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PubMed1993

Study on hydrophilic properties of gelatin as a clinical wound dressing. I. Hydrophilic properties of gelatin as a wound dressing.

A basic study on hydrophilicity of gelatin was made of the fitness, water-absorbing ability, water-holding ability, affinity and stability of included water in order to utilize it as a protective covering for medical use. Gelatin No. 3, being highly viscous and having a lower jelly strength, was strongly viscous and flexible, and thus, it stuck close to the surface of a lesioned site such as a wound or a burn. Since the melting point of a gelatin containing 50% water was in the range of 43 to 45 degrees C, the gelatin will be fully used as a protective covering for a wound. Below 20% relative humidity, water molecules were bound to the polar amino acid side chains of gelatin and the bound water caused a swelling of the gelatin, which is maintained by capillary sorption of water into its collagen-like four-dimensional structure. The amount of water sorbed at a relative humidity of 80% at 11 degrees C was higher by 50 to 80 mg/g compared to that at 37 degrees C. Gelatin No. 3 had a very high water-holding ability and it was very hard for it to release the sorbed water at a relative humidity of 80 to 90%. Water molecules were bound to the strong active sites of the gelatin at low relative humidity. The gelatin swelled and then, newly active sites appeared on the surface of the gelatin. The hydrophilic activity decreased with an increase in moisture content, whereas the stability of water molecules in the gelatin increased.(ABSTRACT TRUNCATED AT 250 WORDS)

Absorption↗
PubMed1998

[Experimental in vitro evaluation of the absorption capacity and control of exudate of 3 wound healing dressings].

INTRODUCTION: The development of materials based in moist wound healing has meant an important step in wound care. The progressive development of knowledge referred to this issue has showed the importance of the management of wound exudate to obtain an optimal wound healing, which has concluded in a development of dressings orientated to manage exudate. METHODS AND MATERIAL: Experimental "in vitro" study to evaluate the absorption capacity and exudate management of three moist wound healing dressings, Allevyn Adhesive (dressing A), CombiDERM (dressing B) and Tielle (dressing C). For each of this dressings the following parameters have been assessed: rate between the total surface and the absorption surface of the dressing, volume needed to saturate the retention capacity, pH evolution on the absorption surface and macroscopic aspect. RESULTS: Dressing A presents the major value in the rate between the total surface and the absorption surface (with a 64% rate, versus 28.7% for dressing B and 40.5% for dressing C). Dressing B was the one which needed a major quantity of exudate to saturate, with statistical significant differences versus dressings A and C (0.51 ml/cm2 versus 0.40 and 0.37 respectively). Dressing B was also the one that presented a best performance in reference to the leakage of exudate under pressure (with a loss of its initial weight of 8.34%, versus dressing C with a loss of 9.48%, and dressing A with a loss of 24.42%). None of the dressings presented pH modifications in the absorption surface. CONCLUSIONS: The results of this study let us establish that according to the used experimental evaluation methodology and the limitations that have been described in the manuscript, the dressing which presents the best performance in reference to absorption capacity and management of wound exudate is dressing B (CombiDERM) followed by dressing A (Allevyn Adhesive) and dressing C (Tielle). Experimental and clinical research will be required to examine thoroughly the absorption capacity and management of wound exudate of these dressings.

Absorption↗