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PubMed2003

Diagnosis and monitoring of hemorrhagic shock during the initial resuscitation of multiple trauma patients: a review.

The initial management of the multiple trauma victim requires evaluation for potential hemorrhage and ongoing monitoring to assess the efficacy of resuscitation and avoid complications related to hemorrhagic shock. A variety of strategies exist to assess circulatory status, including hemodynamic monitoring, tissue perfusion measurement, and use of serum markers of metabolism. We review available technologies used to assess fluid status and tissue perfusion in patients with blood loss or hemorrhagic shock, discuss how these methods can be used effectively and efficiently during initial trauma resuscitation to guide therapy and disposition, and suggest directions for future research to improve outcomes by providing more appropriate and timely care and avoiding unnecessary complications.

Biomarkers↗
PubMed2006

Early apoptosis of monocytes contributes to the pathogenesis of systemic inflammatory response and of bacterial translocation in an experimental model of multiple trauma.

The objective of this study was to investigate the occurrence of apoptosis of monocytes in an experimental model of multiple trauma and its probable correlation to bacterial translocation. Thirty-two rabbits were applied in three groups: A, controls; B, myotomy of the right femur; and C, myotomy and fracture of the right femur. Blood was sampled for the estimation of endotoxins [lipopolysaccharide (LPS)], tumour necrosis factor (TNF)-alpha, malondialdehyde (MDA) and isolation of peripheral blood mononuclear cells (PBMCs). PBMCs, derived after centrifugation over Ficoll, were incubated in flasks and apoptosis of non-adherent lymphocytes and adherent monocytes was estimated after staining for Annexin-V and flow cytometry. TNF-alpha of supernatants of cultured monocytes was also determined. Tissue segments were cultured after death. Median survival of groups A, B and C was > 14, > 14 and 9.00 days, respectively. Apoptosis of lymphocytes in group C was higher than group A at 2, 4 and 48 h and of monocytes in group C higher than group A at 2 and 4 hours. LPS in group C was higher than group A at 2, 4 and 48 h. Apoptosis of lymphocytes and monocytes was correlated positively with serum TNF-alpha and negatively with TNF-alpha of monocyte supernatants. Cultures of organ segments of group A were sterile. Pseudomonas aeruginosa was isolated from liver, lung and spleen in five animals in group B (45.45%) and in six in group C (54.54%). Early apoptosis of blood monocytes supervened after multiple trauma; the phenomenon was accompanied by apoptosis of blood lymphocytes and subsequent bacterial translocation.

Animals↗
PubMedDate not supplied

Venous thromboembolism in multiple trauma patients.

Thromboembolic complications are frequent in patients with multiple trauma. The efficacy of unfractionated heparin for venous thrombosis prophylaxis has not been established. Based on limited prospective data, low-molecular-weight heparin appears to be more effective than unfractionated heparin and at least as effective as compression devices for preventing thromboembolic complications in these patients. Vena cava filters should be considered in high-risk patients who cannot receive anticoagulant therapy, but long-term filter use without concomitant anticoagulant therapy is associated with a substantial risk of recurrent thromboembolism.

Bandages↗
PubMed2006

[Risk factors affecting the survival rate in serious multiple trauma patients associated with acute lung injure/acute respiratory distress syndrome].

OBJECTIVE: To investigate risk factors affecting the survival rate in serious multiple traumatic patients associated with acute lung injure (ALI)/acute respiratory distress syndrome (ARDS). METHODS: The clinical data of 76 serious multiple trauma patients associated with ALI and 95 cases in ARDS, totally 171 patients associated with ALI/ARDS, were retrospectively studied, and stepwise logistic regression analysis was used to analyze 20 possible risk factors affecting survival rate. RESULTS: The risk factors affecting survival rate in the ALI group: included smoking (B = -5.235, OR = 0.005, P = 0.001), sepsis secondary to trauma (B = -2.753, OR = 0.064, P = 0.031), and gastrointestinal hemorrhage (B = -2.876, OR = 0.056, P = 0.033). The risk factors affecting survival rate in the ARDS group included the time of induction factor persisting to attacking (B = 3.524, OR = 33.933, P = 0.008), sepsis secondary to trauma (B = -5.183, OR = 0.006, P = 0.004); renal insufficiency(B = -4.745, OR = 0.009, P = 0.009), and gastrointestinal hemorrhage (B = -6.335, OR = 0.002, P = 0.007). CONCLUSION: Different from the results of study of traditional risk factors affecting survival rate in ALI/ARDS, this study reveals that smoking may be an independent risk factor; the earlier ALI/ARDS appears, the lower the predictable survival rate in condition of serious multiple trauma; MODS is easily induced in the course of complicating renal insufficiency during the time of lung injury; sepsis and gastrointestinal hemorrhage are still the infective factors or infection inducing factors affecting the survival rate after trauma; and the primary disease causing infection must be treated actively.

Acute Disease↗
PubMed1990

Acute obstructive jaundice in the multiple trauma patient.

The appearance of acute jaundice in the multiple trauma patient may result from obstruction of the common bile duct by clot. Management of this problem may be hindered by a delay in diagnosis, especially where alterations in pigment load and hepatic clearance may have produced the jaundice. A high index of suspicion combined with the judicious use of various noninvasive imaging modalities may be helpful in making the diagnosis. The progression of jaundice in a patient suspected of having acute obstructive hemobilia should prompt rapid operative intervention. At laparotomy, cholangiography or common bile duct exploration should be done. Persistent bleeding should be managed initially with angiographic localization and transcatheter embolization; its failure would necessitate surgical control of the source.

Accidents, Traffic↗
PubMed1997

[Cost analysis of primary care and intensive care treatment of multiple trauma patients].

Treatment costs of emergency therapy, surgery and intensive care were analysed in 20 randomly chosen, representative patients with severe multiple trauma (mean ISS 32 p). For an average stay of about 22.5 days in the ICU, the total costs were DM 106,924.36 (about $70,000), which breaks down as DM 39,635.88 (= 37%) for physicians and nurses, DM 67,289.08 (= 63%) for materials, X-rays, laboratory investigations, drugs and blood components. The whole treatment caused daily costs of DM 4,752.22, or DM 3.30 per min. The first emergency diagnostic procedures and emergency therapy take a mean of 451.9 min from admission to the beginning of the ICU treatment and itself generates costs of about DM 12,325.99. In Germany a new system of compensation by diagnosis-related group was introduced in 1996. Therefore, these data indicate that treatment of severe multiple trauma is very expensive and trauma care could be economically by damaging for smaller hospitals. We conclude that treatment of multiply injured patients (ISS > 16 p) should be concentrated in selected trauma centres and compensated by payment of a special daily amount of about DM 5,000 (about $3,500).

Adolescent↗
PubMed1993

Primary intramedullary femur fixation in multiple trauma patients with associated lung contusion--a cause of posttraumatic ARDS?

We investigated whether primary (< 24 hours) intramedullary stabilization of femoral shaft fractures in multiple trauma patients with severe thoracic injury might be associated with an increased incidence of adult respiratory distress syndrome (ARDS). A total of 766 patients with multiple trauma admitted to Hannover Medical School between January 1, 1982, and December 31, 1991, were investigated retrospectively. Of these, 106 patients met the inclusion criteria: Injury Severity Score > 18, femoral midshaft fracture treated by intramedullary nailing, primary admission or referral within 8 hours after injury, and no death from head injury or hemorrhagic shock. Two groups were differentiated according to the presence or absence of chest trauma (severe chest trauma = AIS thorax > or =, group T; no severe chest trauma = AIS thorax < 2, group N). Selection of subgroups according to the time of femur stabilization was group I < 24 hours after trauma, group II > 24 hours after trauma. Injury Severity Scores in the four groups were TI: 29.4 (n = 24); TII 31.4 (n = 26); NI 20.1 (n = 33); NII 25.4 (n = 23). In patients without thoracic trauma the ICU time (NI: 7.3 days; NII: 18.0 days) and intubation time (NI: 5.5 days; NII: 11.0 days) were lower in the patients treated primarily (p < 0.05). In patients with severe chest trauma there was a higher incidence of posttraumatic ARDS (33% versus 7.7%) and mortality (21% versus 4%) when early intramedullary femoral nailing was done. In the absence of severe chest trauma primary intramedullary femoral nailing is beneficial.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2004

Lisfranc fracture-dislocation in patients with multiple trauma: diagnosis with multidetector computed tomography.

BACKGROUND: We assessed acute phase multidetector computed tomography (MDCT) findings of Lisfranc fracture-dislocations in patients with multiple trauma referred to a Level I trauma center over a 29-month period. METHODS: Two hundred and eighty two patients (208 male and 74 female) between the ages of 13 and 89 (mean 42) years had, at the request of emergency room physicians, MDCT of the foot and ankle after acute injury. RESULTS: A total of 21 Lisfranc fracture-dislocations were found in 19 (7%) patients. Two main injury mechanisms were established: falling from high places in 10 injuries (48%) and traffic accidents in five (24%). Primary radiographs were available in 17 (81%) feet, and four (24%) had false negative radiographic results when compared to MDCT. In all Lisfranc fracture-dislocations MDCT showed the joint anatomy and the extent of dislocation better than primary radiographs, and in six (46%) of 13 true positive primary radiographs, MDCT revealed additional occult fractures in the Lisfranc joint. Multidetector CT revealed additional occult fractures in other parts of the foot and ankle in six (35%) of 17 feet. CONCLUSIONS: Standard radiography remains a primary diagnostic modality in acute foot and ankle trauma. Multidetector CT with high-quality multiplanar reconstruction (MPR) is recommended as a complementary examination in high-energy injury in patients with multiple trauma or in patients in whom radiographic images are equivocal. This may reveal Lisfranc fracture-dislocations, show the extent of the fracture-dislocation, and reveal occult fractures in other parts of the foot and ankle.

Acute Disease↗
PubMed2004

Paradoxical embolus after multiple trauma resulting in a cerebrovascular accident.

UNLABELLED: We present the case of a 57-yr-old patient who suffered an unexplained cerebrovascular event 3 days after being struck by a motor vehicle. Workup demonstrated a previously unknown patient foramen ovale. The etiologies of paradoxical embolism in trauma are discussed. IMPLICATIONS: Paradoxical embolism after multiple traumas is described. Delay in diagnosis may occur given the need for near continuous sedation in the patient with injuries undergoing multiple surgeries and diagnostic tests.

Accidents, Traffic↗
PubMed1985

Blunt multiple trauma (ISS 36), femur traction, and the pulmonary failure-septic state.

Fifty-six blunt multiple trauma patients (HTI-ISS 22-57) were studied for the effects of immediate versus delayed internal fixation of a femur or acetabular fracture on the pulmonary failure septic state. The pulmonary failure septic state may be defined as an alveolar arterial oxygen tension difference greater than 100, plus fever and leukocytosis. These patients were divided into four groups. Group I (N = 20) had immediate internal fixation, postoperative ventilatory support, and was sitting up at 30 hours. Group II (N = 20) had 10 days of femur traction and postoperative ventilatory support. Group III (N = 9) was immediately extubated after surgery and had 30 days of femur traction. Group IV (N = 7) had special circumstances that should increase the duration of the pulmonary failure septic state. These four groups of patients were statistically identical by 20 different criteria on admission except that Group I had more recognized chest injuries than Group II (12 vs. 9). Group I required 3.4 +/- 2.6 days of ventilator support and 7.5 +/- 3.8 intensive care unit (ICU) days; they had 12 +/- 8.8 elevated white counts, 3.8 +/- 4 febrile days, 0.05 positive blood cultures per patient, four fracture complications out of 93 fractures, 59 injections of narcotics, and 23 +/- 8.6 acute care days. Ten days of femur traction doubled the duration of the pulmonary failure septic state relative to Group I at a statistically significant level for nine out of 10 criteria, while increasing the number of positive blood cultures by a factor of 10, the number of fracture complications by a factor of 3.5, and the use of injectable narcotics by a factor of 2. Thirty days of femur traction increased the duration of the pulmonary failure septic state relative to Group I by a factor of 3 to 5 for all criteria at a statistically significant level, while increasing fracture complications by a factor of 17, positive blood cultures by a factor of 74, and the use of narcotics by a factor of 2. Group IV, which had four out of seven immediate internal fixations, behaved similarly to Group II. Femoral shaft traction should be avoided in the blunt multiple trauma patients because it greatly increases the cost of care and the risk of multiple systems organ failure.(ABSTRACT TRUNCATED AT 400 WORDS)

Acetabulum↗
PubMed1993

Causes and costs of injuries in multiple trauma patients requiring extrication from motor vehicle crashes.

Prospective and contemporaneous medical and economic cost studies of 144 victims of motor vehicle crashes admitted to a regional level I trauma center with multiple injuries (ISS > or = 16) revealed 122 non-ejected patients, of whom 102 required extrication (EXTRIC) from the vehicle for physical or medical reasons and 20 who did not (N group). There were no differences in age (EXTRIC, 34 +/- 17 years; N, 41 +/- 24 years), type of crash (Frontal: 57% EXTRIC, 60% N; Lateral: 32% EXTRIC, 35% N) restraint use (35% EXTRIC, 35% N), or mortality (29% EXTRIC, 30% N). However, the estimated maximum speed before the crash was higher in EXTRIC patients (50 +/- 16 mph vs. 46 +/- 18 mph N, p < 0.04), as was the change in velocity (delta V) on impact (EXTRIC 30 +/- 15 mph; N, 24 +/- 8 mph, p < 0.01). Brain injuries (51% EXTRIC vs. 35% N) and lower extremity injuries were more numerous in EXTRIC patients (59% vs. 20% N, p < 0.003) and the number of splenic, lower extremity, and pelvic injuries associated with shock was greater in EXTRIC patients, p < 0.02; as were postinjury complications. As a result, operating room costs from orthopedic and plastic surgery increased professional charges in the EXTRIC group versus the N group ($20,000, EXTRIC; $17,000, N) and critical care costs ($13,000, EXTRIC; $4,000, N) with total costs of $72,000 and $77,000, respectively. The lower extremity injuries in EXTRIC patients were primarily a result of body part contacts with intrusions (CIs) of the car occupant compartment structures [73% with vs. 24% without (p < 0.0001)]. In lateral MVCs, brain injuries were also more commonly associated with CIs of the side window frame or A pillar (72% CI vs. 25% no CI; p < 0.035); but as a whole in MVCs in which extrication was necessary, lower extremity injuries from instrument panel or toepan CIs appeared more frequent than those resulting from contacts only (p < 0.0001). In EXTRIC patients, 69% of those in shock had CI injuries, and 80% of the deaths in the EXTRIC group were associated with CI injury. These data suggest that measures designed to prevent CIs by strengthening car passenger compartment structures may reduce the incidence of severe brain and lower extremity injuries and may reduce the need for extrication after MVCs.

Accidents, Traffic↗
PubMed2005

Blunt cerebrovascular injury in patients with blunt multiple trauma: diagnostic accuracy of duplex Doppler US and early CT angiography.

PURPOSE: To retrospectively evaluate the frequency of blunt cerebrovascular injury (BCVI) in patients with multiple trauma and to retrospectively compare the diagnostic accuracy of duplex Doppler ultrasonography (US) and computed tomographic (CT) angiography by using clinical follow-up and subsequent imaging as reference standards. MATERIALS AND METHODS: The institutional review board approved this study; informed consent was not required. Charts and images of consecutive patients treated for multiple trauma (injury severity score, >16) between January 1998 and October 2003 were reread by an experienced radiologist. Until October 2002, subjects were screened for BCVI with US. Since November 2002, patients underwent CT angiography of the carotid and vertebral arteries. Sensitivity and specificity of US and CT angiography were calculated with 95% confidence intervals (CIs). RESULTS: The early cohort included 1471 patients (mean age, 35.8 years +/- 17.7 [standard deviation]), and the late cohort included 407 patients (mean age, 39.2 years +/- 18.8). US depicted five blunt vessel injuries but later missed another eight, which led to cerebral ischemia. With a BCVI frequency of 0.9%, sensitivity and specificity of US were 38.5% (95% CI: 13.9%, 68.4%) and 100% (lower 95% confidence limit, 99.7%), respectively. In the second cohort, the BCVI rate was 2.7%. CT angiography depicted BCVI in 11 patients, with a sensitivity of 100% (lower 95% confidence limit, 71.5%), but produced one false-positive result. CONCLUSION: Injuries to the cervical arteries among blunt trauma patients are more common than previously reported. Duplex Doppler US has inadequate sensitivity to help rule out this condition. The notable morbidity with missed dissections warrants routine contrast material-enhanced studies of the carotid and vertebral vessels if patients are scheduled for CT of the cervical spine.

Adult↗
PubMed1985

Epidemiology, mortality and morbidity in multiple trauma patients.

Three hundred, twenty-nine multiple trauma patients with skeletal injuries admitted to Hennepin County Medical Center, Minneapolis were analyzed for mortality and morbidity based on injury severity score (ISS) and timing of fracture stabilization. Fifty-three deaths (16%) occurred with 38% dying during the first six hours. Survival prospects with injury severity score over 40 were bleak. Age, sex, mechanism of injury, and time of occurrence of injury was also tabulated. Two hundred, twenty-nine patients with 474 long bone fractures were analyzed based on timing of fracture stabilization: immediate stabilization within 24 hours; delayed primary stabilization over 24 hours to one week; secondary osteosynthesis more than one week; non-operative treatment. Respiratory distress syndromes occurred in 6%, 2.4%, 9%, and 12%; mortality rate of 3%, 0%, 6.4%, and 26% for treatment groups A, B, C, and D respectively. However, it must be noted that treatment group B with lower ARDS and mortality rate had no type III open fractures and lower injury severity score.

Adolescent↗
PubMed1998

Outcome in severely head injured patients with and without multiple trauma.

BACKGROUND: This work attempts to analyse the potential role of multiple injury in the outcome of non-shock severely head injured patients with a Glasgow Coma Scale (GCS) of 8 or less. METHODS: 386 non-shock adult patients of < 65 years (mean age 33.74 +/- 14.7), treated with the same therapeutic protocol, were studied retrospectively. Multiple traumatised patients classified into Injury Severity Scale (ISS) of < or = 9 and > 9. The ISS classification was also tested in two subgroups of patients with GCS 3-5 and GCS 6-8. RESULTS: The overall mortality of the 386 patients was 22.79%. Those suffering from extracranial injuries (n = 146, 37.82%) and those without (n = 240), presented similar mortality (21.23% vs 23.75% respectively). The multiple traumatised victims presented mean ISS 9.3 +/- 8.17. Those with ISS > 9 had greater mortality than those with ISS < or = 9, but the difference was not statistically significant (p > 0.05). The influence of ISS was not also significant in the mortality, either patients were of GCS 3-5 or GCS 6-8. CONCLUSIONS: Multiple trauma in non-shock patients, as it is expressed by ISS does not have any influence on mortality. Mortality is depending on the severity of the intracranial pathology. Perhaps head injury and extracranial injuries have synergistic effect on morbidity.

Adolescent↗
PubMed1988

Assessing multiple trauma: is the cervical spine enough?

This retrospective study of multiple trauma patients sustaining spinal column fractures was done to assess whether evaluation of the cervical spine alone is adequate. Sixty-three such patients were identified and further descriptive analyses performed. The majority of spinal fractures occurred not in the cervical spine, but in the thoracic and lumbosacral spine areas. Since a number of these spinal fractures have associated neurologic complications, only by prompt evaluation of the entire spinal column can further injuries be prevented. Based on our data, we feel that patients with multiple injuries and an altered sensorium should have the entire spine protected and evaluated radiologically before being cleared.

Adolescent↗
PubMed1989

Plasma concentrations of granulocytic elastase-alpha 1-proteinase inhibitor complex in patients with severe head injury, multiple trauma or cerebral bleeding.

In patients with severe head injury or multiple trauma a multitude of inflammatory mediators are released. As in cerebral bleeding, elevations of body temperature can be observed even in the absence of bacterial infections. In order to evaluate the diagnostic significance of plasma elastase levels for the exclusion or early detection of infections in the course of the above diseases, quantitative estimations of granulocytic elastase in complex with alpha 1-proteinase inhibitor were carried out in 11 patients using an enzyme-linked immunoassay over a period from 3 to 47 days. Additionally, leukocyte counts were made and body temperatures measured. In all but two cases, elastase levels were elevated at the beginning of the disease and usually decreased over the period of study. In contrast to leukocyte counts and body temperature, the values correlated with the severity of the clinical symptoms. It is concluded that plasma elastase determinations are useful in the differential diagnosis of infection from other causes of elevated body temperatures.

Blood Cell Count↗
PubMed1997

[Acetabular and pelvic fractures in multiple trauma].

We see pelvic fractures in about 50% of all multiple trauma patients. In many cases, these pelvic fractures are complicated by complex pelvic traumata, i.e., a pelvic fracture with pelvic vessel damage, neurological, visceral or soft-tissue damage, and therefore have the character of life-threatening lesions. The incidence of complex pelvic trauma is extremely high in cases of vertical and rotation instability. Most problems come from massive bleeding as a result of presacral venous plexus laceration. This venous bleeding usually tampons its self after stabilization, e.g., with an external fixator. In about half of the cases an immediate laparotomy is performed because of remaining circulatory instability, lesions of the urinary tract, or open fractures. In these cases, stabilization of the pelvis is frequently achieved by ORIF, e.g., plating of the symphysis pubis or the SI joint. Internal stabilization of the pelvis facilitates the following treatment in the ICU, especially when prone-supine positioning is mandatory due to pulmonary indications. For this reason we avoid traction techniques in displaced acetabular fractures, and we achieve stability with a joint-bridging external fixator. Treatment of complex pelvic fracture must be integrated in the overall concept of treatment. Differentiated and situation-adapted action is necessary, depending on the particular situation, as well as the personnel and technical equipment.

Acetabulum↗
PubMedDate not supplied

Treatment of acute hypocalcemia in critically ill multiple-trauma patients.

BACKGROUND: Recent data indicate that critically ill, adult multiple trauma patients receiving specialized nutrition support commonly experience hypocalcemia (ionized serum calcium [iCa] < or =1.12 mmol/L). However, validated methods for the treatment of acute hypocalcemia are lacking. METHODS: The efficacy of a single dose of calcium gluconate using an empiric IV calcium gluconate graduated dosing regimen was evaluated in 37 patients. Patients with an iCa of 1-1.12 mmol/L (mild hypocalcemia) were provided 1-2 g of IV calcium gluconate. Patients with an iCa of <1 mmol/L (moderate to severe hypocalcemia) were given 2-4 g. The calcium gluconate was infused at a rate of 1 g/h in a small-volume admixture. Serum iCa determination was repeated on the following day. RESULTS: One to 2 g of IV calcium gluconate was effective in normalizing iCa for 23 out of 29 patients (79%) with mild hypocalcemia and 2-4 g was effective for 3 of 8 patients (38%) with moderate to severe hypocalcemia. The individual response to calcium therapy (g/d) or when normalized to body weight (mg/kg/d) was highly variable. CONCLUSIONS: One to 2 g of IV calcium gluconate were effective for most patients with mild hypocalcemia; however, treatment of moderate to severe hypocalcemia with 2-4 g of IV calcium gluconate was often unsuccessful. Further study with frequent serial ionized serum calcium and phosphorus determinations and electrocardiographic monitoring appears to be indicated for patients with moderate to severe hypocalcemia.

Acute Disease↗