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At least 145 records · Page 8Linked to original sources
PubMed2004

Some biomechanical and histologic characteristics of early-loaded locking pin and expandable implants: a pilot histologic canine study.

BACKGROUND: A two-stage approach with a 3- to 6-month healing period is recommended for the "conventional" osseointegration technique with oral implants. This may induce inconvenience and discomfort for patients, and immediate early loading protocols are preferable. PURPOSE: To compare a new type of implant with two locking pins, designed to allow immediate loading, with an expandable implant design with regard to bone tissue response and implant stability. MATERIALS AND METHODS: The molars and premolars of two beagle dogs were extracted in the mandible, and two types of implants (an apically expandable implant and a locking pin implant) were immediately placed in the sockets. The dogs received at least four implants (two of each type) in each side of the mandible. Implants were loaded with gold-palladium bridges 15 days later. The loaded implants were left for 3 months, and the dogs were sacrificed. Resonance frequency analysis (RFA) was performed at placement and sacrifice. Ground sections for histomorphometry were produced for each implant. RESULTS: Implant stability as measured by RFA was similar for the two types of implants before healing. At termination of the study, stability was higher for the locking pin implants. Bone histomorphometry showed that both types of implant were anchored by the same amount of bone and that bone-titanium interfaces did not differ. CONCLUSION: The locking pin implant showed better secondary stability than did the expandable implant, probably because of a better transmission of strains to bone.

Animals↗
PubMed1992

Histologic methods and interspecies variations in the laryngeal histology of F344/N rats and B6C3F1 mice.

The relatively high incidence and variety of lesions induced in the upper respiratory tract of rodents by inhalation of xenobiotics has resulted in considerable attention given to the microscopic anatomy of this area. Specific areas of the rodent laryngeal mucosa appear to be more sensitive to inhaled materials and more likely to contain cellular changes in response to injury. These include the epithelium covering the base of the epiglottis, ventral pouch, and the medial surfaces of the vocal processes of the arytenoid cartilages. There are few good landmarks for trimming rodent larynges to get consistent and accurate sections through these target areas. We have obtained consistently reproducible results by cutting transversely through the easily palpable cricothyroid notch and embedding the entire larynx anterior to this in paraffin with the cut surface against the face of the block. Multiple sections are cut from the caudal larynx toward the epiglottis, unstained sections examined microscopically for orientation, and sections from target areas selected for staining and histopathologic examination. Routine use of these methods for preparation and microscopic examination of sections of the larynx has revealed some variations in normal laryngeal anatomy between Fischer 344 (F344/N) rats and B6C3F1 mice.

Aging↗
PubMed2004

Histology of the torn meniscus: a comparison of histologic differences in meniscal tissue between tears in anterior cruciate ligament-intact and anterior cruciate ligament-deficient knees.

PURPOSE: The purpose of this case control study was to evaluate possible preexisting structural differences between torn menisci in anterior cruciate ligament-intact and anterior cruciate ligament-deficient knees. MATERIALS AND METHODS: Subjects were prospectively enrolled into the study from new patient referrals to the orthopaedic clinic. Forty-four meniscal specimens were retrieved during routine arthroscopy. The anterior cruciate ligament-deficient group included 24 patients (15 men and 9 women, average age of 26.5 years, SD = 9.5) with 24 acute, displaced, longitudinal, bucket-handle tears of the medial meniscus in unstable, anterior cruciate ligament-deficient knees. The anterior cruciate ligament-intact group included 20 patients (14 men and 6 women, average age of 30.4 years, SD = 13.4) with similar tears in anterior cruciate ligament-intact knees. Longitudinal and transverse section specimens were stained with hematoxylin and eosin and safranin O, divided into zones based on proximity to the tear, and graded on safranin O uptake or tissue composition. RESULTS: Descriptive statistics and chi2 analyses were used to assess differences between groups within each zone. Significant differences (P < .05) were observed between anterior cruciate ligament-deficient and anterior cruciate ligament-intact specimens stained with hematoxylin and eosin in zone 3 for both transverse and longitudinal cuts. Significant differences were not found between anterior cruciate ligament-deficient and anterior cruciate ligament-intact specimens stained with safranin O. CONCLUSION: Longitudinal meniscal tears occurring in anterior cruciate ligament-intact knees may result from early degenerative disease processes. Attempted repair of this diseased tissue may fail to have a positive effect on long-term preservation of the meniscus.

Adolescent↗
PubMed1989

[Histological examination in Sjögren's syndrome. Relationship between sialography and histological examination].

Although the etiology of Sjögren's syndrome (SJS) remains unknown, Sjögren's syndrome can be diagnosed by means of clinical features and sialographic and histopathological examinations. In this study of 35 patients with primary SJS and 21 with secondary SJS, two parameters, (the findings of sialography of parotid gland and the histopathology of labial minor salivary gland), were evaluated. Then it was concluded that grade of lesion in sialography was parallel to infiltrative grade of round cells around labial salivary gland in primary SJS but not in secondary SJS. Using monoclonal antibodies to cell surface antigens, lymphocyte subsets in 16 patients with primary SJS and 4 patients with secondary SJS were studied. A predominance of T cells was found and there was no definitive characterization of lymphocyte subset infiltration, between CD4 positive cell and CD8 positive cell. This result was different from the previous reports, and needs further studies.

Humans↗