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At least 145 records · Page 8Linked to original sources
PubMed2000

[The smooth musculature of the human bronchi (the structural-metabolic and ultrastructural organizational aspects)].

Comparative study of smooth myocytes in muscular tissue of different order bronchi was carried out by means of complex of electron microscopic, cytophotometric and morphometric methods. Significant difference between the volume of myocytes in major, medium and small bronchi was found. As bronchial diameter reduces the structure of smooth myocyte population changes which is accompanied by decrease of proportion of large myocytes and growth of small myocyte number. The presence of young forms of myoblastic differon in muscular tissue of small bronchi is considered in the aspect of their high functional and adaptive properties.

Adult↗
PubMed1975

[Normal ultrastructure of the small bronchi and bronchioli in man].

Ultrastructural topographic and morphological analysis of the small bronchi and bronchioli was carried out on selected biopsy specimens obtained from 6 operative specimens. The small bronchi had a ciliated cylindrical epithelium identical to that in the large bronchi, apart from a smaller number of goblet cells. Their reticulin layer was thin (1 to 3 microns). The glands in the submucosa were rare whereas there was a rich submucosal vascular network. The lobular bronchioli had a ciliated cylindrical epithelium without goblet cells but possessing rare Clara cells. The epithelium of the terminal bromchioli was characterized by: 1 - The presence of numerous Clara cells, generally grouped in groups of 2 or 3. 2 - The appearance on the opposite side of a satellite artery (this side shows alveoli first) of cells which we interpreted as pre-ciliated cells. These cells possess a range of basal corpuscles under the luminal membrane but do not have cilia. 3 - The appearance of small membranous pneumocytes in islets. The epithelium covering the smooth wall of the respiratory bronchioles still have a gutter of ciliated cells and Clara cells which become thinner towards the periphery. After the secondary respiratory bronchioli, there appears in this gutter a new cell type, the cubical cells. These cells which have poorly differentiated cytoplasmic characteristics, seem to us to be immature bronchial cells, precursors of the Clara cells rather than of the ciliated cells. The remainder of the smooth wall of the respiratory bronchioli is covered with membranous pneumocytes and, in the case of the 3rd order of bronchioli, also by granular pneumocytes. The sub-basal reticulin layer is lacking in the terminal and respiratory bronchioli. The total thickness of the wall becomes considerably thinner, the muscular layer becoming proportionally very thick.

Bronchi↗
PubMed1975

[Preoperative sanation of the bronchi].

Among 255 patients with suppurative pulmonary diseases, aerosol therapy was performed preoperatively in 80 patients, complex sanation of bronchi--in 140, including 30--in association with visual sounding of segmental bronchi and intrapulmonary suppurative foci. As a result of complex sanation of bronchi, as compared with patients in whom no sanation was performed, or it was limited only by aerosol therapy, there was noted a reliable decrease in the number of postoperative pleural empyemas and bronchial fistulas, as well as an increase in the number of patients discharged with a recovery from 74.3% and 78.7% to 90%.

Anti-Bacterial Agents↗
PubMed1999

[Histology and physiological function of dogs after extirpation of bronchi].

OBJECTIVE: To investigate the effect of extirpation of bronchi on histology and physiological function. METHODS: 21 dogs were divided in to two groups: control (3) and experimental (18). After bronchi extirpation one week, two weeks, one month, three months, six months, and twelve months, we used specimens to test the pulmonary surfactant (PS) and to observe the morphological changes. RESULTS: After the operation, the residual lung nearby the operative area had traumatic changes. Around the aforementioned area, the structure of lung was normal. Specially after six months, the lung returned to good status. We found that two weeks after operation, the contents of PS increased remarkably (P < 0.05). After one month the parameter returned to normal (P > 0.05). CONCLUSIONS: The residual lung after bronchi extirpation had ventilation and air-exchange functions. The lung function was preserved directly.

Animals↗
PubMed2002

[Histopathological features of the bronchi in severe bronchial asthma--a statistical analysis].

The aim of this study was to examine the histopathological features of the bronchi in patients with severe bronchial asthma. Seventy-four autopsy cases of death from severe bronchial asthma were analyzed statistically. The areas of the bronchial wall, smooth muscle, bronchial glands, basement membrane, and bronchial bore, were measured at the level of the subsegmental bronchi. Normal lungs from 34 autopsy cases without any respiratory pathology were used as controls. All of these areas but the last were significantly increased in severe bronchial asthma. The bronchial bore area was significantly decreased. Moreover, the above areas in low and moderate goblet cell hyperplasia cases were compared with those in high goblet cell hyperplasia cases. In the latter, the areas of the smooth muscle, bronchial glands and basement membrane were significantly elevated and those of the bronchial bore were significantly decreased. Finally, the areas of the bronchial bore, smooth muscle and bronchial glands were also compared between groups presenting with three different levels of basement membrane thickening, but no significant difference was noted. Further study to examine the precise morphological changes is needed to elucidate the characteristics of bronchi in severe bronchial asthma patients.

Adult↗
PubMed1976

[Aftereffects of long-term stay of foreign bodies in the bronchi].

The author have observed 132 patients with foreign bodies in the bronchi. In 32 of them foreign bodies have been staying in the bronchi for 1 day and longer (up to 24 years). Pathological changes in the lung due to the presence of foreign bodies in the bronchi and the rational therapy are described.

Adult↗
PubMed2003

The AChE-positive ganglia in the trachea and bronchi of the cat.

The tracheal and bronchial parasympathetic ganglia in the cat were studied using the histochemical-tiocholine method of Koelle and Friedenwald and histological techniques. Intensively stained AChE-positive nerve structures, i.e., ganglia and nerve fibres on the wall of the trachea and bronchi, were observed. The ganglia were situated mainly on the dorso-lateral surface of these organs, but they were also present on the ventral surface. The largest ganglia were found in the vicinity of the vagus nerve branches and on the surface of the tracheal smooth muscle. Numerous ganglia (95-210) of different sizes (40 x 230 microm to 260 x 520 microm) and shapes (spindle, longitudinal, oval, elliptical and multiform) were interconnected by nerve fibres and formed a dense ganglionated plexus. The ganglia forming this nerve structure were located mainly on the level of intercartilaginous spaces. They received the nerve branches from the cervical and the upper thoracic branches of vagus nerve and cervical and upper thoracic segments of the sympathetic trunk. Similar AChE-positive ganglionated plexus containing 28-33 ganglia connected by nerve fibres was observed on the posterior wall of the bronchi. Histological investigations confirmed the presence of fascicles of nerve fibers and nerve cells aggregations in the external membrane of the trachea and bronchi. The ganglia consisted of 2-25 cells on the cross-section. They were located mainly on the level of intercartilaginous spaces and contained (except ganglionic neurocytes, nerve fibres) satellite cells and small blood vessels. All the ganglia had thin connective capsule.

Acetylcholinesterase↗
PubMedDate not supplied

Acetaldehyde induces granulocyte macrophage colony-stimulating factor production in human bronchi through activation of nuclear factor-kappa B.

Acetaldehyde, a metabolite of alcohol and primary mediator of alcohol-induced asthma, causes bronchoconstriction via histamine release from airway mast cells. Acetaldehyde also is found in cigarette smoke and may cause airway inflammation. The purpose of this study was to determine the effect of acetaldehyde on cytokine production and nuclear factor kappa B (NF-kappa B) activation in human bronchial tissues. Human bronchi were prepared from normal parts of lung tissues resected for lung cancer (n = 11). The bronchi were cultured in the presence of 5 x 10(-4) M of acetaldehyde for 24 hours and the concentrations of eotaxin, granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5, interleukin-8, and regulated on activation, normal T cells expressed and secreted in cultured supernatants were determined by enzyme-linked immunosorbent assay. Tissues also were immunohistochemically stained for NF-kappa Bp65. Acetaldehyde significantly increased GM-CSF production from human bronchi and nuclear translocation of NF-kappa Bp65 in airway epithelium but had no effects on other cytokines. Our findings suggest that acetaldehyde potentially causes airway inflammation via increased GM-CSF production through nuclear translocation of NF-kappa B.

Acetaldehyde↗
PubMed2003

Dimensions of segmental bronchi of pulmonary lower lobes in humans and Cercopithecus aethiops.

The aim of the study was to determine the bronchial segmental tree dimensions of lower lobes in humans and Cercopithecus aethiops and to estimate the possible relations between them. The study was carried out on a group of 62 human cadavers (aged 20 to 60; 28 men, and 34 women) and 30 sexually mature corpses of Cercopithecus aethiops (14 male and 16 female individuals). The trachea and bronchi were swilled out, injected with duracryl and digested in hydrochloric acid. After washing out an exact model of the topographically unchanged bronchial tree was obtained. Those preparations were dried and the diameters of the segmental bronchi in the lower lobes of both lungs were measured. The statistical analysis was performed using the SAS system v. 6.11. Differences between groups were analyzed by ANOVA. If P < 0.05, differences between the mean values were considered statistically significant. In the studied material almost all measured values in Cercopithecus aethiops were higher in female individuals in contrast to the results obtained for humans. In both sexes of Cercopithecus aethiops medial and anterior basal bronchi have the biggest diameter in both sides, but in male and female humans posterior basal bronchus has the biggest diameter. Unlike humans, where the medial segments are small, the medial segments in Cercopithecus aethiops constitute a significant functional part of the lungs.

Adult↗
PubMed2004

[An experience with argon-plasma coagulation in endoscopic management of obstructive tumors of the trachea and main bronchi].

Endoscopic management of obstructive tumors of the trachea and main bronchi was carried out using argon-plasma coagulation in 39 patients aged 15-75. Thirty four patients had primary malignancies, 2--secondary tumors and 1- metastasis to the lung. Two patients with benign tumors were cured completely. Lobar bronchus lesions involving the extrapulmonary bronchus were identified in 28 patients; involvement of both main bronchi and trachea--5, intermediate bronchus lesions--3, and involvement of one lobar bronchus--3. Stenosis was complete in most patients and full or partial lumen was restored in all of them. Follow-up checks were conducted at 2-, 4- and 12-week intervals under outpatient conditions. Bleeding from the bronchial arteries broke out in 1 patient during examination and was aborted. Our method may be used in emergency to manage tumor-induced obstruction of the trachea and main bronchi, to raise the quality of life in incurable cases and to improve the results of chemoradiotherapy.

Adolescent↗
PubMed2006

[Eight cases report of segmental bronchi foreign body].

OBJECTIVE: To review the clinical features and the treatment of segmental bronchi foreign bodies cases. METHODS: Rigid bronchoscope and endoscope were applied to all 8 cases under general anesthesia. The foreign bodies shape and position were well evaluated under direct view, and the metal ones were located with X ray. RESULTS: Generally, the foreign bodies in segmental bronchi are small size and have a long history, the symptoms are non typical and may be accompanied with recurrent lung infection and haemoptysis. The foreign bodies were successfully removed in 6 patients with bronchoscopy, and the foreign bodies in other 2 cases were removed with thoracotomy. No complications occurred in all cases. CONCLUSIONS: For the segmental bronchi foreign body cases, the non typical history should be well reviewed and a detailed investigation should he performed. Suitable surgical instruments should be well selected so to get higher success rate and effectively prevent potential compilations.

Adolescent↗
PubMed1989

[Macro- and microscopic characteristics of the glands of the human trachea and main bronchi in postnatal ontogenesis].

By means of the macro-microscopical method 68 preparations of the trachea and main bronchi, obtained from persons perished and died at the newborn age up to 90 years and having not any disease of the respiratory pathways by the time of death have been studied. The glands in the walls of these organs are adapted to the surrounding structures and have various topography in the cartilagenous and membranous parts of the trachea and main bronchi. The ductal openings in the membranous part demonstrate a regular longitudinal orientation. Despite the fact that during human life the sizes of the trachea and main bronchi increase, the amount of the glands during the postnatal ontogenesis remains nearly at the same or about the same level. With age, the density of the ductal opening arrangement per 1 cm2 of the mucosal membrane surface changes noticeably. Comparing with the newborn age, in the old age this parameter decreases nearly by 4 times.

Adult↗
PubMed1989

[The relative amount of slow-adapting stretch receptors in the trachea, extrapulmonary bronchi and lungs of the cat].

In 35 anesthetized cats, local mechanical stimulation determined the location of 185 slow-adapting stretch receptors of the lungs. 79.7% of the receptors were found in the lungs and the rest of them in the trachea and extrapulmonary bronchi. Out of the 20.3% of the latters, 9.3% were located in lobular bronchi, 1.5%--in the main ones, 5.5%--in the trachea bifurcation, 3.3%--in the thoracic portion, and 0.8%--in the cervical portion. The greatest density of the receptors was found in the trachea bifurcation and in lobular bronchi. The amount of the receptors in the lung lobes proved to be proportional to the lobes mass. When analysing the mechanisms of the respiration regulation, one should consider the fact that the relative amount of extrapulmonary tracheobronchial stretch receptors is considerably lesser in cats than in dogs and rabbits.

Action Potentials↗
PubMed1987

Characteristics and distribution of specific binding sites for leukotriene C4 in human bronchi.

The binding of [3H]leukotriene (LT) C4 to membranes from human bronchi has been characterized. The specific binding, measured at 4 degrees C, was very rapid, equilibrium being attained within 1 to 5 min. The binding was also rapidly reversible and saturable (maximum binding = 187 pmol/mg of protein). LTC4, LTD4, LTE4 and the LT antagonist FPL 55712 competed with [3H]LTC4 for its binding sites, with the following IC50 values: 0.12; 2.3; 30; and 20 microM. Therefore, the binding sites displayed a higher affinity for LTC4 than for the other sulfidopeptide LTs. Computer-assisted analysis of either the saturation or the competition curves for LTC4 indicated the existence of two classes of binding sites with different affinities (Kd1 and Kd2 = 70 nM and 0.58 microM, respectively), in agreement with the curved semilog plot of the dissociation time course. CaCl2 or MgCl2 increased and GTP or 5'-guanylylimidodiphosphate did not decrease the specific binding. In addition, the distribution of the binding sites for [3H]LTC4 along the human respiratory tree was investigated. At a fixed (10 nM) [3H]LTC4 concentration, membranes obtained from bronchi removed at different levels of the airway tree did not bind LTC4 in a significantly different amount. This is compatible with the finding that LTC4 receptors should be present on bronchi of various caliber, as both small and large airways respond to LTs.

Binding, Competitive↗
PubMed1988

Autoradiographic visualization of muscarinic receptors in human bronchi.

To visualize muscarinic receptors in human bronchi, the stripping film method was used which permits direct autoradiographic localization of tissue labeling. Cryostate sections of human bronchi were fixed in 0.5% glutaraldehyde in Krebs-Ringer buffer, pH 7.0 for 30 min at 0 degrees C, washed in Krebs-Ringer buffer for 20 min at 0 degrees C and incubated with (-)-[3H]Quinuclidinyl benzilate [(-)-[3H]QNB] for 90 min at 37 degrees C. Specific (-)-[3H]QNB binding to tissue sections was saturable (receptor density of 0.14 +/- 0.03 fmol/tissue section) and of high affinity (Kd of 40 +/- 9 pM). For autoradiography, labeled tissue sections were covered with stripping film and exposed for 5 months. Muscarinic receptors in human bronchi were located predominantly in submucosal glands and parasympathetic ganglia. There was less labeling in smooth muscle cells and nerve bundles. Epithelium and blood vessels located within the bronchial wall were devoid of specific labeling.

Aged↗
PubMed1979

[Lymphatic bed of the main bronchi in normal human subjects and in venous stasis].

The lymphatic bed of the main human bronchi has been studied in normal conditions and at venous stagnation. Different methods both with injections and without injections have been applied. Definite regularities in changes occurring in the lymphatic bed of the main human bronchi at venous congestion have been stated. The changes occurring in the lymphatic bed of the mucous membrane of the main human bronchi seem to be a response to those metabolic processes which develop at decompensative heart diseases.

Adult↗
PubMed1978

Neuroendocrine cells in dysplastic bronchi: ultrastructural observations and quantitative analysis of secretory granules and the golgi complex.

Ultrastructural and biochemical studies have suggested that bronchopulmonary carcinoids and oat cell carcinomas may be derivatives of neuroendocrine cells; their amine and/or peptide secretory capabilities may at times be reflected in clinical hormonal syndromes. This investigation was prompted by the hypothesis that dysplastic neuroendocrine bronchial cells may also exhibit structural and functional aberrations of their secretory apparatus. Surgical specimen samples from 5 human dysplastic bronchi were studied ultrastructurally; 7 normal bronchi served as controls. Golgi complexes of dysplastic cells were distinctly less prominent than those of the controls. Moreover, the Golgi vesicles of dysplastic cells appeared significantly smaller than their counterparts in normal cells (P less than 0.01). Also, dysplastic neuroendocrine cells displayed significantly fewer secretory granules per cell than the controls (P less than 0.05). These findings indicate structural abnormalities in the secretory apparatus of neuroendocrine cells in dysplastic bronchi and correlate with experimental observations of aberrant hormonal production associated with bronchial dysplasia. Thus, the possibility arises that bronchial epithelial dysplasias may be detected and monitored through laboratory determinations of their secretory products.

Bronchi↗
PubMedDate not supplied

Bronchiolar pathology. I. Histopathology of small bronchi and bronchioli in some chronic lung diseases.

Different types of lesions in small bronchi and bronchioli in a hundred lungs or lobes resected for chronic lung diseases (suppurations, chronic pneumonitides, tumours) were evidenced and interpreted in the light of experimental results and in relation to the lung processes in their entirety. Inflammatory, exudative and proliferative lesions, primary and secondary changes, as well as evolutive modifications were discerned. Their structural analysis demonstrated the influence of persisting aerogenic agents of the infections, antigenic or common types, some correlations with the surrounding parenchyma primarily or secondarily involved, and possible mechanisms determining the lesions of small bronchi and bronchioli. Inflammatory changes of the lung tissue following those of bronchi are evident within chronic suppurations with or without bronchiolectasias, with a varied restructuration of the lung tissue. The role of the immunopathogenic component was emphasized not only in chronic pneumonitides, but also in other cases. Proliferative changes of respiratory bronchioli were only rarely found in distal zones of lungs resected for tumours. Relationships between bronchiolar lesions and parenchymatous changes of the centrolobular emphysema type were never evidenced in the analysed cases.

Bronchi↗