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At least 145 records · Page 8Linked to original sources

Evaluation of video gray-scale display.

Setting up and maintaining video display monitors properly will help to reduce display variation and improve overall presentation of the radiological image. Display monitor gray-scale characteristics were examined using the SMPTE test pattern. This test pattern may be used as a standard for adjusting brightness and contrast. The controls should be adjusted to display the full dynamic range so that the 5% and 95% signal levels in the pattern are visible. Measured luminance on a laboratory workstation used for radiological perceptual experiments, and on the Siemens CT gray-scale monitor was determined to range from 0.17 to 76.0 nit, and 0.17 to 24.66 nit, respectively. These were compared with the range of approximately 17 to 514 nit for a typical film-viewbox combination. Characteristic curves were determined for both monitors, and CRT gammas were 3.34 and 2.48 for the perceptual workstation and CT console, respectively. The display gamma was determined from fitting luminance data to a log-log plot of luminance versus input gray level. The usefulness of the SMPTE test pattern for visual presentation as well as photometric measurement is demonstrated.

Computer Terminals

[Hygienic substantiation of work schedules of senior students according to the type of video terminal].

As result of psychological and physiological studies, scientific substantiation is given to the continuous duration of work with two types of video terminals: an Elektronika 15IE-00-14 display and a "Yamaha MSX-1" personal computer in 9(10)-10(11)--to form pupils at the lessons on the basis of informatics and computers, as well as the minimal and optimal duration of intervals.

Adolescent

Daily monitoring and correction of radiation field placement using a video-based portal imaging system: a pilot study.

We have developed a video-based portal imaging system for radiotherapy localization. The system can acquire high quality portal images automatically using short (1-3 monitor unit) irradiations and immediately display the images. The major advantage of the imaging system is that it can be used routinely to check and correct patient positioning before much of the daily irradiation has been delivered. The portal imaging system has been used in a pilot study to monitor five patients during each of their daily treatments. The study has shown that: (i) image quality is sufficiently high to detect discrepancies in field placement from that prescribed on the simulator film; (ii) discrepancies in field placement occur frequently; and, (iii) routine correction of patient and block positioning can reduce the size of these discrepancies. This is the first time that field placement in radiation therapy has been checked and corrected routinely, before the treatment irradiation. However, limitations in the size of the field of view and in the methods of extracting and presenting the geometric information to the users limits the clinical utility of the imaging system. Solutions to these limitations are currently under development.

Computer Terminals

[Pregnancy in women working on video terminal units].

Only a small proportion of pregnancy failures could be explained by simple genetic or clear--cut environmental/occupational factors. Adverse reproductive outcomes (spontaneous abortion, preterm delivery, low birth weight and congenital malformations), have been reported in a certain number of retrospective studies which were designed to examine the possible role of occupation and working or living conditions and pregnancy outcome. Future prospective projects should assess the (non)existence of the relationship between radiological risks and job stress with pregnancy outcome. Future prospective projects should assess the (non)existence of the relationship between radiological risks and job stress with pregnancy outcome among female video terminal operators.

Abortion, Spontaneous

Construction of parametric model of operator and workstation.

The purpose of development of a parametric model and the construction and formulation of the parametric model are described. To validate the parametric model, the distribution of the difference between the preferred and theoretical seat height settings of a number of office workers was evaluated from the standpoint of the static posture that does not change with time. The results of precise measurements made for an engineering workstation and an operator were also evaluated. Finally, the theoretical seat height settings with dynamic posture were evaluated. The validity of the parametric model was verified under the experimental conditions.

Algorithms

Obstacles encountered in the development of the low vision enhancement system.

The Johns Hopkins Wilmer Eye Institute and the NASA Stennis Space Center are collaborating on the development of a new high technology low vision aid called the Low Vision Enhancement System (LVES). The LVES consists of a binocular head-mounted video display system, video cameras mounted on the head-mounted display, and real-time video image processing in a system package that is battery powered and portable. Through a phased development approach, several generations of the LVES can be made available to the patient in a timely fashion. This paper describes the LVES project with major emphasis on technical problems encountered or anticipated during the development process.

Audiovisual Aids

On-line computer processing of pressure data from cardiac catheterizations.

A flexible program system for on-line analysis of pressure data from cardiac catheterizations is described. The programs are implemented on an IBM 1800 computer, equipped with remote oscilloscope/keyboard terminals. The current computer system can handle any combination of up to 4 pressure signals. During catheterization, measurement specifications (i.e. calibration levels or sites of pressure recordings) are entered via the keyboard immediately before each recording. As an option the whole expected measurement sequence may be stored on disk before the catheterization starts. This method will minimize the necessary interaction with the computer when the same catheterization procedure is used on several occasions. Changes from the predetermined scheme may, however, be undertaken before each recording to meet with unexpected events that may arise during the catheterization. After computer detection of calibration levels, the recorded signals are digitized during 20 seconds and analysed beat-by-beat. Calculated values are averaged and presented on the terminal oscilloscope in tabular and/or graphic form. The waveform analysis performed by the program system is validated in a statistical comparison between manually and automatically computed values.

Cardiac Catheterization

Catalog card production with a programmable terminal.

Application of a programmable terminal and printer to the cataloging task of a small medical library is described. The application is independent of a computer; the terminal is used in "local" mode only. Full sets of catalog cards are produced, following a single typing of descriptive cataloging data and tracings. Books can be cataloged the same day they are received. Actual cost per book is just over a dollar, for equipment rental, card stock, and the cataloger's time at the console, after call number, tracings, and main entry for the book have been determined.

Catalogs, Library

Conformational analysis of the cholecystokinin C-terminal octapeptide: a nuclear magnetic resonance and computer-simulation approach.

The C-terminal octapeptide portion of cholecystokinin (CCK8) has well-defined biological properties which include action as a neurotransmitter and induction of gall-bladder contraction and pancreatic enzyme secretion. Many analogues of CCK8 have been prepared and tested for potency, making this an ideal model system in which to initiate evaluation of structure-function relationships. The present study uses high-resolution proton nuclear magnetic resonance (NMR) spectroscopy and energy minimization techniques to evaluate the solution (DMSO) and in vacuo conformation(s) of CCK8. The NMR results provide amide and C alpha H alpha chemical shift temperature dependencies and all phi dihedral angles and chi 1 rotamer populations. The energy minimization data located deep potential energy wells, for which all torsion angles are reported. Collectively, the data support models for CCK8 where the structures are characterized by a high degree of folding. These conformations are characterized by sharp turns, possibly stabilized by hydrogen-bonds. Taken together with pharmacologic data and somewhat similar folded structures implied from fragments of CCK8, it is suggested that both electrostatic and steric effects are needed for full biological potency.

Computer Simulation

Computer study of presynaptic inhibition controlling the spread of action potentials into axonal terminals.

1. The effect of presynaptic, axoaxonal inhibition, that exerts its action by producing a local conductance increase, on the behavior of action potentials at postsynaptic axon terminals is analyzed computationally. The significance of the location and strength of the presynaptic inhibition, as well as the morphology and membrane properties of the axonal terminals, are considered. 2. Keeping the specific properties of terminal membrane and axoplasm constant, the critical "silent" steady-state conductance change (gcrit) that blocks propagation is linearly scaled with the terminal diameter raised to the 3/2 power. At the midpoint of a 5 lambda long, 1 micron diameter axon that has the standard Hodgkin and Huxley (1952) kinetics at 18 degrees C (and an input conductance of 8.7 nS), gcrit is 72 nS. At 0 degrees C, gcrit = 200 nS, whereas at 30 degrees C gcrit = 30 nS. 3. The critical conductance change that blocks propagation depends steeply on the density of excitable channels (gNa) at the terminal. For a geometrically uniform terminal at 18 degrees C, the action potential can not be blocked by a local shunt when gNa greater than 600 mS/cm2. 4. An axoaxonal synapse in the proximity of the postsynaptic release site has graded control over the spike amplitude (and, therefore, over the postsynaptic output) at that site. Presynaptic inhibition located remotely from the release site has an all-or-none effect at the release site. 5. Inhibition is more effective in attenuating the spike at the terminal when it impinges onto a passive terminal rather than on an excitable one. 6. The detectability of the conductance increase as well as the change in action potential amplitude associated with the presynaptic inhibition is poor at only a short distance from the axoaxonal synapse. The presence of bottlenecks and varicosities at some axonal terminals enhances this decoupling effect even more. Thus presynaptic inhibition may reduce the potential near the output site of the affected axon significantly, without producing any noticeable conductance or voltage change at a distance of only several tens of micrometers (a few tenths of a space constant) away from it. 7. Varicosities and bottlenecks typically found along axonal terminals are the optimal loci for presynaptic inhibition to be most effective in attenuating the action potential at the terminal. Even with high density of excitable channels, propagation with such terminal geometry is insecure, and one, or few, quanta of inhibitory transmitter (a conductance change of several nanosiemens) can block propagation there.(ABSTRACT TRUNCATED AT 400 WORDS)

Action Potentials