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PubMedDate not supplied

An immunohistochemical study of testicular biopsies in childhood acute lymphoblastic leukemia: reactivity of normal testicular components and leukemic infiltrates.

We performed an immunohistochemical analysis of frozen sections from testicular biopsies from 23 children with acute lymphoblastic leukemia. Eleven cases were infiltrated by leukemia. Tumor cells were immunostained by a panel of antibodies that identified CD10, CD43, CD19, CD3, CD7, and MHC class I and II. The immunoreactivity of normal testicular components was also studied. Normal testis showed no CD10 reactivity. Wide variation in the number of stromal macrophages identified by CD11c was found. Transferrin receptor (CD71) was expressed by some stromal macrophages, by seminiferous tubules, and by Leydig cells. B lymphocytes were absent from the testicular stroma but small numbers of T lymphocytes were consistently present. MHC class I and II were expressed by most stromal cells but not by seminiferous tubules.

Adolescent↗
PubMedDate not supplied

[Leukemic infiltration in the eye].

Among the organ involvements complicating acute leukaemias infiltrations in the visual organ are less frequent. A case is described of acute medullary leukaemia in an adult with exudate in the anterior chamber and infiltrations in the conjunctiva of the eyeball and eyelids. Chemotherapy and local radiotherapy controlled these complications.

Combined Modality Therapy↗
PubMedDate not supplied

[Treatment of leukemic infiltrations of the central nervous system. Preliminary communication].

In a group of 39 patients with acute leukaemias lumbar taps with intrathecal administration of drugs were done. In 20 cases lumbar tap was done at the time of development of neurological signs. In 19 cases one prophylactic intrathecal drug administration was done. In the treatment of leukaemic infiltrations in the central nervous system three methods were used administering intrathecally methotrexate in the first schedule, methotrexate and cytosine arabinoside in the second schedule, and cytosine arabinoside with Ultracorten in the third schedule. These methods caused usually disappearance of most clinical signs and changes in the cerebrospinal fluid. In 7 cases side effects appeared due to chemical irritation of the meninges but disappeared after several days.

Cytarabine↗
PubMed1985

[Leukemic infiltration in the anterior chamber of the eye].

Leukaemic infiltration of the anterior chamber of the eye (hypopyon and corneal opacity) was the only sign of relapse in two girls with acute lymphoblastic leukaemia who had been off treatment for one and three years. The malignant cells had probably been present in the eye since the onset of the disease. The anterior segment of the eye may be a pharmacologycal "sanctuary" in patients with ALL. The response to radiotherapy was good but this treatment should be coupled with systemic chemotherapy and CNS prophylaxis.

Anterior Chamber↗