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Three unusual gangliosides were isolated from frog fat body, and their structures were characterized. The carbohydrate structures were elucidated by determination of the molar ratio of the individual monosaccharides, methylation analysis, galactosidase treatment, and chromium trioxide oxidation studies. The following novel structures were proposed: [Formula: see text].
Brain bovine gangliosides added for 48 hrs. to the culture medium at concentrations ranging from 5.10(-5) mg/ml to 5.10(-7) mg/ml induced a statistically significant (p less than .005 to p less than 000,5) increase of the number of neurites of the outgrowth zone of guinea-pig spinal ganglia. On the contrary, the neurite length was only slightly increased.
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The interaction of myelin basic protein with monosialoganglioside GM1 was investigated. It was found that the emission maximum of the tryptophan of the protein is blue-shifted due to the interaction. In mixtures of the monosialoganglioside with phosphatidylcholine, the myelin basic protein induces phase separation of the lipids as inferred from differential scanning calorimetry experiments.
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Incorporation and metabolism of exogenous GM3 in human myelogenous leukemia HL-60 cells were analyzed using 3H-labeled GM3 ([3H]GM3). [3H]GM3 was rapidly internalized into the cells (trypsin-resistant fraction) 8 times more than the control, 3H-labeled GM1 ([3H]GM1). In addition, not only incorporation but also metabolism of [3H]GM3 was more rapid than [3H]GM1 in HL-60 cells. Moreover, one of the metabolites was found to co-migrate with ceramide in thin-layer chromatography analysis and ceramide formation from exogenous GM3 is more rapid than that from exogenous GM1. These results suggested that there would be some preferential mechanism to produce ceramide from differentiation-inducible GM3 in HL-60 cells rather than from non-inducing GM1.
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