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PubMedDate not supplied

Proportion of homosexual men who owe their sexual orientation to fraternal birth order: An estimate based on two national probability samples.

Homosexuality in men correlates with an individual's number of older brothers, greater numbers of older brothers being associated with a greater probability of homosexuality. There are reasons to believe that this relationship is causal rather than merely statistical, that is, that older brothers produce the increase in the probability of homosexuality for later-born males. It is possible, under this assumption, to estimate the proportion of homosexual men who can attribute their sexual orientation to their birth order among their brothers (fraternal birth order). This statistic, the population attributable fraction (PAF), was computed on the combined archival data of 2,256 heterosexual and 71 homosexual men examined in survey studies of sexual behavior in the UK and the USA. The PAF was 28.6%, with 95% confidence limits of 14.8% and 48.0%. These limits encompass the PAF of 15.1% previously estimated with a Canadian sample. The results indicate that the proportion of homosexual men whose sexual orientation is attributable to fraternal birth order constitutes a minority, but not a negligible minority, of all homosexual men. The fraternal birth order effect may reflect the progressive immunization of some mothers to Y-linked antigens by each succeeding male fetus, and the concomitantly increasing effects of antimale antibodies on the sexual differentiation of the brain in each succeeding male fetus.

Birth Order↗
PubMed1987

Antiviral antibodies in the sera of homosexual men: correlation with their lifestyle and drug usage.

Healthy homosexual men between the ages of 21 and 65 years, from the Washington, DC (n = 162), and New York City (n = 89) areas, were studied for antibodies in the serum against cytomegalovirus (CMV), herpes simplex virus (HSV) types 1 and 2, and Epstein Barr virus (EBV) viral capsid antigen (VCA). CMV-specific antibodies were assayed by enzyme-linked immunosorbent assay (ELISA), anti-HSV-1 and -2 antibodies were measured by indirect hemagglutination (IHA), and antibodies to EBV VCA were measured by the immunofluorescence assay. Antibodies to human T lymphotrophic virus III (HTLV-III) were detected by ELISA and Western blot procedures. T lymphocytes were enumerated using OKT4 monoclonal antibody. Healthy male volunteer blood donors (n = 90) matched for age range and race proportions were used as controls. The percentage of seropositive individuals in the homosexual group was higher (90-98%) for all the viruses tested than in the control group (47-87%). Comparisons of the geometric mean titers, expressed as reciprocal serum dilutions, of seropositive individuals in homosexual (H) vs control (C) group were as follows: CMV-IgG (ELISA) H = 1:794, C = 1:68; HSV-1 (IHA) H = 1:248, C = 1:14; HSV-2 (IHA) H = 1:56, C = 1:17; EBV-VCA (IFA) H = 1:385, C = 1:131. The homosexual group also showed a higher frequency of individuals with elevated titers than the control group. The CMV IgM antibody was prevalent in 17.7% of the homosexual group and 5% of the control group; arithmetic means for ELISA values for CMV IgM were 0.207 for the homosexual group and 0.05 for the control group. In the homosexual group, the anti-CMV antibody titers increased with age (P = 0.01) and with numbers of sex partners (P = 0.06). Both anti-HSV-1 and anti-HSV-2 antibodies correlated with the number of sex partners (P = 0.04 and P = 0.05, respectively). Neither age nor partner number correlated with response to EBV, and no particular sex act was related to the EBV VCA titer level. HTLV-III seropositivity was associated with higher herpes virus group antibody titers, probably because of life style cofactors. Among the HTLV-III-seropositive subjects, those with less than or equal to 400 T-helper lymphocytes/mm3 had lower antibody titers than those with greater than 400 T-helper lymphocytes/mm3 counts, suggesting an impaired immune response secondary to immunosuppression.

Adult↗
PubMed1988

Virus isolation and immune studies in a cohort of homosexual men.

Virus shedding was detected in 77% of homosexual subjects and in only 6% of heterosexual controls. The overall virus isolation rate in homosexual subjects was not significantly different among HIV-seropositive (79%) and HIV-seronegative (74%) individuals. In about 20% of homosexual subjects, virus shedding from multiple sites was observed. The most frequently isolated virus was cytomegalovirus (CMV) (41%), followed by enteroviruses (23%), herpes simplex virus (HSV) (7%), and adenoviruses (6%). In the control group, about 50% of subjects were seronegative for HSV-1 and 2, and about 70% were negative for CMV and Epstein-Barr virus (EBV). Only 2% of homosexuals were seronegative for CMV, about 5% for HSV-1 and 2, and about 20% for EBV. No differences were found in antibody levels against varicella-zoster virus (VZV) among the control and homosexual groups. The proportion of seronegatives for Coxsackie and hepatitis viruses was significantly higher in control than in homosexual subjects. However, no differences in the proportion of seronegatives for measles, mumps, and rubella were observed. No HIV-antibody-negative individual was detected with an OKT4/OKT8 ratio of less than 0.75. On the other hand, only HIV-positive subjects, with a ratio of less than 0.75, had high serum IFN alpha titers. The results suggest that the high rate of virus shedding among HIV-negative homosexual subjects might be a factor in the development of AIDS in this high-risk population.

Adenoviruses, Human↗
PubMed1989

On the question of homosexuality in actors.

There is a belief that a high percentage of male actors are homosexual. The specific linking of actors and homosexuality seems to have first appeared in the Elizabethan Puritan condemnations of the theater. Psychoanalytic theory has tended to further promulgate the linkage between effeminacy, homosexuality, and acting. An analysis of the relevant existing empirical literature indicates that few studies have addressed themselves to evaluating this relationship. Those studies supporting the effeminacy-actor relationship were seriously flawed both in design (e.g., use of indirect measures to infer homosexuality) and interpretation of the data. Only one study used direct measures of sexual orientation. Even though that study had methodological problems, its results indicated that the percentage of homosexuality among actors was not verifiably greater than that found in the general population. It is felt that the current belief of greater homosexuality in actors, as compared to the general population, is a product of our Puritan heritage, the actor's unconventionality, and of public flaunting of the homoerotic behavior of that portion of actors that are homosexual.

Drama↗
PubMed1987

Heterosexual and homosexual gender dysphoria.

This study investigated why more males than females complain of dissatisfaction with their anatomical sex (gender dysphoria). New referrals to a university gender identity clinic were dichotomously classified as heterosexual or homosexual. There were 73 heterosexual and 52 homosexual males; 1 heterosexual and 71 homosexual females. The average heterosexual male was 8 years older at inception than the homosexual groups. The heterosexual males reported that their first cross-gender wishes occurred around the time they first cross-dressed, whereas the homosexual groups reported that cross-gender wishes preceded cross-dressing by 3-4 years. Some history of fetishistic arousal was acknowledged by over 80% of the heterosexual males, compared to fewer than 10% of homosexual males and no homosexual females. The results suggest that males are not differentially susceptible to gender dysphoria per se, but rather that they are differentially susceptible to one of the predisposing conditions, namely, fetishistic transvestism.

Female↗
PubMed1984

Psychosocial development of heterosexual, bisexual, and homosexual behavior.

Relationships with overt adult Kinsey Scale scores (K) indicate that early sexual experiences are most closely related to K, followed in order by gender related and familial variables. A developmental model emphasizing social learning is presented. Interviewees were 7669 American white males and females. Elevated K (more homosexual scores) was found for females who had few girl companions at age 10 and few male companions at 16, had learned to masturbate by being masturbated by a female, had intense prepubertal sexual contact with boys or men, found thought or sight of females, but not males, arousing by age 18, had homosexual contact by age 18, higher K at 17, and higher first-year homosexual behavior frequency. Elevated K (more homosexual scores) was found for males who reported poorer teenage relationships with their fathers, had more girl companions at age 10, fewer male companions at 10 and 16, avoided sports participation, learned of homosexuality by experience, learned to masturbate by being masturbated by a male, had intense prepubertal sexual contact with boys or men, had neither heterosexual contact nor petting to orgasm by age 18, found thought or sight of males, but not females, arousing by age 18, had homosexual contact by age 18, higher K at ages 16 and 17, and had higher first-year homosexual behavior frequency. Behavioral bisexuals, those scoring between 2.0 and 4.0 on the K scale on the basis of overt behavior (0.7% of females, 1.2% of males), reported more arousal to heterosexual stimuli than did exclusive heterosexuals.

Family↗
PubMed1975

Heterosexual interest in homosexual males.

Androphilic, ephebophilic, and homosexual pedophilic males were compared on heterosexual interest and arousal potential. The former was measured by the subjects' retrospective reports and the latter by penile responses to pictures of females. The penile responses of the ephebophilic and homosexual pedophilic groups to pictures of physically mature females were not different from those of androphilic males. In the present study as well as in an earlier one, the ephebophilic males responded significantly more to physically mature males than to physically mature females. Homosexual pedophilic males showed little difference in responses to physically mature males and females. In retrospective reports of heterosexual interest and experience and of development of homosexual interest and activities, there were only two differences among the groups: as opposed to androphilic males, a relatively greater number of ephebophilic and homosexual pedophilic males indicated that up to age 15 or later they had felt attracted exclusively to females and that they had been seduced in childhood or early adolescence by a male. These results will have to be replicated before being accepted as reliable. As in some earlier studies, there was a weak but significant correlation of degree of "feminine gender identity" with age at onset of homosexual interest and with heterosexual interest or experience. A higher degree of feminine gender identity went together with less heterosexual interest and experience and with an earlier onset of homosexual interest and experience.

Adolescent↗
PubMed1983

Comparison of attitudes toward transsexuality and homosexuality.

Attitudes toward transsexuality and homosexuality were compared in a sample of 318 university students. More people felt that homosexuality was "wrong" than felt that transsexuality was "wrong". This difference in favor of transsexuality was more pronounced in female than in male respondents. In addition, more people rejected the notion that biological factors were responsible for homosexuality than was the case for transsexuality. General attitudes about the morality of transsexuality and homosexuality, however, were not mirrored in response to questions pertaining to job discrimination. To the contrary, male respondents, especially, were more inclined toward equal opportunity for homosexuals than for transsexuals. One hypothesis supported by this study was that homosexual denial and "homophobia" in some transsexuals may, in part, be a reflection of society's greater moral condemnation of homosexuality relative to transsexuality.

Adult↗
PubMed1983

Sensation seeking in homosexual and heterosexual males.

The study was designed to test the relationship between the personality trait of sensation seeking and homosexuality. Previous studies had shown a relationship between the trait and variety of heterosexual activity but had not shown a relationship to homosexual behavior. This study compared 19 male homosexuals associated with a gay club in a university, 16 control students belonging to a social club at the same university, 13 members of a gay church group, and 19 members of a nongay church group on conservative vs. liberal attitudes toward religion and politics, attitudes toward homosexuality, heterosexual and homosexual experience scales, and the sensation seeking scales. The control (nongay) church group had more conservative attitudes, less heterosexual experience, and lower sensation scores than the other groups. But the control university group did not differ from the gay university group on any of the sensation seeking scales and differed from the gay church group on only one of the subscales. However, the gay university group was also higher than the gay church group on this subscale, so the difference was probably a function of the younger ages of the university groups than the gay church group. It is concluded that male homosexuals, as a general group, do not differ from heterosexuals on the sensation seeking trait, although the trait might be related to variety of homosexual behavior and partners, just as it is to variety of heterosexual experience.

Adolescent↗
PubMed1980

A pair of monozygotic twins discordant for homosexuality: sex-dimorphic behavior and penile volume responses.

In reports of identical twins discordant for homosexuality, the homosexual twins showed the effeminacy syndrome in childhood. This has been considered evidence that the homosexuality comes from the twin himself. The possibility that the heterosexual twin was denying homosexuality has never been excluded. A pair of identical male twins discordant for homosexuality are reported. They showed significant differences in their penile volume responses to moving pictures of male and female nudes indicative of sexual orientations consistent with their statements. The homosexual twin showed the effeminacy syndrome. Aspects of the syndrome can be induced in mammals by altering their hormonal environment during some critical period in their intrauterine development. Discordance for homosexuality in identical twins could be due to one's being exposed to a different hormonal level during such a critical period.

Adult↗
PubMed1977

"Sex-role preference" as an explanatory variable in homosexual behavior.

Sex-role preference is an important neglected variable in statistically controlled studies of homosexual behavior. This variable must accompany controls for degree of psychopathology of respondents and degree of heterosexual and homosexual behavior experienced by respondents. Cross-cultural differences exist. Mexican males have rigidly defined insertor-insertee roles, with earlier life events serving as predictors of these sex-role preferences. Greece is comparable to Mexico. In Turkey, stigmatization accompanies passive homosexuality. Role playing may be age graded, as in the Southwest Pacific. In lower socioeconomic classes of the United States, sex roles for homosexual males are more stereo-typically and unequivocably defined. Chicanos generally have strong sex-role preferences when involved in homosexual encounters; their attitude is similar to that found in Mexico. Among middle-class Anglo-American males, few or no sex-role feelings are associated with types of sex acts by most homosexually behaving males. This may be related to a focus on oral-genital rather than anal sex acts. The sharply dichotomized gender roles and the cultural formulation linking effeminacy and homosexuality appear to provide the necessary conditions for the development of sex-role preferences in many societies.

Adult↗
PubMed2000

Comparison of auditory evoked potentials in heterosexual, homosexual, and bisexual males and females.

The auditory evoked potentials (AEPs) elicited by click stimuli were measured in heterosexual, homosexual, and bisexual males and females having normal hearing sensitivity. Estimates of latency and/or amplitude were extracted for nine peaks having latencies of about 2-240 ms, which are presumed to correspond to populations of neurons located from the auditory nerve through auditory cortex. For five of the 19 measures obtained, the mean latency or amplitude for the 57 homosexual and bisexual females was different from that of the 49 heterosexual females in a manner that implies a masculinization of the auditory systems of the homosexual and bisexual females. A similar masculinization effect was previously observed for the otoacoustic emissions generated by the cochlea. For five other measures, the mean latency or amplitude for the 53 homosexual and bisexual males was different from that of the 50 heterosexual males in a manner that implies a hypermasculinization of the auditory systems of the homosexual and bisexual males. Hypermasculinization has been reported recently for other physical characteristics of homosexual males. One parsimonious interpretation of these findings is that homosexual males and females both were exposed to higher than normal levels of androgens at some point(s) in development. Data are reported only for the female subjects not using oral contraceptives because those drugs can masculinize certain AEP measures.

Bisexuality↗
PubMed2005

Digit ratio (2D:4D) in homosexual and heterosexual men from Austria.

Neurohormonal theories of sexual orientation emphasize the organizational effects of testosterone on the developing brain. A recent suggestion, that the ratio of the length of the 2nd and 4th digits (2D:4D) is negatively correlated with prenatal testosterone, has led to a number of studies of 2D:4D in homosexual and heterosexual men and women. The results have been mixed. In comparison to heterosexual men, mean 2D:4D in gay men has been reported to be hypermasculinized (lower 2D:4D), hypomasculinized (higher 2D:4D), or to show no significant difference. Here, we report mean 2D:4D in Austrian homosexual and heterosexual men. We found no significant difference between means for homosexual and heterosexual 2D:4D, with values for both falling between 0.96 to 0.97. There are now 6 reports of 2D:4D in heterosexual and homosexual men. Considering Caucasian men, the studies from the United States show low heterosexual mean 2D:4D, and homosexual mean 2D:4D is higher or similar to that of heterosexuals. The European studies show high heterosexual mean 2D:4D, and comparisons with homosexuals reveal the latter to have lower or similar mean 2D:4D to that of heterosexuals. We discuss these results in relation to the suggestion that mean 2D:4D in heterosexual men differs across populations but mean 2D:4D in homosexuals shows less geographical variation (the "uniform mean hypothesis"). It is concluded that more data are required to clarify whether or not there is a 2D:4D effect for sexual orientation in men.

Adult↗
PubMed2006

The sex ratio of older siblings in non-right-handed homosexual men.

This study tested the prediction, based on prior research, that non-right-handed homosexual men will report fewer than expected older brothers. Participants were 2486 heterosexual and homosexual, right-handed and non-right-handed, male and female adults, representing five samples collected for various projects by the second author. Data on sibship composition, sexual orientation, and hand-preference were gathered in the original research using on-line (Internet) or self-administered paper-and-pencil questionnaires. The non-right-handed homosexual men reported 83 older brothers per 100 older sisters, which was significantly lower than the human sex ratio of 106 live-born males per 100 live-born females. In contrast, the right-handed homosexual men reported 125 older brothers per 100 older sisters, which was significantly higher than the expected ratio. One possible explanation of these results is that older brothers increase the odds of homosexuality in right-handed males but decrease the odds of homosexuality in non-right-handed males. A second possibility is that older brothers decrease the probability that non-right-handed homosexual males will be represented in survey research. The latter scenario could arise if the combination of some biological factor associated with older brothers and some biological factor associated with non-right-handedness is so toxic that it kills the fetus or predisposes the individual to a condition (e.g., mental retardation, major mental illness) that makes him less likely to be available for research recruitment at Gay Pride parades (etc.) than other members of the gay community.

Birth Order↗
PubMed1986

Abnormalities in intestinal mucosal T cells in homosexual populations including those with the lymphadenopathy syndrome and acquired immunodeficiency syndrome.

Enteric infections are common in homosexual men. We have characterized the phenotypic distribution of small intestinal mononuclear cells among healthy homosexual men, homosexual men with lymphadenopathy syndrome, homosexual men with acquired immunodeficiency syndrome (AIDS), and a group of healthy heterosexual men. Total numbers of T lymphocytes in the small intestinal mucosa were significantly decreased in homosexual men with lymphadenopathy syndrome and AIDS. This decrease was most striking among the Leu-3a T-cell subset usually associated with helper/inducer function. The proportion of mucosal T cells reacting with Leu-2a (cytotoxic/suppressor phenotype) and lymphoid cells having the T305 antigen was significantly increased only in AIDS subjects. Both lymphadenopathy syndrome and AIDS subjects had a significant reversal of the normal mucosal helper/suppressor T-cell ratio. Mucosal helper/suppressor T-cell ratios and the distribution of mucosal mononuclear cells were normal in healthy homosexual men, although the same individuals had reversed helper/suppressor ratios among circulating T cells. Enteric infections in healthy homosexual men likely reflect sexual practices, and not a primary abnormality in intestinal mucosal immunity. In contrast, specific abnormalities in intestinal mucosal immunity may contribute to the persistent and opportunistic enteric infections that occur in AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Illness concerns, attitudes towards homosexuality, and social support in gay men with AIDS.

High levels of illness-related psychologic distress, marked social stigmatization and loss of social support, and negative internalized feelings towards homosexuality have previously been reported in homosexual men with the diagnosis of acquired immune deficiency syndrome (AIDS). We assessed 50 homosexual or bisexual men who were within 3 months of their AIDS diagnosis with respect to medical status, illness concerns, attitudes towards homosexuality, and social support. Subjects reported levels of illness-related concerns comparable to previously studied cancer patients. Their attitudes towards homosexuality were similar to previously studied healthy homosexual males. Their social support needs were variable, as was their satisfaction with specific types of social support. Their social networks were moderately small. In this AIDS subject group, illness concerns, attitudes toward homosexuality, and social support satisfaction were significantly correlated with each other, and with previously reported levels of psychologic distress and subjective (but not objective) measures of health status.

Acquired Immunodeficiency Syndrome↗
PubMed1991

A cognitive profile of homosexual men compared to heterosexual men and women.

Matched groups of homosexual men, heterosexual men, and heterosexual women (n = 38 per group) were tested on three measures of spatial ability and two measures of fluency that typically reveal sex differences. For the three spatial tests and one of the fluency tests, the mean performance of homosexual men fell between those of the heterosexual men and women. The pattern of cognitive skills of homosexual men was different from that of heterosexual men: homosexual men had lower spatial ability relative to fluency. The cognitive pattern of homosexual men was not significantly different from that of heterosexual women. In addition, the results suggest that homosexual men classified on the basis of hand preference may form two subgroups that differ in cognitive pattern. These findings are compatible with the hypothesis that there is a neurobiological factor related to sexual differentiation in the etiology of homosexuality.

Adolescent↗
PubMed1991

Gene- and environment-dependent neuroendocrine etiogenesis of homosexuality and transsexualism.

Sexual brain organization is dependent on sex hormone and neurotransmitter levels occurring during critical developmental periods. The higher the androgen levels during brain organization, caused by genetic and/or environmental factors, the higher is the biological predisposition to bi- and homosexuality or even transsexualism in females and the lower it is in males. Adrenal androgen excess, leading to heterotypical sexual orientation and/or gender role behavior in genetic females, can be caused by 21-hydroxylase deficiency, especially when associated with prenatal stress. The cortisol (F) precursor 21-deoxycortisol (21-DOF) was found to be significantly increased after ACTH stimulation in homosexual as compared to heterosexual females. 21-DOF was increased significantly before and even highly significantly after ACTH stimulation in female-to-male transsexuals. In view of these data, heterozygous and homozygous forms, respectively, of 21-hydroxylase deficiency represent a genetic predisposition to androgen-dependent development of homosexuality and transsexualism in females. Testicular androgen deficiency in prenatal life, giving rise to heterotypical sexual orientation and/or gender role behavior in genetic males, may be induced by prenatal stress and/or maternal or fetal genetic alterations. Most recently, in mothers of homosexual men--following ACTH stimulation--a significantly increased prevalence of high 21-DOF plasma values and 21-DOF/F ratios was found, which surpassed the mean + 1 SD level of heterosexual control women. In homosexual men as well--following ACTH stimulation--most of the 21-DOF plasma values and 21-DOF/F ratios also surpassed the mean + 1 SD level of heterosexual men. In only one out of 9 homosexual males, neither in his blood nor in that of his mother increased 21-DOF values and 21-DOF/F ratios were found after ACTH stimulation. In this homosexual man, however, the plasma dehydroepiandrosterone sulfate (DHEA-S) values and the DHEA-S/1000 x A (A = androstenedione) ratio were increased before and after ACTH stimulation. Furthermore, highly significantly increased basal plasma levels of dehydroepiandrosterone sulfate were found in male-to-female transsexuals as compared to normal males, suggesting partial 3 beta-ol hydroxysteroid dehydrogenase deficiency to be a predisposing factor for the development of male-to-female transsexualism.

Environment↗