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At least 145 records · Page 8Linked to original sources
PubMed1992

Transformation of C3H 10T1/2 cells with 4.3 MeV alpha particles at low doses: effects of single and fractionated doses.

Oncogenic transformation of C3H 10T1/2 cells was determined after exposure to graded doses of 4.3-MeV alpha particles LET = 101 keV/microns. The source of alpha particles was 244Cm and the irradiation was done in an irradiation chamber built for the purpose. Graded doses in the range of 0.2 to 300 cGy were studied with special emphasis on the low-dose region, with as many as seven points in the interval up to 10 cGy. The dose-effect relationship was a complex function. Transformation frequency increased with dose up to 2 cGy; it seemed to flatten at doses between 2 and 20 cGy but increased again at higher doses. A total of 21 cGy was delivered in a single dose or in 3 or 10 equal fractions at an interval of 1.5 h. An inverse dose-protraction effect of 1.4 was found with both fractionation schemes. Measurements of the mitotic index of the population immediately before the various fractions revealed a strong effect on the rate of cell division even after very low doses of radiation. Mitotic yield decreased markedly with the total dose delivered, and it was as low as 50% of the control value after 4.2 cGy and 20% after 14 cGy with both fractionation schemes.

Alpha Particles↗
PubMedDate not supplied

[Modification of the process of resorption of alpha-emitting nuclides from the gastrointestinal tract depending upon the properties of administered compounds and the physiological state of rats].

In experiments on rats a study was made of resorption from the gastrointestinal tract of simple salts, complex compounds and "biologically incorporated" forms of transuranium nuclides, the influence of age, pregnancy and chemically active substances (for instance, trivalent iron and ethyl alcohol) on this process.

Age Factors↗
PubMed1977

[Short time afterloading curietherapy of gynecological carcinomas: technique and problems (author's transl)].

A short time remote afterloading curietherapy system for treatment of carcinoma of the cervix using one 50 to 150 Ci 192 Ir source in newly constructed kidney shaped applicators in connection with the Gamma-Med is presented. Computer calculated and plotted symmetric and asymmetric isodoses have been drawn by a plotter, adapted to individual cases. Dosage problems and solutions respecting clinical experiences as well as radiobiological information are discussed. Short time irradiations don't offer radiobiological advantages by themselves. On the other hand, flexibility in modelling absorbed dose distributions, excellent reproducibility of applications and therefore possibility of reliable procedures in higher fractionation, and above all the possibility to avoid hospitalisation or the great majority of patients are a decisive argument in favour of the proposed system, not only from a medical and psychological point of view, but also for economic reasons.

Curium↗