[Effect of tetracycline therapy on cyclase system in patients with acute dysentery].
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The in vitro and in vivo (white mice) studies have shown that female sex hormones, especially folliculin and hexestrol, as well as the deficiency of the T-lymphoid system of the organism in which the microbe is circulating, and also some microbial cell components accelerate the synthesis of S. typhi antigens serologically similar to the antigens of the microorganism. Antibiotics, especially oxacillin and ampicillin, sulfa drugs, especially sulfadimethoxine, inhibit antigenic mimicry in S. typhi. A suggestion is made on the interrelationship between the factors responsible for the mimicry antigens production and those for the formation of hydrogen sulfide.
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Widespread dermatitis developed in three women after use of vaginal preparations. Besides allergic contact dermatitis, these cases involved erythema multiforme and a photosensitive eruption. Antigen absorption into the general circulation through the vaginal wall, and its deposition at distant skin sites, appeared to account for the spread of the eruption. This type of eruption is akin to the systemic, eczematous, contact-type dermatitis mediated by a systemically given drug in a primarily cutaneously sensitized person.
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A study was carried out on the influence of the treatment with furasolidon and altabactin, alone and in combination with spectam and Esb3, in naturally infected and chronically suffering from typhus-puporosis fowls. It was proved that the treatment leads to a clinical but not to a epizootological recovery. It was also proved that the treatment of fowls against typhus-pulorosis, did not have any effect on the sensitivity, the specificity and the detectability of the allergic reaction, whereas the diagnostic value of the serological reaction always diminished. With all the fowls treated, characteristic pathohistological changes were detected, typical of typhus-pulorosis, which make more complete the results of the serological, the allergic and the bacteriological studies, and contributed to the detection of chronically ill fowls.
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