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[Periodic diseases].

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Familial Mediterranean Fever↗

[Periodic disease].

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Familial Mediterranean Fever↗

A discrete-time model for the spread of periodic diseases without immunity.

We investigate the properties of a discrete-time model for the spread of an infectious disease that does not confer permanent immunity. The contact rate is assumed to be constant. Our major result is that oscillations occur in the levels of the diseased population. The consequences of vaccination are also studied.

Communicable Disease Control↗

[Recurrent aseptic meningitis in periodic disease or Mollaret's meningitis?].

A 33 year-old Sephardic Jewish man with familial mediterranean fever (FMF), presented during a 7 year period, 6 episodes of aseptic meningitis, improving within less than 24 h after spinal tap. Cerebrospinal fluid analysis showed a mixed leucocytic pleocytosis ranging from 100 to 1,000 cell/mm3. Spinal fluid cultures for bacteria, viruses and viral antibodies were always negative. Our case supports other reports showing that recurrent aseptic meningitis, although rare, may occur in FMF. It usually responds to treatment with colchicine, like other manifestations of the disease. FMF meningitis has been compared to Mollaret's meningitis whose cause is undetermined. However, Mollaret's meningitis, unlike FMF, is sporadic and ubiquitous, is not transmitted genetically and affects men and women equally. Moreover, in Mollaret's meningitis transient neurological abnormalities, such as signs of encephalitis have often been reported: polyserositis or associated amylosis are absent, there is no biological inflammatory syndrome, and in 65% of the patients the CSF contains specific large mononuclear-derived cells called endothelial cells. Such abnormalities have not been described in FMF.

Adult↗

[Periodic disease].

Explore the source record for details and available documents.

Familial Mediterranean Fever↗