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PubMed1978

Physicochemical properties of a proline-rich polypeptide (PRP) from ovine colostrum.

Properties of a proline-rich polypeptide (PRP) accompanying ovine colostral IgG2 are described. PRP is soluble at 4 degrees C but reversibly precipitates by warming to room temperature. Maximal precipitation is observed at pH = 4.6, temp. 48 degrees C, and ionic strength higher than 0.6. There is a linear dependence of precipitation on concentration of PRP. Molecular weight of PRP is 38,000 daltons. It is not changed in the presence of 6 M guanidine hydrochloride, SH-compounds, and in the presence or absence of metal ions. PRP is built of one polypeptide chain. No difference in proteolysis of IgG2 by pepsin, papain and trypsin in the absence or presence of PRP was found.

Animals↗
PubMed1987

[Vitamin C concentrations in maternal plasma, amniotic fluid, umbilical cord blood, the plasma of newborn infants, colostrum and transitory and mature breast milk].

Vitamin C concentrations have been measured in the plasma of 200 mothers and their newborns as well as in amniotic fluid and breastmilk. Out of this group 19 mother-infant-pairs were taken as normal control group with no risk factors, complications or diseases during pregnancy or delivery or in the newborn infant. Vitamin C concentrations in plasma showed great variability. This is true for both the entire study group and the normal control group. A positive correlation was found between the vitamin C concentrations in maternal plasma at the time of admission to the obstetric unit and that in the second stage of labor immediately before delivery. Cord blood and newborn plasma vitamin C concentrations were nearly twice as high compared to maternal concentrations. They too correlate with the concentrations in the maternal plasma. A further correlation was found between maternal plasma and amniotic fluid at the time of delivery (ratio about 1:3). No more significant correlations of vitamin C concentrations have been found in the normal control group. Various diseases or risk factors in mother and/or child were shown to be associated with lower vitamin C concentrations. Vitamin C concentrations were considerably lower in all biological fluids in smokers and mothers with diabetes. Other statistical correlations will be shown and possible casualties will be discussed. In this study vitamin C concentrations in groups with abnormal states are documented only with small numbers of cases and are therefore considered as a basis for further more specific investigations.

Adolescent↗
PubMed1985

Effect of human colostrum and infant formula on the phagocytic activity of macrophages. I. Resident and stimulated mouse peritoneal macrophages.

Phagocytosis and degradation of radiolabelled human transferrin-anti-transferrin immune complexes by resident and stimulated mouse peritoneal macrophages was inhibited by liquid infant formula, particularly in the case of resident cells. Mouse peritoneal macrophages exposed to infant formula were shown by immunofluorescence to bind casein and beta-lactoglobulin, but there was little binding of alpha-lactalbumin. Comparison of various artificial milks, cow's milk and purified casein indicated that both the concentration and the degree of denaturation of casein may be important in the impairment of macrophage function by milk. It is suggested that bottle feeding of infants might result in impairment of macrophage function in the small intestine.

Animals↗