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At least 145 records · Page 8Linked to original sources
PubMed2003

[Ecthyma contagiosum (Orf) as an uncommon differential diagnosis of infections of the hand].

Orf of the hand is considered as an uncommon viral infection which is usually acquired through contact with infected sheep and goats. Indirect infections through contaminated knives or meat have been reported. Many authors feel that the disorder is more common than reported because the disease is often misdiagnosed and the course is usually self-limiting with spontaneous healing within several weeks. Diagnosis is mainly made by patient's history and clinical course. It is important to know the benign nature of human orf, since complications seem to be caused by overtreatment.

Biopsy↗
PubMed2005

Human ORF (ecthyma contagiosum).

Orf is a viral cutaneous infection typically seen on the hands of people involved in sheep and goat farming. We report 31 cases of orf and consider its pathology, characteristic appearance, diagnosis, treatment and complications.

Adolescent↗
PubMed2005

In vitro activity of VEGF-E produced by orf virus strains isolated from classical and severe persistent contagious ecthyma.

Proliferative orf virus infections in adult sheep have increased in Italy in the past few years: these extreme cases are frequently fatal and difficult to differentiate from other infectious diseases of sheep such as blue tongue. A probable explanation for the proliferative and highly vascularized nature of the lesions was found in the expression of the VEGF-E gene encoded by the orf virus. To investigate a possible role of the viral VEGF in the pathogenesis of severe persistent orf virus lesions, the activity of four VEGF-E variants was compared by an angiogenesis in vitro model. Similar angiogenic activity was found between strains isolated from the classical and the proliferative forms of the disease, even if the latter was able to develop a higher number of vessels during the first 24 h of infection. Our in vitro findings seems to exclude that the VEGF variants encoded by the strain isolated from the atypical form of the disease could be the responsible for the histopathological aspect of the proliferative lesions.

Analysis of Variance↗
PubMedDate not supplied

Ecthyma gangrenosum.

Explore the source record for details and available documents.

Acute Disease↗
PubMed1999

Ehrlichia (Cytoecetes) phagocytophila predisposes to severe contagious ecthyma (Orf ) in lambs.

Eight lambs experimentally infected with Ehrlichia (Cytoecetes) phagocytophila 7 days before exposure to orf virus were compared with control lambs infected with orf virus alone. The dually infected animals differed from the controls in showing skin lesions of greater severity, prolonged viral shedding, and lower antibody titres. Infection with E. phagocytophila had no significant effect on virus-specific lymphocyte proliferation. Such proliferation was detected in the peripheral blood of all lambs as early as 7 days after exposure to orf virus.

Animals↗
PubMed2001

[Stay away from surgery: ecthyma contagiosum].

15 patients with Orf's disease were evaluated. Seven out of 15 patients (Group 1) were treated surgically because of different diagnoses. Seven patients who were misdiagnosed and treated surgically (Group 1), and eight patients (Group 2) were followed conservatively. The aim of this study is to compare the treatment period of the misdiagnosed surgically treated (Group 1) group and conservatively treated group (Group 2). Lesions were aggravated and delayed healing was observed in Group 1. Diagnosis of Orf disease may sometimes be difficult because of concominant bacterial superinfections and surgical trauma. Careful history and clinical findings point to the correct diagnosis. Contrary to other infections of the hand, surgery can cause further complications in this disease. Conservative treatment is the gold standard, even in complicated cases.

Adult↗
PubMed2005

Rapid improvement of human orf (ecthyma contagiosum) with topical imiquimod cream: report of four complicated cases.

Orf is a zoonosis caused by an epitheliotropic DNA parapox virus. Human orf is a generally benign, self-limiting condition that usually regresses in 6-8 weeks without specific treatment. However, it may be accompanied by local symptoms including pain, pruritus, lymphangitis and axillary adenitis, or less frequently by systemic symptoms such as fever or malaise. Furthermore, it may be complicated by erythema multiforme, Stevens-Johnson syndrome, erysipelas, generalized mucocutaneous eruption, toxic erythema, eyelid oedema and giant, persistent or recurrent lesions in immunocompromised patients. Imiquimod, a potent topical immune response modifier, enhances both the innate and acquired immunity by stimulation of immune system cells resulting in local antiviral, antitumour and immunoregulatory activity. We present, for the first time, four complicated cases of orf successfully treated by topical imiquimod resulting in rapid regression of both orf and associated lesions. Two of the cases were complicated with erythema multiforme, one with recurrent eyelid oedema, and another had giant orf associated with axillary lymphadenitis. We suggest that topical imiquimod may be an effective and safe therapy for complicated orf cases.

Adjuvants, Immunologic↗