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At least 1,423 records · Page 79Linked to original sources
PubMed1981

[Chromatin structure with no nucleosomes: dissociated SV40 virus].

The mild dissociation of SV40 virus particles at pH 7.5 yields a nucleoprotein complex containing all the capsid proteins and histones of the intact virion. Electron microscopic observations show a bead-on-a-string structure comprising about 70 particles 7 nm in diameter along the viral DNA. No particle of nucleosome size was visible. The compaction of DNA in this complex is lower than 2 and is likely to be close to unity.

Animals↗
PubMedDate not supplied

[Experimental infection of green monkeys with adenoassociated virus].

Primary infection and reinfection with adeno-associated virus type 4 (AAV-4) was reproduced in green monkeys experimentally infected with AAV-4 in mixture with adenovirus. Wide dissemination of the satellite virus in animals was observed. AAV-4 and its antigen were detectable 5 to 23 days after inoculation. In monkeys infected with a mixture of AAV-4 and adenovirus or with one of them the infection was accompanied by a marked fever persisting from the 5th to the 20th day after inoculation. The infected monkeys showed an intensive rise of homologous antibody titer most marked on the 10th-15th day after inoculation with AAV-4. AAV-4 and its antigen were detected in smears from conjunctival and tonsillar mucosa, rectal specimens in the time course of the infectious process, as well as from the trachea, lungs, liver, spleen, intestines and kidneys of the sacrificed monkeys. Besides, AAV-4 antigen was found in cells of the tonsils and blood leukocytes of the sacrificed monkeys. No virus or its antigen were found in the brain and heart tissues. Virions of adeno-associated virus were found by electron microscopic examinations of kidney cells of one of 3 monkeys infected with AAV-4.

Adenoviruses, Simian↗
PubMedDate not supplied

[Isolation of adeno-associated virus type 4 from a culture of green monkey kidney cells].

In the process of biological control of uninfected green monkey kidney (GMK) cell cultures a thermostable hemagglutinating agent designated No. 5056 was isolated alongside with adenovirus-SV. By its antigenic properties the 5056 strain was identified as adeno-associated virus type 4 (AAV-4). In control of 574 specimens of GMK culture batches, 40 AAV-4 strains were isolated in the presence of a helper adenovirus. Some biological properties of the isolates and their resistance to certain physical and chemical treatments were studied. Two isolates of the satellite virus were examined in the electron microscope. A correlation between the rate of AAV-4 isolation from GMK cultures and the presence of complement-fixing antibody to AAV-4 in monkey sera was observed.

Animals↗
PubMed1976

Studies on the characteristics of poliovirus type 3. II. Characteristics of "hot" clones.

Markers d, IST, EA1(OH)3, rct (at sub- and supraoptimal temperatures) and neurovirulence were determined for clones isolated from two lots (S2 and S3) of vaccines containing poliovirus strain Leon 12a1b. Changes of markers rct, d and neurovirulence were observed in several clones isolated from S2 vaccine. No changes were observed in IST and EA1(OH)3 markers.

Animals↗
PubMed1984

Chromosome study of Presbytis cristatus: presence of a complex Y-autosome rearrangement in the male.

The karyotypes of a female and of a male Presbytis cristatus are analysed. In the latter, there is a complex Y-autosome rearrangement. The phyletic position of this species, in relation to genus Colobus, previously studied, is proposed, considering the sequence of chromosomal rearrangements which occurred during their evolution. These rearrangements, in addition to the t(Y-autosome), are characterized by a high frequency of inversions, and above all, by several non-Robertsonian translocations which occurred very rarely during evolution of other Primates.

Animals↗
PubMed1984

The grivet monkey as a model for study of vaginitis. Challenge with anaerobic curved rods and Gardnerella vaginalis.

The grivet monkey was used as an experimental model for vaginitis. Gardnerella vaginalis was used for challenge in one monkey. G. vaginalis plus a long variant (LCR) of a hitherto unclassified anaerobic curved rod (CR) in another 2 monkeys, this LCR alone in 2, a short variant (SCR) of CR in 2, and G. vaginalis plus SCR in one monkey. All the bacterial strains had been isolated from human vaginal specimens. In the 2 monkeys exposed to G. vaginalis plus LCR, distinct signs of bacterial vaginosis characterized by a thin, grey and translucent discharge appeared after 5 days and were still present at the end of the 6-week observation period. LCR alone produced, if anything, a slight increase in the vaginal discharge after about 4-5 weeks. In the remaining monkeys there was no increase of vaginal secretion. The CR could still be isolated at the end of the observation period. LCR persisted for 9 months in one monkey, without having produced any obvious signs of vaginitis, which, however, did appear when the monkey was challenged with G. vaginalis too. G. vaginalis could be recovered up to 12 days after incubation in the monkeys also infected with CR, but at no time from the monkey challenged with G. vaginalis only. Bacteria of the G. vaginalis morphotype could be observed in Gram-stained vaginal smears collected throughout the observation period. Although having certain limitations, the model would seem to be of use for the study of bacterial vaginosis. Such a model in primates has not hitherto been available.

Animals↗
PubMedDate not supplied

Comparative effects of meal timing on circadian rhythms of plasma insulin and skin surface temperature in non-human primates.

Circadian rhythms of plasma immunoreactive insulin and skin surface temperature were demonstrated in a group of African green vervets. Alteration in the timing of a single daily meal of fixed calorie content resulted in an acrophase shift of plasma immunoreactive insulin for the group of animals and in an acrophase shift of skin surface temperature in 7 or the 8 animals studied. The acrophase shift of skin surface temperature was considerably less then the shift of acrophase of plasma immunoreactive insulin, which closely approximated the shift in meal timing. The results of this study are compared with results of similar studies in human beings.

Animals↗
PubMed1983

Measurement of apolipoprotein A-I concentration in nonhuman primate serum by enzyme-linked immunosorbent assay (ELISA).

A sensitive and specific enzyme-linked immunosorbent assay (ELISA) for nonhuman primate serum apolipoprotein A-I (apoA-I) is described. The assay is a noncompetitive, sandwich ELISA in which polystyrene microtiter plates were used with purified, monospecific goat anti-monkey apoA-I antibodies adsorbed on the wells. The serum samples were added to the coated wells, incubated, and after washing, antibodies conjugated to horseradish peroxidase were added. After further washing, the bound label was assayed. A heat treatment step, 52 degrees C for 3 hr, was used to maximize the apoA-I immunoreactive sites in diluted serum. Serum samples extracted with chloroform-methanol, delipidated with tetramethylurea, or denatured by heating gave essentially equivalent results. The working range of the apoA-I standards was 0.5 to 5 ng and parallel responses were observed for apoA-I in serum, in isolated HDL, and in buffer as a purified apoprotein. Recovery of apoA-I added to serum was quantitative (106 +/- 3%). The intra- and interassay coefficients of variation were 6.2 and 6.9%, respectively. The enzyme immunoassay yielded values that compared favorably with those obtained by radial immunodiffusion (r = 0.84). ApoA-I concentration in African green monkey serum was highly correlated with the HDL cholesterol concentration (r = 0.86). It is concluded that this ELISA is an accurate and precise method for determination of apoA-I concentrations in primate serum.

Animals↗
PubMedDate not supplied

Monkey animal model for study of mycoplasmal infections of the urogenital tract.

Various experimental monkey models have been used for the study of mycoplasmal infections of the urogenital tract. Direct inoculation of Mycoplasma hominis and Ureaplasma urealyticum into the urethra of male monkeys resulted in successful reisolation of the organisms from the urethra without giving rise to signs of urethritis during the observation period. The organisms were inoculated into the posterior fornix of the vagina of female grivet monkeys. During the ten-week observation period, there was no clinical, histologic, or serologic evidence of lower genital tract infection. Inoculation of M. hominis and M. fermentans into the upper genital tract of grivet monkeys produced parametritis and salpingitis. It was concluded that grivet monkeys are apparently suitable for study of the pathogenicity of genital mycoplasms.

Animals↗
PubMed1983

Cardiac lymph drainage in experimental African trypanosomiasis in vervet monkeys.

In group I (15 monkeys) the infection time was less than 70 days with one exception and histologically 14 had trypanosomal pancarditis with morphological evidence of lymph stasis. Trypanosomes served as markers of the dilated cardiac lymphatics seen at apices, atrioventricular junctions, near the His bundle, at the base of cardiac valves and around the root of the aorta and pulmonary artery. 3 hearts had apical aneurysms. In group II (6 monkeys) the infection time exceeded 130 days and despite specific non-arsenical treatment all relapsed. Histologically focal cardiac fibrosis and extravascular trypanosomes within the brain were seen (encephalitis), the latter was absent in group I. The impairment of the cardiac lymph flow is contributory to the development of pericarditis, valvulitis, myocytolysis, apical aneurysm as well as fibrosis, and it may well be a common denominator in the pathogenesis for cardiopathies induced by various pathogenes .

Animals↗
PubMed1983

Plasma cortisol response to feeding in African green vervets.

The timing of a single daily meal of monkey chow in African green vervets exerts a synchronizing influence on plasma cortisol concentrations with an initial increase after feeding followed by a decrease to minimal levels five hours after feeding.

Animals↗