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At least 1,423 records · Page 79Linked to original sources
PubMed2026

Rapidly progressive steroid-resistant focal segmental glomerulosclerosis associated with an INF2 exon 6 variant.

Variants in the inverted formin-2 (INF2) gene are a known cause of hereditary focal segmental glomerulosclerosis (FSGS) and Charcot-Marie-Tooth disease. We report a case of rapidly progressive FSGS associated with a rare INF2 variant. A 12-year-old boy developed proteinuria and was diagnosed with FSGS at age 14 following a renal biopsy. Steroid therapy and subsequent immunosuppressive treatments, including plasma exchange, were ineffective. At age 15, a heterozygous missense variant in exon 6 of the INF2 gene (c.763G>A, p.Asp255Asn) was identified. Despite conservative management, the patient progressed to end-stage kidney disease at age 17. Although exon 6 variants are rarely reported, the present case showed a relatively aggressive renal course.

Humans↗
PubMed1975

Attempted orthodontic movement in the presence of suspected ankylosis.

A 37-year-old man with suspected ankylosis ("submerged" teeth, radiographically obliterated periodontal membranes, and sharp or ringing percussion tests) was subjected to attempted orthodontic movement. The maxillary canine and posterior segments were chosen as treatment areas. While the terms "light" and "heavy" are relative, forces ranging from 6 to 24 ounces were variants great enough in the areas treated to have elicited movement if movement were possible. After continuous forces had been applied for 110 days, measurements showed no movement in either maxillary quadrant.

Adult↗
PubMed1980

Ankylosed teeth as abutments for palatal expansion in the rhesus monkey.

The maxillary permanent lateral incisors of three rhesus monkeys were intentionally ankylosed by a replantation and splinting technique. A 1-pound expansion force was applied to the ankylosed teeth for 5 to 15 weeks. The intermaxillary and interpremaxillary sutural expansion was monitored radiographically during the experimental period. Two animals were killed for histologic examination after 13 and 23 weeks, and the third animal was monitored radiographically for 21 weeks. Skeletal expansion of the maxilla was achieved without concomitant buccal tipping of the abutment teeth. Osteoid tissue was deposited on localized areas of the resorbed cementum and dentin of the ankylosed teeth. The periodontal ligament showed atrophic and degenerative changes similar to those found with increased age in human beings.

Animals↗
PubMed1981

Primary failure of eruption: a possible cause of posterior open-bite.

Failure of posterior teeth to erupt fully into occlusal contact produces a lateral open-bite. These problems usually are attributed to a mechanical interference with the eruptive process, either ankylosis or some soft-tissue interference. In some patients, lateral open-bite is due to a disturbance of the eruption mechanism itself so that nonankylosed teeth cease to erupt. Influences on the eruption of teeth are reviewed, and possible causes of "primary failure of eruption" are discussed. The limitations of treatment for patients with eruption failure are described and illustrated by case reports.

Adolescent↗
PubMed1985

The effect of extraction of infraoccluded deciduous molars: A longitudinal study.

Infraocclusion of deciduous molars is often associated with ankylosis. Such teeth are believed to be potential sites of malocclusion, with a risk of tipping of neighboring teeth and loss of space. Extraction has therefore been the most widely recommended treatment. The aim of this study was to follow longitudinally the effect of extraction versus nonextraction treatment in twenty-three homologous pairs of mandibular deciduous molars with infraocclusion when unilateral extraction was performed. The study comprised fifteen children with a mean age at the start of 10.1 years. Recordings were made at the start of the study and every 6 months thereafter until eruption of permanent successors. Periodic identical periapical radiographs and study models were taken every 6 months. Ten of the twenty-three mandibular deciduous molars on the nonextraction side showed progression of the degree of infraocclusion. All infraoccluded deciduous molars exfoliated within the normal time. There was a normal alveolar bone height on both sides after eruption of the successors. Extraction resulted in a gradually increasing space loss in fourteen of the fifteen children. In two cases a definite space deficiency at the time of eruption of the successors was registered. It has been possible to confirm very few of the previously reported negative effects following nontreatment of infraoccluded deciduous molars on exfoliation, eruption, and occlusal development in this study. The results favor a more conservative approach to extraction therapy of infraoccluded deciduous molars.

Adolescent↗
PubMed1977

5'-AMP aminohydrolase activity in erythrocytes from normal and dystrophic individuals.

5'-AMP aminohydrolase activities in red blood cells from normal human adults and from patients with pseudohypertrophic dystrophy, myotonic dystrophy, limb girdle dystrophy, neuromuscular atrophy, Charcot-Marie Tooth Disease, and spinal muscular atrophy were examined. In contrast to the greatly decreased skeletal muscular levels of 5'-AMP aminohydrolase observed in Pseudohypertrophic muscular dystrophy, levels in red blood cells of all patients were not significantly different from normals. Pyruvate kinase and creatine kinase activities were determined for comparative purposes. The density distribution of normal and dystrophic erythrocytes were essentially identical.

AMP Deaminase↗
PubMed1979

Posterior maxillary osteotomies: an aid for a difficult prosthodontic problem.

Patients who have supereruption of posterior dentoalveolar segments provide an interesting challenge to the dentisr. The severe problems require a team approach to achieve the best results. Factors influencing the treatment include the periodontal status of the involved teeth as well as the concern of the patient. The posterior maxillary osteotomy provides the chance to maintain the vital functional teeth in an otherwise difficult situation. It must be emphasized that the patient must wear an opposing splint or prosthesis following surgery to prevent relapse. This conservative approach maintains the teeth and their vitality and anatomically repositions the supererupted segment to an improved functional position.

Adult↗
PubMed1985

Bruxism and its effect on the natural teeth.

Bruxism is one of the most prevalent, complex, and destructive dental functional disorders. It is difficult to identify, especially in its early stages, because most patients are unaware of the habit. Although many factors contribute to the etiology of the disorder, there is little valid and reliable clinical research to assure a correct diagnosis. The effects of bruxism are multiple and diverse and include temporomandibular joint pain and dysfunction, head and neck pain, tooth wear, mobility, erosion, abrasion, loss of and damage to supporting structures, muscle pain and spasm, disturbance of esthetics, and interference and oral comfort. Treatment may be simple or complex, depending on the nature of the disorder. More severe disorders are difficult to treat, and the prognosis may be questionable. Because the diagnosis and treatment of bruxism is inadequately defined and poorly understood, carefully designed clinical research projects are encouraged.

Bruxism↗