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PubMed1984

Psychotic patients' impressions of a person from written descriptions.

The present study examined the impressions of personality formed from written descriptions of behavior by over 200 hospitalized male schizophrenics, tested individually when they seemed in contact with reality. One description was of extrovert (E) behavior by a youth named Jim; another was of his introvert (I) behavior in similar settings. Combined communications gave one description immediately after the other. After 150 patients read one of the communications, they were generally willing and able to respond to a 36-item questionnaire about Jim. This also occurred when 96 patients were asked to answer it before any communication, on the basis of their expectations about Jim; 56 subsequently received a communication, followed by readministration of the questionnaire. Patients' responses, before or after the communications, revealed few pathological signs and, like those of normal Ss, could usually be classified as E or I. Patients had less differential effects, and far fewer I responses than normal Ss. Patients and normals showed preconceptions of Jim as extrovertive. Results were discussed in light of the projective hypothesis and other theories.

Communication↗
PubMed2005

The laparoscopic performance of novice surgical trainees: testing for acquisition, loss, and reacquisition of psychomotor skills.

BACKGROUND: It has been suggested that virtual reality (VR) might be useful for the selection of surgical trainees and the measurement of technical performance during preoperative training and retraining. This study was designed to determine whether it is possible to define and measure the acquisition, loss, and reacquisition of psychomotor skills in novice surgical trainees. METHODS: Novice surgical trainees (NSTs n = 10, junior surgical registrars with little or no prior experience with laparoscopic surgery) were tested and retested after 1 month using the Minimally Invasive Surgical Trainer-Virtual Reality. Two tasks were used: the simple task [stretch diathermy (SD)] and the more complex task [manipulation diathermy (MD)]. The score was derived from the time taken to complete the task and the number of errors that occurred. Acquisition is the difference between the first and last score of the first training session, loss is the difference in score that occurs between the last score of the first training session and the first score of the second training session, and reacquisition is the difference in the first and last scores of the second training session. A performance criterion level was defined for each task by testing a group of experienced laparoscopic surgeons (n = 10). Groups were compared using the nonparametric Wilcoxon signed rank test, with p < 0.05 considered to be significant. RESULTS: Acquisition of skill was found for five of 10 NSTs with the SD task and 10/10 for the MD task. As a group the NSTs achieved the criterion level from the outset with the SD task and exceeded it by the eighth attempt for the MD task. The best score was achieved with fewer attempts during the second training session for the SD but not the MD task. The defined parameters are expressed as mean percentage score +/- SD for the 10 NSTs and for each task. There was a 36% (+/- 26) acquisition for the SD task compared with 50% (+/- 4) for the MD task (Wilcoxon p = 0.241). There was a 23% (+/- 19) loss for the SD task compared with 81% (+/- 16) for the MD task (p < 0.005). There was a 20% (+/- 10) reacquisition for the SD task compared with 54% (+/- 7) for the MD task (p < 0.005). The mean scores were greater for the more complex task (MD), which was more useful in discriminating between the individual trainees and the two training sessions. CONCLUSIONS: It is possible to use VR to define the acquisition, loss, and reacquisition of psychomotor skills in individual NSTs and to compare them with a predefined performance criterion level. This study defines parameters that will be useful in repeated training sessions of NSTs in the preoperative phase of training and during retraining.

Clinical Competence↗
PubMed2001

Virtual reality simulators for dermatologic surgery: measuring their validity as a teaching tool.

Surgical simulation is increasingly being considered for training, testing, and possibly credentialing in medicine and surgery. At the University of Washington we have been developing a virtual reality (VR) suturing simulator. In the course of development it must be realized that expensive new technologies should bear the burden of proof of their effectiveness and reliability before they are put into training programs. The purpose of this article is to define the concept of surgical skill and to discuss how it can be measured in the context of validating VR surgical simulators. Specific measures of validity and reliability are reviewed and discussed.

Computer Simulation↗
PubMed1997

Testing for interference in human genetic maps.

Known methods of testing for interference in human genetic maps are reviewed. Two aspects of interference are distinguished, numerical interference referring to the numbers of crossovers occurring and positional interference referring to the positions of crossovers. Tests for interference generally address only one or the other of these two aspects. Published investigations of interference presume fully informative marker maps, while in reality genetic markers are of limited heterozygosity, which weakens some of the tests for interference. The conclusion is drawn that rigorous tests for interference have not yet been carried out for human data.

Chromatids↗
PubMed1999

Creativity and imagination in autism and Asperger syndrome.

Three studies are reported that address the often described impoverished creativity in autism. Using the Torrance Creativity Tests, Experiment 1 found that children with autism and Asperger syndrome (AS) showed impairments. Experiment 2 tested two explanations of these results: the executive dysfunction and the imagination deficit hypotheses. Results supported both hypotheses. Children with autism and AS could generate possible novel changes to an object, though they generated fewer of these relative to controls. Furthermore, these were all reality-based, rather than imaginative. Experiment 3 extended this using a test of imaginative fluency. Children with autism and AS generated fewer suggestions involving attribution of animacy to foam shapes, compared to controls, instead generating reality-based suggestions of what the shapes could be. Although this is evidence of executive dysfunction, it does not directly account for why imaginative creativity is more difficult than reality-based creativity.

Autistic Disorder↗
PubMedDate not supplied

Investigating visual knowledge in dementia of the Alzheimer type (DAT): evidence for a structured organization.

Given that certain types of semantic dysfunction in DAT have been attributed to difficulties in accessing visual knowledge, the issues of integrity of access to, and format of storage, within the "visual store" are particularly important. In these experiments, we tested 10 DAT patients and matched controls on the reality decision and part-whole matching tasks. Visual knowledge was found to be significantly impaired in the DAT group. Moreover, DAT patients displayed disproportionate deficits in accessing visual knowledge of items from nonliving categories. Results are interpreted within a framework of differential hierarchical access to visual representations of perceptually similar and perceptually distinct categories of items.

Aged↗
PubMed2002

[External quality assessment of the genetic testings for hematopoietic tumor, CML].

Genetic testings are commonly employed in various fields of clinical medicine and the test items performed at clinical laboratories are increasing rapidly in number. They are utilized to make early and/or definite diagnoses of infectious diseases, leukemia, cancers and molecular inherited diseases and also to monitor the progress of the diseases. However, these genetic testings except for infectious diseases have been developed independently at each clinical laboratory and the test results obtained at each laboratory are not always compatible each other. Under these situations it is widely expected to construct advanced genetic testing systems that can supply standardized data at any of domestic and international clinical laboratories. For the period from April, 1999 to March, 2002 three major clinical laboratories, SRL, Inc., BML, Inc. and MBC, Inc., were consigned by JBA (Japan Bioindustry Association) to collaborate in standardizing the evaluation methods for genetic testing systems among the clinical laboratories. The aim of the study is to develop the standardized genetic testing systems and to propose them as international standard operational procedures to the ISO/TC212 working group. Although one of the most important issues for standardization is the external quality assessment, they have not been carried out in reality. In this study we evaluated the difference of the genetic testing results obtained during the year of 2000 and 2001 among the clinical laboratories. The genetic testings for hematopoietic tumor, CML were selected to be evaluated since they are widely accepted as clinically useful tests.

Blotting, Southern↗
PubMed1985

Statistical studies in genetic toxicology: a perspective from the U.S. National Toxicology Program.

This paper surveys recent, as yet unpublished, statistical studies arising from research in genetic toxicology within the U.S. National Toxicology Program (NTP). These studies all involve analyses of data from Ames Salmonella/microsome mutagenicity tests, but the statistical methodologies are broadly applicable. Three issues are addressed: First, what is a tenable sampling model for Ames test data, and how does one best test the adequacy of the Poisson sampling assumption? Second, given that nonmonotone dose-response curves are fairly common in the Salmonella assay, what new statistical techniques or modifications of existing ones seem appropriate to accommodate to this reality? Finally, an intriguing question: How can the extensive NTP Ames test data base be used to assess the characteristics of any mutagen-nonmutagen decision rule? The last issue is illustrated with the commonly used "two-times background" rule.

Animals↗
PubMed1998

[Straying in the methodology. II. Bias introduced by questionnaires].

Some characteristics of self-report questionnaires can result in bias in responding. When a test item or a questionnaire is biased, the observed scores form an imprecise measurement of reality as a consequence of systematic errors of measurement. Causes of such bias are: unclear instructions, vague wording of the test items, culture-bound item content, suggestive questions, framing of questions, social desirability of certain answers, faking good, faking bad and the recall bias.

Bias↗
PubMed2006

Visuospatial abilities correlate with performance of senior endoscopy specialist in simulated colonoscopy.

Visuospatial abilities have been demonstrated to predict the performance of medical students in simulated endoscopy. However, little has been reported whether differences in visuospatial abilities influence the performance of senior endoscopists or whether their vast endoscopy experience reduces the importance of these abilities. Eleven senior endoscopists were included in our study. Before the simulated endoscopies in GI Mentor II (gastroscopy: case 3, module 1 and colonoscopy: case 3, module 1), the endoscopists performed three visuospatial tests: (1) pictorial surface orientation (PicSOr), (2) card rotation, and (3) cube comparison tests that monitor the ability of the tested person to re-create a three-dimensional image from a two-dimensional presentation as well as mentally manipulate that re-created image. The results of the visuospatial tests were correlated to the performance parameters of the virtual-reality endoscopy simulator. The percent of time spent with clear view in the simulated colonoscopy correlated well with the performance in the visuospatial PicSOr (r = -0.75, P = 0.01), card rotation (r = 0.75, P = 0.01), and cube comparison (r = 0.79, P = 0.004) tests. The endoscopists who performed better in the visuospatial tests also were better at maintaining visualization of the colon lumen. Those who performed better in the PicSOr test formed fewer loops during colonoscopy (r = 0.60, P = 0.05). In the technically less demanding simulated gastroscopy, there were no such correlations. The visuospatial tests performed better in endoscopists not playing computer games. Good visuospatial ability correlates significantly with the performance of experienced endoscopists in a technically demanding simulated colonoscopy, but not in the less demanding simulated gastroscopy.

Adult↗
PubMed2006

Remarkable experiences of the nuclear tests in residents near the Semipalatinsk nuclear test site: analysis based on the questionnaire surveys.

The main objective of this paper is to identify salient experiences of those who were exposed to radiation by the nuclear tests at the Semipalatinsk Nuclear Tests Site (SNTS). In 2002, our research team of the Research Institute for Radiation Biology and Medicine, Hiroshima University, started to conduct some field research by means of a questionnaire survey. Through this, we expected to examine the health condition of the residents near the SNTS, identify their experiences from the nuclear tests, and understand the exposure path. This attempt at clarifying the reality of radiation exposure at Semipalatinsk through the use of a survey research method is the first of its kind. Among the responses to our survey, the present paper focuses mainly upon responses to the questions concerning the experiences of the nuclear tests. It deals mainly with direct experiences of nuclear tests of the residents characteristic to Semipalatinsk, including some new experiences hitherto unnoticed. The present paper touches upon their concrete direct experiences of flash, bomb blast, heat, rain and dust. We also discuss distinct experiences in Semipalatinsk such as evacuation, through the additional use of their testimonies. The data have been compared with the results obtained in a similar survey made in Hiroshima and Nagasaki. For the data analysis, a statistical method called logistic multiple linear regression analysis has been used.

Adult↗
PubMed1994

Report on a molecular diagnostic service for familial hypercholesterolemia in Afrikaners.

The development of DNA-based methods for the direct detection of specific low density lipoprotein receptor (LDLR) gene mutations enabled us to establish a molecular diagnostic service for familial hypercholesterolemia (FH). This specialised service is of particular relevance and can be applied in the Afrikaner population of South Africa, where a founder gene effect increased the prevalence of FH to about 5-10 times greater than that found in most other population groups. Three point mutations in the LDLR gene were shown to account for approximately 90% of all Afrikaner FH cases. We report on the results obtained in 354 Afrikaner hyperlipidemics, from 274 unrelated families, referred for mutation screening-during the four-year period following the elucidation of the molecular basis of FH in this South African population group. By screening for the three founder-related LDLR gene mutations, approximately 50% of referrals were diagnosed as having FH. Presymptomatic diagnosis of FH by DNA analysis overcame the difficulties involved in the clinical diagnosis of some heterozygous cases. We could offer appropriate genetic counselling to FH patients, in addition to optimal clinical management by clinicians who referred the patients. Genetic testing has made early diagnosis of FH, including prenatal diagnosis, a reality.

Adult↗
PubMedDate not supplied

[French version of TASTE (test for the ability and evaluation)].

Ability to study and evaluation is only one example of performance among many others but research and publications concerning this issue for more than 50 years, especially in the context of test anxiety and need of achievement, conferred upon it a prototypical dimension. Investigations about motivation also stimulate many scientists and constitute another foundation of this study (13). The level of performance depends on knowledge and motivation (33). Time devoted to study is essential to succeed; so motivation and procrastination are in competition. The importance of reinforcement (extrinsical motivation) and the desire for learning and knowing (intrinsical motivation) are determinant. Other elements must be emphasized: guarantee of obtaining rewards, self efficacy and causal attribution. These considerations point out the multidimensional and interactive aspects of test anxiety (7, 31). The number of components is not described unanimously but experts agree with emotional, cognitive and behavioral dimensions (25). So, anxiety was approached in its motivational properties, and it was the case until the sixties, in terms of drive corresponding to a need like thirst or hunger (18); then it was conceptualized in a dynamic context broader than that of stress and coping (29, 30). Last, it constitutes the object of theories highlighting cognitive interference (9, 23, 26) or defective skills (8, 32). A lot of questionnaires were built without answering the different aspects and for instance without linking the theoretical and therapeutic components concerning this problem. Committed to the traditional fields of research (test anxiety and need of achievement), to Weiner's work about attribution theory (34) and that of Bandura in self efficacy (4, 5), E. Depreeuw (10) was particularly interested in Heckhausen's model (16, 17), trying to associate experimental conceptions with the clinical reality. On this basis, he elaborated the TASTE (10, 12, 20): test for ability to study and evaluation. At first constituted of 121 items, the self-questionnaire, after factorial analysis, was reduced to 78 items assessing 4 factors which represent the 8 components of Heckhausen's model (16). The first factor (30 items) concerns anxiety in its emotional and cognitive characteristics. Interesting data were observed by Depreeuw and confirmed in the Netherlands and in Greece (19), especially the fact that anxiety of girls is higher than that of boys when they are confronted with an exam. The second one (19 items) represents self-confidence: confidence in ability to succeed and on using adequate strategies. The third factor (14 items) squared with value attributed to performance. It especially comments on the intrinsical component of motivation. The fourth factor (15 items) corresponds to procrastination; study is postponed on behalf of activities which actually reduce the achievement process. The self-report questionnaire (where answers run from total disagreement to total agreement whether they correspond to the way of thinking or acting) takes account of the emotional, cognitive and behavioral dimensions of the model. The multidimensional aspect of this questionnaire, but mainly its connections with theory and clinic, are convincing; we adopted it with other tests in research about fear of failure. Validation of the French translation is the subject of this article. In order to realize this operation, we chose the initial version of TASTE (121 items) to assess a Belgian sample of french-speaking students in the first year of University of Liège (n = 617). They are differentiated by gender, faculty (Economy, Medicine, Philosophy, Psychology, Applied Sciences) and experience of failure, i.e. the fact of repeating a school year. Statistics were realized with SPSS and SAS. A comprehension test and a back translation are satisfactory. The stability over time too: the one week test-retest was achieved with a sample of 33 student nurses; comparing the factors two by two, intra-class correlations ranged from 0.5 to 0.95. The component analysis with Varimax rotation does not allow us to find the four factors of construction. We obtain the same disappointing results with the version of 78 items. According to the screentest, we adopted the solution of five factors which confirms the original construction. A fifth particularly strong factor (Cronbach's alpha 0.82) corresponds to devalorisation. The internal reliability is very satisfactory. If we consider the items strong loading (more than 0.30), the French version is constituted of 94 items. If we consider the items which are specifically loading each factor, we can reduce the questionnaire to 50 items. Internal reliability remains the same. Correlations between the data obtained with this brief version are satisfactory; comparing the factors in pairs. Pearson's coefficients range from 0.8 to 0.89. The study of E. Depreeuw was realized ten years ago with a Belgian sample of Flemish-speaking students; is the cultural context or an evolution in test anxiety which explains such a difference in the results? We are now assessing a sample in another country which used the TASTE in 1996 in order to have some information about comparison of samples. In any case, the questionnaire of E. Depreeuw respects the multidimensional aspect of test anxiety. Our choice of 5 factors according to principal components confirms the original structure of the test but also discriminates another factor which could be predictive of psychopathology (panic, depression). This new dimension measures negative perception of ability and achievement especially when compared with other students. One aim of such a study is to discern clusters of students i.e. groups of students with characteristics such as Covington (7), Depreeuw (20) and Zeidner (35) describe them. This description is very important; the French version is only a part of a very broader study including other tests and could differentiate student's profiles. The French version of 5 factors finally gives results in agreement with the original. The items (10 per factor) are selected according to their highest specificity and after elimination of redundancy. Validity remains in the short version, making it more useful in clinical practice.

Adolescent↗
PubMed2005

An integrated mini biosensor system for continuous water toxicity monitoring.

An integrated water toxicity monitoring system that uses recombinant bioluminescent bacteria was successfully developed for the continuous monitoring and classification of toxicities present in water. This system consists of four channels arranged horizontally inside of a cylinder, with each channel having two small bioreactors that are vertically connected to each other to maintain a separation of the culture reactor from test reactor. This system is easily handled and installed, making its application in the field a potential reality. As well, it performed stably and continuously due to the vertical separation of the culture reactor from the test reactor and a long term operation was also performed because of its small working volume, i.e., only 1 ml for the 1st bioreactor and 2 ml for the 2nd. During an operation with four strains, i.e., EBHJ2, DP1, DK1 and DPD2794, which are responsive to superoxide damage (EBHJ2 and DP1), hydrogen peroxide (DK1), and DNA damage (DPD2794), the O.D. and bioluminescence of the bacterial cultures inside the system were constant when no chemical was injected. However, with the addition of paraquat, hydrogen peroxide or mitomycin C, the bioluminescent responses of the strains were found to be dose-dependent to different concentrations of these chemicals.

Biological Assay↗
PubMed1989

Lumped versus distributed thermoregulatory control: results from a three-dimensional dynamic model.

In this study we use a three-dimensional model of the human thermal system, the spatial grid of which is 0.5 ... 1.0 cm. The model is based on well-known physical heat-transfer equations, and all parameters of the passive system have definite physical values. According to the number of substantially different areas and organs, 54 spatially different values are attributed to each physical parameter. Compatibility of simulation and experiment was achieved solely on the basis of physical considerations and physiological basic data. The equations were solved using a modification of the alternating direction implicit method. On the basis of this complex description of the passive system close to reality, various lumped and distributed parameter control equations were tested for control of metabolic heat production, blood flow and sweat production. The simplest control equations delivering results on closed-loop control compatible with experimental evidence were determined. It was concluded that it is essential to take into account the spatial distribution of heat production, blood flow and sweat production, and that at least for control of shivering, distributed controller gains different from the pattern of distribution of muscle tissue are required. For sweat production this is not so obvious, so that for simulation of sweating control after homogeneous heat load a lumped parameter control may be justified. Based on these conclusions three-dimensional temperature profiles for cold and heat load and the dynamics for changes of the environmental conditions were computed. In view of the exact simulation of the passive system and the compatibility with experimentally attainable variables there is good evidence that those values extrapolated by the simulation are adequately determined. The model may be used both for further analysis of the real thermoregulatory mechanisms and for special applications in environmental and clinical health care.

Body Temperature Regulation↗
PubMed1993

Pancreatic islet transplantation: is purification necessary?

Successful islet allotransplantation in diabetic patients has been slow to develop. In the past, it has been assumed that the low success rates are, in part, due to difficulty in obtaining high-quality human islet preparations. The assumption has been that purified islets are essential because exocrine contamination hampers engraftment and makes islets more vulnerable to rejection by increasing graft immunogenicity. We reviewed the existing experimental data on the consequences of exocrine contamination and concluded that most clinical trials of islet allotransplantation have involved efforts to over-purify the allograft. Until antigen-specific tolerance or the biohybrid artificial pancreas is a reality, the best strategy for clinical trials is to test new immunosuppressive protocols in a search for a more effective way of modifying the host's immune response while maximizing islet yield by using less pure preparations.

Animals↗