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A comparative study of the relative efficacy of pyrantel pamoate, bephenium hydroxynaphthoate and tetrachlorethylene in the treatment of Necator americanus infection in Ceylon.

The clearance of hookworm (Necator americanus) ova by a single dose of tetrachlorethylene (T.C.E.) was compared with that produced by single and multiple dose regimes of bephenium hydroxynaphthoate and pyrantel pamoate. Single doses of bephenium and pyrantel were inferior to T.C.E. Three daily doses of bephenium or pyrantel produced effects comparable with a single dose of T.C.E. Because of the low cost and lack of side effects, T.C.E. remains the drug of choice in the treatment of N. americanus in infections; the only disadvantage of T.C.E. is its unnoticed deterioration under tropical conditions.

Administration, Oral↗

Filariasis in Ceylon then (1961) and in Sri Lanka now (1990-30 years on).

The changes in the prevalence and distribution of bancroftian filariasis in Ceylon/Sri Lanka since Professor Kershaw's visit in 1961 show that the infection has spread over a wider area, although the microfilaria rates have decreased. New information is available on the vector, Culex quinquefasciatus, and more details are available on the animal filariae and their vectors. Dirofilaria repens infection of dogs is now a proven zoonosis in the country.

Animals↗