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PubMedDate not supplied

Individual fertility rate: a new individual fertility measure for small populations.

Fertility measurement in small preindustrial societies is hampered by small numbers and the lack of some essential data. Most measures of fertility are collective and require large enough populations to permit grouped data analysis. Existing individual measures of fertility are often unsatisfactory. This paper presents a new measure of individual fertility, the Individual Fertility Rate (IFR), which is constructed by dividing parity by reproductive span in years and multiplying the product by 100. The result is a number which may be used as a dependent individual or cumulative variable to study the effects of health and socioeconomic factors on fertility.

Adult↗
PubMed2006

Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple.

BACKGROUND: Thiols are scavengers of reactive oxygen species (ROS). We aim to investigate associations between thiols in various fluids in (sub)fertile couples and fertility outcome parameters. METHODS: In 156 couples undergoing assisted reproduction techniques (ART), we measured the concentrations of glutathione (GSH), cysteine (Cys), homocysteine (Hcy) and cysteinylglycine (CGS) and fertility outcome parameters in the ejaculate, purified spermatozoa and follicular fluid. RESULTS: All thiols were detectable in most ejaculates, spermatozoa and follicular fluids, of which Cys concentrations were highest. Thiol concentrations in the ejaculate were similar in fertile and subfertile men. However, Hcy in follicular fluid was higher in women with endometriosis compared with women in the idiopathic subfertile group (P=0.04). The GSH, Cys, Hcy and CGS concentrations in spermatozoa of subfertile men were significantly higher compared with men in the idiopathic subfertile group and fertile men (P<0.001). Most notably, Hcy concentrations in both the ejaculate and follicular fluid were negatively associated with embryo quality on culture day 3 in the IVF/ICSI procedure. CONCLUSIONS: Spermatozoa of subfertile men contain significantly higher thiol concentrations as compared with those of fertile men. The detrimental effect on embryo quality of a high Hcy concentration in the ejaculate and in follicular fluid is intriguing and may suggest that Hcy is inversely associated with fertility outcome.

Adult↗
PubMed2004

Impact of child mortality and fertility preferences on fertility status in rural Ethiopia.

OBJECTIVES: To determine the effects of child mortality and fertility preference on fertility status in rural Ethiopia. DESIGN: Case-referent where the cases were women with number of children ever born alive was less than five and controls were women with number of children ever born alive greater or equal to five. SETTING: Butajira rural health project study base which is a field epidemiologic laboratory found 35 Kms south of the capital city of Ethiopia, Addis Ababa run by the Department of Community Health of Tikur Anbessa Medical Faculty. MAIN OUTCOME MEASURES: Fertility status measured by number of children ever born alive; death of a child or an infant is a predictor. SUBJECTS: A total of 219 women with number of children ever born alive less than five and 899 women with number of children ever born alive greater or equal to five were included in the study. RESULTS: Child mortality affected number of children ever born alive significantly (OR= 7.39, 95% CI: 4.62, 9.08). As the number of children died increased proportionally, there is a proportional increase in the risk of higher fertility (X2 for trend 4.92, d.f =4, p-value 0.02). Number of children desired before marriage, desire for more children and sex preference were not associated with increased fertility in this study. Of all the socio-demographic and reproductive variables, later age at first marriage and first birth showed lower number of children ever born alive with (OR= 1.82, 95 % CI: 1.24, 2.83) and (OR= 3.08, 95 % CI: 2.03, 4.68) respectively. Breast-feeding duration of more than six months showed association with less number of children ever born alive (OR= 1.92, 95% CI: 1.30,2.80). CONCLUSION: The study finding implies high fertility status is strongly associated with child death and hence measures that curb child mortality are believed to decrease fertility status besides promoting child survival.

Adult↗
PubMed1978

Age, biological factors, and socioeconomic determinants of fertility: a new measure of cumulative fertility for use in the empirical analysis of family size.

To influence the number of children ever born to a woman, socioeconomic variables must operate through behavioral and biological mechanisms such as the age at marriage, the level of fertility in the absence of deliberate fertility control, and the level of control exerted to reduce fertility within marriage. In this paper, we propose a new measure of cumulative fertility which is standardized for the age-fecundity relationship and for exposure to the risk of conception associated with duration of marriage. A simple model of fertility behavior which incorporates some of the mechanisms through which socioeconomic factors may affect fertility is developed and applied to data from the United States to demonstrate the properties of alternative measures of family size. The results indicate that use of the new measure allows more precise estimates of socioeconomic fertility relationships than would be obtained with children ever born or by sample stratification.

Adult↗
PubMed2003

Fertility assurance through extrapair fertilizations and male paternity defense.

Extrapair paternity has been observed in many formally monogamous species. Male pursuit of extrapair fertilizations is explained by the advantages of having offspring that receive essential paternal care from other males. Since females are capable of exercising a degree of control over the post-copulatory sperm competition, extrapair paternity cannot persist unless it confers fitness benefits on cuckolding females. Thus, extrapair paternity involves cooperation between mated females and extrapair males. On the other hand, paired males frequently exhibit strategies that minimize their loss of paternity and/or conserve paternal investment if paternity is lost. Hence, extrapair attributes of diverse species and populations reported in the literature are particular solutions of evolutionary games involving gender-specific cuckolding/anti-cuckolding strategies. Here we use methods of evolutionary game theory to study the role of male paternity guarding strategies in situations where females seek extrapair fertilizations for reasons of genetic compatibility and/or in pursuit of genetic diversity for their offspring. Our results indicate that in these circumstances pursuit of extrapair fertilizations is the only evolutionary stable female strategy. Males, on the other hand, have two, mutually exclusive, evolutionary stable strategies: full time pursuit of extrapair fertilizations and a compromise strategy wherein they protect in-pair paternity during their mate's fertile periods and pursue extrapair paternity the rest of the time. The relative merits of these two strategies are determined by the efficiency of male in-pair paternity defense, breeding synchrony, fitness advantages of extrapair over in-pair offspring, and the intensity of competition for extrapair fertilizations from floater males.

Animals↗
PubMed1987

The fertilization antigen (FA-1) causes a reduction of fertility in actively immunized female rabbits.

Female rabbits were actively immunized against the fertilization antigen (FA-1) isolated from lithium diiodosalicylate (LIS)-solubilized murine testis. Three trials were performed in order to check the effect of immunization on fertility. In all of these trials, there was a significant (P less than 0.001) reduction of fertility as determined by the percentage of 9-day implants/corpora lutea ratio (FA-1, 0-26.3%; adjuvant control, 79.4-100%). A complete block was observed in animals which received intravenous booster immunization with the antigen. Antisera collected from FA-1-immunized rabbits were negative in the agglutination and the immobilization techniques, and demonstrated modal titers of greater than or equal to 1:2560 in the enzyme linked immunosorbent assay (ELISA) using FA-1. Antisera were tissue-specific and showed binding to the specific protein bands of 47,000 and 23,000 Mr, dimeric and monomeric forms of FA-1, respectively, in the Western blot procedure. Ova collected from rabbits inseminated with sperm which had been treated with antiserum from immunized rabbits showed reduced fertilization rates (anti-FA-1, 3.9-27.7%; control rabbit serum, 87.8%). There was again a reduction in percentage of the 9-day implants/corpora lutea ratio in the rabbits inseminated with treated sperm (anti-FA-1, 10.7%; control rabbit serum, 72.7%). It is concluded that active immunization with FA-1 resulted in a tissue-specific immune response which caused a reduction of fertility in rabbits, by a mechanism(s) involving an inhibition of the fertilization process.

Animals↗
PubMed1995

The effect of pentoxifylline on sperm motility, oocyte fertilization, embryo quality, and pregnancy outcome in an in vitro fertilization program.

OBJECTIVE: To study the effect of pentoxifylline on sperm motility, oocyte fertilization, embryo cleavage, and quality as well as pregnancy outcome on asthenospermic patients participating in an IVF program. DESIGN: Prospective randomized study. SETTING: Private IVF unit. PATIENTS: Ninety-seven couples, 24 of whom were repeating IVF. Two semen specimens were obtained from each patient and each specimen was divided equally into two parts, nontreated (control semen) and pentoxifylline-treated (treated semen). MAIN OUTCOME MEASURE: Sperm progressive motility, oocyte fertilization. RESULTS: Overall and progressive motility did not differ significantly between the two semen specimens. There was a significant increase in the progressive motality of the pentoxifylline-treated semen compared with control semen. No significant difference was noticed between control and treated semen in fertilization rate, cleavage rate, embryo quality, and pregnancy rate. The percentage of patients who fertilized only with control semen (9.3%) was not significantly different from that of patients who fertilized only with treated semen (10.3%). Couples who were repeating IVF did not show significant difference in fertilization between the present study and previous attempts. CONCLUSION: Our results showed that although the sperm progressive motility is improved after pentoxifylline treatment, it is doubtful whether this effect is of any clinical significance.

Cleavage Stage, Ovum↗
PubMed1995

The correlation between follicular measurements, oocyte morphology, and fertilization rates in an in vitro fertilization program.

OBJECTIVE: To explore the relationship between follicle size and the morphology of the oocyte-cumulus-corona complex with fertilization rates in stimulated cycles of IVF. DESIGN: Retrospective comparison of measurements and observations of 2,429 oocytes from 215 patients undergoing 324 stimulated IVF cycles. SETTING: A large hospital-based IVF program. MAIN OUTCOME MEASURES: Individual follicles were measured by ultrasound before transvaginal aspiration and the size was recorded. The oocyte-cumulus-corona complex from each follicle was examined and classified. The oocytes were checked for evidence of fertilization 17 to 22 hours after insemination. RESULTS: The fertilization rate of all oocytes regardless of morphological type revealed a positive linear correlation with increasing follicle diameter. The fertilization rates of type I oocytes was marginally higher than type II oocytes, controlling for follicle diameter; however, this difference did not achieve statistical significance. Oocytes from follicles with a mean diameter > or = 16 mm had significantly higher fertilization rates than did oocytes from follicles with a mean diameter < or = 14 mm. CONCLUSIONS: Follicle size is a better predictor of fertilization than is morphological characterization of the oocyte-cumulus-corona complex in IVF.

Female↗
PubMed1999

Comparison between intracytoplasmic sperm injection and in-vitro fertilization (IVF) with high insemination concentration after total fertilization failure in a previous IVF attempt.

The aim of this prospective study was to evaluate whether couples with total fertilization failure in a previous in-vitro fertilization (IVF) attempt should be offered an additional IVF treatment with elevated insemination concentration or should be treated with intracytoplasmic sperm injection (ICSI). In 23 cycles 228 sibling metaphase II (MII) oocytes were randomly divided: 143 and 85 oocytes were utilized for ICSI and IVF respectively. Of the 143 injected (ICSI) oocytes, 90 (62.9%) were normally fertilized (two pronuclei), whereas 21 (14.7%) oocytes were damaged by the ICSI procedure. Of the fertilized oocytes 72 (80%) developed into transferable embryos. No fertilization at all was observed in the 85 sibling MII oocytes which were inseminated (P < 0.001). In all 23 cycles at least one embryo, obtained by ICSI, could be replaced. Eight pregnancies were achieved of which six resulted in the delivery of nine healthy children. In conclusion, for couples with no or almost no fertilization of oocytes in previous IVF attempts, ICSI appeared to be far superior to an additional IVF attempt with further elevated insemination concentrations.

Adult↗
PubMed2004

Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report.

The aim of this study was to compare the sperm protein expression profile (proteome map) from a patient who experienced failed fertilization at IVF with fertile controls. One patient and three fertile donor sperm samples were characterized using two-dimensional electrophoresis. Differences in protein expression were established using gel analysis software before attempted protein identification. Gel analysis of the fertile donor proteome maps revealed excellent reproducibility as well as very low intra-donor and inter-donor variability in the presence of protein spots. In the patient samples, we have noted 20 consistent differences in protein expression (six spots missing, three additional spots, four less abundant, seven more abundant) compared with the controls. Two proteins that were more intense in the patient have been conclusively identified as secretory actin-binding protein and outer dense fibre protein 2/2. In conclusion proteome variation between different fertile donors was very low. In contrast, the patient proteome exhibited 20 differences compared with controls, which we believe is an underestimate. These proteins merit further investigation to determine whether failed fertilization at IVF might be caused by abnormalities in their expression. This case report represents a proof of principle that proteomics may be useful to study defects in sperm function.

Case-Control Studies↗
PubMed1996

Cytogenetic and fluorescent in-situ hybridization chromosomal studies on in-vitro fertilized and intracytoplasmic sperm injected 'failed-fertilized' human oocytes.

This study was undertaken to establish baseline data on the chromosomal status of 'failed-fertilized' oocytes derived from in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) procedures. A cytogenetic analysis was undertaken on 162 IVF and 51 ICSI oocytes. In all, 82.1% (133/162) of the IVF and 78.4% (40/51) of the ICSI oocytes had metaphase II (MII) plates, of which 50.4% of the IVF and 47.5% of the ICSI oocytes were analysed further. Chromosomes of the G-group (21-22) were identified with the majority of the anomalies. No overall significant difference in the aneuploidy rate was found for the IVF (37.3%) of ICSI (31.6%) oocytes, or with maternal age. However, chromosome anomalies, e.g. diploidy, fragmented and broken chromatids, single sperm and oocyte chromatids, were found in oocytes from IVF patients aged > 36 years and in the ICSI oocytes throughout the maternal age range (31-38 years). The status of the polar body chromatin indicated that there was no overall significant difference in the maturation of the IVF and ICSI oocytes. Evidence of successful sperm delivery was found in 72.5% (37/51) of the ICSI failed-fertilized oocytes. In this group there was a significant increase in the incidence of premature chromosome condensation: 19.6% (10/51) contained sperm chromosomes, 7.8% (4/51) had swollen sperm heads, and the remaining 45.0% had condensed sperm heads. The presence of both sperm and MII oocyte chromosomes was found in 19.6% (10/51) of the ICSI and 8.6% (14/162) of the IVF failed-fertilized oocytes. Specific fluorescent in-situ hybridization DNA probes were used to re-analyse the chromosomes of karyotyped 'failed-fertilized' IVF oocytes and, for the first time, applied to the karyotyped chromosomes of failed-fertilized ICSI oocytes. The hybridization efficiency was 86-95% for the centromere probe and 100% for probes 21 and 18.

Adult↗
PubMed1995

The role of luteinizing hormone in human follicle development and oocyte fertility: evidence from in-vitro fertilization in a woman with long-standing hypogonadotrophic hypogonadism and using recombinant human follicle stimulating hormone.

To evaluate the relative importance of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in follicular development and oocyte fertility in the human species, the use of recombinant human FSH, human menopausal gonadotrophin (HMG), and very highly purified urinary human FSH (FSH-HP) plus oestradiol valerate for ovarian stimulation and in-vitro fertilization (IVF) were compared in three cycles in a woman with isolated congenital gonadotrophin deficiency who had never been treated with ovarian stimulating agents. The total number of ampoules of gonadotrophins used was lower in the HMG treatment cycle. Ovarian response and IVF outcome in the three treatment cycles were as follows: (i) HMG cycle: normal follicular growth, normal pattern of oestradiol and inhibin through the menstrual cycle, high fertilization rate (93%); (ii) recombinant FSH cycle: normal follicular growth, low oestradiol and abnormal inhibin, finally poor rate of fertilization (28%); (iii) FSH-HP plus oestradiol valerate cycle: normal follicular growth, normal pattern of inhibin and poor fertilization rate (27%). Luteal plasma progesterone concentrations were much higher in the HMG treatment cycle. This case shows that FSH is the only factor required in order to induce follicular growth in the human, although LH or a product derived from its action may assist in order to achieve full follicular maturity and oocytes capable of fertilization. Though oestradiol might have a mediatory role in the process of follicular maturation, our results favour a direct primary role of LH in complete maturation of the follicle.

Adult↗
PubMed2004

[The applied value of rescue intracytoplasmic sperm injection after complete fertilization failure during in vitro fertilization cycles].

OBJECTIVE: To discuss the applied value of rescue intracytoplasmic sperm injection(ICSI) after complete fertilization failure during in vitro fertilization (IVF) cycles. METHODS: After 16-18 h co-culture with sperm, all the unfertilized oocytes with the first polar body were re-fertilized by ICSI. RESULTS: After rescue ICSI, the abnormal fertilization rate was 17.9% and the normal fertilization rate was 42.7%. Twenty-four hours later, the normal cleavage rate of the normal fertilized oocytes was 79.6%. On the day of embryo transfer, the good-quality rate of embryos was 29.7% (22/74). A mean number of 3.4 (54/16) embryos were transferred to the patient during each cycle. Clinical pregnancy was found in 3 cases out of the 16 (18.8%). CONCLUSION: The applied value of rescue ICSI may be correlated with the number and maturity of oocytes on the retrieval day.

Female↗
PubMedDate not supplied

A regression approach to the projection of U.S. fertility based on past fertility data.

The method of fertility projection used by the U.S. Bureau of the Census involves assumptions about the ultimate cohort total fertility rate and the ultimate cohort mean age at childbearing based on recent levels of fertility and women's birth expectations. This paper provides an outline of a general regression approach to fertility projection based on past data which would generate these two ultimate cohort characteristics. The technique is illustrated by using the U.S. single-year age-specific fertility rates up to 1986 for total women and projecting them indefinitely into the future until they become stable for both calendar years and cohorts.

Adolescent↗
PubMedDate not supplied

The contribution of the World Fertility Surveys to an understanding of the relationship between women's work and fertility.

A consistent negative association between women's paid work and fertility in developed countries has emerged from many years of research. Results from research in developing countries are more ambiguous, with as many examples of a positive association as of a negative one. Lack of data comparability has often hampered interpretation of results. The World Fertility Surveys (WFS)--undertaken in 40 developing countries between 1974-81, using a common core questionnaire that included numerous questions on women's work--have created a unique opportunity to evaluate this association in a comparative framework. This article reviews and interprets the major findings on the work-fertility relationship from this and other published research on women's work and fertility, and assesses the data limitations. The article concludes with recommendations for the treatment of women's work in the design of future fertility and family planning surveys.

Adolescent↗
PubMed1991

Treatment of sperm with high-ionic strength medium increases microsurgical fertilization rates of rabbit oocytes fertilized by subzonal placement of sperm.

This study was conducted to investigate the requirement for sperm processing in microsurgical subzonal placement of sperm in rabbit oocytes. Fertilization rates with standard in vitro fertilization and microsurgical subzonal sperm placement were found to be similar (56 and 55%) when sperm treated with high-ionic strength Brackett's defined medium to initiate capacitation were used. Statistically significant reductions in fertilization rates for both standard in vitro fertilization and subzonal placement were noted when twice-washed spermatozoa were used. Initiation of capacitation of spermatozoa results in higher fertilization results even when the zona pellucida is bypassed during fertilization.

Animals↗
PubMed1991

The predictive value of idiopathic failure to fertilize on the first in vitro fertilization attempt.

OBJECTIVE: To investigate the subsequent performance of patients with idiopathic fertilization failure on the first in vitro fertilization (IVF) cycle. DESIGN: A retrospective study of 2,322 consecutive patients undergoing their initial IVF cycle. SETTING: Advanced infertility treatment in an IVF/general infertility clinic. PATIENTS: In 5 years, 94 couples with unexplained failed oocyte fertilization had 270 cycles of treatment. Each couple's performance was tracked through subsequent cycles of treatment. INTERVENTIONS: In vitro fertilization with husband and donor sperm. MAIN OUTCOME MEASURE(S): Investigated retrospectively after 5 years of data collection. RESULTS: Sixty-five couples of the original 94 had a second IVF attempt. Fifty of these successfully fertilized oocytes with husband's sperm and 4 with donor sperm. Nineteen of the 65 couples who continued treatment achieved a pregnancy, and only one couple had continuing fertilization failure. CONCLUSIONS: The prognosis in the study group was surprisingly favorable despite the initial failed IVF treatment cycle.

Adult↗
PubMed2002

Fertilization efficiency of in vitro matured oocytes transferred to oviducts of inseminated goats: a model to assess in vivo fertilization performance of goat spermatozoa.

An alternative to conventional in vivo validation of sperm assays might be to assess the fertilization rate of multiple oocytes transferred to the oviducts of inseminated females. Increasing the number of oocytes increases the egg-sperm ratio in the oviduct under an unaltered endocrine milieu, setting the basis for picking up statistical differences between treatments in small populations. The study evaluated the model by transferring oocytes to females inseminated under conditions that are known to modify the fertilization rate in the field. The study then evaluated the use of cattle oocytes to replace goat oocytes for assessing sperm function under this model. In Experiment 1, 12 females were inseminated at estrus with either 100 or 300 million spermatozoa 20 h before transferring homologous oocytes into the oviduct ipsilateral to the ovulation point. In Experiment 2, 10 females were inseminated either once or twice; 10-20 h later, homologous oocytes were transferred into the oviduct ipsilateral to the ovulation point. In Experiment 3, 13 bilateral-ovulated females were inseminated and 20 h later goat and cattle oocytes were transferred to contralateral oviducts. Then, 16-20 h later, oocytes were flushed from the oviduct, cleaned of spermatozoa and stained to assess the fertilization rate. The fertilization rate was improved by increasing sperm numbers at insemination (P < 0.04) and by increasing the number of inseminations (P < 0.02). The results in Experiment 3 showed that fertilization rates were similar for goat and cattle oocyte (P > 0.05) and that fertilization values were highly correlated (r = 0.811, P < 0.001). Results suggest that the model can be used for in vivo validation of in vitro sperm assays by facilitating the expression of statistical differences in small number of animals. In addition, cattle oocytes can be used to replace goat oocytes to study in vivo sperm function in goats.

Animals↗