The effect of chlorpromazine upon psychophysiological, endocrine and information processing measures in schizophrenia.
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Visual, auditory and brainstem event-related potentials were obtained from patients with hepatocellular and cholestatic disease and a control group of normal subjects. The results did not reveal systematic neurophysiologic disturbances in persons with well compensated cirrhosis. It is concluded that short-latency event-related potentials are rather insensitive for detecting subclinical hepatic encephalopathy.
Cognitive event-related potentials (ERP) were recorded in 100 HIV-positive patients of all CDC stages without clinical CNS deficits with an auditory oddball paradigm. Four latency peaks and three amplitudes were evaluated (N1, P2, N2 and P3 latencies, N1-P2, P2-N2 and N2-P3 amplitudes). In contrast to an age-matched control group of comparable education and social environment, a statistically significant N2-P3 amplitude reduction was found in the patient group deteriorating with the CDC stages. The physiological N2-P3 amplitude reduction with age in normals was found to be twice as fast in HIV-positive individuals. No group-statistically relevant EEG abnormalities were found in the patient group. In psychometric testing, there was no marked depressive syndrome in the HIV-positive individuals, but a mild slowing of speed-dependent abilities.
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Hydrocephalic, letter reversal and normal children were tested with a tactile matching-to-sample task, a tachistoscopic matching-to-sample task, and a dichotic listening paradigm. For hydrocephalics, intrahemispheric as well as interhemispheric errors occurred; the partial callosal hypothesis was not supported. Letter reversal children demonstrated an interhemispheric deficit only in tactile performance.
A theory of anaesthesia is presented. It consists of four hypotheses: (1) The occurrence of states of consciousness causally depends on the formation of transient higher-order, self-referential mental representations. The occurrence of such states is identical with the appearance of conscious phenomena. Loss of consciousness will occur, if and only if the brain's representational activity falls below a critical threshold. (2) Mental representations are instantiated by neural cell assemblies. (3) The formation of assemblies involves the activation of the NMDA receptor channel complex. The activation state of this receptor determines the rate at which assemblies are generated. (4) General anaesthetics have a common operative mechanism: they directly or indirectly affect the function of the NMDA system.
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