[Potentialities of fluorine-19 and phosphorus-31 NMR for studying the metabolism and pharmacokinetics of fluorinated or phosphoric antineoplastic agents].
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A series of new 1-dialkylaminoacetyl-5/6-fluoroindole-2,3-diones and 3-arylhydrazino-5/6-fluoro-1-morpholinomethylindol-2-ones have been synthesized; the former by the reaction of different secondary amines with N-chloro-acetyl-5/6-fluoroindole-2,3-diones and the latter, by the condensation of substituted phenylhydrazines with 5/6-fluoro-1-morpholinomethylindole-2,3-diones. All synthesized compounds have been characterized by their IR, 1H-NMR and elemental analysis. These compounds have been screened for their antibacterial activity against the Gram positive bacterium Staphylococcus albus and the Gram negative bacterium Escherichia coli.