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[Enteral tube feeding early after surgery on the stomach and the duodenum].

Experience in enteral tube feeding (ETF) early after stomach resection, gastrectomy, reconstructive surgeries for chronic duodenal obstructions and postgastroresection disorders in 1716 patients is presented. Irrigators were installed in the jejunum during surgery, more rarely--through gastroscope below distal anastomosis. During the first day saline solutions were administered, further--nutritional cocktails. Period of ETF was 5.8 +/- 0.8 days in uncomplicated postoperative period and from 9 to 73 days in postoperative complications. ETF stimulates motor, resorption, synthetic, barrier functions of the small intestine. ETF permits to improve immediate results of stomach and duodenum surgery and to reduce cost of treatment.

Duodenal Obstruction↗

[Selective anterior vagotomy of the duodenum. Propositions, technics and experimental results].

Previous studies have demonstrated that changes in endoduodenal pressure may cause pancreatic alterations in biliary diseases. Anterior selective vagotomy of the duodenum was devised to reduce duodenal motility. An experimental study showed that such a surgical procedure is followed by a marked decrease in the overall duodenal kinesis, with disappearance of the highest pressure peaks.

Animals↗

[Quantitative study of serotonin-containing cells in fetal rabbit duodenum].

In order to attempt identification in vitro of parameters involved in the cellular differenciation, it was necessary to possess a standard material with identical content and distribution of serotonin cells; these two properties are investigated in this paper. Falck's technic is the only sensitive and specific method in demonstrating serotonin young cells devoid of argentaffinity. From 21, 22, 23 and 25 days old rabbit foetuses, 10 mm length duodenal pieces were treated according to Falck and sections serially cut at 8 microns. Some of these specimens were divided prior to Falck treatment in two pieces 3 mm away from the pylorus and in each piece 200 paraffin sections were cut at 8 microns beginning by adjacent ends and progressing in opposite direction. The number of EC sections in 400 whole transverse sections were determined for each foetus. Great variations were observed from one foetus to another, along the intestine, with weight and age. The Student-Fisher test applied to two consecutive pieces of the same duodenum gathering foetuses in groups of 5 animals did not show significative differences from a group to another. Thus, this material can be employed for comparisons under experimental conditions.

Animals↗

Mechanism of the relaxant response of the rat duodenum to bradykinin.

Bradykinin (BK) did not increase cyclic AMP production in cultured rat duodenum smooth muscle cells. Its relaxant effect on the tissue was inhibited by apamin and potentiated by phorbol dibutyrate (PDBU). PDBU also caused a relaxation which was inhibited by apamin. BK's relaxant effect, and its potentiation by PDBU, are due to activation of Ca(2+)-dependent K+ channels.

Animals↗

[The osmotic regulation of gastrin secretion by the isolated rat duodenum].

Activating effect of osmotic irritant agent was suppressed by N- and M-cholinoblocking agents, benzohexonium and pyrenzepine in the rat isolated duodenum. The same was true for phentolamine and not for obsidan. The data obtained suggest that the osmotic regulation of the gastrin secretion is performed through the mechanism of a local intramural reflex with participation of N- and M-cholinoreactive and alpha-adrenoreactive agents.

Animals↗

[The characteristics of the opioid regulation of the afferent reactions of the stomach and duodenum to the early stages of their acute damage].

Acute cat experiments were conducted to study the effect of naloxone, moradol and dalargin on the formation of afferent reactions of gastroduodenal complex components by registration of cortical and subcortical evoked potentials during electrostimulation of the stomach and duodenum at an early stage of their acute lesion. It is found that agonists and antagonists of opiate receptors prevent the depression of afferentation of gastroduodenal complex components early after acute lesion. It is suggested that the main mechanism underlying the depression of gastric and duodenal afferent reactions at early post-alteration period may be related to activation of intraorganic opioid systems.

Afferent Pathways↗

[Primary adenocarcinoma of the duodenum: a report of 2 cases and a review of the world literature].

We presented two cases of adenocarcinoma of the duodenum diagnosed at the Gastroenterology Unit of the General Hospital of Lidice Dr. Jesús Yerena and reviewed retrospectively the pathology cases from 1980-1990. We review the world literature and found that the most common clinical presentation was as obstructive type. In our cases perforation and jaundice were the presentation.

Adenocarcinoma↗

Subtotal gastric resection; an appraisal of a means of treatment of benign peptic ulceration of the stomach and duodenum.

In a series of 400 cases of subtotal gastric resection for the treatment of benign ulceration of the stomach and duodenum, the mortality, morbidity and recurrence rate was acceptably low. Fifty-six per cent of the patients had a perfect result, 38 per cent satisfactory, and 6 per cent unsatisfactory. However, the postoperative nutritional status was sufficiently interfered with in a number of patients whose preoperative weight was subnormal that the routine adoption of 75 per cent gastric resection must be questioned. Vagotomy with either pyloroplasty or partial resection may prove to be the most valuable procedure for patients of this type. In properly selected patients, however, gastric resection is a rewarding procedure for both patient and surgeon.

Duodenum↗

Iron malabsorption in a patient with large cell lymphoma involving the duodenum.

Iron malabsorption compounded the anemia in a patient with diffuse large cell lymphoma involving the small intestine. Both upper gastrointestinal series with small bowel follow-through and computerized tomographic scan demonstrated lymphomatous involvement of the duodenum and proximal jejunum by a retroperitoneal mass. An oral iron-loading absorption test was consistent with malabsorption of iron. After two cycles of systemic chemotherapy, the retroperitoneal mass resolved and the iron loading test normalized.

Adult↗

Endocrinocarcinomas (carcinoids and their variants) of the duodenum. An evaluation of 927 cases.

This study was undertaken to supplement our previous analysis of 635 duodenal carcinoids to give both wider and different viewpoints on a larger series of duodenal endocrinocarcinomas, and to provide up-to-date clinicopathologic information regarding these neoplasms. A total of 927 cases of such neoplasms of the duodenum were collected from the Niigata Registry for gut-pancreatic endocrinomas, consisting of the carcinoid group with 897 cases, 857 typical carcinoids and 40 atypical varieties, and the variant group with 30 remaining endocrinocarcinomas expressed by various terminology. Significant statistical differences between these two groups were evident in various aspects: in sites of tumor growth, aggressiveness of invasion to the extra-duodenal structures, rates and sites (liver, lymph nodes and bone) of metastases, average tumor-size, immunohistochemistry of gastrin and serotonin, rates of recurrence, five-year survival rates and others. In addition, a close similarity between these two groups was noted in several aspects of histology, histochemistry and immunohistochemistry, rendering the variant group in a member of the carcinoid family. Regarding the carcinoid group in comparison with that in other organs may be summarized as follows: a reasonable male/female ratio of 1.39, a reasonable average age of 55.9 years, a high typical/atypical ratio of 21.4, a relatively small average tumor-size of 17.7 mm, a relatively low metastasis rate of 27.4%, a high histologic B-type dominance of 75.5%, a high postoperative survival rate of 83.3% and a reasonable incidence of the carcinoid syndrome of 3.1%.

Adolescent↗

[Early diagnosis of intra-abdominal complications after surgery on the stomach and the duodenum].

Ultrasonic examination early after surgery permits to visualize "zone of surgery", to evaluate stomach, duodenum or their stump, to diagnose motor-evacuatory and purulent-septic complications, to determine policy of their treatment. Dynamic ultrasonic examinations permit to realize daily monitoring of "surgical zone" and timely correction of therapy, to reduce number of x-ray and endoscopic examinations after surgery that leads to improving of treatment results.

Abdomen↗

[Effect of DOPA and dopamine on the motility of isolated rat duodenum in vitro].

The motor effects of DOPA and Dopamine on the isolated rat duodenum in vitro have been studied by establishing successive dose- response curves. These effects are either excitatory or inhibitory according to the concentrations used. In every case they are of small amplitude. The inhibitory effects do not exist in the presence of alpha, and beta blocking agents. The excitatory effects are suppressed by using a serotoninergic blocking agent.

Animals↗

Primary papillary adenocarcinoma in the third portion of the duodenum.

We herein report a rare case of papillary adenocarcinoma which occurred in the third portion of the duodenum. The patient was a 62-year-old Japanese male who was admitted due to vomiting and right lower abdominal pain. No abnormal findings were found in the laboratory examinations. After a diagnosis of primary duodenal carcinoma was made by radiologic, endoscopic and ultrasonographic studies, a pancreatoduodenectomy was performed. The histology of the resected specimen revealed papillary adenocarcinoma, with invasion reaching to the pancreatic body. Some characteristic features of the disease are also reviewed.

Adenocarcinoma, Papillary↗

[Morphofunctional characteristics of secretion-producing structures of the gastric and duodenal mucosa in liquidators of aftermaths of the Chernobyl accident with peptic ulcer of the duodenum].

With the aid of the comparative structural analysis of 145 biopsy specimens of the gastric and duodenal mucosa obtained from two groups of patients with peptic ulcer of the duodenum (liquidators of effects of the Chernobyl power plant accident and those subjects comprizing the control group), particular morphological features were revealed in the liquidators. These included the following: significant decline in parameters for parietal cells (mostly nuclei), striking alterable changes in their cytoplasma; transformation of the process of glycosylation of glycoproteins in the course of mucus production with disturbances of formation, excertion of the secretion and cytoprotective properties of the mucus; increase in the proliferative activity of the epithelium with insufficiency of cytodifferentiation and functional inadequacy.

Biopsy↗

Endocrine tumors of the duodenum. A study of 55 cases relative to clinicopathological features and hormone content.

BACKGROUND/AIMS: Study of prognosis of duodenal endocrine tumors. METHODOLOGY: Retrospective study concerned 55 duodenal endocrine tumors discovered in biopsy or surgical specimens. Follow-up records available for 49 patients indicated that inconspicuous associated clinical manifestations were often found subsequently. Seven patients were classified as Zollinger-Ellison syndrome and seven as multiple endocrine neoplasia (6 MEN I and 1 MEN II). RESULTS: Tumors were small (mean 1.28cm) and located preferentially in the first and second part of the duodenum. Fifty-four were well-differentiated and one poorly differentiated. Immunochemistry revealed 30 G-cell tumors (54.6%), 15 D-cell (27.3%), two plurihormonal (EC cell and G cell), and one GRH-cell, whereas seven could not be classified. Fifteen patients died (five in relation to their disease). Twenty-one had metastases (liver, nodes, lung), eight of whom are still alive. CONCLUSIONS: Eighty-eight percent of duodenal endocrine tumors were gastrinomas, small plurifocal tumors and somatostatinomas preferentially located in the ampullar region and diagnosed because of hematemesis or icterus. Size is an important prognostic factor in determining whether surgery is required. The prognosis is better for D- and G-cell tumors than pancreatic endocrine tumors. Duodenal endocrine tumors in multiple endocrine neoplasia have a good prognosis, but can be associated with pancreatic plurihormonal tumors and metastases.

Adolescent↗