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Results for “Promedol”

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At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Clinical aspects of using patient-controlled analgesia with nonsteroidal anti-inflammatory agents in postoperative period].

We used lornoxicam (n = 16) and ketorolac (n = 20) to study the possibilities of applying the non-steroid anti-inflammatory drugs within the postoperative patient-controllable analgesia (PCA). With respect to a used analgetic, the frequency rate of good PCA anesthetic results was found, on day 1, to be 60-77%. The good anesthetic results were registered in 25% of patients when the routine scheme was in use. Non-steroid anti-inflammatory agents (lornoxicam, ketorolac) can be prescribed within the early postoperative PCA as basic analgetics, which essentially reduces the need in promedol without worsening the analgesia efficiency.

Adolescent↗
PubMedDate not supplied

[Comparative analysis of antiarrhythmic and proarrhythmogenic effects of drugs for neuroleptanalgesia, ataralgesia, and antidepranalgesia in experimental acute myocardial infarction].

Proarrhythmogenic and antiarrhythmic effects of drugs for neuroleptanalgesia (NLA), ataralgesic (ATA) and antidepranalgesia (ADA) in chronic experiments on sleepless rabbits with acute myocardial infarction, with and without tachyarrhythmias, were studied using ECG, intraventricular electromanometry and tetropolar rheography. NLA (phentanylum, 1 microg/kg + droperidol, 5 microg/kg), ADA (pyrazidole, 1 mg/kg + tramal, 1 mg/kg) and ATA (diazepam, 1 mg/kg + promedol 0.5 mg/kg) produce antiarrhythmic effect with maximum manifestation of NLA on the 3rd day, and of ATA and ADA on 3-5th day. This medication increased blood supply and contractility of ischemic myocardium. Proarrhythmogenic effects of this medication were not observed.

Analgesia↗
PubMedDate not supplied

[Complications occurring on the administration of morphine hydrochloride into the epidural space in patients after radical cancer operations on the gastrointestinal tract].

169 patients operated on for gastrointestinal tumors have been examined. In 119 patients postoperative analgesia was performed by epidural administration of different morphine doses (2, 5 and 8 mg). The time of analgesia onset, its duration and complications were registered. Patients on intramuscular promedol injections served as the control. The study performed makes it possible to conclude that epidural administration of 5 mg morphine diluted in 5-10 ml of physiologic saline ensures in 92.4% of patients effective and durable analgesia with practically no side effects.

Analgesia, Epidural↗
PubMed1978

[Effect of narcotic analgesics on excitatory transmission in the spinal cord].

As demonstrated on nonanesthetized curare-immobilized spinal cats morphine, promedol and fentanyl failed to alter the amplitude of induced potentials in the ventro-lateral columns of the lumbar spinal cord, evoked by a single or repetitive stimulation of the cutaneous or pelvic nerves. In some experiments the same drugs inhibited the nerurons of the posterior horns of the spinal cord activated by the nociceptive stimulation of the peripheral receptors in intraarterial administration of bradykinin. It is suggested that a spinal component was involved in the action of hypnotic analgetics.

Analgesics, Opioid↗
PubMedDate not supplied

[The spectrum of analgesic activity of baclofen and tolibut].

Spectrum of the analgetic activity of GABA derivatives baclofen (2.5-10.0 mg/kg) and tolibut (12.5-100.0 mg/kg) was studied in experiments on albino mice and rats. Baclofen and especially tolibut showed a dose-dependent inhibition of perceptive, emotional and autonomic manifestations of nociceptive reactions at the tail's thermal and electrical stimulation and enhancement of the analgetic effect of promedol. The regressive analysis made it possible to show dependence of the analgetic effect on the level of pain sensitivity and emotional reactivity of the animals. Tolibut deepens and prolongs sombrevin anesthesia, baclofen fails to alter it.

Analgesics↗
PubMed1985

[Effect of analgesics on the growth and metastasis of sarcoma 37].

Treatment with such analgetics as analginum, promedol and pantopon was shown experimentally either to inhibit or to stimulate the growth of sarcoma-37 and its dissemination. It was also found to reduce the tumor growth--stimulating effect of operative trauma.

Amputation, Surgical↗
PubMedDate not supplied

[Evaluation of the pain-alleviating properties of a combination of analgesic and tranquilizer using multiple stepwise regression].

A method for preclinical evaluation of the optimal ratio (for analgesia) of an analgesic to a tranquilizer has been devised. It is based on the drug threshold dose decrease on the drug combined use. The multiple stepwise regression analysis of the data discovered the correlations between diazepam and promedol, optimal for pain perception decrease and nociceptive emotional responsiveness inhibition.

Analgesics↗
PubMedDate not supplied

[Effect of narcotic analgesics of nociceptive transmission in the spinal cord].

The action of morphine, promedol, fentanyl and pentazocin on nociceptive transmission in the spinal cord was studied in unanesthetized spinal rats with the use of intraarterial injection of bradykinin. When used in the same doses, the opiates also reduced the firing of the axons of the ascending portions of the spinal cord. Naloxon rapidly antagonized the action of the narcotics.

Analgesics, Opioid↗
PubMed1984

[Mechanism of the intracardiac interactions of the vagus and sympathetic nerves: is a serotoninergic mechanism possible?].

A study was made of the conditions of the occurrence and mechanisms of the enhancement by the sympathetic nerve of the vagus-induced inhibition of rabbit heart work. It was discovered that to obtain such a phenomenon, it is necessary that stimulation of the stellate ganglion be made in the presence of perithreshold stimulation of the vagus after blockade of beta-adrenoreceptors. The inhibitory effect was not abolished by dihydroergotoxin but was blocked by promedol, aminazine and diprazine. It is suggested that the serotoninergic component is involved in the mechanism of the enhancement of the vagus-induced inhibition that occurs during stimulation of the sympathetic nerve.

Animals↗
PubMedDate not supplied

[Acupuncture analgesia and analgesic transcutaneous electroneurostimulation in the early postoperative period].

Efficacies of two methods of nondrug analgesia: acupuncture (1000 cases) and antipain transcutaneous electroneurostimulation (91 cases), as well as of narcotic analgesics omnopon and promedol (229 cases) were compared in the immediate and early postoperative period. In 229 cases acupuncture was used for the treatment of other functional complications of the postoperative period. The efficacies of the methods in question were assessed by formalized verbal estimation scales. Narcotic analgesics provided adequate analgesia in 75 to 79% of patients, electrostimulation in 61 to 64%, acupuncture in 50% of patients. Acupuncture, though less effective than narcotic analgesics, helped arrest or noticeably alleviate the severity of such postoperative complications as reflex retention of the urine, impairment of hte drainage function of the bronchi, intestinal paresis, bronchial asthma, vomiting, nausea, pain or itching in the stoma, chill, hyperthermia in 43 to 81% of cases. The authors come to a conclusion on the desirability of an integrative approach (combined use of drugs and nondrug methods of analgesia) in the management of postoperative pain.

Acupuncture Analgesia↗
PubMedDate not supplied

[First experience in the use of a new Russian narcotic analgesic prosidol in oncology].

Prosidol, a new Russian narcotic analgesic, was used in various dosage forms (buccal and oral tablets, injection solution) in 113 cancer patients for the treatment of chronic pain, as a component of total anesthesia, and for postoperative analgesia. The best results were attained with the universal noninvasive dosage form, buccal tablets, used for the treatment of chronic pain in incurable patients. Analgesic properties of buccal prosidol are close to those of tramadol, the drug is well tolerated by the patients and causes no grave side effects. As a drug for postoperative analgesia prosidol was highly effective in patients after extracavitary oncologic surgery and less effective after thoracal and abdominal interventions. As a component of total anesthesia prosidol is inferior to fentanyl and approximately similar to promedol. An advantage of prosidol is its highly effective universal noninvasive dosage form, buccal tablets, which may be used for rapid analgesia in any situation.

Administration, Buccal↗
PubMedDate not supplied

[Insomnia and its treatment during the postoperative period].

A total of 108 patients have filled in questionnaires on falling asleep, sleeping, night awakenings and other characteristics. Their answers have been analysed and it was concluded that night sleep of patients especially in the postoperative period was characterized by prolonged period of falling asleep (over 30 min in 50% of patients), reduced duration, in 77% of patients night awakenings have been recorded. The use of analgin (1000 mg) in combination with dimedrol (10 mg), promedol (20 mg) for tramal (100 mg) for normalization of sleep in the postoperative period was of little efficacy. Therapy of night sleep disturbances will improve the patients' condition and enhance the efficacy of management after surgical interventions.

Diphenhydramine↗
PubMedDate not supplied

[A pharmacological analysis of the antiedematous action of GABA-ergic and opioidergic agents in craniocerebral trauma].

Experiments on rats with skull inquiry show that biculline (dose 2 mg/kg) removes antiedematous effect of fenibut (50 mg/kg), sodium hydroxybutirate (200 mg/kg), promedol (1 mg/kg), and synthetic analogs of encephalines DAGO and DSLET (100 mg/kg). Naloxon at a dose 1 mg/kg blocks antiedematous effect of ligands of opiate receptors, but does not change the effect of fenibut and sodium hydroxybutirate. The presence of close inter-regulatory interactions between GAMK-ergic and opioidergic systems in forming the traumatic correction is suggested.

Analgesics, Opioid↗
PubMed1996

[Postoperative analgesia in cesarean section].

60 parturients were given the following drugs on purpose to achieve painless postoperative period--group 1--moradol--M, group 2--tramal--T, group 3--lydol--L, and group 4--promedol--P. Preparations M and T compared with L and P proved to be with better analgetic effect with no suppression on the contractile activity of the uterus, no blockade of hypothalamus-hypophysis-adrenal system and no influence on the respiration, pulse, blood pressure, acid-base balance and interchange of gases.

Analgesia, Obstetrical↗
PubMedDate not supplied

Behavior of rats during chronic activation and blockade of the neostriatal opiate system.

The effects of daily microinjections (MI), over of three weeks, bilaterally into the rostral striatum, of morphine, promedol, native leu-enkephalin and its synthetic tetrapeptide analogs were studied in experiments on rats. Naloxone was used as an antagonist. An active avoidance conditioned reflex was developed preliminary in a shuttle box. A decrease in the accuracy of the realization and an increase in the latent period of the reflex were observed after the first MI of morphine and enkephalins. The effect of the most stable aminated ornithine-containing tetrapeptides proved to be the strongest. A search stereotypy and increased motoric activity were recorded in the rats during the development of the chronic effects of the activators of the opiate system. A clear correlation was not found between the motor and conditioned reflex shifts. The blockade of the opiate receptors with naloxone did not lead to substantial changes in behavior. The data obtained confirm the current hypothesis regarding the important role of the enkephalinergic system of the neostriatum in the regulation of complex forms of behavior and its close functional association with the dopaminergic system.

Amino Acid Sequence↗
PubMed1991

Simple methodology of assessment of analgesics' addictive potential in mice.

Comparative investigation of analgesic (writhing test) and reinforcing (conditioned place preference) effects of 11 opioids over a wide range of doses was performed in mice. On the basis of the dose-response curves analysis, parameters of potency and efficacy of the reinforcing effect were determined. In one group of analgesics (etorphine, fentanyl, buprenorphine, morphine, promedol) ED50 in both tests were approximately equal. The other compounds (pentazocine, nalbuphine, nalorphine, butorphanol, U50,488H) demonstrated dissociation of two effects. The new indices (addictive index and safety index) for the prediction of analgesics' as well as other psychotropic drugs' abuse potential at the preclinical stage of their study have been suggested.

Analgesics, Opioid↗
PubMedDate not supplied

[Effect of thyrocalcitonin on the pain sensitivity in animals].

With a single parenteral introduction of thyrocalcitonin (TCT) the algesthesia of soft tissues (tall skin, paw) is moderately increasing, while the algesic action of morphine and promedol against the background of TCT-gets weaker. And contrarywise algesthesia of hard tissues of the tooth becomes significantly lower under the effect of TCT and this continues for a long time.

Aminopyrine↗