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Sympathetic vesicovascular reflex induced by acute urinary retention evokes proinflammatory and proapoptotic injury in rat liver.

Increased hepatic sympathetic activity affects hepatic metabolism and hemodynamics and subsequently causes acute hepatic injury. We examined whether the vesicovascular reflex evoked by bladder overdistension could affect hepatic function, specifically reactive oxygen species (ROS)-induced inflammation and apoptosis, through activation of the hepatic sympathetic nerve. We evaluated the hepatic hemodynamics, hepatic sympathetic nervous activities, and cystometrograms in anesthetized rats subjected to acute urinary retention. We used a chemiluminescence method, an in situ nitro blue tetrazolium perfusion technique, and a DNA fragmentation/apoptosis-related protein assay to demonstrate de novo and colocalize superoxide production and apoptosis formation in rat liver. Acute urinary retention increased the hepatic sympathetic-dependent vesicovascular reflex, which caused hepatic vasoconstriction/hypoxia and increased superoxide anion production from the periportal Kupffer cells and hepatocytes, which were aggravated by the increase in volume and duration of urinary retention. The ROS-enhanced proinflammatory NF-kappaB, activator protein-1, and ICAM-1 expression also promoted proapoptotic mechanisms, including increases in the Bax/Bcl-2 ratio, CPP32 expression, poly-(ADP-ribose)-polymerase cleavages, and DNA fragmentation and apoptotic cells in the liver. The proinflammatory and proapoptotic mechanisms were significantly attenuated in rats treated with hepatic sympathetic nerve denervation or catechin (antioxidant) supplement. In conclusion, our results suggest that acute urine retention enhances hepatic sympathetic activity, which causes hepatic vasoconstriction and evokes proinflammatory and proapoptotic oxidative injury in the rat liver. Reduction of the hepatic sympathetic tone or antioxidant supplement significantly attenuates these injuries.

Acute Disease↗

A probability model for ultrasound estimation of bladder volume in the diagnosis of female urinary retention.

OBJECTIVE: The aim of this study was to evaluate a probability model for ultrasound estimation of bladder volume in the diagnosis of female urinary retention, which is a common condition in the postpartum period. METHODS: A total of 53 women with vaginal delivery were recruited on postpartum day 1, and their bladder volumes were first estimated by ultrasound. Immediately after the ultrasound scans the bladders were catheterized for the true bladder volumes. The ultrasound-estimated bladder volumes were then compared with the catheterized bladder volumes. The data were first tested for non-normality, and then logarithmic transformed in order to conform to normality. A probability model was built using the logarithmic-transformed data, based on the following: an arbitrary cut-off value of 150 ml for urinary retention, linear regression analysis, and paired difference analysis. RESULTS: There was a linear relationship between the ultrasound-estimated and catheterized bladder volumes, which can be represented by the equation: log(10) (Vc) = 0.2959 + 0.8853 log(10) (Vu), where Vc = catheterized bladder volume, and Vu = ultrasound-estimated bladder volume. A normogram was constructed, and the probability of urinary retention presented. CONCLUSIONS: The results of this study showed that our method and statistics are logical by which the probability model of urinary retention is precise enough to support clinical decision-making.

Female↗

Questionnaire survey of urologists' initial treatment practices for acute urinary retention secondary to benign prostatic hyperplasia in Korea.

BACKGROUND: We undertook a survey of Korean urologists to establish initial treatment practices for acute urinary retention secondary to benign prostatic hyperplasia. METHODS: Probability samples were drawn from the Korean Urological Association Registry of Physicians, and a random sample of 850 Korean urologists were asked to complete a questionnaire that explored practice characteristics and treatment strategies in the management of acute urinary retention. The returned questionnaires were statistically analyzed. RESULTS: Of the 850 questionnaires sent, 302 were returned, and 277 of those were included in the final analysis (response rate 32.6%). Korean urologists preferred urethral catheterization as the initial management. Of respondents, 154 (55.6%) and 109 (39.4%) started their patients on alpha-blockers and alpha-blockers with finasteride, respectively. Nearly half (50.2%) used a trial without catheter 7 days after catheterization. One failed trial without catheter was an indication for surgery for only 69 (24.9%) of the respondents. A second trial without catheter was advocated by 108 (39.0%). Most urologists (82.3%) expected to be successful with the above management in 50% or greater. Physician's demographics or types of initial management did not influence physician's perception of expected success rate when the expected success rate was divided as < or =50% and >50. CONCLUSIONS: These data provide a picture of current practice regarding the management of acute urinary retention secondary to benign prostatic hyperplasia in Korea. There is no uniformity in the management of acute urinary retention in Korea.

Acute Disease↗

Posthernioplasty urinary retention: a noninvasive work-up for prediction.

The prognostic value of various subjective and objective noninvasive urological parameters was evaluated for their possible role in the prediction of post-hernioplasty urinary retention. In a prospective study, 35 patients aged 55-85 years without previous micturition complaints or urological surgery were evaluated 1 day prior to inguinal hernioplasty. This included medical history for modified Madsen subjective scoring profile, physical examination and uroflowmetry. Bladder capacity, residual urine and prostatic volume were measured by ultrasound. All patients underwent a similar method of hernioplasty, were closely followed 48 h postoperatively and any voiding difficulties or urinary retention were noted. Urinary retention occurred in 12 patients. None of the remaining 23 patients had urination difficulties. Comparing these two groups, we concluded that patient age, bladder capacity and prostatic volume have no prognostic value for potential postoperative urinary obstruction. On the other hand, obtaining a good anamnesis of obstructive and irritative symptoms for scoring, measuring maximal flow rate on urinary flowmetry and estimating residual urine volume may predict patients who are potentially at high risk for posthernioplasty urinary retention.

Aged↗

Effect of the surface treatment of plain carbon fiber posts on the retention of the composite core: an in vitro evaluation.

This study aims to evaluate the role of surface treatments performed on plain carbon fiber posts, in relation to serrated carbon fiber posts, in the retention of the composite core. Fifty carbon fiber posts received surface treatments in order to verify their influence on the retention of the core material. An acrylic resin mold was developed in order to precisely fit the post, leaving a machined space to accommodate a self-curing composite resin. After the surface treatment, a primer was applied on the coronal portion of all posts, which were then dried. They were fitted to the mold and received a 3 mm composite core. All specimens were thermocycled and then stored in distilled water for a week. Tension test was performed at a speed of 0.5 mm/min until there was lack of adhesion or fracture of the core. The conclusions were: a) the values of retention related to aluminum oxide spray (group A), depth cutter diamond burs (group C) and posts with machined coronal portion (group D) were comparable to those of serrated posts (group E), although no statistically significant difference between these groups was found; b) the mean values of core retention in group B (medium grit diamond burs) were statistically lower than those of other groups.

Carbon↗

Variability effects on retention of a motor skill in elementary school children.

Variability effects on learning, retention, and transfer of motor skills have been a main issue for scientists involved in laboratory and field research. Variable practice is intended as parameter variations of a generalized motor program as well as rehearsal of different motor programs. Although the benefits deriving from variable practice on motor skill retention appear quite robust in laboratory settings, field investigations have produced mixed results. Hence, the aim of this study was to examine the effects of different variable schedules on the retention of a complex min tor skill in a physical education setting. 61 elementary school children were assigned Blocked/Nonvariable, Blocked/Variable, Serial/Nonvariable, or Serial/Variable schedules, and practiced two tasks (throwing and hurdle running) and a complex skill (jumping) across 14 lessons. Improved performance in the complex skill was found after practice, with the Serial/Nonvariable group outperforming all other groups. Therefore. the rehearsal of different motor programs was beneficial for jumping skill retention, whereas parameter variation was not.

Child↗

Mental and physical practice schedules in acquisition and retention of novel timing skills .

Research has indicated that random physical practice of a motor skill enhances effects of long-term learning more than blocked practice. Moreover, the use of mental rehearsal coupled with physical practice has been shown to accelerate motor skill acquisition in many different contexts and is better than no practice at all. Others have found that some mental rehearsal strategies are better than others for maximizing performance. This study examined how combinations of mental and physical practice schedules affected the learning of a coincidence timing task. 30 college students were randomly assigned to one of four treatment groups involving combinations of imagery and physical practice. Three tasks were utilized, each involving a particular speed (slow, medium, fast) on the Bassin Anticipation Timer. Conclusions were based on a three-way analysis of variance, using type of mental practice, type of physical practice, and sex as between-group factors, conducted separately for acquisition and retention trials. Type of physical practice was significantly related to performance. On the acquisition trials, random practice was associated with larger mean errors than blocked practice; however, the reverse was true for retention trials. There was no significant effect of type of mental practice in either the acquisition or retention phase. Sex was significantly related to performance for the retention trials only, where the 15 men made smaller errors than the 15 women.

Adult↗

Effect of cleansing procedures on the retentive ability of two luting cements to ground dentin in vitro.

A method has been described to measure the retention of luting cements to ground dentin in vitro. Using a specially designed apparatus, a circular disc of cement was produced on a ground dentin surface of equal diameter. In a universal testing machine a tensile stress was applied to the cement disc pulling it parallel with the dentin surface at right angles to the diamond grooves until separation. The effect of two different cleansing procedures on the retentive ability of two dental cements was investigated. The cleansing procedures were: rubbing ground dentin with Tubulicid or polishing with wet pumice. The cements studied were a polycarboxylate cement (Durelon) and a zinc phosphate cement (De Trey's Zink Zement Improved). The retentive ability of the polycarboxylate cement showed values from six to seventeen times those of the zinc phosphate cement. The retentive ability of zinc phosphate cement was only slightly affected by the two cleansing procedures, while for polycarboxylate cement it was somewhat reduced following rubbing with Tubulicid and greatly improved after polishing with pumice and water.

Adhesiveness↗

Retention of complete maxillary dentures as a result of changes in design.

The influence of complete maxillary denture design on retention was studied under clinical conditions simulating chewing. Five persons with an edentulous maxilla and a natural dentition of at least 10 teeth in the mandible participated. Retention was measured with a miniature bite force sensor. The occlusal load required to provoke denture dislodgement was recorded. The general principles of denture design were as follows: the bicuspids and molars were set on top of the residual ridge; the thickness of the denture borders was determined functionally; and the palate was covered to the vibration line, without attempts at border compressions. The details that were changed to evaluate their influence on denture retention were as follows: the point of attack of the dislodgement-provoking load alternated between three distinct pits, situated 2 mm apart in the buccopalatal direction on the occlusal surface of the first right bicuspid; the vestibular denture border on the left side was reduced stepwise to 75%, 50%, and 25% of its original thickness; and the distal extension of the palatal denture border was shortened stepwise (2 + 2 mm, as measured in the midline). Measurements pertaining to one specific problem were carried out within a period of 2 h. The results confirmed the concepts that lingualized occlusal contact, functionally determined filling in of the vestibular sulcus, and full palatal coverage to the vibration line all have a positive influence on the retention of complete maxillary dentures.

Aged↗

Remembering the news: modeling retention data from a study with 14,000 participants.

A retention study is presented in which participants answered questions about news events, with a retention interval that varied within participants between 1 day and 2 years. The study involved more than 14,000 participants and around 500,000 data points. The data were analyzed separately for participants who answered questions in Dutch or in English, providing an opportunity for replication. We fitted models of varying complexity to the data in order to test several hypotheses concerning retention. Evidence for an asymptote in retention was found in only one data set, and participants with greater media exposure displayed a higher degree of learning but no difference in forgetting. Thus, forgetting was independent of initial learning. Older adults were found to have forgetting curves similar to those of younger adults.

Humans↗

Are false memories more difficult to forget than accurate memories? The effect of retention interval on recall and recognition.

What is the effect of retention interval on accurate and false recollection in the Deese, Roediger, and McDermott (DRM) procedure? Previous research has suggested that false recall is more persistent than accurate recall but the recognition results have been inconsistent. In two parametric studies, we tested recall and recognition for the same DRM lists, over retention intervals that ranged from no delay to a 2-month delay. We found that accurate and false memory were diminished by increases in retention interval, false memory persistence was present for recall and recognition, greater persistence for false memory than for accurate memory was more readily observed for recall than recognition, and the high-threshold (Pr), signal detection (d'), and nonparametric (A') recognition measures differed in their sensitivity for detecting change. The effect of retention interval on accurate and false memory is consistent with expectations from fuzzy trace theory. In the DRM procedure, truth is not more memorable than fiction.

Humans↗

Urinary retention in hospitalized elderly women.

Unrecognized urinary retention may be a factor in the development of recurrent urinary tract infections, urinary incontinence, bladder dysfunction, and upper urinary tract disease. Because urinary retention is often asymptomatic in elderly women, with amounts of up to 1,500 mL retained in the bladder often causing little or no discomfort, nurses need to have a high index of suspicion about its occurrence. A post-void residual is the best way of determining the presence of urinary retention. The goal of treatment for urinary retention is bladder decompression via catheterization followed by voiding trials and determination of residual volumes.

Aged↗

Teaching methodologies: knowledge acquisition and retention.

In studying the curriculum of a nursing program, knowledge acquisition and retention by nursing students is a primary concern of nursing instructors. The purpose of this study was to determine if a lecture which stimulated several senses would significantly increase knowledge acquisition and retention compared to lectures that stimulate only the auditory sense. Forty-three, junior year, diploma nursing students who had essentially the same clinical experience were the subjects randomly assigned to either Group A or B for this study. Group A (control group) attended a formal lecture on "Spinal Cord Injuries" which stimulated only the auditory sense. Group B (experimental group) attended a lecture on the same subject which stimulated the auditory, visual, and tactile senses. A pretest was given to evaluate the knowledge base prior to the lecture, a posttest was given immediately after the lecture to evaluate initial knowledge acquisition, and a retention test was given three weeks later to evaluate amount of knowledge retained. Students attending the multimodal lecture demonstrated a significantly higher retention test score at the .05 level although they did not demonstrate a significantly higher gain score from pretest to posttest.

Cognition↗

Retention of Basic Cardiac Life Support content: the effect of two teaching methods.

Does the method of instruction affect retention of Basic Cardiac Life Support (BCLS) knowledge and skill? This was the primary question addressed in a study conducted in a university school of nursing. The teaching methods studied were a lecture-demonstration-return demonstration method and a self-paced method. The sample consisted of 63 baccalaureate nursing students who were assigned to one of the two teaching methods. American Heart Association instructional materials and cognitive and performance tests were used with both treatment groups. Initial mastery and retention were tested during week two and eight respectively. Cognitive knowledge was retained at a mastery level by both groups at eight weeks. In addition, there was no difference in retention of performance skills based on teaching methods. However, neither group was able to demonstrate retention of performance skills at a mastery level. Additional data indicate the self-paced subjects spent less time in BCLS learning activities. While the self-paced instructional package was more costly on a one-time basis, repeated applications would decrease the cost/student.

Adult↗

Knowledge, retention, and attitude effects of computer-assisted instruction.

The effects of computer-assisted instruction (CAI) and lecture upon knowledge, retention, and attitudes of baccalaureate nursing students were compared in this research study. Retention was of particular interest, since few nursing CAI studies have investigated this concept. A two-group posttest design with a second posttest eight months later was used. Lesson content for both the CAI and lecture groups was the nursing research problem. The CAI group used an interactive tutorial written in BASIC. The lecture group was presented the same content using transparencies. There were no significant differences in knowledge, retention, or attitudes between the CAI and lecture group. Attitudes toward CAI were positive. CAI is as effective as lecture for learning knowledge and retention.

Attitude to Computers↗

[The usefulness of clinical history for the diagnosis of lower urinary tract obstruction in patients with acute urinary retention].

OBJECTIVES: To determine the diagnostic usefulness of data provided by clinical history for the diagnosis of lower urinary tract obstruction in patients with acute urinary retention. METHODS: We performed a transversal study in a series of 70 patients (19 women and 51 men) with a mean age of 61.5 years (typical deviation 20.7 years), who underwent urodynamic study due to acute urinary retention. Past medical history was recorded in all patients. Physical exam was also carried out, evaluating prostate size in males, presence of genital prolapse in females, and neurourological examination. Urodynamic tests consisted on flowmetry, pressure/flow studies with simultaneous perineal electromyography, and voiding cystourethrogram or videocystogram. Student's t mean comparison and chi-square tests were used for the statistical analysis. RESULTS: The only clinical data that showed a statistically significant relationship with obstruction of the lower urinary tract were: age, sex, prostate size, and existence of infrasacral neurological lesion (absence of bulbocavernous reflex). Age > 74 years showed a sensitivity of 71 % for lower urinary tract obstruction and a specificity of 60%. Male sex showed a sensitivity of 88% and specificity of 36%. Prostate size > or ='3d grade II sensitivity was 58% and specificity 82%; and absence of infrasacral lesion a sensitivity of 77% and specificity of 48%. CONCLUSIONS: Provided that a negative result in a test with high sensitivity makes the likelihood of disease low, in women the presence of infrasacral neurogenic dysfunction or age < or ='3d74 years diminish the probability of obstruction in patients with acute urinary retention. On the other side, if a negative result of a test with high specificity increases the probability of having the disease, a prostate size > or ='3d grade II and age > 74 years favour the likelihood of having urinary tract obstruction for a patient with acute urinary retention.

Cross-Sectional Studies↗

[Serum gamma-seminoprotein on patients suffering from urinary retention due to BPH].

Serum gamma-Seminoprotein (gamma-Sm) of 33 patients suffering from urinary retention due to BPH was evaluated. In acute urinary retention gamma-Sm was 17.1 +/- 54.9 ng/ml (N = 33) and its positive rate was 72.7%. After indwelling urethral catherization for one week gamma-Sm fell to 3.7 +/- 3.6 ng/ml (N = 17) and its positive rate was 42.8%. gamma-Sm measured after one month was negative on all cases. It was showed that gamma-Sm in acute urinary retention increased and after releasing from urinary retention it was rapidly normalized. It is necessary to take into account the above mentioned findings on evaluation of gamma-Sm as a tumormarker of prostatic carcinoma.

Aged↗

Spinal morphine anesthesia and urinary retention.

Spinal anesthetic is a common form of surgical anesthetic used in foot and ankle surgery. Spinal morphine anesthetic is less common, but has the advantage of providing postoperative analgesia for 12 to 24 hr. A number of complications can occur with spinal anesthesia, including urinary retention that may be a source of severe and often prolonged discomfort and pain for the patient. Management of this problem may require repeated bladder catheterization, which may lead to urinary tract infections or impairment of urethrovesicular function. This study reviews the incidence of urinary retention in 80 patients (40 after general anesthesia and 40 after spinal anesthesia) who underwent foot and ankle surgery at Saint Joseph's Hospital, Philadelphia, PA. Twenty-five percent of the patients who had spinal anesthesia experienced urinary retention, while only 7 1/2% of the group who had general anesthesia had this complication. Predisposing factors, treatment regimen, and recommendations for the prevention and management of urinary retention are presented.

Adult↗