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PubMed1991

Prenatal hemoglobinopathy screening. IV. Follow-up of women at risk for a child with a clinically significant hemoglobinopathy.

To determine the benefits and burdens of prenatal hemoglobinopathy carrier identification and genetic counseling and its impact on subsequent reproductive behavior, we recontacted women whom we had previously identified as at risk for having a child with a clinically significant hemoglobinopathy, regardless of whether they had accepted the offer of prenatal diagnosis. Of the 46 such women, 31 were available for interview. These 31 women had received offers of prenatal diagnosis in 47 pregnancies. Seventeen had been accepted, and 30 had been declined. The proportion of patients accepting the offer of prenatal diagnosis was higher for the index pregnancy (50%) than for subsequent pregnancies (22%). The mean interval between the initial counseling of the patient and the follow-up interview was 43 mo (standard error +/- 2.7 mo). Ninety-four percent of those interviewed recalled having received information from the screening program; 74% recalled the name of their condition; 90% knew that trait did not affect their health; 84% recalled the name of the condition for which their fetus had been at risk; and 77% could state at least one symptom of the disease. Of the 29 women asked whether they intended to use prenatal diagnosis in future pregnancies, 13 said yes and 16 said no. Of the 26 patients asked about satisfaction with their previous decision about prenatal diagnosis, all were satisfied with their decision. Eighteen said they would make the same decision in their next pregnancy, but seven patients said they would not, and one was undecided.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Contraceptive use at first premarital intercourse: United States, 1965-1988.

The proportion of U.S. women who used a contraceptive method at their first premarital intercourse rose from 47 percent in 1975-1979 to 65 percent in 1983-1988. Overall, and among non-Hispanic white women, this change resulted entirely from an increase in the use of condoms by their partners. The proportion of whites who used a condom at first premarital intercourse, for example, increased from 24 percent to 45 percent. Among blacks, condom use at first intercourse increased from 24 percent to 32 percent during that period, and pill use rose from 15 percent to 23 percent. Among all women, the method most often used at first intercourse during every period in the study was the condom, followed by the pill and withdrawal. The proportion of women using a method at first premarital intercourse varies strikingly according to individual characteristics. Among the various demographic subgroups, the proportion who use a method varies from 32 percent of Hispanic women to 68 percent of Jewish women. Whites are more likely to use a method than are blacks, and fundamentalist Prostestants are less likely to use a method than are other Protestants or Catholics. The proportion using a method is higher among women whose mothers completed high school than among those whose mothers did not. In addition, the proportion rises with age at first intercourse. Multiple logistic regression showed that the independent effects of Hispanic origin, Jewish or fundamentalist Protestant religious affiliation and the education of a woman's mother are large and significant.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

[Sex education, sex behavior, contraception].

Sexual behavior has changed during the last decades. Teenage fertility rate, and the number of gonococcal infections are both extremely high; the incidence of HIV-infections is increasing. Preventive measures include sex education. Sex education may help the adolescents to identify their own goals for sexual behavior, to avoid unintended and unwanted pregnancy, and to avoid sexually transmitted diseases.

Adolescent↗
PubMed1990

[Sexual activity, contraception and unwanted pregnancy at puberty and adolescence].

The sexual activity during the pubertal-adolescent age and the closely connected with it questions about psychological consequences, extramarital conceptions, deliveries and abortions is a problem with more and more increasing significance in the world. The present study includes an inquiry on 468 girls and boys at the age of 17-18 years, and 120 girls at the age of 14 to 17 years with interrupted pregnancy 214 girls with interrupted pregnancy at the age of 13 to 17 years and 120 girls at the age of 14 to 17 years, who delivered extramaritally at the Higher Research Institute of Obstetrics and Gynecology. It is established that 48.6% of girls have sexual life, but 92.1% of girls, aged 17-18 years, have sexual life. The question was studied when, why and with whom the first sexual contact was made. The questions about contraception, sexual education, abortions, deliveries and the fate of the newborn are discussed as well. Inferences for prophylactic work among the coming generation are made.

Adolescent↗
PubMed1990

The contraceptive needs of midlife women.

For those women who have not been contraceptively sterilized, midlife is a period of waning fertility. However, the occurrence of anovulatory menstrual cycles is unpredictable. Contraceptive methods also become increasingly contraindicated, both medically and physiologically. This article reviews the physiology of waning fertility and midlife contraceptive options, and discusses implications for helping women meet their contraceptive needs throughout the perimenopausal period.

Adult↗
PubMed1990

Alcohol use as a situational influence on young women's pregnancy risk-taking behaviors.

Recent studies have found that many young women just beginning their sexual lives use alcohol prior to intercourse. A large number appear to drink heavily enough prior to sex to compromise their ability to use contraceptives. The question emerges whether there is a relationship between drinking before intercourse, the nonuse of birth control methods, and unplanned pregnancies. The present research describes 43 instances of intercourse which resulted in unplanned pregnancies in 14- to 21-year-olds. Variables examined included alcohol use prior to sex, amount of alcohol consumed, the use of other drugs, the planning of intercourse, respondents' stated reasons for nonuse of contraceptives, and other general demographic data.

Adolescent↗
PubMed1990

Contraceptive use for planned parenthood patients.

Three hundred consecutive new patients coming to Planned Parenthood clinics were reviewed. Of these patients, 68.3 percent were not using contraception and 67.8 percent had never used contraception. Also, 35.1 percent had experienced one or more pregnancies, and 52 percent had first coitus before 16 years of age.

Adolescent↗
PubMed1988

Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons.

Stimulation of the bag cell neurons of Aplysia triggers a long-lasting afterdischarge in these cells. In vivo, such a discharge causes the onset of a sequence of reproductive behaviors. We have found that treatments that trigger discharges in vitro stimulate the hydrolysis of phosphoinositides in the bag cell neurons, as measured by increased incorporation of 3H-inositol into fractions containing membrane lipids and water-soluble inositol phosphates. The electrophysiological effects of inositol trisphosphate, one of the products of phosphoinositide turnover that has been shown to mobilize intracellular calcium in non-neuronal cells, were investigated using isolated bag cell neurons in cell culture. Microinjection of inositol trisphosphate into cultured bag cell neurons caused a transient hyperpolarization of the membrane (approximately 35 sec), together with an increase in conductance. This effect of inositol trisphosphate was abolished by 50 mM tetraethylammonium ions. Inositol trisphosphate also reduced the amplitude of action potentials. Injection of calcium ions directly into bag cell neurons mimicked these responses seen after inositol trisphosphate injection. Using the cell-attached patch-clamp technique in conjunction with inositol trisphosphate microinjection, we observed that inositol trisphosphate evoked increases in the activity of a channel carrying outward current at the resting potential and more positive potentials. The estimated slope conductance of the channel modulated by inositol trisphosphate was approximately 40 pS, and its reversal potential was close to that predicted for potassium ions. The increased opening of this channel in response to inositol trisphosphate injection appeared to result from a transient shift of its voltage-dependence to more negative potentials. In a few cases, inositol trisphosphate injection also elicited an increase in the activity of a channel passing inward current at rest. Direct measurements of changes in intracellular calcium in response to inositol trisphosphate were made using digital imaging of isolated neurons loaded with the fluorescent calcium indicator fura-2. These revealed that injection of inositol trisphosphate significantly elevated intracellular calcium levels, and that this inositol trisphosphate-induced rise in cytosolic calcium was not affected by removal of extracellular calcium. In contrast to the effects of trains of action potentials in calcium-containing media, which produced increases in calcium primarily in neurites, the inositol trisphosphate-induced elevation of calcium appeared more localized to the somata of these neurons.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1989

Fertility and fertility-related behavior among Mexican-American and non-Hispanic white female adolescents.

Ethnic differences in fertility-related behavior are examined in a community-based probability sample of 706 Mexican-American and 317 non-Hispanic white females aged 13 through 19 years. Mexican-Americans are more likely than whites to have had a live birth, but are no more likely to have been pregnant and are less likely to have had sexual intercourse. Sexually experienced Mexican-Americans, however, are twice as likely as whites to have been pregnant. Among those ever pregnant, Mexican-Americans are more likely to have had a live birth, while whites are more likely to have had an abortion. Ethnic differences remain strong when socioeconomic status and indicators of social instability are controlled statistically, lending more support to the "minority status" hypothesis than to the "characteristics" hypothesis concerning the fertility-related behavior of minority group members.

Adolescent↗
PubMed1989

[Health status of pregnant women and infants in their first year of life in the Lithuanian S.S.R].

The analysis of a modern demographic situation, dynamics and causes of child mortality, the levels and patterns of pregnancy and childbirth pathology, the newborn and infants' disease rates in the Baltic Republics and the Byelorussian SSR enabled one to determine priority directions for the development of a complex programme on the improvement of mother and child health and reduction of child mortality in the Baltic Republics, these directions involve intensification of antenatal fetus protection due to the improvement of females' working conditions, development of medico-genetic counselling and wide application of prenatal diagnostic procedures for the detection of fetus developmental defects, optimization of women reproductive behavior under the conditions of complete provision with modern contraceptive means, propaganda of breast feeding.

Adult↗
PubMed1986

A model for polygenic inheritance of abdominal tergal scale pattern in Aedes aegypti.

There is much variation in the amount of white scaling on the abdominal tergites of Aedes aegypti. The genetic basis for this white scale pattern was investigated in two laboratory strains established by selection from the CARN Strain of Ae. aegypti. These experimental strains were crossed in all possible directions in single pair matings. Based on analysis of their progeny it is proposed that genes at three separate independently assorting loci control abdominal tergal scale pattern. Correlation of observed data and expected data was high. Since the abdominal tergal scale pattern in Ae. aegypti appears to be controlled by one major polygenic system with modifiers, it is proposed that it is better to consider differences in ethology, physiology, and reproductive behavior as the bases for separation of the species into intraspecific groups.

Aedes↗
PubMed1987

Sociobiology of addiction in adolescence.

The authors review the application of evolutionary theory to the study of social, including parental and reproductive, behavior through a system of ideas known as sociobiology. Using this approach they suggest that evolutionary models predict the conflicts of adolescence. They develop a model explaining the genetic association of alcoholism and the tendency for antisocial behavior, and suggest why such behaviors most commonly begin in adolescence. Potential implications for the treatment of adolescent substance abusers are explored.

Adolescent↗
PubMed1987

Planned Parenthood experience with triphasil.

Triphasil, a low-dose combination oral contraceptive containing levonorgestrel and ethinyl estradiol, was tested in four Planned Parenthood clinics on 317 women between 18 and 34 years of age (mean, 23) for a total of 4,692 cycles, or 361 woman-years of usage. Approximately half these volunteers (165) were nulligravidas, and 309 (97.5%) were white. Despite instructions on proper tablet usage, there were 416 cycles (8.9%) in which one or more tablets were missed. Only one pregnancy occurred, in a cycle in which a total of four tablets was missed, for an uncorrected Pearl index of 0.28 pregnancies per 100 woman-years of usage. No pregnancy resulted from method failure, indicating a 100% efficacy rate for Triphasil when taken properly. The mean length of the menstrual cycle with Triphasil was 27.9 days; the mean length of menses, 4.4 days; and the mean latency period, 2.1 days. Menstrual flow was average in 64.1% of the subjects, light in 34.1%, heavy in 1.3% and variable in 0.5%. Amenorrhea during the tablet-free interval occurred in only 0.6% of the 4,692 cycles in which Triphasil was used. Breakthrough bleeding occurred in 6.9% of first cycles and 3.2% of total cycles; spotting, in 10.7% of first cycles and 4.4% of total cycles. Other symptoms that occurred with an incidence of greater than or equal to 1% were acne (1.0%), appetite increase (1.2%), breast discomfort (2.8%), breast enlargement (1.3%), gastrointestinal symptoms (1.7%), simple headache (1.4%) and nausea (1.1%). A total of 44 women (13.9%) discontinued treatment for medical reasons.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

The effects of sex education on adolescent behavior.

By age 18, according to the 1982 National Survey of Family Growth, 68 percent of 15-19-year-old women have received formal instruction about pregnancy and contraceptive methods, 16 percent have had instruction about pregnancy only, and another 16 percent have received neither type of education. The age at which formal contraceptive education is first provided has been declining; among 15-year-olds, for example, 47 percent have had instruction by their 15th birthday, compared with 33 percent of 17-year-olds and 26 percent of 19-year-olds. Forty-six percent of adolescent women have had premarital intercourse. Exposure to formal sex education appears to have no consistent effect on the subsequent probability that a teenager will begin to have intercourse. Sex education does influence contraceptive knowledge and behavior, however. Sexually active teenagers who have had formal instruction report knowing how to use more methods than do adolescents who have had no instruction. The former group is also significantly more likely to have practiced contraception at some time. And among ever-users, those who have received pregnancy and contraceptive education before first coitus are significantly more likely to have used a method at first intercourse. Nearly one-third of premaritally sexually active adolescents have had at least one premarital pregnancy. The NSFG data reveal no significant relationship between exposure to sex education and the risk of premarital pregnancy among sexually active teenagers.

Adolescent↗