Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “OSTEOPERIOSTITIS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 145 records · Page 8Linked to original sources
PubMed1991

[Cranioplasties using free femoral osteo-periostal flaps].

Injuries, osteomyelitis, tumors are responsible of large skull defects. Their management is difficult. Three post traumatic and post infectious defects were repaired with an osteoperiostic flap taken from the internal face of the femur. A large defect due to the removal of a metastatic tumor was repaired with an iliac osseous flap. The choice of the donor site depends on the defect size (the femur provides a flap of 13 cm x 8 cm, the iliac bone a flap of 17 x 17 cm). The three head injured patients had a range of six previous unsuccessful surgical attempts using polymerised material or bone grafts. The post operative course in the post traumatic patients was uneventful, the domestic result good, the periostic consolidation less than three months. The free flap seems a good method for the management of risky cases.

Bone Transplantation↗
PubMed1991

Autoclaved partially decalcified bone as osteogenic substances--an experimental study.

A large osteoperiosteal gap was created in rabbit's ulna. A total of 18 allogenic decalbone grafts in left ulnar gap and 20 autoclaved allogenic decalbone grafts on right ulnar gaps were implanted. Five gaps were left unbridged to serve as controls. The results were assessed by clinical, radiological, macroscopic, histological and tetracycline fluorescent studies. It is observed that whereas the decalbone can successfully bridge a large gap in a vast majority of cases; the standard autoclaving of decalbone denatures its proteins which melt and cover the outer surface. The union, incorporation and remodelling of autoclaved decalbone grafts are slower as compared to that with unautoclaved decalbone.

Animals↗
PubMed1990

[Current role of decortication in problems of bone healing].

The authors present the results of 101 osteo-periostal decortications. This technique was used in 72 cases of aseptic non-union, 15 cases of infected non-union and 14 cases with malunion. Stable fixation was carried out using a plate or an external Judet fixator. An autologous cancellous or cortico-cancellous bone graft was added in 12 cases. Union was achieved in 98 of 101 patients after an average of 45 days to 4 months, depending on the localisation and the etiology involved. The 3 failures were due to technical errors or presence of an unfilled bone defect. Osteoperiostal decortication is a reliable and reproductible solution to many problems of malunion or non-union. We consider bone grafting to be necessary only in patients with a major bone defect.

Bone Transplantation↗
PubMed1990

Tibial tubercle osteotomy for exposure of the difficult total knee arthroplasty.

Tibial tubercle osteotomy provides a safe and reliable means of extensile exposure of the knee. A technique was developed using a long osteoperiosteal segment including the tibial tubercle and upper tibial crest leaving lateral muscular attachments intact to this bone fragment. The bone fragment was reattached to its bed with two cobalt-chromium wires passed through the fragment and through the medial tibial cortex. The procedure was used in 71 knees to expose the joint for total knee arthroplasty, and the follow-up period was one to five years. All healed uneventfully, and no significant complications occurred. Mean postoperative flexion was 97 degrees. No extension lag occurred, and mean flexion contracture was 2.5 degrees. Excellent exposure can be achieved by means of a viable bone flap below the knee. Early rehabilitation and weight bearing can be done with low potential for complications.

Adult↗
PubMedDate not supplied

[Granular otitis externa].

These authors examined 18 patients with granular external otitis. As other clinicians, the authors believe that the disease should be viewed as a separate nosological pathology. In the case of granular myringitis it is important to differentiate between this disease and chronic suppurative otitis media complicated with polyps or granulations. The granular tissue on the walls of the external acoustic meatus can develop due to inflammation of the skin alone without periosteum or bone involved. It may also occur as a result of suppurative osteoperiostitis of the external acoustic meatus. This pathology also requires differential diagnosis because different therapeutic approaches are to be applied.

Adolescent↗
PubMed1989

[Diagnostic problems in Ewing's sarcoma].

Ewing's sarcoma presents diagnostic problems with several inflammatory processes (osteomyelitis, osteoperiostitis, eosinophilic granuloma) and other bone tumors. Clinical, radiographic and laboratory findings must be supported by a careful biopsy. Delimitation of reticulosarcoma and metastatic neuroblastoma is also extremely difficult from a histopathological point of view.

Adolescent↗
PubMed1989

The biologic concept of continuous passive motion of synovial joints. The first 18 years of basic research and its clinical application.

The notoriously limited capacity of articular cartilage to heal or to regenerate plus the author's clinical observations and research on the deleterious effects of immobilization on joints led him to the biologic concept of continuous passive motion (CPM) of synovial joints in 1970. The hypothesis that CPM should stimulate pluripotential mesenchymal cells to differentiate into articular cartilage and should accelerate the healing of articular tissues has been validated by numerous scientific investigations of a variety of experimental models of the knee joint. These models have included full-thickness defects, intraarticular fractures, acute septic arthritis, partial thickness lacerations of the patellar tendon, semitendinosus tenodesis to replace the medial collateral ligament, autogeneic osteoperiosteal grafts in major defects, free autogeneic periosteal grafts, and periosteal allografts. In 1978, the author collaborated with Saringer, an engineer, to develop CPM devices for humans. CPM is clinically indicated following such procedures as open reduction of fractures, arthrolysis for posttraumatic arthritis, synovectomy, drainage of septic arthritis, release of joint contractures, total arthroplasty, tendon repair, and ligament reconstruction. Clinically, CPM is an important stimulus to joint regeneration processes.

Animals↗
PubMed1989

[Repair of the attic wall by a mastoid osteofibrous graft].

Closed techniques for the management of cholesteatomas often require repair of the external auditory meatus. Small losses of substance around the tympanic membrane or in the attic wall can be repaired by a mastoid cortical autograft. The originality of the procedure described on the basis of the various operative stages is based above all on the preservation of an osteoperiosteal fringe contiguous with the bone graft used. The value of the technique lies in availability of the graft at the operative site and the ease of its insertion into the defect requiring repair.

Cholesteatoma↗
PubMed1987

The role of the tibiofibular interosseous membrane in the repair of fractures of the tibia and fibula.

Anatomical studies were carried out to explore the relationship between the tibiofibular interosseous membrane and the long bones of the leg. Based on the data obtained from experimental fractures it appears that the interosseous membrane, which forms the so-called osteoperiosteal pocket, plays an important role in the repair of leg fractures. Further studies are being undertaken to validate this hypothesis and arrive at a more accurate interpretation of the phenomena observed.

Bony Callus↗
PubMedDate not supplied

Modified Phemister grafting in potentially infected non-union of tibial shaft fractures.

Modified Phemister bone grafting consisting of the raising of an osteoperiosteal flap, bone petalling and a cancellous onlay graft for non-union of tibial shaft fractures was tried in 43 cases. Thirty-eight out of 43 fractures united after one bone grafting procedure, giving a success rate of 88%. The procedure can even be used in the presence of low-grade, active infection. This method of bone grafting is simple and has no significant complications. Knee motion recovers well but ankle and toe stiffness do not improve appreciably from the preoperative status. We recommend that Phemister grafting be performed early.

Adolescent↗
PubMedDate not supplied

A method of repair of late quadriceps rupture.

Delayed treatment of a quadriceps rupture is an infrequent but difficult situation. The fibrous degeneration and muscle retraction and subsequent hiatus present a challenging technical problem. A 54-year-old laborer with a 7-week quadriceps rupture was treated by a method that seems not to have been previously reported. At surgery there was a 9-cm gap that could not be approximated by either a Bunnell suture, or Codvilla lengthening of Scuderi inverted triangle. Repair was successfully accomplished by transposing the inner one-third of the patellar tendon. The tendon was split longitudinally and separated from the medial and lateral aspects in a distal to proximal direction with an osteoperiosteal flap. This was proximally sutured across the gap in the quadriceps mechanism. Eighteen months postoperatively there was no extension lag with knee range of motion of 0 degrees-125 degrees and good power.

Humans↗
PubMed1994

Effect of size and shape of the allogeneic bone grafts in bridging experimental ulnar gap in rabbits.

Partially decalcified allogeneic bone matrix was cut into the sizes and shapes of cylinders, bone strips and pulverized bone powder. Large osteoperiosteal gaps were created in rabbit's ulnae. A total of 14 gaps were filled with bone strips, 20 with powder, six with cylinders and two were left unbridged to serve as control. The healing of gap was assessed at intervals with a maximum follow up of 24 weeks. Clinically at 12 weeks the bone strips could not be moved separately from each other, the whole tubular bone had also united whereas gaps filled with bone powder did not diminish in size. Radiologically union occurred earlier (around 12 weeks) in bone strips as compared to cylinders (approx-18 weeks). With bone powder only a faint line of the remnants was visible. Gross examination findings of the grafted area were in concurrence with the clinical and radiological findings. Overall the gaps filled with bone strips had 100 per cent success with early osteo induction and remodelling as compared to long cylinders whereas gaps filled with bone powder had complete failure.

Animals↗
PubMed1994

Use of osteoinductive implants in the treatment of bone defects.

Osteogenic proteins (OPs) are a family of bone matrix polypeptides isolated from a variety of mammalian species, including mouse, rat, bovine, monkey, and man. OPs initiate chondroblastic differentiation in pluripotent mesenchymal progenitor cells, followed by the synthesis of new bone by endochondral ossification. OPs have the ability to induce healing of osteoperiosteal defects in several animal models, supporting a possible therapeutic role in the reconstruction of bone defects. OPs are responsible for the osteoinductive capacity of demineralized bone matrix (DBM) implants, which may also prove to be clinically useful. Preliminary studies using purified, naturally occurring human osteogenic proteins in the clinical management of non-unions have reported promising results. A prospective, randomized clinical trial is currently underway, comparing recombinant human osteogenic protein-1 (rhOP-1) to autograft in the treatment of tibial non-unions. The use of osteogenic protein implants to augment or replace autogenous and allogenous bone grafts will reduce morbidity, and circumvent the risk of disease transmission associated with transplantation.

Animals↗
PubMed1994

Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model.

An ulnar segmental defect model was used in adult male dogs to examine the effect of recombinant human bone morphogenetic protein-7 (recombinant human Osteogenic Protein-1 [rhOP-1]; Creative Biomolecules, Hopkinton, Massachusetts) on new bone induction and healing, and to test the mechanical strength of healed 2.5-cm segmental bone defects. The rhOP-1 composites consisted of a carrier of 500 mg of demineralized, guanidine-extracted, insoluble bovine bone matrix (collagen carrier), reconstituted with rhOP-1. Six animals received 1200 micrograms rhOP-1 unilaterally and were killed at 12 weeks for torsional load-to-failure testing using the contralateral side as a control. Two further animals received varying amounts of rhOP-1 bilaterally and were studied histologically. All defect sites receiving rhOP-1 were completely bridged radiographically by eight weeks. A control composite, containing no rhOP-1, failed to induce new bone formation at any time. Histologically, rhOP-1-treated sites examined at 16 weeks had formation of new cortical and cancellous bone, with normal appearing marrow elements in the reconstituted medullary canal. The torsional strength of the rhOP-1-implanted ulnae averaged 72% of control (range, 30-99%). The angular deformation to failure averaged 92% of control (range, 39-122%). The energy absorption to failure averaged 67% of control (range, 27-111%). This study demonstrates the efficacy of rhOP-1 in healing segmental osteoperiosteal defects in a canine model.

Animals↗
PubMed1994

Periosteal and perichondral grafting in reconstructive surgery.

Periosteum consists of multipotent mesodermal cells, and the influence of the environment on differentiation of cells of free periosteal grafts has been demonstrated in experimental studies. Periosteum has the capacity to form all varieties of connective tissue. The periosteum has osteogenic capacity, but it can also be used to promote cartilage formation in a chondrotrophic environment. Free periosteal grafts transplanted to the completely chondrectomized articular surfaces of patellae in experimental animals differentiated into cartilage. Joint motion appeared to be one of the chondrogenesis-promoting factors. The authors are optimistic about the potential clinical results with these types of grafts. Also, periosteal resurfacing of the metatarsal head was found to be suitable in the treatment of hallux rigidus and Freiberg's disease. Findings in growing rabbits showed that spinal fusion can be achieved with free periosteal grafts. This technique has been used to treat lumbar lytic spondylolisthesis in young patients, and the method produced clinical and radiologic results that were comparable with those obtained using bone transplants. This work indicates that some of the adverse effects of lumbar spinal fusion (e.g., postoperative spinal stenosis) can be avoided by using osteoperiosteal fusion. Also, periosteal grafting has proved useful in the treatment of thoracolumbar scoliosis. Free periosteal grafting has been used to treat congenital clefts of the maxilla and tracheal cartilage defects.

Adolescent↗
PubMed1993

Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein.

A middiaphyseal, 2.5-cm osteoperiosteal segmental defect stabilized by plate fixation was created in the right femur of 17 sheep. Four treatment groups were included: Group I, no implant; Group II, inactive bone matrix; Group III, recombinant human bone morphogenetic protein (rhBMP-2) mixed with inactive bone matrix; and Group IV, autogeneic bone graft. Three animals had early failure of fixation, and the remaining 14 were evaluated at three months after implantation. Radiographs showed bony union of all defects treated with rhBMP-2 (six) and a lack of bony union in the negative-control groups treated with no implant (three) and inactive bone matrix without BMP (three). Both defects treated with autograft healed. New bone formation in the defect sites treated with rhBMP-2 first appeared one month after implantation and had a mean bending strength (expressed as a percentage of the contralateral femur) of 91% +/- 59% (mean +/- standard deviation) for defects treated with BMP-2, 77% +/- 34% for autograft, 9% +/- 8% for no implant, and 11% +/- 7% for inactive matrix without BMP. Three sheep treated with rhBMP-2 had their fixation plates removed at four months and were followed for one year. Their bone defect sites remained solidly healed one year after the initial operation.

Animals↗
PubMed1995

[1984-1994: Ten years of skin flaps. Prefabricated flaps].

The term prefabrication of flaps corresponds to completely different technical modalities, often complementary and associated, which share the common feature of extending the indications and potential of pedicle or free flaps. Current methods of prefabrication of flaps can be considered to be based on one or several basic principles of reconstructive surgery. The authors discuss and analyse various modalities: a free flap can be made autonomous or can be expanded prior to transfer. A transfer can be initially prefabricated at its donor site by performing several operative steps in situ. A free transfer can be performed on the main vascular axis of a flap which is subsequently transferred, for example: free scalp transfer to reconstruct an eyebrow on a donor site reconstructing half of the face, but the first in situ operative phase usually consists of performing cutaneous, bone, cartilaginous or even alloplastic material transplants. The transfer is only performed after a sufficiently satisfactory complex anatomical, functional or esthetic unit has been achieved, in order to avoid difficult or dangerous remodeling operations after transfer. The most revolutionary appearance in the area of prefabrications is certainly induction of a pedicle or free neoflap in a so-called random territory. The addition of an arteriovenous pedicle associated with fascia underneath a muscle, underneath a skin cover, in contact with an osteoperiosteal segment allows a perfectly transferable neovascularized unit to be obtained after several weeks. All of the procedures described: autonomization before transfer, expansion before transfer, in situ prefabrication of a complex unit by addition of several tissue units (autologous or alloplastic) in one or several stages and finally vascular induction of a muscular, cutaneous or bone unit, etc. by transfer of a vascular axis in contact with this anatomical structure and combinations of these various modalities obviously open up a new approach which will considerably extend the already remarkable possibilities offered by free tissue transfers.

Adult↗