Assignment of the porcine acrosin gene, ACR, to chromosome 5p15 by fluorescence in situ hybridization (FISH).
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In 1984, the American College of Radiology administered its first in-training examination to residents in radiation oncology. This paper provides a summary of the overall results of the first 4 years of experience with this evaluatory instrument.
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OBJECTIVE: To evaluate the interrater reliability of rheumatologist diagnosis of rheumatoid arthritis (RA) and the concordance between rheumatologist and computer algorithms for assessing the accuracy of a diagnosis of RA. METHODS: Self-reported data regarding symptoms and signs for a diagnosis of RA were considered by a panel of rheumatologists and by computer algorithms to assess the probability of a diagnosis of RA for 90 patients. The rheumatologists' review was validated through medical record. RESULTS: The interrater reliability among rheumatologists regarding a diagnosis of RA was 84%; the chance-corrected agreement (kappa) was 0.66. Agreement between the rheumatologists' rating and the best-performing algorithm was 95%. Using rheumatologist's review as a standard, the sensitivity of the algorithm was 100%, specificity was 88%, and the positive predictive value was 91%. The validation of rheumatologist's review by medical record showed 81% sensitivity, 60% specificity, and 78% positive predictive value. CONCLUSION: Reliability of rheumatologists' assignment of a diagnosis of RA by using self-report data is good. Algorithms defining symptoms as either joint swelling or tenderness with symptom duration >or=4 weeks have a better agreement with rheumatologist's diagnosis than do ones relying on a longer symptom duration. RELEVANCE: These findings have important implications for health services research and quality improvement interventions pertinent to case finding for RA through self-report data.
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The Cambridge Healthtech Institute's second international conference entitled "Recombinant Therapeutics: Antibodies and Biomolecules" was held in Baltimore, MD, USA, 30 May-1 June 2001.
At screening mammography, lesions must be assigned to BI-RADS classification. Category 3 is used for nonpalpable probably benign lesions. This category is defined either by a subset of lesions that are so likely to be benign that follow-up is a reasonable alternative to immediate biopsy, or by a less than 2% malignancy rate for American BI-RADS, or than 5% for French ANAES. The initial work-up to analyze the lesion must be complete, not only with four screening standard views but with magnification views and sonography if necessary. The risk of malignancy is very low and the pronostic factors are the same as in screening detected carcinomas.
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Thrombocytopenia is a common feature in ICU patients which occurs usually in case of infection or septic shock. Its mechanisms, which are often unclear, include the haemophagocytic syndrome initially linked with histiocytic proliferation but probably also associated with infectious diseases. This syndrome is characterized by a phagocytosis of medullar blood cells. Reactive haemophagocytic syndrome can probably lead to thrombocytopenia in ICU patients as in this case report of a E. Coli infection.
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