SEARCH · Search PubMed

Results for “PLEURA”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 145 records · Page 8Linked to original sources

PubMedDate not supplied

[Epithelioid haemangioendothelioma of the pleura: 29 months survival].

Epithelioid haemangioendothelioma of the pleura is a rare neoplasia with a very poor prognosis due to aggressive involvement of the pleura and incomplete surgical treatment. Histological diagnosis and imagiology is also controversial, related to discrete development of the lesions that later reveal nodules. In 2005 there were 31 cases of vascular tumours described in the pleura. Eleven were epithelioid haemangioendotheliomas. This is another case, a 52 year old woman who suffered a traumatism and died 29 months after the histological diagnosis because CAT revealed discrete pleural involvement and a 2 cm nodule was seen only one month before death.

Female↗

PubMedDate not supplied

[Localized fibrous tumor of the pleura: analysis of 11 new cases].

We present a retrospective revision of a pathology, rare in his incidence (5% of the pleural tumours) and singular in his characteristics, analyzing the presentation forms, surgical treatment and results. The solitary tumours of the pleura are a rare entity, whose biological behaviour is not related with immunohistochemical characteristics; although considered benign, they present sensitive recidivation index and metastization, independently of the volume that they present. he surgery is the only available treatment, and complete surgical excision is decisive. From August 1995 to January 2003, in the casuistry of the Department of Cardiothoracic Surgery in Santa Marta's Hospital, were analyzed all the patients with the diagnosis of localized fibrous tumour of the pleura (TFLP). In this context, were identified 11 patients with a medium age of 57,54 years old, 6 of them females, in which the diagnosis of located fibrous tumour of the pleura was established; 6 of the tumours were classified as malignant. All the patients were submitted to surgical excision, with different techniques, without significant intra-operative mortality or intra-hospital morbidity, despite the difficulty of surgery in the most voluminous tumours (one of the tumours weight was 2,5 kg). The follow up elapsed between 4 and 84 months (average - 39,4 months). One patient died 13 months after the surgery, after several crises of lung embolism (that began without determinable relationship with the surgery or the initial pathology), despite the controlled ambulatory anti-coagulation.

Female↗

PubMed2006

[Clinicopathological features of solitary fibrous tumors of the pleura: a case series and literature review].

We assessed the clinicopathological features of solitary fibrous tumors of the pleura in a case series comprising 30 patients (20 women, 66.6%) with a mean age of 58.39 years. Forty-five percent of the cases were asymptomatic. In 70% of the cases the tumors arose in the visceral pleura. Twenty percent presented multiple tumors, a finding that was associated with intrapulmonary localization and malignant behavior (P<.0001) Histology revealed low cell density in 15% of the cases, moderate density in 50%, and high density in 35%; further findings showed atypia in 45% of the cases, necrosis in 25%, and hemorrhage in 15%. More than 4 mitoses per 10 high-power fields were noted in 30% of the cases. Immunohistochemistry results were positive for vimentin in all cases; cells were CD34+ in 85% of the cases, BCL2+ in 65%, and CD99+ in 40%. Findings for keratin and protein S100 were negative in all cases. Malignant biological behavior (local recurrence and metastasis) was observed in 4 cases, 2 of which were CD34-. Solitary fibrous tumors of the pleura are uncommon neoplasms with unpredictable biological behavior; follow-up should therefore be based on early detection of recurrence or metastasis.

Adolescent↗

PubMed2003

Desmoplastic malignant mesothelioma of the pleura: autopsy reveals asbestos exposure.

Desmoplastic mesothelioma is a rare subtype of diffuse malignant mesothelioma, and is often difficult to distinguish from reactive pleural fibrosis because of associated extensive collagen fibrosis. An 82-year-old woman with a severe cough was revealed to have pleural effusion and diffuse pleural thickening on the right side. Antibiotics were ineffective, and a compression fracture of the ninth and tenth thoracic vertebral bodies was recognized on X-ray. Autopsy revealed a diffuse pleural thickening with hyalinized collagen tissue in the central part of the pleura. However, the peripheral part of the fibrous tissue was composed of spindle and polygonal cell proliferation that were immunohistochemically positive for antibodies against cytokeratin and vimentin. In addition, the ninth and tenth thoracic spines were infiltrated by similar cells. The condition was diagnosed as desmoplastic mesothelioma with bone metastases. Asbestos bodies were detected in the thickened pleura and fibrosed alveolar septa, and it was suggested retrospectively that the patient had been exposed to asbestos. Thus, autopsy analyses of fibrous pleurisy are necessary to detect a desmoplastic variant of mesothelioma of the pleura and its association with asbestos exposure.

Aged↗

PubMed1988

Three types of spindle cell tumors of the pleura. Fibroma, sarcoma, and sarcomatoid mesothelioma.

The clinicopathologic features of 17 fibrous tumors of the pleura are presented. Eight were benign localized fibrous tumors; all of these were negative when stained with antibodies to keratin. Eight were diffuse malignant tumors that demonstrated intense immunohistochemical staining of the spindle cells with antibodies to keratin. One case presented as a histologically malignant spindle cell tumor that was initially localized but recurred subpleurally three times in 12 years. This spindle cell tumor was consistently negative when stained for keratin. We conclude that there are three types of fibrous tumors of the pleura: (a) a localized, histologically benign, keratin-negative spindle cell tumor that might be termed "fibroma," (b) a diffuse, histologically malignant, keratin-positive neoplasm that might appropriately be termed a "sarcomatoid mesothelioma," and (c) a histologically malignant, keratin-negative, spindle cell tumor with the potential to spread under the pleura that might appropriately be termed a "sarcoma." Immunohistochemistry proved to be useful in distinguishing the sarcomatoid mesothelioma from the sarcoma.

Adult↗

PubMed1997

Malignant peripheral nerve sheath tumor of the pleura with epithelial and rhabdomyoblastic differentiation: report of a case clinically simulating mesothelioma.

A primary malignant peripheral nerve sheath tumor (MPNST) of the pleura that clinically mimicked a malignant mesothelioma in a 57-year-old man is described. Histologically, the tumor had features similar to those described in cases of the so-called epithelioid MPNST. A unique finding in this case was the demonstration of keratin expression in the epithelioid component of the tumor, as well as the presence of rhabdomyoblasts. This is the first example of an MPNST with heterologous elements arising in the pleura. Immunohistochemical and ultrastructural studies were important in differentiating this tumor from other malignancies with sarcomatoid and epithelioid features involving the pleura.

Actin Cytoskeleton↗

PubMedDate not supplied

Localized benign fibrous tumors of the pleura: MR appearance.

PURPOSE: Our goal is to describe the MR findings in benign localized fibrous tumors of the pleura. METHOD: Chest radiographs, CT scans, and MR images of four patients with localized benign fibrous tumors of the pleura were retrospectively reviewed and correlated with the pathologic findings. RESULTS: Tumors ranged from 4 to 18 cm in their largest diameter. Three tumors were located in the diaphragmatic region, and one was within the left major fissure. All tumors were round to ovoid, pedunculated, and well delineated. On T1-weighted SE MR images, tumors showed low signal intensity. All tumors had heterogeneous but predominantly low signal intensity on proton-density-weighted images and lower signal intensity on T2-weighted images. CONCLUSION: Localized benign fibrous tumors of the pleura were characterized by low signal intensity on all MR sequences that is explained by high collagen content within the tumors' stroma and should suggest the diagnosis preoperatively.

Adult↗

PubMed1977

Squamous-cell carcinoma of the pleura.

There are few reports of primary malignant tumours of the pleura other than mesothelioma. Reports of squamous-cell carcinoma of the pleura are especially rare. Epidermoid carcinoma of the pleura may occur in connection with persistent empyema drained by a pleurocutaneous fistula or long-standing extrapleural pneumothorax without fistula.

Adult↗

PubMedDate not supplied

Fine needle aspiration biopsy of solitary fibrous tumor of the pleura. A report of two cases with a discussion of diagnostic pitfalls.

BACKGROUND: The diagnosis of a peripheral pulmonary nodule presents a challenge due to many diagnostic possibilities and pitfalls. We describe the cytologic features of solitary fibrous tumor of the pleura, differential diagnoses, pertinent immunohistochemical stains and histogenesis. CASES: Two cases of solitary fibrous tumor of the pleura showed two cell populations on cytologic preparations; mesothelial cells and spindle cells. The neoplastic spindle cell component was positive for CD-34 and vimentin but not for cytokeratin. CONCLUSION: Solitary fibrous tumor of the pleura is rare but should be included in the differential diagnosis of a peripheral pulmonary nodule. Fine needle aspiration biopsy is a safe and rapid method of providing a confirmatory diagnosis.

Aged↗

PubMed2004

Video-assisted thoracoscopic surgery is a promising treatment for solitary fibrous tumor of the pleura.

STUDY OBJECTIVES: Solitary fibrous tumors of the pleura (SFTPs) are slow-growing neoplasms. Approximately 800 cases have been reported in the literature to date. The aim of this study was to address our experience with the management of SFTPs and to evaluate the advantage of video-assisted thoracoscopic surgery (VATS) in SFTP treatment. DESIGN: Retrospective analysis of our experience. SETTING: Department of Thoracic and Cardiovascular Surgery, Nara Medical University. PATIENTS: From January 1992 to August 2002, 13 patients with a SFTP were referred to us for surgical resection after VATS was adopted in our hospital. The study group consisted of seven men and six women with a mean age of 49.8 years (age range, 37 to 72 years). RESULTS: Surgical excision was performed with VATS only in nine patients, with VATS plus a small thoracotomy in three patients, and by a posterolateral thoracotomy without VATS in one patient. The mean chest-drain duration was 1.3 days (range, 1 to 3 days), and the mean duration of hospital stay was 8.6 days (range, 3 to 30 days). Eleven tumors, originating from the visceral pleura, were pedunculate, and 2 tumors from the parietal pleura were not pedunculate. Two cases were focally characterized by a mitotic count in excess of four mitoses per 10 high-power fields and by cellular pleomorphism. Follow-up periods ranged from 6 to 120 months, with a mean of 49.7 months and a median of 42 months. All patients have remained well with no recurrence or metastasis. CONCLUSIONS: Complete surgical resection is the treatment of choice for SFTPs. For the pedunculate tumors, therefore, VATS is a powerful and useful approach. Even when it is necessary to perform a small thoracotomy in addition to VATS for the removal of a large tumor, VATS may play an important role in reducing the size of the thoracotomy incision, which results in less invasive surgery. To minimize postoperative morbidity, VATS may be the most promising surgical approach for the resection of SFTPs.

Adult↗

PubMed1999

[A case of localized fibrous tumor of the pleura after four years follow up and evaluate the doubling time with computed tomography].

Thirty-five-year female had taken video assisted thoraco-surgery (VATS) and resected her localized fibrous tumor of parietal pleura. She suspected chest tumor with annual X-ray survey for lung disease four years ago. She complained of left side back pain recently. Her chest CT revealed that the tumor enlarged than before. She was performed video assisted thoraco-surgery. The tumor was solid hard and connected to the parietal pleura with pedicle, which was resected easily from her pleural cavity. Histrogical examination detected that her tumor was localized fibrous tumor of parietal pleura. CD 34 and Vimentin were positive and cytokeratin was negative in this case. Four year and two examinations of the chest CT later, we could determine the doubling time (800.7 days) of localized fibrous tumor in this case.

Adult↗

PubMed1999

[Solitary fibrous tumor of the pleura with elevated high-molecular-weight insulin-like growth factor II and hypoglycemia].

Recurrent hypoglycemia occurred in a 58-year-old woman with a solitary fibrous tumor of the pleura and exhibiting CD34 immunopositivity. During episodes of hypoglycemia, serum high-molecular-weight insulin-like growth factor II (big IGF-II) was elevated. After removal of the tumor containing IGF-II, the hypoglycemia and serum big IGF-II disappeared. This was followed by an increase in normal IGF-II. We speculate that the primary cause of hypoglycemia in this patient was the presence of big IGF-II produced by the solitary fibrous tumor of the pleura. To our knowledge, the presence of this type of IGF-II in CD34+ solitary fibrous tumors of the pleura has not been described to date in the literature.

Female↗

PubMed2000

Huge malignant localized fibrous tumor of the pleura.

Localized fibrous tumor is an unfrequent mesenchymal neoplasm. The malignant variant of the pleura is exceptional and differential diagnosis with the more frequent benign type or with other neoplasms such as soft tissue sarcoma and mesothelioma is rarely possible in a preoperative setting. The best treatment of this disease is radical surgical resection. No definitive data exist about the role of chemotherapy. We report a case of a giant right intrathoracic mass whose preoperative diagnosis, from an open biopsy, was consistent with sarcoma and, in a second review, with fibrous tumor of the pleura without any indication about malignancy. A right pleuropneumonectomy and pericardial resection was performed through a right hemiclam-shell approach. Histology demonstrated an aggressive behaviour: high mitosis rate, Ki 67 of 34% and diffuse necrosis were present. In consideration of the apparent local radicality we did not perform any adjuvant treatment. Six months after the operation a wide local recurrence was evident and a systemic treatment with Ifosfamide and Adriamicina is still in progress. So far a good response has been documented. Preoperative diagnosis of malignancy has an important role as a therapeutic strategy in management of fibrous tumours of the pleura. When there is suspicion of a malignant form neoadjuvant chemotherapy can represent a further tool to control poorly differentiated and large tumors, and a wide surgical resection of the lesion must be performed.

Antineoplastic Combined Chemotherapy Protocols↗

PubMedDate not supplied

[Malignant localized fibrous tumor of the pleura].

The authors report a case of a localized fibrous tumour of the pleura with huge proportions of 26 x 14 x 12 cm and 1.25 Kgr of weight, in a 56 year old female patient. The tumour occupied practically the inferior 2/3 of the right pulmonary field and had an unusual insertion in the diaphragmatic parietal pleura. It was non pediculous and had histological features of malignancy. The diagnosis of localized fibrous tumour of the pleura was achieved through observation of the sample obtained by fine needle aspiration. The immunohistochemical study subsequently done on the surgical specimen, confirmed the previous diagnosis. The evaluation of malignancy was based ou the following histological criteria: high cellularity, cellular pleomorphism, mitotic activity (more than four mitotic figures per 10 high power fields), hemorrhagic areas and necrosis.

Female↗

PubMed2002

Application of digestive tract anastomotic device in super-cupula pleurae anastomosis of the esophagus and stomach.

OBJECTIVE: To evaluate the clinical value of mechanical anastomosis in super-cupula pleurae anastomosis (using mechanical anastomosis connecting esophagus and stomach above the diaphragm) of the esophagus and stomach within the thoracic cavity. METHODS: A total of 98 cases of esophageal carcinoma were treated surgically by super-cupula pleurae anastomosis of the esophagus and stomach by anastomotic tube. RESULTS: All anastomoses were completed in single attempt without mortality among the patients, who did not show signs of fistula of anastomosis or injury to recurrent laryngeal nerve and ductus thoracicus. The incidence of anastomosis stricture was 2.04 %(2/98), with tumor remnant rate of the resected end of 1.02 % (1/98). CONCLUSION: Mechanical esophagus and stomach anastomosis of super-cupula pleurae in the thoracic cavity can expand the scope eligible for resection in esophageal carcinoma, resembling neck anastomosis that is simple, quick, dependable and safe.

Adult↗

PubMed2004

[Solitary fibrous tumor of the pleura--description of two cases with features of malignancy].

Two cases of solitary fibrous tumor of the pleura with features of malignancy are described. In the first case, the tumor macroscopically showed noncircumscribed growth. Microscopically, on low power examination, the tumor was characteristically "patternless", with alternation of cellular areas and hypocellular, prominently collagenized areas. There was an infiltrative growth present at the margins. Cytological atypias were not present. In the second case, the tumor was macroscopically circumscribed. Microscopically, on low power examination, the tumor had characteristical "patternless" appearance again. Pleomorphic cells with high mitotic activity dominated in cellular areas on high power examination. The infiltrative pattern of growth was not present at the margins. Both tumors were classified as malignant solitary fibrous tumors of the pleura, or fibrosarcomas of the pleura. The criteria of malignancy for solitary fibrous tumor are discussed.

Female↗

PubMed2005

[Recurrent pneumothorax as alone manifestation of mesothelioma pleurae].

Malignant mesothelioma of the pleura is a rare neoplasm with a poor prognosis. The most often symptoms of this disease are dyspnoe and chest wall pain, which is often associated with pleural effusion. We present 35-years old woman with 5 epizodes of pneumothorax during 3 years (4 of right side and 1-bilateral) in whom bilateral pleurodesis was performed. Specimens of lung and pleurae were examinated. Result of microscopic and immunohistochemical examination was: mesothelioma epithelioides pleurae (mesothelium +, calretyninaa +, EMA+ membrane reaction, desmine +/-).

Adult↗

PubMed1989

[A case of adenomatoid mesothelioma of the pleura].

A case of adenomatoid mesothelioma of the pleura was presented. The patient was a 69-year-old woman with diabetes mellitus. She was admitted to our hospital because of a chest roentgenographic abnormality, which was pointed out during her clinical course. Chest X-ray-film on admission revealed a semicircular lesion located in the left lower lung field. The physical examination and laboratory data showed no abnormalities. Left lower lobectomy was performed. The tumor was approximately, 3.0 x 3.0 x 3.0 cm, elastic soft, encapsulated, and originated from the pulmonary pleura. The histological findings of the tumor showed benign epithelial localized pleural mesothelioma. However histologically, the tumor tissue was not like the usual epithelial type. That is, most cells which had intracellular vacuoles, were similar to signet ring cell. The tumor was diagnosed as adenomatoid mesothelioma of the pleura.

Aged↗