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PubMed2003

Estimated daily energy expenditure and blood lipids in adolescents: the Québec Family Study.

PURPOSE: To examine the association between estimated daily energy expenditure and blood lipids in a sample of adolescents. METHODS: The sample consisted of 415 males and 356 females aged 10-19 years, mainly French Canadian, recruited from the greater Quebec City area through the media as part of Phase I of the Quebec Family Study. Estimates of daily energy expenditure (DEE) were obtained with a 3-day physical activity record. Blood lipids were measured by standard procedures. The sample was stratified into three activity groups (least active, less than 25th percentile of DEE; moderately active, 25-74th percentile of DEE; and most active, 75th percentile or greater of DEE), and also by clinical cutpoints for blood lipids. Analysis of covariance, controlling for age and fatness, was conducted to compare blood lipids within gender across activity groups. Logistic regression analysis, controlling for age and fatness, was used to estimate the relative risk of being classified with an undesirable level of a blood lipid parameter on the basis of the DEE. RESULTS: Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were not significantly different across activity groups in males or females. High-density lipoprotein cholesterol (HDL-C) was significantly different across activity groups in males (p <.05) and females (p <.05), but the pattern of variation was different between genders. In males, the TC/HDL-C and LDL-C/HDL-C ratios decreased between the moderately active and most active groups (p <.05). Significant differences remained when subcutaneous fatness was considered as a covariate. The results from logistic regression analysis indicated that the odds ratios for low HDL-C levels was significant only in low DEE girls (odds ratio 2.83) compared with high DEE girls. CONCLUSIONS: The results suggest that increased energy expenditure and physical activity are associated with higher levels of HDL-C in adolescents of both sexes.

Adolescent↗
PubMed1991

Effect of lignocaine on blood lipid in relation to partition coefficient and biological activity.

To correlate lipophilicity of lignocaine with changes in lipid composition of blood as a result of in vitro incubation with the drug, phosphorus content and fatty acid compositions of blood lipids before and after lignocaine treatment have been compared with those of a standard phospholipid, lecithin, under similar conditions of drug treatment. The change in fatty acid constituents has been correlated with the biological activity (both therapeutic and toxic) of lignocaine.

Animals↗
PubMed1996

A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids.

A double-blind crossover study comparing the effect of aged garlic extract with a placebo on blood lipids was performed in a group of 41 moderately hypercholesterolemic men [cholesterol concentrations 5.7-7.5 mmol/L (220-290 mg/dL)]. After a 4-wk baseline period, during which the subjects were advised to adhere to a National Cholesterol Education Program Step I diet, they were started on 7.2 g aged garlic extract per day or an equivalent amount of placebo as a dietary supplement for a period of 6 mo, then switched to the other supplement for an additional 4 mo. Blood lipids, blood counts, thyroid and liver function measures, body weight, and blood pressure were followed over the entire study period. The major findings were a maximal reduction in total serum cholesterol of 6.1% or 7.0% in comparison with the average concentration during the placebo administration or baseline evaluation period, respectively. Low-density-lipoprotein cholesterol was also decreased by aged garlic extract, 4% when compared with average baseline values and 4.6% in comparison with placebo period concentrations. In addition, there was a 5.5% decrease in systolic blood pressure and a modest reduction of diastolic blood pressure in response to aged garlic extract. We conclude that dietary supplementation with aged garlic extract has beneficial effects on the lipid profile and blood pressure of moderately hypercholesterolemic subjects.

Adult↗
PubMed1987

[Blood lipid levels in various forms of ischemic heart disease].

Enzyme assays of major blood lipid parameters detected no differences between peripheral venous blood specimens of normal subjects and functional cardiologic patients, nor between peripheral and central flow specimens of patients with neurocirculatory dystonia. Alpha cholesterol was typically decreased in all types of coronary disease, the decrease being particularly marked in central cardiac flow. Chronic coronary disease is associated with a rise of total cholesterol, its atherogenic fractions, the atherogenic coefficient and blood triglycerides, as compared to the respective parameters of functional cardiac patients. Acute and subacute coronary disease is associated with decreased blood lipid values, as compared to chronic coronary disease. Blood lipid phenotyping and secondary preventive procedures should rather be done in the absence of aggravations.

Adult↗
PubMed2002

[Effect of propylene glycol mannate sulfate on blood lipids and lipoprotein lipase in hyperlipidemic rat].

AIM: To study the effect of propylene glycol mannate sulfate (PGMS) on blood lipids and lipoprotein lipase in hyperlipidemic rat, and its anti-hyperlipidemic mechanism. METHODS: PGMS was administered ig at different doses (37.8 mg.kg-1.d-1 and 75.6 mg.kg-1.d-1) to hyperlipidemic rats for three weeks and blood serum was obtained after starved 12 h. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were examined. The mRNA expression of lipoprotein lipase (LPL) in liver, spleen and artery was detected by reverse transcription polymerase chain reaction (RT-PCR). RESULTS: PGMS significantly decreased the levels of TC, TG and LDL-C and increased that of HDL-C in hyperlipidemic serum dose-dependently. PGMS was shown to increase the level of LPL mRNA expression, which is related directly to the controlling effects of PGMS on blood lipids. CONCLUSION: PGMS modulated blood lipids by promoting mRNA expression of LPL. This may be one important mechanism of PGMS to modulate blood lipids.

Animals↗
PubMed2001

Changes in blood lipids consequent to aerobic exercise training related to changes in body fatness and aerobic fitness.

The contribution of changes in body fatness and aerobic fitness to changes in blood lipids after aerobic exercise training was investigated. The sample included 295 men (77 black, 218 white) and 355 women (131 black, 224 white), aged 17 to 65 years, from the HERITAGE Family Study. Participants underwent measurements at baseline and after 20 weeks of supervised exercise training on a cycle ergometer. Body fat mass (FM, in kilograms) was determined by underwater weighing, and aerobic fitness (maximal oxygen uptake, VO(2max), in milliliters per minute) was assessed by cycle ergometry. Blood lipid measurements included fasting plasma levels of high-density lipoprotein cholesterol (HDL-C), HDL(2)-C, HDL(3)-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol (CHOL), CHOL/HDL, and triglycerides (TG). A composite lipid change index (LCI) was derived by subjecting the Delta scores for the individual blood lipids to principal components analysis. The exercise training was accompanied by a mean increase of 17.5% in VO(2max) and a mean decrease of 3.3% in FM. Partial correlations, controlled for age, between absolute changes in VO(2max) and changes in the blood lipids were consistently low and nonsignificant. On the other hand, absolute changes in FM were significantly (P <.05) associated with changes in HDL-C (r = -.23), HDL(2)-C (r = -.17), and CHOL/HDL (r =.24) and the LCI (r = -.27) in men and with changes in LDL-C (r =.22), CHOL (r =.19), and CHOL/HDL (r =.15) and the LCI (r = -.19) in women. Forward stepwise regression confirmed that the change in FM was a better predictor of changes in blood lipids than the change in VO(2max), entering as a predictor in 4 of 8 regressions in both men and women. Change in VO(2max) did not enter as a significant predictor in any regression. Further, there were no differences in LCI between the upper and lower quartiles of VO(2max) change. On the other hand, there were significant differences between the low and high quartiles of FM change. No race effects were observed in any of the relationships, except that race was a significant predictor of changes in TG in both men and women. In conclusion, changes in blood lipids associated with aerobic exercise training do not appear to be related to changes in aerobic fitness per se; rather, they are weakly to moderately associated with changes in body fatness.

Adipose Tissue↗
PubMed1982

Antihypertensive drugs and blood lipids: the Oslo study.

The effects on blood lipids and uric acid of six different antihypertensive drugs used alone, and of five different combinations of two antihypertensive drugs, are reported here. Prazosin significantly lowered serum low density lipoprotein and very low density lipoprotein (LDL + VLDL) cholesterol and total triglycerides while maintaining high density lipoprotein (HDL) levels. Atenolol lowered LDL + VLDL cholesterol slightly. Both pindolol and hydrochlorothiazide (HCTZ) were neutral, while oxprenolol increased total triglycerides. Propranolol lowered HDL cholesterol and increased total triglycerides and uric acid. The combination of prazosin plus pindolol has a direct favorable lipid profile, while the combination of propranolol plus HCTZ lowered HDL cholesterol and increased total triglycerides. The combination of propranolol plus prazosin lowered HDL cholesterol, but to a lesser degree than propranolol alone, which suggests that prazosin was not able to completely counteract the negative effects of propranolol on HDL. Methyldopa plus HCTZ, and HCTZ plus amiloride were neutral with regard to effects on blood lipids. It is suggested that the metabolic effects of antihypertensive drugs could be of special importance in the long-term treatment of mild hypertension.

Adrenergic alpha-Antagonists↗
PubMed2002

Blood lipids and lipoproteins in child and adolescent athletes.

The purpose of this review is to describe the age- and gender-associated variation in blood lipids of young athletes and examine the association between training status, peak oxygen consumption (VO(2peak)), and body fatness with blood lipids in young athletes. Results from cross-sectional studies suggest similar levels of total cholesterol (TC), lower levels of triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and higher levels of high-density lipoprotein-cholesterol (HDL-C) in young athletes compared with controls. Longitudinal data show that the age- and gender-associated variation in blood lipids in young distance runners is similar to youth in the general population; TC and LDL-C remain stable, HDL-C declines during adolescence (especially in males), and TG increases with age. Considerable heterogeneity exists in the blood lipids of young athletes, including dyslipidaemic values. Age, sexual maturity status, training status, VO(2peak) and body fatness are determinants of blood lipids in young athletes. VO(2peak) is a significant predictor of HDL-C independent of body fatness. Further research is warranted to examine: the prevalence rates of dyslipidaemia in various sport groups; and the complex interactions of genes, biological maturation, exercise training, dietary intake and composition, skeletal muscle and adipose tissue properties on lipoprotein metabolism in young athletes.

Adipose Tissue↗
PubMed1999

Impact of different blood lipid evaluation and treatment guidelines on the proportion of Canadians identified and treated for elevated blood cholesterol. Canadian Heart Health Surveys Research Group.

OBJECTIVE: To report on the impact of different blood lipid evaluation and treatment guidelines on the proportion of Canadians identified and treated for high blood cholesterol. DESIGN, SETTING AND PARTICIPANTS: The Canadian Heart Health Surveys were carried out in Canada between 1986 and 1991. The data used in this study were from cross-sectional probability samples of adults aged 18 to 74 years, gathered in four provincial health surveys (Quebec, Alberta, Manitoba and Ontario) between 1989 and 1992, which obtained information on family history of heart disease. Data reported are for 7238 subjects fasting 8 h or more and providing a blood sample. All blood lipid analysis were done at the J Alick Little Lipid Research Laboratory, University of Toronto, which is standardized according to the National Heart, Lung, and Blood Institute, Centers for Disease Control (Atlanta) Lipid Standardization Program. OUTCOME MEASURES: With respect to the four guidelines examined--the Canadian Consensus Conference on Cholesterol (CCCC), 1987; the Toronto Working Group on Cholesterol Policy (TWG), 1990; the Canadian Task Force on the Periodic Health Examination (PHE), 1993; and the National Cholesterol Education Program (NCEP), 1993, in the United States--a comparison of the proportion of individuals in the population for whom a lipid profile was constructed, and who were prescribed a diet and drug therapy under different assumptions of success with dietary therapy for each guideline. MAIN RESULTS: Major differences were observed in the impact of the various guidelines with respect to the percentage of subjects who were tested, provided with a lipid profile, and eligible for diet and/or drug therapy. In general the percentages in each group were higher for the CCCC and the NCEP guidelines than for the PHE and TWG guidelines. CONCLUSION: The divergent results obtained from the application of the various guidelines are cause for concern and explain in part the confusion that surrounds the topic of blood cholesterol in public health and clinical contexts. Public health policy in the area of cardiovascular disease prevention would benefit from explicit consideration of various types of criteria for formulation of identification and treatment guidelines.

Adolescent↗
PubMed1992

The effects of two fixed hormonal replacement therapy protocols on blood lipid profile.

Hormonal Replacement Therapy (HRT) is known to be accompanied by changes in blood lipid profile. The present prospective cohort study compared the blood lipid profile of healthy postmenopausal women treated with either (a) a preparation containing a fixed regimen of estradiol, estriol and norethisterone acetate (EENA, marketed under the trade name Trisequens); (b) a fixed protocol of conjugated equine estrogen and medroxyprogesterone acetate (CEEMPA, marketed under the trade name Premaril Plus); or with (c) a concurrent group which underwent no treatment. Blood lipid profiles (total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TG)) were performed at the beginning of the study and at 3-month intervals, for 9 months. The EENA-treated women showed a significant and profound decrease in TC and LDL-C when compared with their initial values, with the control group, and with the CEEMPA group. The CEEMPA group showed an increase in HDL-C values and a decrease in LDL-C values when compared with their initial values and with the control group, but no increase was shown when compared with an EENA group. There was a favorable decrease in the TC/HDL-C and LDL-C/HDL-C ratios in both treatment protocols. As the primary goal of prevention of coronary artery disease is total cholesterol reduction, the EENA protocol seems to be preferred.

Clinical Protocols↗
PubMed1991

Blood pressure and blood lipids in relation to body size in hypertensive and normotensive adults.

The relationship between relative fatness and subcutaneous fat distribution was examined in a sample of 124 hypertensive and 402 normotensive individuals. We explored the interactions between relative weight, adiposity, and preferred sites of fat accumulation in relation to disease risk, as measured by hypertensive status, blood pressure levels, and blood lipid concentrations (total cholesterol, triglyceride and HDL cholesterol). The participants were classified into quintiles of age-adjusted weight, body mass index (BMI), waist-to-hip ratio (WHR), subscapular skinfold, and a relative fat pattern index (RFPI). The mean values for blood pressure and blood lipids at each quintile of the anthropometric indices were compared by sex and hypertensive status. In the normotensive men and women, blood pressure and blood lipids levels were strongly associated with all indices of body size and adiposity. However, among hypertensive men and women the associations between blood pressure and blood lipids with anthropometric indices were significantly different across quintiles of distribution for the different indices. Our study suggests that in medicated hypertensives blood pressure and blood lipid levels can be present in the very lean and unrelated to body size, or they can be strongly associated with ponderosity and fat distribution. The difference in blood pressure and blood lipid levels from the second to the third quintiles on any one of the anthropometric indices considered is greater that the difference between the top quintiles.

Adipose Tissue↗
PubMed1976

Dose-dependent effects of milk lipids on sex hormone and blood lipid levels in male mice.

Diets containing powdered whole milk caused a dose dependent increase in seminal vesicle weights when fed to 21 day old intact male mice. Blood cholesterol levels increased as the lipids in the diet increased. Triglyceride levels were high and inversely related to lipid intake. Peripheral androgen concentrations decreased as the lipid intake and seminal vesicle weights increased, indicating a possible shift of the hormone to the target organ tissue.

Administration, Oral↗
PubMed2000

[Variation of blood lipids and circulatory endocrine factors in patients with acute myocardial infarction].

OBJECTIVE: To observe the dynamic variations of blood lipids and circulatory endocrine factors in acute myocardial infarction(AMI) patients. METHODS: We determined plasma levels of ET-1, ANP, insulin and serum lipids on the 1st, 3rd, 7th and 14th day in 41 patients with acute myocardial infarction. RESULTS: The serum levels of TC, LDL-C obviously decreased from the 3rd to the 7th day, and gradually elevated on the 14th day. The serum level of TG elevated gradually and showed significant difference after one week. HDL-C had no significant difference. The levels of ET-1 and insulin increased to highest level on the 1st day and decreased gradually since then. However, ANP reached the highest value on the 3rd day, and decreased markedly in fourteen days later. On the 1st day, only the concentration of insulin was negatively related with serum levels of TC, LDL-C(r = -0.376, -0.388, respectively, P < 0.05). The concentrations of blood lipids weren't related with circulatory endocrine factors during other phases. CONCLUSION: The primary characteristics of blood lipids dynamic variations are the decrement of TC, LDL-C and the increment of TG during acute phase of AMI. Meanwhile, the concentrations of ET-1, ANP and insulin present dynamic variations and may effect the metabolism of blood lipids through some cytokines.

Aged↗
PubMed2000

Ethinyl estradiol: its interaction on blood-lipid.

Lipophilicity (log P) of the drug plays an important role when drug reaches in the critical reaction site, i.e., active site cum receptors where the major constituent is lipid moieties. The drug molecule may be responsible for altering the lipid constituents, which is measured in terms of phosphorus content and can be explained by their fatty acid changes that are linked with biological effect of the drug. Having considered the lipophilicity of ethinyl estradiol (log P = 3.67), its interactions with the whole lipid of goat blood have been investigated along with fatty acid changes and lipid peroxidation phenomena. There was significant loss of phosphorus content of phospholipid and change of fatty acid constituents of whole lipid. This may be ascribed to binding affinity of ethinyl estradiol with lipid constituents in blood. Lipid binding potential of the drug may have role in its therapeutic effect. The peroxidation induced by drug has been quantitatively measured along with its suppression by using antioxidant. The results reveal that ethinyl estradiol caused significant extent of lipid peroxidation. Ascorbic acid, a promising antioxidant could significantly reduce drug induced lipid peroxidation.

Animals↗
PubMed1997

[Dynamics of post-infarction blood lipids].

During 1993-1994, 3590 patients who recovered from acute myocardial (undergone 1 to 6 years earlier) were examined by 139 ambulatory cardiologists. Aim of the study was to investigate blood lipid changes in 2435 (67.82%) patients in whom total-HDL-and LDL-cholesterol and triglycerides were obtained. These lipids were not abnormally elevated and actually very similar to (or slightly lower than) those of the general population examined in Italy in the context of the RIsk Factors and Life Expectancy Pooling Project (including 70,000 individuals). However, blood lipids were, in general, higher in women than in men and declined as age increased (unless HDL-cholesterol which tended to increase). Among postinfarction patients lipid-lowering drugs were taken by 19% of men and 14% of women, which contrasts with proportions observed in the general population (5 and 4%, respectively). Mean blood lipid values were higher among those who were treated with lipid-lowering drugs, either from the postinfarction series or the general population (unless HDL-cholesterol which had an opposite trend). These data may indicate why treatment was undertaken, although no conclusion may be drawn about drug-efficacy. Postinfarction patients examined after 1-2 years from illness showed lower values of mean blood lipids than those examined 3-6 years after the acute episode (however, the opposite was true for HDL-cholesterol). There are several possible explanations for these observations: high lethality in infarction-patients with high blood lipids, efficacy of lipid-lowering drugs, diet or metabolic changes following acute myocardial infarction. Nevertheless, the proportion of postinfarction patients treated with lipid-lowering drugs was lower than anticipated from (and/or recommended based on) results of recent secondary preventive trials. It seems necessary to repeat (possibly periodically) this investigation in large samples of postinfarction patients to assess whether and how, in clinical practice, indications are applied from recent large trials on secondary prevention of ischemic heart disease.

Adult↗
PubMed1988

Quinapril and blood lipids.

To assess the effects of angiotensin-converting enzyme inhibition with quinapril on blood lipid profile, serum total cholesterol and triglycerides, together with high-density and low-density lipoprotein cholesterol were analysed in 23 hypertensive patients receiving either placebo (7 patients) or quinapril hydrochloride (16 patients). After 12 weeks of therapy there were no significant changes in blood lipids in either group. No unfavourable changes in blood lipid profile were observed even after 1 year of therapy with quinapril hydrochloride in 13 patients.

Adult↗
PubMed2003

Effect of leisure time physical activity on blood lipid levels: the ATTICA study.

OBJECTIVE: We aimed to evaluate the effect of leisure time physical activity on blood lipid levels, in a random sample of cardiovascular disease-free individuals from the Attica basin. DESIGN AND METHODS: The ATTICA study is a population-based cohort, which during 2001-2002 randomly enrolled 2772 men (n = 1376, 45 +/- 12 years old) and women (n = 1396, 45 +/- 13 years old). Physical activity status was evaluated through intensity (kcal/min expended per day), frequency (per week) and duration (min). Multivariate data analysis evaluated the association of blood lipids with physical activity levels. RESULTS: 578 (42%) men and 584 (40%) women were physically active. Compared to sedentary women, physically active women had lower levels of total cholesterol (P < 0.05), low-density lipoprotein (LDL) (P < 0.05), oxidized LDL-cholesterol (P < 0.05), triglycerides (P < 0.05) and apolipoprotein B (P < 0.05) and higher levels of high-density lipoprotein (HDL)-cholesterol (P < 0.05) and apolipoprotein A1 (P < 0.05). Similar associations were observed in men, but they did not reach statistical significance. However, after adjustments for age, smoking habits, body mass index and dietary intake were made, the effect of physical activity on blood lipids remained statistically significant only for HDL-cholesterol (P < 0.05) and apolipoprotein A1 (P < 0.05) levels in women. Moreover, physical activity was associated with lower total cholesterol levels both in nonsmoker men (-7%, P = 0.032) and nonsmoker women (-2%, P = 0.064) and lower triglyceride levels in nonsmoker men (-15%, P = 0.086) and nonsmoker women (-9%, P = 0.036). CONCLUSIONS: Although almost all blood lipids were inversely associated with physical activity status, only HDL-cholesterol and apolipoprotein A1 concentrations were significantly affected by exercise in women.

Adolescent↗