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PubMed2000

The taste of ethanol in a primate model. II. Glossopharyngeal nerve response in Macaca mulatta.

The glossopharyngeal nerve (NG) mediates taste from the posterior part of the tongue. Here, we studied the effects of ethanol on the tongue in recordings from both the whole NG and individual taste fibers of the rhesus monkey, Macaca mulatta. The results show that the nerve activity increased at 0.7 M ethanol, reaching half maximum at around 4 M alcohol. Previously, we identified three types of taste fibers in the rhesus monkey NG: S fibers predominantly responding to sweeteners, Q fibers responding to bitter, such as quinine hydrochloride (QHCl), and M fibers responding best to monosodium glutamate, NaCl and acids [Hellekant, G., Danilova, V., & Ninomiya, Y. (1997). Primate sense of taste: behavioral and single chorda tympani and glossopharyngeal nerve fiber recordings in the rhesus monkey, Macaca mulatta. J Neurophysiol 77, 978-993]. Here, this fiber classification was used to elucidate the oral effects of ethanol and ethanol mixtures with NaCl, sucrose, citric acid and QHCl. One and three molar concentrations of ethanol stimulated all fiber types. Mixtures of ethanol with QHCl elicited a smaller response in Q fibers than did QHCl alone. In S fibers, mixtures of ethanol with sucrose gave a larger response than did sucrose alone. The variability of M fibers was too large to allow a conclusion about the effect of ethanol. These results suggest that ethanol suppresses the taste of QHCl. Similarly, the taste of sucrose might be enhanced by adding ethanol to sucrose. These effects and conclusions corroborate an earlier ethanol study of the chorda tympani (CT) nerve [Hellekant, G., Danilova, V., Roberts, T., & Ninomiya, Y. (1997). The taste of ethanol in a primate model: I. Chorda tympani nerve response in Macaca mulatta. Alcohol 14, 473-484].

Analgesics, Non-Narcotic↗

PubMed2005

Phylogeography of Barbary macaques (Macaca sylvanus) and the origin of the Gibraltar colony.

The Barbary macaque (Macaca sylvanus) is the earliest offshoot of the genus Macaca and the only extant African representative, all other species being Asiatic. Once distributed throughout North Africa, M. sylvanus is now restricted to isolated forest fragments in Algeria and Morocco. The species is threatened; the maximum total wild population size is estimated at 10,000 individuals. Relationships among surviving wild subpopulations in Algeria (96 samples) and Morocco (116 samples) were examined by using 468-bp sequences from hypervariable region I of the mitochondrial DNA control region. Twenty-four different haplotypes were identified, differing by 1-26 mutational steps (0.2-5.6%) and 1 insertion. With one exception (attributable to secondary introduction in coastal Morocco), Algerian and Moroccan haplotypes are clearly distinct. However, whereas Moroccan subpopulations show little divergence in hypervariable region I sequences and little correspondence with geographical distribution, there is a deep division between two main subpopulations in Algeria and one marked secondary division, with haplotypes generally matching geographical distribution. Accepting an origin of the genus Macaca of 5.5 million years ago, the Moroccan population and the two main Algerian subpopulations diverged approximately 1.6 million years ago. Distinction between Moroccan and Algerian haplotypes permitted analysis of the origin of the Gibraltar colony of Barbary macaques (68 samples; 30% of the population). It is generally held that the present Gibraltar population descended from a dozen individuals imported during World War II. However, the Gibraltar sample was found to include Algerian and Moroccan haplotypes separated by at least 16 mutational steps, revealing a dual origin of the founding females.

Algeria↗

PubMed1997

Hand preference in infant rhesus macaques (Macaca mulatta).

In this research we examined hand preference in infant rhesus macaques (Macaca mulatta). The subjects were 20 Macaca mulatta, each aged between 4 and 11 months. We assessed hand preference using both a unimanual reaching task and a bimanual coordination task. In the unimanual reaching task, we presented subjects with raisins and noted which hand the animals used to retrieve the food. In the bimanual coordination task, we presented the same subjects with plastic tubes filled with raisin paste and noted which hand the animals used to hold the tubes and which hand the animals used to remove the food. We noted a population-level bias toward use of the left hand for both tasks. These results suggest early right hemisphere advantage for reaching and bimanual coordination in Macaca mulatta, although we acknowledge that this issue needs to be examined more directly through neuroimaging procedures such as Positron Emission Tomography (PET) or functional Magnetic Resonance Imaging (fMRI). We speculate that early right hemisphere advantage contributes to differential patterns of hand preference development for unimanual and bimanual action, and that the development of hand preference for bimanual coordination is related to the emergence of hemispheric specialization for processing species-specific vocalizations.

Animals↗

PubMedDate not supplied

A longitudinal study of the growth pattern of the maxillary sinus in the pig-tailed macaque (Macaca nemestrina).

The ontogeny of sexual dimorphism in maxillary sinus size in a nonhuman primate was studied longitudinally for a period of 8 years in 25 female and 25 male Macaca nemestrina via lateral cephalograms. The maxillary sinus was traced and its area digitized. The growth of female maxillary sinuses was described with a Gompertz model; the best fit to the male data was obtained by the logistic model. Growth curves and confidence intervals revealed that the sinuses grew in a similar fashion for 3-4 years in both sexes. After this, female sinuses achieved a plateau in their development while male sinuses continued to grow. Confidence intervals suggested that size dimorphism appeared at the age of 6.3 years. Lowess regression indicated growth spurts in both sexes. Females experienced an earlier and smaller spurt than males. Sexual dimorphism in maxillary sinus size seems to represent a combination of differences in velocity and length of growth. This study indicates that growth of the maxillary sinus follows closely the growth in body size. Nevertheless, due to the variation in sinus size in Macaca, it is questionable if body size is the main determinant of maxillary sinus size. It is suggested that Macaca, with its wide geographic range and different environments, is an especially appropriate genus to use to test hypotheses about the evolution of skull pneumatization in primates.

Animals↗

PubMed1996

Comparison of locomotor patterns and the cerebellar complex in Ateles and Macaca.

Kinetics and kinematics of the quadrupedal walking of Ateles and Macaca were studied, and the results were compared with those of vertical climbing. Macaca seems to use similar strategies for locomotion in climbing and walking horizontally, whereas Ateles apparently changes strategies. Next, volumetric comparisons of three cerebellar nuclei (M, I, L), the ventral pons (VP), the inferior olivary principal (Pr) and accessory (Ac) nuclei, and the vestibular nuclear complex (VES) were made by using size indices of each nucleus. Higher values are recognized clearly in the medial zone group (M, Ac, VES) of Macaca, whereas almost similar values are shown to exist in the lateral zone group (L, Pr, VP) of both species. Relationships between the kinesiological results and the development of the cerebellar system are discussed.

Animals↗

PubMed1998

Long-term toxicity of modified recombinant human tumor necrosis factor in Macaca mulatta.

AIM: To study the long-term toxicity of modified recombinant human tumor necrosis factor (rhTNF-NC) in Macaca mulatta compared with recombinant human tumor necrosis factor (rhTNF). METHODS: rhTNF-NC 93, 9.3 GU/m2, and rhTNF 62 GU/m2 were injected i.v. daily to 16 Macaca mulatta for 1 month and 10 d, respectively. Hematologic, chemical, urinalysis values, ECG, specific antibody, bone marrow, and pathologic profile of organs were measured. RESULTS: No more adverse effects of rhTNF-NC were found in spite of anorexia in 4 monkeys and palpebral edema in 2 monkeys of 93 GU/m2 group. Besides, in rhTNF group, the injury of liver and kidneys, the decrease of erythron, the phlebitis, and thrombosis at injection site occurred. Both drugs caused the production of specific antibody. CONCLUSION: No serious adverse effects of rhTNF-NC were found in Macaca mulatta. The toxicity of rhTNF-NC was much lower than that of rhTNF.

Animals↗

PubMed2003

[Serial pathologic changes in livers of Tree shrews and Macaca assamensises infected with human Hepatitis B virus].

BACKGROUND: To serially observe the pathologic changes in livers of tree shrews and macaca assamensises infected with HHBV. METHODS: 10 adult tree shrews and 28 macaca assamensises were inoculated with HBV rich human sera. The liver of the animals were regularly biopsied. The liver samples were examined histopathologically by HE staining. Some samples were stained for HBsAg by immunohistochemistry (IH), and HBV DNA by in situ hybridization (ISH). RESULTS: HBsAg in 80% of tree shrews infected with HHBV can be detected by IH, HBV DNA in 50% of those can be found by ISH.The positive rates of HBsAg in macaca assamensises' livers were 25% by IH, none HBV DNA was detected. CONCLUSION: The tree shrew model seems to be applicable for the research of human hepatitis B.

Animals↗

PubMed2006

[Expression and role of nitric oxide synthase in the testis and epididymis of Macaca fascicularis].

OBJECTIVE: To investigate the expression and the role of nitric oxide synthase (NOS) in the testis and epididymis of macaca fascicularis. METHODS: The immunohistochemical ABC method was used to observe the localization of nitric oxide synthase in the testis and epididymis of the macaca fascicularis. RESULTS: (1) nNOS immunoreactivity was found in the spermatogenic cells of seminiferous tubules, the epithelia of epididymal efferent ducts, sperm and the endothelia of blood vessels; (2) iNOS was expressed in the epididymal efferent duct, the sperm inside the duct, and the myoid cells and endothelia of blood vessels; (3) eNOS immunoreactivity was detected in the interstitial cells of the testis, the epididymal efferent duct, the sperm inside the duct, and the myoid cells and endothelia of blood vessels. CONCLUSION: NOS is extensively expressed in the testis and epididymis of the macaca fascicularis and it may play an important role in such processes as spermatogenesis, sperm maturation and testosterone secretion.

Animals↗

PubMed1991

Some monoclonal anti-human lymphocyte and class II MHC antigen antibodies do not stain snap frozen Macaca fascicularis lymphocytes or tissue sections.

Experiments were designed to stain snap frozen and fixed Macaca fascicularis peripheral blood mononuclear cell (PBMC) preparations and colon sections assuming that monoclonal mouse anti-human lymphocyte and class II major histocompatibility complex antigen antibodies would cross-react with the monkey counterparts to the human antigens. Most of the monoclonals used in this study did not stain the monkey frozen and fixed tissues in immunoenzymatic protocols despite adequate staining of control human tissues. The fact that snap frozen Macaca fascicularis PBMCs and tissue sections were not always stained is of practical importance for experimental design in Macaca fascicularis using anti-human reagents.

Animals↗

PubMed1975

[Chromosome identification in Macaca arctoides based on study of the differential staining pattern (G-discs). Comparison with Papio hamadryas G-discs].

Linear chromosome differentiation pattern of Macaca arctoides was studied using the Romanovsky-Gimsa stain (G-banding). The possibility of the identification of all chromosome pairs according to these data is demonstrated. The phenomenon of the irregular intercellular and chromosome differentiation is found out and a suggestion is made about its relation to a real mosaic functional activity of cell genomes. A great similarity in linear chromosome differentiation for 2 from 42 studied chromosome types of Macaca arctoides (genus Macaca) and Papio hamadryas (genus Papio) is shown. On the basis of these data it is supposed that in the divergency process of these species the chromosome microaberrations and molecular mutations played an important role, while large chromosome reconstructions were of no importance. The similar G-banding pattern of both metacentric chromosome arms in two species is found and this suggests an isochromosome mechanism of their occurance.

Animals↗

PubMedDate not supplied

[Coronary arteries in the Macaca fascicularis monkey].

The coronary arterial epicardial network in the monkey Macaca fascicularis was studied. The study concerned 11 hearts of healthy and fertile animals of both sexes. The morphological and morphometric results of the studies performed by microdissection revealed that: In all examined cases of the Macaca fascicularis the heart was supplied by blood through the left and right coronary arteries. The left coronary artery had a larger external diameter (1.2 mm-2.5 mm, average 1.8 mm) than the right one (0.7 mm-1.2 mm, average 0.9 mm). The left coronary artery, with the average length of 4.3 mm (1.8 mm-6.5 mm), usually (82%) ended by bifurcation in to the anterior interventricular and the circumflex branch, and less frequently (18%) by trifurcation forming, in this way, another branch: the left marginal branch. The anterior interventricular branch had the larger external diameter (0.9 mm-1.7 mm, average 1.3 mm) than the circumflex one (0.7 mm-1.7 mm, average 1.1 mm). Most frequently (73%) it could be traced along the diaphragmatic cardiac surface. The circumflex branch usually (73%) terminated as the posterior interventricular branch, and less frequently (9%) as one of the right posterior ventricular branches. The long type of the right coronary artery was observed in 45% of the cases. The presence of the myocardial bridges over the branches of the left coronary artery was found in 54% of the examined hearts. The great resemblance between the Macaca fascicularis subepicardial network with the corresponding one in humans suggest that Macacus fascicularis is a suitable experimental animal for functional studies of the cardiovascular system.

Animals↗

PubMed1996

[Phylogenetic relationships among six species of Macaca inferred from ribosomal DNA variations].

Restriction maps of ribosomal DNA repeating units of six species of Macaca (M. mulatta, M. facsicularis, M. arctoides, M. assamensis, M. thibetana, M. nemestrina) and two outgroup species, Rhinopithecus bieti and Hylobates leucogenys, were constructed with 15 restriction endonucleases and 28S, 18S rDNA probes cloned from human, M. arctoides shares a common restriction map with M. assamensis. Phylogenetic tree derived from the neighbor-joining was somewhat different that derived from the maximum likelihood methods using the NEIGHBOR and RESTML program in PHYLIP version 3.5c. However, the consensus of our phylogenetic trees supports the viewpoint that M. facsicularis and M. mulatta were maybe diverged first in the genus Macaca. Further studies using DNA sequencing method are required to resolve the phylogeny of the genus Macaca.

Animals↗

PubMed1989

Anatomical brain asymmetry in monkeys: frontal, temporoparietal, and limbic cortex in Macaca.

Measurements evaluating possible cerebral hemispheric asymmetries were taken by hand on frontal, parietal, and temporal cortex on 60 formalin-fixed Macaca mulatta and Macaca fascicularis brain specimens. No statistically significant (P less than 0.05) right/left side differences in the mean length of four sulci in visual-processing areas of the cortex were found. The sulcus adjacent to the region cytoarchitecturally homologous to the motor speech area in the human brain did not show pronounced asymmetry. In both species, however, a small parietal lobe sulcus showed greater development on the left hemisphere than in the right. In measurements made using digital planimetry, right/left side differences in the area of the dorsal cingulate gyrus were not found. Behavioral evidence suggests that monkeys do not exhibit a consistent pattern of cerebral dominance for functions associated with most of these regions of the brain.

Animals↗

PubMed1981

Neuronal and synaptic structure of the dorsal lateral geniculate nucleus in normal and monocularly deprived Macaca monkeys.

The dorsal lateral geniculate nucleus (dLGN) of Macaca monkeys was studied by Golgi and quantitative electron microscopic (EM) methods to determine if differences in neuronal morphology exist which might correlate with the known physiological separation of X-type cells into the parvocellular and Y-type cells into the magnocellular laminae. Monocularly lid-sutured Macaca monkeys were also studied by quantitative EM methods to compare the synaptic organization within laminae innervated by the deprived and nondeprived retinae. We have divided our sample of Golgi-impregnated neurons into three groups: Types A, B, and C. Type A neurons comprise the majority of the projections cells and are quite heterogeneous in their overall morphology. Type B neurons have long dendrites with multiple appendages; some have a locally ramifying beaded axon Type C neurons are characterized by dendrites which are mainly restricted to the interlaminar zones. We found Type A and B neurons in both the parvocellular and magnocellular laminae. The cell bodies of Type C neurons lay within the interlaminar zones or the parvocellular laminae. All three types contributed dendrites to the interlaminar zones. No significant differences in Golgi morphology other than overall size were found in parvocellular or magnocellular laminae that would explain the previously demonstrated electrophysiological differences. Terminal profiles and synapses in the parvocellular, magnocellular, and interlaminar zones were classified and counted using quantitative EM methods. RSD and F terminals were most numerous in all three zones. RLP terminals were rare in the interlaminar zones. A new type of terminal, RMD was found in the magnocellular interlaminar zones. The laminar and interlaminar zones have the same overall synaptic density, but differed in types of synaptic terminals. The only quantitative difference between any of these regions was in the magnocellular laminae where the counts showed 70% more F terminals per unit area. The same quantitative methods were applied to the laminar and interlaminar zones of dLGNs from monocularly lid-sutured monkeys. We found no qualitative or quantitative difference between the synaptology of zones receiving input from the deprived retina compared to the open eye retina, nor between any regions of the dLGN in deprived monkeys compared to normal monkeys.

Animals↗

PubMed2001

Serum antibody responses of cats to soluble whole cell antigens and isolated fimbriae of feline Porphyromonas salivosa (macacae) and associations with periodontal disease.

The whole cell soluble antigens of two strains (NCTC 11632 and VPB 3313) of feline Porphyromonas salivosa (macacae) were analyzed by Western blotting using serum taken from 40 domestic cats with various grades of periodontal disease. Nine strongly immunogenic protein bands (66, 52, 42, 29, 27, 23, 22, 21 and 19kDa) were selected from both strains for further study. Both strains showed a significant association between overall periodontal grade and serum responses to the 66 and 21kDa bands with significant responses across both strains to all other bands except the 52kDa band. Similarly, both strains showed a significant association between the total colony forming units and serum responses to the 66 and 42kDa bands with significant responses across both strains to all other bands except the 19kDa band. When sera from 25 of these cats were tested by Western blotting against the isolated fimbriae of VPB 3313, there was a significant association between the grade of response of cats to the 42kDa fimbrial preparation and (1) the total reactivity of the mouth (the sum of the responses to all individual whole cell antigens), (2) the total colony forming units of P. salivosa (macacae) at the premolar site, and (3) to their responsiveness to the 42kDa band in the soluble whole cell antigen preparations. These findings suggest that P. salivosa (macacae) is a strong immunogen in the mouths of cats and those cats with more severe periodontal disease have a greater serum antibody reactivity to various soluble whole cell antigens, specifically including the fimbriae of this organism, than those with less severe periodontal disease. Overall, the findings suggest that this organism may be a contributor to periodontal disease in cats.

Animals↗

PubMed1987

[Increase in plasma levels of active and inactive renin after inhibition of renin activity by SR 42128 in conscious Macaca monkeys].

Plasma active renin (PAR), plasma inactive renin (PIR), and plasma renin activity (PRA) were determined after intravenous bolus injection of the renin inhibitor SR 42128, in sodium repleted and sodium depleted macacas. The kit renin of Pasteur Diagnostics allows determination of PAR after renin inhibition by SR 42128. PAR and total plasmatic renin (TPR) were determined before and after treatment of plasma using trypsin. IR = TPR-PAR. ARP was measured by RIA of angiotensin I. Sodium depletion induced a dramatic increase of PAR (1,678 + 11.5 pg/ml compared to 94.4 + 11.5, n = 6). PIR rose from 322.1 + 34.3 pg/ml to 1,137 + 206 (n = 6). In sodium repleted macacas, SR 42128 (3 mg/kg and 9 mg/kg) induced a PRA inhibition of 90 to 100 p. 100, for 4 h post-injection. PAR increased to reach maximal level after 90 min and remained constant up to 4 h post-injection (increase of 420 p. 100 at 3 mg/kg and 620 p. 100 at 9 mg/kg). PIR increased more slowly for 4 h (maximum increase of 250 p. 100). PRA was also inhibited in sodium depleted macacas by SR 42128 at the doses of 3 mg/kg and 9 mg/kg ARP was inhibited. PIR increased more slowly, but significantly at 9 mg/kg. We conclude that the activity of SR 42128 on PAR and PIR levels is the sole consequence of the inhibition of the Renin Angiotensin system.

Animals↗

PubMed1976

The density of long limb bones and the percentage ash weight of the skeleton of Macaca mulatta.

The gravimetric density of humeri, radii, femora and tibiae from a series of 274 male and female skeletons of rhesus monkeys, Macaca mulatta, was determined for fetal, young and adult periods. The ages of 171 of the animals were known: they ranged from 57 days of gestation to 13.6 years; the ages of an additional 103 skeletons were estimated. The mean density of the fetal bones was found to increase linearly with age and was higher for males than females, and higher for the superior than for the inferior limb bones. During the young period the pattern of increase in density can be represented by a power-type curve, and the density is significantly higher in females than in males and in superior than in inferior limb bones. The densities of the long limb bones of the adult skeletons show a slight, but not significant, negative trend with increasing age. In this age group the mean densities are higher for males than females and higher for the superior than for the inferior limb bones. The percentage ash weight was determined for the total skeleton and for 21 subdivisions of 23 postnatal skeletons with estimated ages. The skull and long limb bones were found to have higher mean percentage ash weights than the vertebral segments and the sternum. Both the density and the percentage ash weight of the Macaca mulatta skeletons examined exceed those found in our earlier studies of the human skeleton.

Age Factors↗

PubMed1978

Scaling of organ weights in Macaca arctoides.

The allometric scaling of nine internal organs was examined for Macaca arctoides. Significant organ weight-body weight regressions were obtained for heart, lungs, kidneys, pancreas, thyroid, liver, and testes. The spleen and adrenal glands exhibited strong variability and were only loosely correlated to body weight. Using allometry as a criterion of subtraction, observed sex differences in mean organ weights were seen to be primarily the result of differences in average body weight. It is postulated that analysis of observed differences in organ weights between this species and Macaca mulatta would yield similar conclusions. Comparison of intraspecific slope values obtained in the present study with interspecific values reported in the literature reveals a pattern paralleling the brain-body weight relation. A discussion of the relationship between intra- and interspecific slopes is presented.

Adrenal Glands↗