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Diagnostic significance of late cutaneous allergic responses and their correlation with radioallergosorbent test.

In order to study the clinical significance of late cutaneous allergic responses 178 intracutaneous tests were done on the forearm of forty-three allergic patients with perennial allergy and twelve patients with pollen allergy. The allergen concentration was chosen to give a moderate immediate response with a weal diameter of about 15 mm. Late cutaneous allergic responses (LCAR) were elicited in eighty-two intracutaneous tests in thirty-one patients with perennial allergy and in nine intracutaneous tests in eight patients with pollen allergy, with almost all the allergens frequently responsible for allergy in this area. Their occurrence was found to be related to the size of the immediate reaction. Almost all the patients showing LCAR had positive provocation tests and were clinically sensitive to the corresponding allergen.

Adolescent↗

Agreement between radioallergosorbent test and skin test.

A total of 4,260 RAST results were compared with the same number of prick and intracutaneous skin test results. Intracutaneous test was done only when the prick test was negative. The mean agreement between positive RAST and positive prick test was 81.3% for five grasses, 45.1% for seven weeds, 42.2% for two trees, 42.6% for two molds, and 45.8% for two environmental antigens. The mean agreement between positive RAST and positive intracutaneous test ranged from 0 to 4.9% for the same antigens.

Adolescent↗