[The effect of macrodispersion colloids on the development of experimental atherosclerosis].
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Two cases of thorotrastosis unsuspected by the patients themselves are reported. Attention is drawn to the relevance of this disease at the present time. Reference is made to the relevant literature in asserting that the pathology of thorotrastosis must be understood if early diagnosis is to be obtained, and so initiate suitable treatment and satisfy medicolegal requirements.
Primary carcinoma of the liver is rare in Western countries but it is a common malignant tumour in many parts of the tropics. Much has been learnt in recent years about its pathology, manifestations, and aetiology that is relevant to the whole field of oncology. The important distinction between carcinomas of liver-cell and bile-duct origin, the phenomenon of alpha-fetoprotein production, and the role of cirrhosis are discussed in the context of newly discovered aetiological factors such as gonadal steroids, mycotoxins, and the hepatitis B virus.
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A case of multiple primary malignant tumors of the liver (cholangiocarcinoma and malignant hemangioendothelioma) that developed 40 years after Thorotrast administration is described, with radiological and autoradiographic findings. The estimated organ dose to the liver was approximately 580 rads.
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The occasion of transferring old archives of angiograms done between 1935 and 1940 to our present department led to the review of techniques and problems of angiography in these days; including a review of contrast agents, initial possibilities for series arteriography, puncture methods and catheter technique.
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