up study (10-15 years later as young adults) of adolescent major depressives and normal control subjects. Polysomnographic data were obtained during the original study period when the subjects were adolescent (time 1). With clinical follow-up (time 2) assessments in hand, our objective was to ascertain whether there were any premorbid polysomnographic signs associated with depression during adolescence. METHODS: Based upon initial (during adolescence) and follow-up clinical assessments (as adults), new subject groupings were generated: depression-free normal subjects and original normal subjects who experienced a depressive episode during the follow-up period (latent depressives). Suicidality and recurrence of depression were also examined. Multivariate analysis of covariance was used to analyze group differences in sleep measures and logistic regression for predicting three outcomes: lifetime depression, lifetime suicidality, and recurrence. RESULTS: Comparison of the depression-free normal subjects, the latent depressives, and the original major depressives revealed significant differences for sleep latency and sleep period time. Comparing all lifetime depressives (original major depressives and the latent depressives) to depression-free normal subjects revealed significantly more stages 3 and 4 combined (ST34) sleep and greater sleep period times among the depressives. An analysis involving the presence or absence of suicidality revealed no overall significant differences between the groups. Comparison of the lifetime depressives grouped by nonrecurrent and recurrent depressive course to the depression-free normal subjects revealed significant difference for sleep period time. Using logistic regression, we found that a longer sleep latency and sleep period time significantly predicted lifetime depression. Gender, ST34 sleep, and an interaction term for ST34 sleep and REM latency significantly predicted lifetime suicidality. CONCLUSIONS: There was evidence of premorbid sleep abnormalities during adolescence. A general pattern of sleep disruption around sleep onset and during the first 100 min of the sleep period and overall sleep was evident among the major and lifetime depressives, involving sleep latency (initial insomnia), sleep period time (hypersomnia), REM latency, and slow-wave sleep. This adds to the body of literature that highlights the importance of the first 100 min of the sleep period in depression.

Adolescent↗
PubMed1991

A reanalysis of the Stanton et al. pleural sarcoma data.

An analysis of the Stanton et al. (1981, J. Natl. Cancer Inst. 67, 965-975) data reconfirms number of index particles as the primary dimensional predictor of tumor incidence. Fitting separate intercepts and/or slopes to each mineral type results in substantial significant improvement in fit, indicating the importance of mineral type. This contrasts with the "Stanton hypothesis," which states that dimensional properties alone determine carcinogenesis. Log mean aspect ratio is not as good a predictor of tumor incidence as the number of index particles; among those samples that did not have index particles, log mean aspect ratio is not a significant predictor of tumor incidence.

Air Pollutants, Occupational↗