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At least 145 records · Page 8Linked to original sources
PubMed1994

Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene.

Lapidin, a bicyclic sesquiterpene from Ferula linkii Webb, has been evaluated for antinociceptive, anti-inflammatory, and antipyretic activities in mice and rats. Lapidin, vehicle, or the appropriate reference analgesic and anti-inflammatory compounds (acetylsalicylic acid [ASA] and indomethacin) were injected i.p. The more conspicuous effects of lapidin were: 1) a significant protective effect (17-62%; 2.5-20 mg/kg) towards writhings and stretchings induced by acetic acid in mice; 2) a significant antinociceptive effect on jumping responses in the hot-plate test (120 seconds at 15 mg/kg vs. 40 and 85 seconds in vehicle and ASA-treated mice, respectively); 3) a significant dose-dependent (5-15 mg/kg) antinociceptive effect against mechanical noxious stimuli; 4) a dose-dependent anti-inflammatory effect in the carrageenan-induced edema which, at the higher dose (20 mg/kg), was comparable (65% inhibition of paw swelling at 3 hours) to that obtained after indomethacin (10 mg/kg); and 5) a moderate antipyretic effect against yeast-induced hyperthermia. Present results demonstrate that lapidin possesses antinociceptive, anti-inflammatory, and less pronounced antipyretic effects comparable to those of classical non-steroid anti-inflammatory drugs, which make it worthy of further investigations as an antinociceptive and anti-inflammatory drug.

Analgesics↗
PubMedDate not supplied

[Testing CK group preparations in hymenolepiasis in white mice].

The drugs CK-1 and CK-2 are a kerosene milky-stage walnut (Juglans spp.) extract. The drugs CK-3, CK-4, and CK-5 are derived from monkshood (Aconitum) roots, garlic (Allium sativum), and Ferula, respectively. Albino mice were infected with hymenolepiasis by the procedure of B.A. Astafyev et al. (1989). The mice were aged 3 weeks, weighed 7-8 g, and spontaneous invasion-free. The doses of 25 to 100 mg/kg were tested. The antihelminthic effects of the extragent of the drugs--aircraft kerosine purified by the authors' procedure--were additionally examined. The purified aircraft kerosine was found to have moderate antihelminthic effects, but failed to provide 100% antihelminthic activity when given even in very high doses (500 mg/kg or more). The drug CK-1, 100 mg/kg, completely eliminated hymenolepiasis in the experimental animals. Other drugs CK-3, CK-4, and CK-5 used in doses of 100 mg/kg body weight failed to provide 100% antihelminthic efficiency.

Animals↗
PubMed1998

[The effect of antioxidant sodium ferulate on human lymphocytes apoptosis induced by H2O2].

OBJECTIVE: Sodium ferulate is a potent antioxidant purified from ferula assafoetida L. The effect of sodium ferulate on apoptosis of human lymphocytes induced by H2O2 in vitro was studied. METHODS: Apoptosis was detected by light and electron microscopic, DNA electrophoresis and Flow cytometric cell cycle analysis. mitochondrial function was detected by MTT method. BCL-2 and Bax expression was detected by confocal laser scanning microscope. RESULTS: The morphological and biochemical changes characteristic of apoptosis were partially restored after treatment with sodium ferulate, Immunofluorescence assay showed a decrease in BCL-2 and an increase in Bax oncogene proteins in lymphocytes treated with H2O2 and an improvement of cell apoptosis was found after sodium ferulate treatment. CONCLUSION: Oxidative stress can induce apoptosis in lymphocytes, and this induction can be partly prevented by sodium ferulate.

Apoptosis↗
PubMed2002

[Studies on immunocompetent constituents of Patrinia scabra Bunge].

Five compounds were isolated from the roots of Patrinia scabra Bunge separated and purified on sillica gel column chromatography. Their structures were elucidated on the physico-chemical properties and spectral data as lariciresinol(I), syringaresinol(II), scopoletin(III), quercetin(IV), ferulaic acid(V). All compounds were obtained from P. scabra for the first time. In vitro biological test of these compounds showed that syringaresinol was able to stimulate T and B lymphocyte proliferation.

B-Lymphocytes↗
PubMed2003

[Use of Ancient texts in modern therapeutic research].

Two main purposes were assigned to this study of medicinal prescription of spices at the time of the Roman Empire: analyze Roman pharmacopoeia of spices in reference to modern criteria and assess a new discipline, close to "ethno-botany" and "ethno-pharmacology", aiming to a new approach of drug research: "archeopharmacology". A brief overview is given of the Roman world of spices : all aromatic substances from Orient, India and Far-East held a major place which can only be compared to the role of petroleum in our modern times. The study is conducted on a thesaurus of 2600 quotations from twelve authors: Apicius, Caelius Aurelianus, Cassius Felix, Celsus, Dioscorides, Galen, Marcellus,(Anonymous) Mulonmedicina, Pelagorius, Pliny the Elder, Serenus Sammonicus and Scribonius Largus and a set of 33 medicinal spices among which: cyperus, ferulas (Asa foetida), frankincense, pepper, myrrh and saffron. Medicinal use of spices (mainly for pneumology, dermatology and gastroenterology) do not differ notably from the rest of Roman pharmacopoeia: the main criteria for prescription of spices is not their place of origin but a "therapeutic profile" which is clearly assigned to each substance by tradition. During the last decades, new methods of therapeutic research: ethno-botany and ethno-pharmacology have been used extensively to explore traditional medicines. A new discipline is ready to emerge: "archeo-pharmacology", aiming towards a drug research based on Ancient texts.

Archaeology↗
PubMed1993

[The sesquiterpene lactone "azerin" has memory enhancing properties].

The memory property of Sesquiterpene Lactone Azerin, isolated from the plant species Ferula compared with placebo (PCO) and clinical well known drug Nootropyl/Piracetam (NOO) were studied on rats. The experiments showed that Azerin in 7-8 times improved the ability of rats to keep the signs of Passive Avoidance Response (PAR), when NOO only in 3-4 times. The learning and transcorneally amnesic electro-shock leaded to 100% PCO, 63% NOO and only 20% Azerin rats retrograde amnesia syndrome. Thus, the mechanisms of amnestic and antiamnestic properties of Azerin have been studied.

Amnesia↗
PubMed1989

Mycoflora of anise and fennel seeds in Egypt.

Using four medium types (glucose-, cellulose-, 50% sucrose- and 10% NaCl-Czapek's agar), it was possible to isolate 15 fungal genera, 78 species and 6 varieties. The collective fungal spectrum varied from one medium to another where the highest number of species (57 species/1000 seeds) was obtained on glucose- and the lowest (31 species/1000 seeds) on 10% NaCl-Czapek's agar. Aspergillus, Penicillium, and sometimes Rhizopus and Chaetomium were the most common genera on the different medium types. The most common fungal species especially on glucose- and cellulose-Czapek's agar were, Aspergillus niger, A. flavus, A. ochraceus, A. fumigatus, A. flavus var. columnaris, Penicillium chrysogenum, Rhizopus stolonifer and Chaetomium globosum. Members of A. glaucus group were more frequently recovered on 10% NaCl- and 50% sucrose-Czapek's agar.

Agar↗
PubMed2001

Contact and fumigant activities of constituents of Foeniculum vulgare fruit against three coleopteran stored-product insects.

The insecticidal activities of materials derived from the fruit of fennel, Foeniculum vulgare, against adults of Sitophilus oryzae, Callosobruchus chinensis and Lasioderma serricorne were examined using direct contact application and fumigation methods. The biologically active constituents of the Foeniculum fruits were characterized as the phenylpropenes (E)-anethole and estragole, and the monoterpene (+)-fenchone, by spectroscopic analysis. Responses varied with insect species, compound, dose and exposure time. In a filter paper diffusion test, estragole at 0.168 mg cm-2 caused 91% mortality to S oryzae adults within 1 day after treatment (DAT), whereas (+)-fenchone and (E)-anethole gave over 90% mortality at 2 and 4 DAT, respectively. Against C chinensis adults, all test compounds revealed potent insecticidal activities at 0.021 mg cm-2 at 2 DAT. Against L serricorne adults at 0.105 mg cm-2, (E)-anethole gave 100% mortality at 1 DAT, whereas 90 and 60% mortality at 4 DAT was achieved with estragole and (+)-fenchone, respectively. In a fumigation test, the compounds were much more effective against adults of S oryzae, C chinensis and L serricorne in closed cups than in open ones, indicating that the insecticidal activity of test compounds was largely attributable to fumigant action. As naturally occurring insect-control agents, the F vulgare fruit-derived materials described could be useful for managing field populations of S oryzae, C chinensis and L serricorne.

Allylbenzene Derivatives↗
PubMed1990

Tumour reducing and anticarcinogenic activity of selected spices.

Tumour reducing activity of extracts of eight commonly used spices in India were studied in mice transplanted intraperitoneally with Ehrlich ascites tumour. Oral administration of extracts of black pepper, asafoetida, pippali and garlic could increase the percentage of life span in these mice by 64.7%, 52.9%, 47% and 41.1%, respectively. However intraperitoneal administration of spice extracts did not produce any significant reduction in tumour growth except for sesame (38.8%). Garlic extract and asafoetida extracts also inhibited two stage chemical carcinogenesis induced by 7,12 dimethyl benzanthracene and croton oil on mice skin with significant reduction in papiloma formation. These results indicate the potential use of spices as anti-cancer agents as well as anti-tumour promoters.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1992

The application of 3D chemical shift microscopy to noninvasive histochemistry.

Three-dimensional chemical shift imaging methods offer significant advantages over two-dimensional (chemical shift selective) techniques for the study of biological samples which exhibit complex spectra. We have applied 3D-CSI methods to the study of a plant system, (dried fennel mericarps) previously studied by 2D-CSI techniques, obtaining images with in-plane resolution down to 30 microns and special resolution of 0.4 ppm. A modification of the 3D-CSI technique which incorporates water suppression by a combination of pre-saturation and selective excitation is also described and its performance evaluated on both a phantom and a fresh fennel sample.

Ferula↗
PubMed1998

Chemical structure of two phytotoxic exopolysaccharides produced by Phomopsis foeniculi.

The two main exocellular polysaccharides produced in vitro by Phomopsis foeniculi, a fungal pathogen of fennel, were isolated and characterized by chemical and spectroscopic methods as a galactan with the known structure [-->6)-beta-D-Galf-(1-->5)-beta-D- Galf-(1-->5)-beta-D-Galf-(1-->]n and a mannan. The latter consists of a backbone of alpha-(1-->6)-linked mannopyranose units. Almost all of these are branched at the 2 position with arms containing 2- and 3-linked mannopyranose units. The crude polysaccharide fraction and its components, galactan and mannan, showed phytotoxic effects, i.e. chlorosis, necrosis and/or wilting, on fennel and on two non-host plants, tobacco and tomato.

Ascomycota↗
PubMed2000

Constituents of aromatic plants: II. Estragole.

Estragole (ES) is a natural constituent of a number of plants (e.g. tarragon, sweet basil and sweet fennel) and their essential oils have been widely used in foodstuffs as flavouring agents. Several studies with oral, i.p. or s.c. administration to CD-1 and B6C3F1 mice have shown the carcinogenicity of ES. The 1-hydroxy metabolites are stronger hepatocarcinogens than the parent compound. Controversial results are reported for the mutagenicity of ES. However, the formation of hepatic DNA adducts in vivo and in vitro by metabolites of ES has been demonstrated.

Allylbenzene Derivatives↗