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PubMedDate not supplied

[Effects of a synthetic carbon-mineral sorbent and antibiotics on the development of combined radiation and thermal injury].

Male Wistar rats exposed to whole-body irradiation, the midline absorbed dose was 7.5 Gy. Full-sickness thermal burn 15% of body surface inflicted immediately after irradiation. Experimental study of the therapeutic efficacy of enterosorption alone or in combination with antibiotics doxycycline and ciprofloxacin performed. The strong decrease of bacterial endotoxemia, toxic oligopeptides' level and general blood toxicity revealed after treatment compared with non-treated animals with combined injuries. Corrections of postirradiation intestinal dysbacteriosis revealed too. The best result observed when carbon mineral sorbent and antibiotics administered daily within the first 10-14 days after combined injury. Survival of treated animals increased up to 80% (all rats of control group died during 30 days after combined injury).

Animals↗
PubMed1997

[Use of trans-tube treatment program in patients with acute intestinal obstruction and peritonitis].

In 92 patients with enteral insufficiency syndrome, an acute ileus (AI) and diffuse peritonitis (DP) the prolonged small intestine decompression, the small intestine lavage with solution analogous to the chyme by electrolyte composition, medicinal decontamination, enterosorption and intraluminal electrophoresis of medicinal preparations was conducted. The pH magnitude and the degree of microbial contamination were determined; the toxicity in the probe contents according to paramecium test coefficient value was estimated. The advantage of transtube treatment over passive decompression of small bowel was proved, the hospitalization period reduced in AI on average by 7.5 days, for DP--by 11 days, mortality--by 13.2% and 22.5% accordingly.

Acute Disease↗
PubMed1998

[The combined treatment of patients with digestive tract diseases by the action of the enterosorbent Enterosgel and of the intravascular laser irradiation of the blood].

Rehabilitative, medical treatment involved a combined use of enterosorption (the drug Enterosgel) and intravascular laser irradiation of blood (ILIB). The results obtained showed the adopted combined mode of treatment (Enterosgel + ILIB) to have a positive effect on the patients' body. The above alternative while eliminating the remainder from the body promotes an increase in the content of large granule-containing lymphocytes, which events result in restoration of those morphology of those leucocytes having undergone degeneration, with crystallization of saliva getting back to normal. Considering the present health-hazard conditions, negative environmental effects on human organism, the above treatment option is indicated not only to patients having disorders of the alimentary canal but also to those presenting with other pathologies, as well as for preventive and health-promoting purposes.

Blood↗
PubMed2005

Chronic toxicological evaluation of dietary NovaSil clay in Sprague-Dawley rats.

NovaSil (NS) clay, a common anti-caking agent in animal feeds, has been shown to sorb aflatoxins in the GI tract and diminish their bioavailability and adverse effects in short-term animal studies. Based on this evidence, it is hypothesized that clay-based enterosorption of aflatoxins may be a useful strategy for the prevention of aflatoxicosis in human populations. However, the potential toxicity of long-term dietary exposure to NS has not been determined. In this research, 5-6-week-old male and female Sprague-Dawley rats were fed rations containing 0, 0.25, 0.5, 1.0, or 2.0% (w/w) levels of NS for 28 weeks. Analysis of the NS showed negligible levels of dioxin and furan contaminants. Total feed consumption, cumulative feed consumption, body weight, total body weight gain, feed conversion efficiency, cumulative feed conversion efficiency, and relative organ weights were unaffected in either sex at the doses tested. No NS-dependent differences in relative organ weights or gross or histopathological changes were observed. Analysis of hematological parameters, clinical chemistry, and selected vitamin and mineral levels revealed isolated significant differences between some treatments and control groups (mean corpuscular hemoglobin, serum Ca, serum vitamin A, and serum Fe). However, the differences observed in each case were not dose-dependent. These results suggest that dietary inclusion of NS at levels as high as 2.0% (w/w) does not result in overt toxicity. These findings (as well as others) support the use of NS clay for dietary intervention studies in human populations at high risk for aflatoxicosis.

Absorption↗
PubMed1975

Use of the K88 antigen for in vivo bacterial competition with porcine strains of enteropathogenic Escherichia coli.

Infant mice were used to measure the amount of fluid accumulation (enterosorption) in the intestinal tract after oral inoculation of a porcine strain of enteropathogenic Escherichia coli (K88-+, Ent-+). Significant reduction in the amount of fluid found in the intestinal tract was observed if the mice were first inoculated with a K88-possessing, non-enterotoxigenic strain of E. coli. The protection provided is thought to be due to specific competition for attachment sites on cells of the small intestine.

Agglutination Tests↗
PubMed1982

Effects of indomethacin, acetazolamide, ethacrynate sodium, and atropine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum.

Intraluminal perfusion of pig jejunum with Escherichia coli heat-stable enterotoxin reversed net absorption of water and electrolytes to net secretion. Addition of atropine (2 x 10(-5)M) to the perfusate reduced the secretory response to enterotoxin and enhanced sodium and chloride absorption in control segments. Indomethacin (1.4 x 10(-3)M), acetazolamide (2.2 x 10(-3)M), or ethacrynate sodium (3.1 x 10(-4)M) had no effect. Mucosal disaccharidase activity and Na-K-ATPase activity were not altered by enterotoxin. The results suggest that blockade of cholinergically mediated secretion in the small intestine attenuates the enterosorptive effects of heat-stable enterotoxin and may be useful therapeutically in the management of secretory diarrhea.

Acetazolamide↗
PubMed1987

Complex sorption therapy of locomotor system traumatic suppurative complications.

Complex sorption therapy efficacy in treating 271 patients with suppurative complications of extremity traumas is analyzed. All patients underwent 1-3 enterosorption courses, the wounds were treated with application of sorbents against the background of traditional therapy. In the event of aggravating intoxication, developing first symptoms of sepsic condition, or the desease chronic course 1-5 hemosorption sessions were performed. Clinical and laboratory-instrumental examination demonstrated positive effect of the complex of sorption methods on the patient' general state, temperature curve dynamics, blood indices, microcirculation, function of liver, kidneys, and immune system status. Pathogenic flora stability decreased, wound cleaning and healing was 1.5 times faster. The total therapeutic period was 28% shorter compared to the control group of patients, treated without sorption methods.

Administration, Oral↗
PubMed1989

Bunched and dispersed carbon fiber adsorbents for dextoxication.

"Actilen" and "Vaulen" carbon fiber adsorbents in bunched, stapled and dispersed form for haemosorption, topical application and enterosorption have been developed. The sorbents possess homogeneously porous structure and chemically active surface which may be controlled in the process of material synthesis. Fiberous sorbents have stood toxicological trials and are now approved for clinical application. "Vaulen" enterosorbent developed by Leningrad Institute of Man-made Fibers and Composite Materials, Institute of General and Inorganic Chemistry of White Russian Academy of Sciences, Military Medical Academy and White Russian Scientific Research Sanitary Institute is recommended by the Pharmacological Committee of Soviet Ministry of Public Health to be ready for clinical application. Actilen carbon fiber adsorbent for haemosorption and topical application therapy was awarded a gold medal at the 1984 Leipzig Fair.

Adsorption↗
PubMed1989

Comparative evaluation of the structure and properties of certain granulated and fibrous activated carboniferous sorbents.

This paper presents the results of the comparative evaluation of the structure and sorption properties of fibrous (AYBM- -MH) and granulated (CKH-IK) carboniferous sorbents. The structure of sorbents was investigated using scanning electron microscopy (SEM) and electron paramagnetic resonance (EPR), while the sorption properties were studied through application of adsorption-desorption of markers (medinal, creatinine, uric acid, vitamin B12). Carbon fiber sorbents have been found to possess more favorable characteristics of the sorptive capacity and a better porous structure. The EPR spectrum of a fibrous sorbent contains the signal in the form of a solitary line with a g-factor of 2.0025 +/- 0.0003, while the granulated sorbent has no signal. Such properties of fibrous sorbents as nontoxicity, biological compatibility, variety of textile patterns, elasticity, strength, etc. promote their application in capacity of versatile, high-quality medical materials. Due to their compatibility with blood cells and body tissue, spherical sorbents found extensive application in the clinical practice (1,2). However, considering the potential application of sorbents in modern medicine (hemosorption, enterosorption, application therapy) it is important that sorbents with improved sorption, kinetic and other operational characteristics be developed. The results presented demonstrate properties of granulated and fibrous sorbents produced using different technologies and source materials. Also indicated are the differences related to the pattern of sorbents.

Adsorption↗
PubMed1999

[The characteristics of the pathogenesis, course and treatment of psoriasis in younger and older patients].

A clinical and laboratory examination was carried out in two groups of patients with psoriasis who ranged from 20 to 30 years old (n = 20), aged 50 and older (n = 30). Associated pathology of the cardiovascular system was recordable in 32, digestive abnormalities--in 19 of the 50 patients. In the elderly patient group, disorders occurred 6 and 3 times as frequently as in the young group: blood count showed lowering of the level of hemoglobin, leucocytosis, eosinophilia, lymphocytosis, rise in the level of bilirubin, decrement in the phagocytic potential of neutrophiles as per averaged cytochemical coefficient, with defence reactivity (decreased level of T- and B-lymphocytes, increased CIC) being depressed. Bearing the findings obtained in mind, there has been instituted antiinflammatory, hyposensitizing, immunomodulating, vitamin, antioxidant, enterosorption complex therapy with making use of ultraviolet zonal irradiation and balneoprocedures together with ointments for external use. 20 elderly patients in addition to the above therapy treatment, were prescribed phenihidin, 0.01 gr on a three-times daily schedule, sublingual, and cholenzim per os, 0.3 gr. twice a day. There was significant improvement in this subgroup of patients on all the items of the test they had been exposed to.

Adult↗
PubMed1999

[The quantum and efferent correction of the gastroenterological disorders in patients with chronic glomerulonephritis].

The article is dedicated toward examining the problem of treatment of gastroenterological disturbances in patients with chronic glomerulonephritis (ChGN). A positive clinical and endoscopical effect was higher in those groups in which the combined treatment involved the quantum methods (such as informationwave and microwave resonance therapy) as compared to the group having received drug therapy only. The results secured suggest that methods of quantum therapy may be used in combination with efferent therapy (programme hemodialysis, enterosorption) in ChGN patients. A multimodality treatment has a detoxicating and a sanogenic effects, improves the functional condition of the alimentary canal and kidneys.

Adolescent↗
PubMed1993

[In Process Citation]

Prolonged decompression of the small intestine was used in the complex surgical treatment of 85 patients with acute ileus (67) and peritonitis (18). The main stage of the operation included liquidation of ileus and elimination of a source of peritonitis. Antegrade nasogastral intubation of the intestine was performed in 54 patients, via gastrostomy--in 3, retrograde intubation via cecostomy--in 15, via appendicostomy--in 4, via ileostomy--in 9. Performance of active transtubal sanation of the intestine by means of antiseptic solutions (53 cases) in combination with enterosorption (17) contributed to essential increase in the effectiveness of treatment.

Journal Article↗
PubMed1992

[Tactics of the surgical treatment of acute intestinal obstruction].

The results of treatment of 184 patients with acute ileus of non-tumour genesis operated on at the clinic within the period of from 1981 to 1990 are presented. In elimination of ileus without the surgical intervention, together with intensive therapy, intestinal decompression was used. Of 19 patients with acute ileus associated with peritonitis operated on, 12 underwent resection of the intestine. The use of enterosorption as well as extracorporeal hemosorption contributed to elimination of endogenous intoxication.

Acute Disease↗
PubMedDate not supplied

[The correction of the humoral and hemodynamic disorders in patients with urolithiasis complicated by chronic kidney failure].

The paper presents the analysis of 52 cases of urolithiasis complicated by chronic renal failure in the intermittent stage. The patients were examined for renal blood flow, central hemodynamics, myocardial function, factors of humoral regulation of the circulation kallikrein-kinin, sympathoadrenal systems, renin activity, renal function. The test were performed preoperatively and 1, 3, 7, 14 days after surgery. The patients entered two groups. 24 patients of group I received routine symptomatic treatment, 28 patients of group II were treated with regard to the changes revealed and underwent preoperative enterosorption. Group I demonstrated severe shifts in renal and central hemodynamics, reduction of renal circulation, hypokinetic circulatory syndrome, phasic syndrome of myocardial hypodynamics, hypoactivity of kallikrein-kinin and sympathoadrenal systems, hyperactivity of renin. The disturbances aggravated postoperatively and disappeared only on day 14 since the operation. having been corrected by cardiac glycosides, desaggregants, hypotensive drugs diuretics. Group II patients developed increased renal circulation, weak activation of humoral blood regulation factors. Hemodynamic disorders showed no progression. As a results, renal postoperative function improved.

Adult↗
PubMedDate not supplied

[Zeolite-containing tripoli powder in experimental hepatology].

Biological activity of zeolite-containing tripoli powder was studied in rats. Biochemical, enzymatic and lipid peroxidation indices were assessed. The results of the study confirm enterosorption and detoxication activity of the powder.

Animals↗
PubMed2005

[Assessment of efficacy of the drug litovit as a novel pathogenetic modality in acute virus hepatitis].

AIM: To study clinical and laboratory parameters in patients with acute viral hepatitis (AVH) given basic therapy in combination with a novel pathogenetic drug litovit versus ursosan. MATERIAL AND METHODS: 155 patients with AVH were divided into three groups: 70 patients of group 1 received basic therapy plus litovit, 10 patients of group 2--basic therapy plus ursosan, 60 patients of group 3--basic treatment only. RESULTS: Litovit was well tolerated. Side effects were absent. Hospital stay and severity of clinical AVH symptoms were significantly less in patients of group 1. Less pronounced were also hyperbilirubinemia, cytolytic and mesenchymal-inflammatory syndromes. CONCLUSION: Clinical and laboratory parameters in AVH patients treated with adjuvant litovit improve quicker than in those with adjuvant ursosan or basic therapy. Litovit has enterosorptive and hepatoprotective activity. Low cost of vitovit therapy makes the drug applicable in wide practice.

Drug Therapy, Combination↗
PubMed1991

[Hemosorption in the combined treatment of acute 1,2-dichloroethane poisonings].

Carbon hemosorption was carried out in 41 patients suffering of 1,2-dichlorethane intoxication (acute). Complex methods of therapy included also methods of potentiation of natural processes of detoxication, enterosorption, specific antidote treatment with acetylcysteine and vitamin E. Use of hemosorption favoured essential reduction of lethality, decrease of the number of severe complications (exotoxic shock, hepatopathy).

Acute Disease↗