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PubMed1990

[Nonspecific spondylodiscitis in childhood. New findings about the disease].

Nonspecific spondylodiscitis at the child age represents a distinctive disease of intervertebral disc and adjacent subchondral parts of vertebral bodies. Their early diagnostics may be difficult due to latency of radiographic manifestation of the finding and possible mistaking for other pathological conditions, especially tuberculosis spondylitis. The paper demonstrates several cases of the disease which we encountered recently. The authors discuss clinical and X-ray symptoms of the disease with a particular attention to modern methods of visualization, especially computer tomography. Etiopathogenesis of the disease is analyzed and some new knowledge of the disease is presented, differential diagnosis is discussed. In the conclusion attention is paid to early diagnosis of the disease and introduction of proper therapy.

Adolescent↗
PubMed2004

Finding new clock components: past and future.

The molecular mechanism of circadian clocks has been unraveled primarily by the use of phenotype-driven (forward) genetic analysis in a number of model systems. We are now in a position to consider what constitutes a clock component, whether we can establish criteria for clock components, and whether we have found most of the primary clock components. This perspective discusses clock genes and how genetics, molecular biology, and biochemistry have been used to find clock genes in the past and how they will be used in the future.

Animals↗
PubMed2002

Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings.

The endocrine control of oocyte maturation in fish has proven to be a valuable model for investigating rapid, nongenomic steroid actions at the cell surface. Considerable progress has been made over the last decade in identifying and characterizing progestin membrane receptors mediating these actions in fish, in understanding the hormonal regulation and physiological roles of these receptors in oocyte maturation, in elucidating the signal transduction pathways they activate, and in determining their nature. Recent advances on these topics are briefly reviewed. New data demonstrating the involvement of pertussis toxin-sensitive inhibitory G-proteins in induction of oocyte maturation by the maturation-inducing steroid (MIS) in teleosts is also presented. In addition, the cloning strategy to isolate the MIS receptor gene from spotted seatrout ovaries and the characteristics of a novel gene and protein discovered by this approach are discussed. Current evidence suggests this G-protein-coupled receptor-like protein is the long sought after MIS receptor mediating meiotic maturation of teleost oocytes.

Animals↗
PubMedDate not supplied

Levels-of-processing effects on a variety of memory tasks: new findings and theoretical implications.

Three experiments investigated level of processing (LOP) effects on a variety of direct and indirect memory tasks, in the context of a processing theory of dissociations. Subjects studied words in five encoding conditions and received one of ten memory tests. In Experiment 1, four tests previously classified as conceptual showed a robust LOP effect, as did a direct perceptual test of graphemic cued recall. An indirect perceptual word fragment completion test was unaffected by LOP. Experiment 2 showed that a new indirect version of a graphemic cued test was not affected by LOP. In Experiment 3, guided by a generation/recognition model, we constructed three new direct tests in which subjects identified words that were graphemically, phonologically, or semantically similar to studied words. The three tests differed in their sensitivity to study conditions, but LOP had no effect in any case, despite the involvement of deliberate conscious recollection. Contemporary explanatory frameworks couched as dichotomies (e.g., implicit/explicit, perceptual/conceptual) do not provide an adequate account of the results. It seems necessary instead to specify the types of information activated by each encoding condition, the types of information required by each test, and how encoding and retrieval processes are modified by task instructions.

Adult↗
PubMed2003

New findings from the 2002 Minnesota Resident Physician Exit Survey.

The 2002 Minnesota Resident Physician Exit Survey was administered to 698 residents and fellows scheduled to complete training programs in Minnesota during 2002. The Resident Physician survey is 1 of 6 exit surveys administered annually to exiting students, residents, and fellows in a variety of health care disciplines in Minnesota. Of the 698 survey recipients, 387 (55%) returned completed surveys. The results confirm the importance of geographic area of origin in the practice decisions of new physicians. Respondents who had graduated from Minnesota high schools, colleges, or medical schools were significantly more likely to remain in Minnesota to practice than were respondents who had attended secondary, postsecondary, or professional schools in other states or countries. The results also indicate that for most new physicians, educational debt load is not a major factor in practice decisions.

Career Choice↗
PubMed1996

Levels-of-Processing Effects on a Variety of Memory Tasks: New Findings and Theoretical Implications

Three experiments investigated level of processing (LOP) effects on a variety of direct and indirect memory tasks, in the context of a processing theory of dissociations. Subjects studied words in five encoding conditions and received one of ten memory tests. In Experiment 1, four tests previously classified as conceptual showed a robust LOP effect, as did a direct perceptual test of graphemic cued recall. An indirect perceptual word fragment completion test was unaffected by LOP. Experiment 2 showed that a new indirect version of a graphemic cued test was not affected by LOP. In Experiment 3, guided by a generation/recognition model, we constructed three new direct tests in which subjects identified words that were graphemically, phonologically, or semantically similar to studied words. The three tests differed in their sensitivity to study conditions, but LOP had no effect in any case, despite the involvement of deliberate conscious recollection. Contemporary explanatory frameworks couched as dichotomies (e.g., implicit/explicit, perceptual/conceptual) do not provide an adequate account of the results. It seems necessary instead to specify the types of information activated by each encoding condition, the types of information required by each test, and how encoding and retrieval processes are modified by task instructions.

Journal Article↗
PubMed2006

Pontobulbar palsy and neurosensory deafness (Brown-Vialetto-van Laere syndrome) with hyperintense brainstem nuclei on magnetic resonance imaging: new finding in three siblings.

Three siblings (one boy and two girls) with Brown-Vialetto-van Laere syndrome are reported. A peculiar feature of onset with hearing loss in a patient with multiple cranial nerve palsies and a positive family history suggests this diagnosis. In our family, an autosomal recessive mode of inheritance was seen. In addition, we observed that early onset was associated with rapid deterioration and death. Optic nerve involvement and hyperintensity of the brainstem nuclei on magnetic resonance imaging (MRI) are two new features described in this report.

Adolescent↗
PubMed1996

The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans.

The original hypothesis that brain monoamine systems have a primary direct role in depression has been through several modifications during the past 30 years. In order to test this hypothesis and more fully characterize the role of serotonin and catecholamines in the pathophysiology of depression and the mechanism of action of antidepressant treatments, our research group has conducted a series of studies evaluating monoamine depletion induced brief clinical relapse following different types of antidepressant treatment of depressed patients. We have also studied the effects of monoamine depletion (SD) on depressive symptoms in depressed and recovered patients off medication and in healthy controls. Relapse to serotonin depletion or to catecholamine depletion (CD) was found to be specific to the type of antidepressant treatment, i.e., patients responding to selective serotonin reuptake inhibilitors relapsed more frequently following SD than CD and patients responding to selective catecholamine reuptake inhibitors relapsed more frequently following CD than SD. Neither CD or SD increased depressive symptoms in clinically ill patients off treatment, or produced clinical depression in normal controls. However, recovered patients with a prior history of depression had a relapse with SD. Patients with obsessive compulsive disorder who improved on SSRI treatment, did not have an increase in OCD symptoms but those with prior depressive symptoms did have an increase in depressive symptoms with SD. The findings that relapse during treatment is specific to the type of treatment and type of depletion, that neither SD or CD produced an increase in clinical depression in healthy controls or depressed patients off medication, and that recovered patients off medication have a return of symptoms following SD, forces a major revision of the current monoamine theories of depression. The new hypothesis most consistent with this new data is that the monoamine systems are only modulating "other" brain neurobiologic systems which have a more primary role in depression. The modulatory or "antidepressant" function of the monoamine systems appears to be only necessary during drug induced recovery and the maintenance of recovery after a prior episode. These clinical studies point to the need for more fundamental research on the interaction of monoamine systems with other brain neurobiologic mechanisms relevant to depression.

Adrenergic Uptake Inhibitors↗
PubMed2001

Brain-gut interaction in irritable bowel syndrome: new findings of a multicomponent disease model.

Knowledge on the pathophysiology of irritable bowel syndrome has evolved, beginning with disturbances in motility to visceral hypersensitivity, and ultimately to alterations in brain-gut bi-directional communication, where neurotransmitters such as serotonin play a key role. Recently, a multicomponent disease model that integrates all these alterations was proposed. This model is divided into physiological, cognitive, emotional and behavioral components that explain the gastrointestinal as well as the constitutional symptoms. In recent years there has been an explosion of research together with new developments in pharmacological treatments for IBS that support each component of this model. This review presents recent data in favor of these alterations in IBS.

Brain↗
PubMedDate not supplied

Children's health insurance, access to care, and health status: new findings.

Despite various policy initiatives, a substantial number of children in the United States remain uninsured, have problems with access to health care, or are in fair or poor health. These difficulties are not evenly distributed across the population. Hispanic children, those whose parents have little education, and those who live in families without an employed parent are at disproportionately high risk of encountering these problems. Although multivariate analyses would be required to disentangle the complex relationships among these factors, these descriptive data reveal the segments of the population to which new health-related programs, such as CHIP-funded state plans, might most productively be directed. Issues concerning children's health are likely to remain on the national policy agenda for some time to come. Because MEPS is a continuing data collection effort, it will enable researchers and policymakers to follow trends in these issues over time. For example, MEPS data will support evaluations at the national level to determine whether children who lack health insurance or a usual source of care will actually face fewer barriers after CHIP-funded programs are implemented. This paper provides a baseline against which to evaluate the impact of CHIP and other policy changes on the health and well-being of America's children.

Adolescent↗
PubMed1996

[New findings on the etiopathogenesis and clinical manifestations of Epstein-Barr virus infections].

Epstein-Barr virus is an ubiquitous member of the human herpes virus family. A specific antigen structure of the Epstein-Barr virus was discovered in the last decade. It was possible to diagnose some unusual clinical manifestations of EBV infections and its clinical course by different serologic analyses (immunofluorescent tests, immunoenzyme assay and polymerase chain reaction). This is very important in cases of atypical primary infections (hepatitis, meningoencephalitis), chronic mononucleosis and lymphoproliferative disorders and nasopharyngeal carcinoma. Famciclovir, a new antiviral agent (peroral form of penciclovir) may play an important role in the therapy of these infections.

Herpesviridae Infections↗
PubMed1994

[New findings on serum lactate dehydrogenase isoenzymes in pigs during slaughter].

In the article we describe lactate dehydrogenase-(LD) (EC 1.1.1.27) isoenzyme pattern detected in the sera of pigs at slaughter. The pattern was different from that of normal serum (Fig. 1) and was characterized by the occurrence of an extra LD-fraction in the cathodic site of LD4 (Fig. 2). This fraction was unusual due to its unwillingness to separate by native polyacrylamide gel electrophoresis (PAGE) and took shape of a diffuse zone. The presence of the extra LD-zone caused a proportional decrease in quantitative distribution of the other LD forms, especially LD1 to LD3, in slaughtered pig sera (Tab. I). We examined the homogeneity of an apparent LD5-fraction using gel isoelectric focusing (IEF). We found out that after separation in a gradient of pH (3-9) two to three new extra bands with LD activity appeared in the area with relatively high pH value (pH 9) (Fig. 3). Their localization in the gradient of pH was greatly different from that of true LD molecules, the latter being situated in more acidic area. It is obvious from the finding described above that the diffuse LD-zone, detected in the serum of pigs at slaughter by native PAGE, was in no case a homogeneous protein. Consequently, it eliminates a possibility that the extra LD fraction reflects an increased LD5 activity in serum of affected animals. On the contrary, the IEF showed that the diffuse LD-zone consisted of two to three electrophoretically distinct proteins with relatively high pI values. As these proteins differed in their electrophoretic properties from the true LD isoenzymes we denoted them LD-like proteins. An origin of the unusual LD-like proteins detected in the serum of pigs at slaughter remains unknown for us for the time being.

Abattoirs↗
PubMed1986

New findings on sleep stage organization in squirrel monkeys.

The EEGs of 11 squirrel monkeys were studied during nocturnal sleep under conditions maintaining relative freedom of movement and minimal social intercourse. For the amount and partition of the different sleep stages, the present findings markedly differ from previous observations in experimental restrained conditions. Six sleep stages were defined by both EEG and spectral analysis criteria. Wakefulness, which occurred during the first period of the night, was more abundant (45%) and deep sleep (SIII) and REM sleep were less abundant (SIII: 5.1%; REM: 3.1%) in unrestrained squirrel monkeys. With predominant light sleep (85%), less abundant deep sleep and a REM sleep organization in short episodes, the sleep pattern in this New World monkey appeared fragmented and close to African monkey sleep.

Animals↗
PubMed2000

[New findings on the pathogenesis of psoriasis].

Psoriasis is currently considered to be an inflammatory disease of the skin mediated by T-lymphocytes. The key role in the pathogenesis of psoriasis is played by IL-8 which together with INF-gamma have a mitogenic effect on keratinocytes and trigger their hyperproliferation and activation of neutrofile leucocytes as well as the inflammatory reaction. The skin afflicted with psoriatic lesions contains 100-times increased expression of active IL-8. Its most significant source is probably represented by keratinocytes, but it is produced also by endothelial cells, fibroblasts, T-lymphocytes, polymorphonuclear leucocytes, fibroblasts, Langerhans cells, macrophages. The revealed pathogenetic coincidences render new prospective possibilities in the treatment of psoriasis.

Humans↗
PubMedDate not supplied

The contribution of new findings and ideas to the old principles of teratology.

Although the last generally accepted concept of principles of teratology was issued more than 30 years ago, the cause of less than 50% of all congenital anomalies is known and no substantial change in their incidence has been observed worldwide. In the meantime, powerful techniques of molecular biology as well as many sophisticated preventive measures have been introduced with marginal effects on the overall birth defects numbers. In this paper, we follow the history of basic concepts of teratology starting with Isidore Geoffroy Saint-Hilaire and Dareste, followed in the 20th century by James Wilson. Since that time no bright and completely new idea, which would deserve the name principle, has emerged. The advanced molecular studies support the long-existing principles and disclose the great variability of individuals and their responses to adverse exposures. In this way, the future of teratology counseling may be seen in a deep analysis of any individual case.

Adult↗
PubMed2004

Inter- and intracellular interactions of Nogo: new findings and hypothesis.

The molecule Nogo has captured the imagination of many as a possible key player, and therefore therapeutic target, in the pathological settings of central nervous system (CNS) injury and degenerative pathology. Found in both glial cells and neurons, the endogenous, physiological role of Nogo is as yet unknown. Recently reported targeted disruption of the Nogo gene did not result in any obvious neuro-anatomical or neurological phenotype. Compared with wild-type mice, Nogo-deficient mice also did not exhibit a truly convincing enhancement in their ability to regenerate CNS neurons upon injury. Does the molecule have any important physiological function at all? Other recent discoveries of new interacting partners of Nogo at the mitochondria and the CNS paranode suggest intriguing links to the modulation of apoptosis and developmental organization or signalling at the axoglial junction.

Animals↗
PubMed1988

New findings in the pharmacokinetic, metabolic, and drug-resistance aspects of mitomycin C.

The pharmacokinetics of mitomycin C are reviewed from reports using specific and sensitive high-performance liquid chromatography (HPLC) assays. These studies demonstrate a rapid, biphasic elimination pattern for the drug: alpha half-life of 8 minutes and beta, or terminal, half-life of 48 minutes. Urinary elimination of intact drug is minimal (8% to 10% of a dose), whereas biliary drug levels may exceed those in the plasma. There was no evidence of dose dependent pharmacokinetics over a wide range of doses and patient populations, including pediatric solid tumor patients. Metabolic studies with mitomycin C have demonstrated an absolute requirement for reductive enzymatic activation of the drug to mono- and bifunctional alkylating species. The preferred DNA target for covalent attachment by mitomycin C was found to be the N2 position of guanine. Chemical metabolites of activated mitomycin C were also demonstrated to include 2, 7 diaminomitosene and its cis- and trans-1-hydroxy or 1-phosphate analogues. Also, there was no evidence for hypoxic cell selectivity for mitomycin C in several human tumor cell lines, although some animal tumors unequivocally display this phenomenon. Finally, there are new observations of the development of the multidrug-resistance phenotype in mitomycin C-treated L-1210 cells in vitro. These cells became collaterally resistant to anthracyclines and vinca alkaloids and expressed the P-glycoprotein in cell membranes. The implications of these findings for mitomycin C use in solid tumors in humans is discussed.

Biotransformation↗
PubMed1996

Electromyography of levator scapulae: new findings allow tests of a head stabilization model.

OBJECTIVE: Understanding the recruitment patterns of shoulder girdle prime-mover muscles will allow meaningful exploration of non-prime-mover neck muscle activity during arm and shoulder efforts. This study identifies exercises that isolate recruitment of levator scapulae from recruitment of upper trapezius. The exercises will be used for electromyographic experiments in which the head stabilizing roles of other neck muscles will be explored. DESIGN: Right levator scapulae and upper trapezius were electromyographically monitored with indwelling, fine-wire, bipolar electrodes. Subjects performed isometric arm exercises and movements of the upper limb, shoulder and head. SETTING: Electromyography facilities of the department of Anatomical Sciences of the State University of New York at Stony Brook were used. PARTICIPANTS: Six adult subjects participated; one had reduced shoulder girdle mobility and a history of multiple shoulder separations. MAIN OUTCOME MEASURES: Raw electromyographic data were scored visually on a scale from 0 to 4, with 4 being the signal observed in a maximal voluntary contraction. RESULTS: All subjects recruited levator scapulae alone during arm extension. Only the subject with reduced shoulder mobility recruited levator scapulae during scapular plane arm elevation and arm abduction. CONCLUSIONS: The levator scapulae torque to be counteracted in arm extension produces ipsilateral rotation, lateral flexion and extension of the neck; trapezius rotates the head contralaterally during scapular plane arm elevation. These distinct and relatively simple cases (one shoulder girdle prime-mover affecting head posture at a time) are appropriate exercises for experimental exploration of the recruitment patterns of potential head stabilizers during arm/shoulder efforts.

Adult↗