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At least 145 records · Page 8Linked to original sources
PubMed1986

Vertical flux of hexachlorobenzene in coastal waters of the north-west Mediterranean Sea.

In a study on the biogeochemistry of chlorinated hydrocarbons in the Mediterranean Sea, hexachlorobenzene (HCB) has been analysed in particulate matter collected in sediment traps moored 2 km off the coast of Monaco. HCB concentrations in this material, which was composed largely of biogenic debris, ranged from non-detectable to 7.3 ng/g dry weight. Time-series measurements (n = 18) made between March-September 1981 demonstrated that the vertical flux of HCB through 100 m averaged 59 (range, non-detectable to 153) pg/cm2 per year. There was no clear relationship between the HCB flux and the time of year. Nor were there any correlations between either HCB concentrations in fast-settling particles or the HCB flux and that of organic carbon. The similarity in concentration of HCB in sediment-trap particulates and freshly excreted zooplankton faecal pellets suggests that faecal pellet deposition acts to remove this contaminant from surface waters. Comparison of the observed average HCB flux through 100 m with estimates of the flux to sediments at 250 m depth (7.3 pg/cm2 per year, based on HCB concentrations in surface sediments and independently derived average sediment-deposition rates) indicates that as much as 87% of the particulate-associated HCB is dissolved or degraded before burial into sediments. These results demonstrate that HCB is removed from the euphotic zone by sedimentation processes less rapidly than polychlorinated biphenyls but on the same time-scale as the pesticide lindane. An upper limit on the residence time in surface waters was calculated to be 135 years.(ABSTRACT TRUNCATED AT 250 WORDS)

Chlorobenzenes↗
PubMed1975

Radiocopper in L-tryptophan 2,3-dioxygenase isolated from Pseudomonas acidovorans grown in the presence of 64Cu (II).

L-Tryptophan 2,3-dioxygenase (EC 1.13.11.11), isolated from L-tryptophan-induced Pseudomonas acidovorans, ATCC 11299b, which has been grown in a medium containing 64Cu(NO3)2, has been shown to contain radiocopper. At several stages of purification of the enzyme samples were taken, and these were subjected to disc acrylamide gel electrophoresis in the presence of 10 mM L-tryptophan. After electrophoresis the position of the yellow heme band, corresponding to tryptophan oxygenase, was visually located, and the gels were sliced and counted. A large peak of radioactivity was seen to occur at the location on the gel of tryptophan oxygenase no matter what the stage of purification. Treatment of each sample before electrophoresis for 30 min at 37 degrees with gamma-globulins prepared from rabbits sensitized to homogeneous pseudomonad tryptophan oxygenase greatly reduced this peak of radioactivity, whereas treatment of each sample with rabbit preimmune gamma-globulin did not. This direct demonstration of the presence of coper in pseudomonad tryptophan oxygenase, using 64-Cu, avoided the problems and artifacts inherent in the usual techniques of copper analysis and unequivocally refutes the recent contention of Ishimura and Hayaishi ((1973) J. Biol.Chem. 248, 8610-8612) "that copper is not an essential component of L-tryptophan 2,3-dioxygenase of Pseudomonas." The presence of copper in pseudomonad and rat liver tryptophan oxygenases, previously reported by us (Brady, F. O., Monaco, M. E., Forman, H. J., Schutz, G., and Feigelson, P. (P. (1972) J. Biol. Chem. 247, 7915-7922), is reaffirmed by the experiments reported herein.

Animals↗
PubMed1995

Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients.

A 37-kDa protein was immunopurified from human erythrocytes as a complex with a monoclonal antibody directed against the Kell blood group protein of 93 kDa. A rabbit antibody raised against the purified complex reacted on a Western blot with the 93-kDa and 37-kDa proteins and was able to immunoprecipitate the 37-kDa component from K0 erythrocytes which express large amount of the Kx antigen, but not from erythrocytes of patients suffering from McLeod syndrome, a X-linked disorder in which the Kx antigen is lacking. Additional studies have shown that the 37-kDa protein is not glycosylated, and permitted the sequence of the 22 first N-terminal amino acids to be established. This sequence was identical to the predicted protein product of the XK gene cloned recently, which is deleted or mutated in McLeod patients [Ho, M., Chelly, J., Carter, N., Danek, A., Crocker, P. & Monaco, A. P. (1994) Cell 77, 869-880]. Our findings provide strong evidence that the 37-kDa red cell membrane protein is identical to the Kx protein produced by the XK structural gene and demonstrate that Kx and Kell proteins are two subunits expressed as a complex hold by disulfide bond(s) at the red cell surface.

Amino Acid Sequence↗
PubMed1997

Surgical management of left ventricular aneurysms: a clarification of the similarities and differences between the Jatene and Dor techniques.

In the mid 1980s, two highly innovative and entirely new approaches to the surgical treatment of left ventricular aneurysms were introduced almost simultaneously and completely independently by Dr Adib Jatene in Sao Paulo, Brazil and Dr Vincent Dor, then at the University of Nice, France and now at the Centre Cardio-Thoracique de Monaco. The similarities between these two approaches to the repair of left ventricular aneurysms and their close temporal evolution have caused confusion regarding their differences and the precise surgical technique of each approach. It is the purpose of this article to clarify the similarities and differences between these two techniques.

Heart Aneurysm↗
PubMed1997

[Comparative study of the acceptability of a new estradiol Tx 11323 (A) gel and a transdermal matrix system].

OBJECTIVE: to compare the acceptability of a new estradiol gel TX 11323 (A) and a transdermal matrix system. METHOD: this randomised open crossed study was conducted on 80 healthy menopausal female volunteers treated successively with 1.5 mg of estradiol per day in gel form (Estreva Gel, Theramex, Monaco) and by a transdermal matrix twice-weekly system delivering 50 micrograms/24 h of estradiol (Oesclim 50, Fournier, Dijon-France). The treatment was applied for 25 days with an interval of 6 days between the 2 administration cycles. Acceptability was evaluated and compared by a self-questionnaire given on D1 and D25 of each therapeutic cycle. RESULTS: the 2 treatments, after 25 days of use, were judged convenient, easy and fast to use by more than 90% of subjects. There was, nevertheless, a significant difference in favour of the gel in respect of the estimation of the "visual aspect" of the treatment, reported skin problems, problems with application technique, as well as discomfort during intimacy found in 11% of cases using the transdermal system. It is noted that 80% of the women consider the gel treatment more feminine (p < 0.001) and that 61.3% prefer this treatment compared to 32.5% preferring the transdermal system studied (p = 0.005). CONCLUSION: this study shows a better acceptability of the estradiol gel TX 11323 (A) compared to that of the transdermal matrix system studied.

Administration, Cutaneous↗
PubMed2002

Femur bone mineral density, age and fracture type in 300 hip-fractured women.

BACKGROUND AND AIMS: Several studies showed that cervical and trochanteric hip fractures were associated with different levels of bone mineral density (BMD). Our aim was to investigate the association between femur BMD and hip fracture type at different ages. METHODS: We studied 300 postmenopausal women affected by their first hip fracture. 17 women could not undergo BMD measurement and were excluded. The fractures of the remaining 283 women were classified as either cervical (N=129) or trochanteric (N=154). The BMD of the unfractured femur was assessed by DXA. RESULTS: The women with trochanteric fracture had significantly lower BMD than those with cervical fracture at four sites: total proximal femur (p<0.001), trochanter (p<0.001), intertrochanteric area (p<0.01), and Ward's triangle (p<0.05). Logistic multiple regression showed that the association between hip fracture type and BMD was independent of age, weight, height, time between fracture occurrence and DXA assessment, number of concomitant diseases and number of drugs administered when BMD was evaluated at total proximal femur (p<0.001), trochanter (p<0.001), and intertrochanteric area (p<0.01). Age stratification showed that BMD was actually lower in the group with trochanteric fracture in the women aged 69 years and younger, and in those aged 80 years and older, but not in the intermediate age group (70-79 years). CONCLUSIONS: Data confirm previous reports showing that the two types of hip fractures are associated with different levels of BMD. Moreover, we show that the role played by BMD as a determinant of the hip fracture type varies with age.

Age Factors↗
PubMed2006

Body mass index and functional recovery after hip fracture: a survey study of 510 women.

BACKGROUND AND AIMS: Low body mass index (BMI) is associated with high risk of osteoporosis and fractures, but its impact on functional recovery after fractures is unknown. Our aim was to investigate the association between BMI and both functional recovery and period of rehabilitation in hip-fractured women. METHODS: 510 out of 580 Caucasian women with hip fracture, admitted consecutively to a rehabilitation hospital, were investigated in this retrospective study. Functional recovery was assessed using the Barthel index score. RESULTS: In the 510 women, BMI was 22.8 +/- 4.1 kg/m2 (mean +/- SD). After adjustment for age, femur bone mineral density, and the Barthel index assessed on admission to rehabilitation, a significant negative association was found between BMI and both the Barthel index score after rehabilitation and changes in it resulting from rehabilitation (p < 0.001). After adjustment for age and the Barthel index assessed on admission to rehabilitation, a significant positive association was found between BMI and period of rehabilitation (p < 0.001). The results were similar when BMI was evaluated either as individual values or after categorization according to World Health Organization criteria. CONCLUSIONS: In a sample of hip-fractured women, BMI was negatively associated with Barthel index scores and positively associated with period of rehabilitation. BMI may affect function after hip fracture, apart from hip fracture risk: subjects with higher BMI and low hip fracture risk may have poorer functional recovery in case of hip fracture, despite prolonged rehabilitation. Conversely, subjects with lower BMI and high hip fracture risk may have better functional recovery in case of hip fracture.

Aged↗
PubMed2003

Fat body mass, leptin and femur bone mineral density in hip-fractured women.

Fat body mass (FBM) is a strong predictor of both bone mineral density (BMD) and risk of hip fracture, but the mechanisms responsible are not completely understood. We addressed whether leptin is the link between FBM and BMD in hip-fractured women. Sixty-two of 74 women with hip fractures were evaluated. Serum leptin was measured by radioimmunoassay, 23.4+/-9.1 days (mean+/-SD) after fracture occurrence. BMD and body composition were assessed by dual-energy X-ray absorptiometry (DXA). As expected, a positive linear correlation was found between FBM and both leptin (r=0.782; p<0.001) and femur BMD measured at five sites (r value ranging from 0.293 to 0.498 depending on the site of the femur BMD assessment, p<0.05). A positive correlation between leptin and BMD measured at the intertrochanteric area (r=0.259; p<0.05) but not at the other four sites was shown. At linear multiple regression [dependent variable = femur BMD; independent variables = age, weight, height, body mass index, fracture type, term fracture-DXA, Barthel index score, FBM, lean body mass, serum PTH, serum 25(OH)vitamin D and leptin], FBM was positively associated with BMD measured at all the five sites. The association between leptin and BMD was inverse and it was significant at four of the five sites of the BMD assessment. In conclusion, in a sample of hip-fractured women, the positive association between FBM and femur BMD was not explained by serum leptin. On the contrary, after adjustment for FBM and other confounding variables, an inverse association between leptin and BMD was found.

Aged↗
PubMed2004

Total lymphocyte count and femoral bone mineral density in postmenopausal women.

In vitro studies showed that several cytokines produced by the immune system can play a relevant role in modulating bone turnover, thus affecting the health of bone tissue. Our aim was to evaluate the association between total lymphocyte count (TLC) and femoral bone mineral density (BMD) in a sample of postmenopausal women. We studied 114 out of 124 consecutive, caucasian, home-dwelling, apparently healthy postmenopausal women referred for osteodensitometry by general practitioners. Femoral BMD was measured by dual-energy X-ray absorptiometry at five sites. A significant positive correlation (p < 0.001) was observed between TLC and BMD (T score) measured the five sites: total proximal femur ( r = 0.45), trochanter (r = 0.43), intertrochanteric region (r = 0.38), femoral neck (r = 0.49), and Ward's triangle (r = 0.42). With a linear multiple regression model, TLC adjusted for age, weight, height, body mass index, and erythrocyte sedimentation rate showed a significant association with femoral BMD assessed at each of the five sites. The R(2) values ranged from 0.33 with BMD measured at Ward's triangle to 0.51 with BMD measured at the trochanter. The significance of the association between TLC and BMD ranged from P < 0.001 with BMD measured at the femoral neck to P < 0.05 with BMD measured at the intertrochanteric area. The results were similar when BMD was expressed as either a Z score (in the 110 of the 114 women aged 84 years or younger) or as absolute values. Our data show a positive association between TLC and femoral BMD in a sample of apparently healthy, postmenopausal women, supporting the view of a close connection between the immune system and bone tissue.

Absorptiometry, Photon↗
PubMed2004

Primary hyperparathyroidism in elderly patients with hip fracture.

Primary hyperparathyroidism (PHPT) is associated with low bone mineral density (BMD), but its association with fractures is controversial. Our aim was to evaluate the prevalence of PHPT in hip fracture patients. We studied 444 of 450 consecutive elderly patients (404 women and 40 men) admitted to a rehabilitation hospital after hip fracture. All the fractures were either spontaneous or sustained as a result of minimal trauma. The diagnosis of PHPT was established when both serum calcium adjusted for serum albumin exceeded the normal range and PTH was either elevated or high normal. Also, 444 sex-matched subjects, aged 65 years and older, who were referred for their first osteodensitometry, were studied as controls. Among the hip fracture patients, 21/444 (i.e., 4.7%) fulfilled the diagnostic criteria of PHPT. Logistic multiple regression showed no meaningful associations between PHPT and sex, age, weight, height, fracture type (cervical or trochanteric), and femoral BMD in the hip fracture patients. Among the 444 controls, 5 patients (i.e., 1.13%) fulfilled the diagnostic criteria of PHPT. When evaluated by Pearson's chi-square, the difference in PHPT prevalence between the hip fracture patients and the controls was significant ( P < 0.01). Data show that the prevalence of PHPT in a sample of elderly patients after hip fracture was increased when compared to that found in a sample of control subjects, suggesting that PHPT enhances hip fracture risk.

Aged↗
PubMed2006

25-hydroxyvitamin D, parathyroid hormone, and functional recovery after hip fracture in elderly patients.

There is increasing interest in the effects of vitamin D and parathyroid hormone (PTH) on extraskeletal tissues, including the muscle. These effects may explain impairment in functional ability found in vitamin D-deficient subjects. Our aim was to investigate the roles of vitamin D and PTH in affecting the ability to perform activities of daily living after hip fracture. We studied 456 of 521 hip-fracture patients admitted consecutively to a rehabilitation hospital. Functional outcome was assessed after acute inpatient rehabilitation by using the Barthel index score. The functional scores were significantly correlated with serum levels of 25-hydroxyvitamin D (rho = 0.190; P < 0.001) and PTH (rho = -0.164; P < 0.001) and the 25-hydroxyvitamin D/PTH ratio (rho = 0.261; P < 0.001). At multiple regression, 25-hydroxyvitamin D and PTH levels were independently associated with Barthel index scores. The correlation between the 25-hydroxyvitamin D/PTH ratio and Barthel index scores was significantly stronger than the one between 25-hydroxyvitamin D and Barthel index scores (difference between the two correlation coefficients = 0.071; 95% CI = 0.009-0.133; P = 0.011). The significant association between the 25-hydroxyvitamin D/PTH ratio and the Barthel index scores persisted after adjustment for 12 prognostic factors (P = 0.012). On the whole, the panel of prognostic factors we studied predicted 50.1% of the variance of the functional score. Data shows that PTH and 25-hydroxyvitamin D were significantly associated with the ability to function after hip fracture and suggest that the two hormones act through independent mechanisms. The 25-hydroxyvitamin D/PTH ratio significantly contributed to a predictive model of functional outcome.

Activities of Daily Living↗
PubMed2003

Body composition and hip fracture type in elderly women.

Many observations support the view that there are significant differences between patients sustaining trochanteric fractures and those sustaining cervical fractures of the hip. Our aim was to evaluate the association between soft tissue composition (fat and lean compartments) and the type of hip fracture sustained. Of 120 consecutive women affected by their first hip fracture admitted to our rehabilitation hospital 102 were included in this cross-sectional study. Body composition was assessed by DXA. Body fat mass was lower in the women with trochanteric fracture than in those with cervical fracture (difference between groups: 2.86 kg; 95% CI 0.10-5.61 kg; p=0.042). The percentage of fat was 30.75+/-8.77 (mean+/-SD) versus 34.75+/-7.29 (difference between groups: 4.00; 95% CI 0.84-7.16; p=0.014). In contrast, no meaningful differences in body lean mass were shown between the two groups. Logistic multiple regression showed that fat mass was associated with the type of fracture independently of age, height, weight, time between fracture occurrence and DEXA assessment, comorbidity, number of drugs in use, lean mass and bone mineral content. The logistic regression results were similar when fat percentage was substituted for fat mass. The data show that fat but not lean body mass is associated with the type of hip fracture, contributing to the definition of the differences between patients sustaining cervical or trochanteric fractures. We stress the importance of distinguishing the two types of fracture when clinical or epidemiological studies related to body composition, including those regarding nutrition or physical exercise, are performed.

Absorptiometry, Photon↗
PubMed2000

Handgrip strength is an independent predictor of distal radius bone mineral density in postmenopausal women.

Several cross-sectional studies have reported a positive correlation between muscle strength and local bone mineral density. However, very few studies have evaluated the possible role of confounding variables, which may be substantial as both bone mineral density and muscle strength are multifactorial variables. We studied 140 postmenopausal women who underwent their first osteodensitometry in our hospital. Of these, 102 women affected neither by bone diseases apart from primary osteoporosis nor treated with drugs affecting bone mass were selected. Distal radius bone mineral density of the non-dominant arm was assessed by dual photon absorptiometry. Handgrip strength was measured by a handheld dynamometer. The following factors influencing bone mass were also considered: age, years since menopause, years of cyclic ovarian activity, body weight, body height, body mass index, and both calcium and alcohol dietary intake. Statistical evaluation was performed by stepwise multiple regression analysis. This showed that only two variables were independently related to bone mineral density: handgrip strength (which was the best bone density predictor among the studied independent variables) and years since menopause. R2 value was 0.43 (F=38.04, p < 0.001). All the other variables studied were not significantly related to bone density when the effects of both strength and years since menopause were considered. In conclusion, the data showed that handgrip strength was a strong independent predictor of distal radius bone mineral density in postmenopausal women. Clinical assessment of osteoporosis risk factors, including muscle strength, is recommended: although it is not an adequate substitute for bone densitometry, it can help clinicians to identify the risk groups at which to direct bone density measurement.

Adult↗
PubMed2005

Serum levels of 25-hydroxyvitamin D and functional recovery after hip fracture.

OBJECTIVE: To evaluate the association between serum levels of 25-hydroxyvitamin D (25[OH]D(3)) and functional recovery after hip fracture. DESIGN: Cross-sectional study. SETTING: Rehabilitation hospital in Italy. PARTICIPANTS: A total of 350 white hip-fracture patients consecutively admitted to a rehabilitation hospital. Thirty-five patients were excluded because their hip fracture was caused by major trauma or cancer affecting the bone or they could not complete rehabilitation. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Patients underwent 25(OH)D(3) assessment at a mean +/- standard deviation of 21.3+/-8.1 days after the hip fracture. Functional recovery was evaluated by using Barthel Index scores. RESULTS: Low levels of 25(OH)D(3) were found (median, 6.9 ng/mL). By using the Spearman rank correlation test, a significant positive correlation was observed between serum 25(OH)D(3) and Barthel Index score assessed on admission (rho=.218, P <.001) and discharge (rho=.198, P <.001), but not with the change in Barthel Index score attributable to rehabilitation. Linear multiple regression showed that the association between 25(OH)D(3) and Barthel Index score was independent of 11 confounding variables: age, sex, hip-fracture type, pressure ulcers, cognitive impairment, neurologic impairment, infections, time between fracture occurrence and 25(OH)D(3) evaluation, comorbidity, surgical procedure type, and previous hip fractures. CONCLUSIONS: In the study population, serum 25(OH)D(3) was an independent predictor of functional recovery assessed by Barthel Index score after hip fracture but not of the change in the functional score resulting from rehabilitation.

Aged↗
PubMed2006

Bone mineral density in hip-fracture patients with Parkinson's disease: a case-control study.

OBJECTIVE: To investigate bone mineral density (BMD) levels in patients with Parkinson's disease (PD) who sustained a hip fracture. DESIGN: Case-control study. SETTING: Rehabilitation hospital in Italy. PARTICIPANTS: We investigated 831 out of 887 white patients consecutively admitted to a rehabilitation hospital because of an original hip fracture resulting from a fall. Twenty-eight (3.37%) of the 831 patients were affected by PD. Twenty-eight controls matched for sex, age, and hip-fracture type (cervical or trochanteric) were found among the 803 non-PD patients. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: BMD was assessed by dual-energy x-ray absorptiometry (DXA) at the unfractured femur. Five sites were investigated in each subject: total proximal femur, femoral neck, trochanter, intertrochanteric area, and Ward's triangle. DXA scan was performed a mean +/- standard deviation of 22.2 +/- 7.8 days after fracture occurrence in the 28 patients and 22.0 +/- 5.3 days after fracture occurrence in the 28 controls. RESULTS: BMD expressed as a T score did not differ significantly between the 28 PD patients and the 28 controls, whereas z score in the PD patients was significantly lower than 0 +/- 1 in the age- and sex-matched general population at 4 of the 5 sites of BMD assessment. CONCLUSIONS: A sample of PD fallers who sustained a hip fracture had femoral BMD levels similar to those found in matched hip-fracture fallers who did not suffer from PD and significantly lower than those found in the matched reference population.

Aged↗
PubMed2006

Fat mass and skeletal muscle mass in hip-fracture women: a cross-sectional study.

OBJECTIVES: To investigate the association between appendicular lean mass (aLM) and age, fat mass (FM), serum levels of Vitamin D, parathyroid hormone, three parameters of the protein nutritional status (total lymphocyte count, serum albumin, and insulin-like growth factor I), levels of independence in activities of daily living (assessed by using Barthel index scores), type both of hip fracture and surgical operation, number of medications in use, and number of concomitant diseases in hip-fracture women. METHODS: We investigated 299 of 327 hip-fracture women admitted consecutively to a rehabilitation hospital. Soft tissue body composition was assessed by dual-energy X-ray absorptiometry, 22.1+/-7.5 (mean+/-S.D.) days after fracture occurrence. Appendicular LM was calculated as the sum of LM in arms and legs. Because metal implants (prostheses and nails) affect the regional assessment of body composition, aLM was corrected by substituting LM in unfractured leg for LM in fractured leg: corrected aLM=(LM in unfractured leg x 2)+LM in arms. We divided corrected aLM by height squared (aLM/ht(2)), to adjust it for body size. RESULTS: Four variables were significantly correlated with corrected aLM: age, height, FM, and Barthel index score. FM was the only variable significantly correlated with aLM/ht(2) (r=0.492; p<0.001). This significant correlation was not affected after adjustment for age and Barthel index score. CONCLUSIONS: FM measured after hip fracture was significantly associated with aLM/ht(2) in women.

Absorptiometry, Photon↗
PubMed2001

[Stomach surgery--are the requirements for specialist in general surgery still realistic?].

This paper discusses the possibility for a surgical trainee to acquire the necessary experience in gastric operations for his fellowship in general surgery. All operations of the stomach performed at the surgical unit of Lucerne Hospital between January 1994 and September 1997 were analysed retrospectively. Of 184 operations performed only nine were done by a trainee, four of which were gastrostomies and five operations of a perforated ulcer. These results prove the difficulties for a trainee to achieve the required number of operations. Possible solutions would be the acknowledgement of assisted operations for the fellowship in general surgery and/or the limitation of gastric operations performed by the trainee himself to the curriculum for the fellowship in visceral surgery.

Clinical Competence↗
PubMed1998

Risk factors of stroke after percutaneous transluminal coronary angioplasty.

Objective: to determine possible risk factors of a stroke after percutaneous transluminal coronary angioplasty (PTCA). Design: this is a retrospective evaluation of a consecutive group of 4088 patients undergoing PTCA between 1988 and 1995. We have studied the incidence, clinical characteristics, risk factors, and outcome. Results: seven patients, six males and one female (0.17%) developed a stroke after this procedure. In comparison with the control group, the stroke group did not differ regarding age or gender. The existence of a stroke (six located in the brain, and one in the spinal cord), represented 1.24% of all complications (P < 0.001), and 5% of all deaths (P < 0.01) of PTCA. Three patients developed TIA, two patients developed hemorrhagic strokes (in which they received previous thrombolytic therapy), and the other two patients suffered from an ischemic stroke. The statistically significant risk factors of a stroke after PTCA included: intracoronary thrombolytic therapy (P < 0.01), hypercholesterolemia (P < 0.001) and a prior PTCA (P < 0.05). Conclusions: although these procedural complications are infrequent, they are usually serious and important risk factors which could be identified prior to the procedure. These risk factors would allow identification of patients who are prone to a stroke after PTCA. Intracranial hemorrhage occurred only after thrombolytic therapy, and the factors related to hemorrhagic strokes were probably different from those predisposed to ischemic strokes and TIA. Copyright 1998 Lippincott Williams & Wilkins

Journal Article↗