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Kinetics and mechanism of decomposition of some derivatives of 5-allylbarbituric acid. Part V. The course of hydrolysis of 5 allyl-5-(2'-hydroxypropyl)barbituric acid.

The course of hydrolysis of the title compound was investigated in a broad pH range. It was found that undissociated and monoanionic forms are reversibly isomerized to alpha-allophanyl-alpha allyl-gamma-valerolactone. This last compound simultaneously hydrolyzes to alpha-allyl-gamma-valerolactone and urea. After the hydrolysis in strongly alkaline medium (dianionic form) alpha-allyl-alpha-carboxy-gamma-valerolactone was isolated and the presence of urea was proved. The course of hydrolysis of the investigated drug in the applied pH range have been discussed. Kinetic parameters of hydrolysis at ph=5.4 were evaluated using high-performance liquid chromatography as the analytical method.

Barbiturates↗