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At least 145 records · Page 8Linked to original sources
PubMed1988

A partial characterization of uterine and mammary growth stimulatory activity from placenta.

Both placenta and prolactin are required for maintenance of gestation in rabbit. This study was undertaken to characterize the influence of placenta on uterus and mammary gland using the virgin pseudopregnant rabbit as a model system. Homogenates of 20-day rabbit placenta were found to stimulate increased growth of uterine and mammary tissue in pseudopregnant rabbits. Essentially, all of this uterine growth occurred in endometrium and represented growth of both stromal and epithelial cell types. After fractionation by successive extraction of rabbit placenta with acetone and bicarbonate, both extracts were found to stimulate uterine and mammary growth in pseudo-pregnant rabbits when measured on day 20 of pseudopregnancy after 13 days of treatment at extract doses equivalent to that found in 0.1 gram of placenta. Approximately 75% of this stimulatory activity is found in the acetone extract and the remainder appears in the aqueous extract. The extracts stimulate a maximum 90% increase in uterine growth and 400% increase in mammary pad area. Both activities exhibit logarithmic response characteristics, yet significant changes in serum 17 beta estradiol, progesterone, 20 alpha dihydroxyprogesterone and prolactin did not occur. These observations suggest the presence of an unidentified factor in rabbit placenta which has a non-ovarian mediated stimulatory activity on endometrial and mammary growth.

Algestone↗
PubMed1978

[Characteristics of the ovarianc cycle in the baboon (Papio hamadryas)].

The dynamics of estradiol, estrone, 17 alpha-hydroxyprogesterone, progesterone and 20 alpha-dihydroprogesterone were investigated in the blood plasma of the pavian (papio, hamadryas) with regard to the menstrual cycle and in comparison with the human. Furthermore results were presented about the basal temperature, the fern phenomenon and the development of the sex-skin in the pavian.

Algestone↗
PubMed1985

[Kinetics of the testicular steroidogenic response to stimulation by placental gonadotropin hormone. VI. Enzyme deficiencies of testicular biosynthesis].

The kinetics of the responses of plasma testosterone (T) its precursors and estrogens to a single injection of human chorionic gonadotropin (hCG) was studied in 9 46 XY subjects affected with one of 4 inborn errors of testicular biosynthesis. In the adults (n = 4), the kinetics and profile of the hormonal responses to hCG were qualitatively comparable to those previously described in normal adult men, and the profile of response characteristic of the hCG-induced steroidogenic desensitization was observed, suggesting that the 17,20 desmolase blockade induced by hCG is superimposed to the inborn enzymatic defect. In the prepubertal patients (n = 5), testicular desensitization was not observed, as in prepubertal controls. However, T precursors, each marker of a given enzymatic blockade, significantly rose several fold 2-5 days after the hCG injection, while they do not in normal children. The results also show that an hCG test is necessary for a clear-cut diagnosis of a given enzymatic block in children, but is not in adults. The single hCG injection protocol used in this study offers a sophisticated way of a qualitative analysis of the testicular secretory products, but is not a must.

17-Hydroxysteroid Dehydrogenases↗